Genentech

Many personalized cancer treatments aim to block out-of-control signals that drive tumor growth. However, some pathways, like PI3K in breast cancer, have proven challenging to target given their vital role in normal cell processes. Anwesha Dey, Senior Director & Scientist in Discovery Oncology at Genentech, uses everyday objects to explain how a new scientific advancement selectively destroys the mutant PI3K protein in cancer cells. Watch her explain how this discovery offers a new, more precise way of targeting the pathway and the significant implications for the treatment of breast cancer: http://spr.ly/6041sPZd7

Macrophages play a vital role in the immune system and are implicated in various diseases, especially during chronic inflammation. In a recent Nature Genetics study, our scientists used single-cell CRISPR screening to identify key genetic regulators in macrophages that influence different inflammatory “states.” Their findings highlight potential therapeutic targets that could lead to new treatments for inflammatory diseases. In the image shown here, macrophages are shown in green in intestinal tissue. Learn more about this research at the intersection of immunology and inflammation: http://spr.ly/6047s3C4H

One of the most commonly mutated genes in breast cancer is PIK3CA, which is found in over 40% of HR+ breast cancers. This mutation occurs when the signaling in the PI3K pathway goes haywire, leading to uncontrolled cell growth. Targeting the PI3K pathway has been a compelling goal, as it enables new ways to fight cancer. With three everyday objects, Marie-Gabrielle Braun, Senior Principal Scientist & Project Leader at Genentech, explains how advancements in targeting PI3K have allowed scientists to inhibit the out-of-control signaling that fuels cancer growth while minimizing disruption of healthy cells. Learn more: http://spr.ly/6044sJrWy

Applications are now open for our 2025 Graduate Student Symposium in Chemical Research! We invite 4th-year Ph.D. students specializing in organic chemistry, chemical biology, or computational chemistry to take part in this exciting event. Participants will be able to network with biotech professionals and enjoy a guided tour of our South San Francisco campus. Don't miss out—learn more and apply by December 31st. http://spr.ly/6044sBC2i

Cancer occurs when normal biological signals in the body go haywire. Known as dysregulation, this can drive uncontrolled tumor growth and lead to poor prognosis. In breast cancer, PI3K is a commonly impacted signaling pathway that’s important for cell function. Jennifer Schutzman, Lead Medical Director at Genentech, uses everyday objects to explain haywire PI3K signaling in breast cancer and the impact of turning off this signal with targeted treatments. Learn more: https://lnkd.in/gajy3cMB

Meet Denise Gastaldo, a Postdoctoral Fellow in Neuroscience from Italy, who is studying amyotrophic lateral sclerosis (ALS). Her research aims to characterize the molecular mechanisms underlying neuroprotection and to identify targets that could prevent neuronal degeneration and promote neuronal survival in ALS. Denise aspires to develop life-changing treatments for brain disorders and lead her own research team. Learn more in the video below and explore our postdoctoral programs here: http://spr.ly/6042SAC7M

Today, as we honor Veterans Day, we’re shining a spotlight on our employee resource group, gVETS, and its impact on our company and the communities we serve. From lifting up veteran stories to organizing mentorship and volunteer initiatives to support local communities, gVETS honors the contributions of veterans at Genentech and supports veterans and their families, while cultivating inclusion, professional development and camaraderie. Below, Holly Kingston, Therapeutic Area Manager, gVETS Communications Lead and Active Duty Air Force Nurse veteran, reflects on the group’s meaning and impact. #VeteransDay

As part of our ongoing efforts to advance women’s health, we recently joined our Roche LATAM colleagues for a two-day event in Miami, convening healthcare providers, patient advocates, policymakers, and thought leaders for keynotes and panel discussions on closing the gender health gap. Events like this are just one of many ways we are working to change the trajectory of women’s health across the globe. Learn more about how we’re working #TogetherForChange. http://spr.ly/6042Saj76 #RochePressDay

Congratulations to the first graduating class of the Genentech-funded Gateways to Medicine and Research Master’s Program at the University of Minnesota! Through this program, we’re helping to equip students from Native communities with training and research opportunities to prepare them for careers in healthcare. During the recent graduation ceremony, graduates including Kayli and Andyr (pictured below) received traditional ceremonial blankets – symbols of warmth, ancestral wisdom, resilience and interconnectedness in Ojibwe culture. This #NativeAmericanHeritageMonth, learn more about how we’re collaborating to advance diversity in STEM to create a more equitable and inclusive healthcare system: http://spr.ly/6048Ssaqg

We're presenting new and long-term follow-up data at #ASH24 reflecting our long-standing commitment to further improve outcomes for people living with #lymphoma. Learn more about our efforts to advance treatment options: http://spr.ly/6043S9ffW