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Volume 30
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10.3390/molecules30030624
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Design of Decanoic Acid/Polysorbate 80 Composite Vesicles as Cosmetics Carrier: Stability, Skin Permeability, Antioxidant and Antibacterial Activity

by
Ying Yang
1,
Bohang Zou
1,
Xinyu Fan
1,
Xinyue Ma
1,
Siqi Li
1,
Xiangyu Zhang
1,2,*,
Jinlian Li
1,2 and
Dongmei Wu
1,2
1
College of Pharmacy, Jiamusi University, Jiamusi 154007, China
2
Heilongjiang Provincial Key Laboratory of New Drug Development and Pharmacotoxicological Evaluation, Jiamusi University, Jiamusi 154007, China
*
Author to whom correspondence should be addressed.
Molecules 2025, 30(3), 624; https://doi.org/10.3390/molecules30030624
Submission received: 30 December 2024 / Revised: 23 January 2025 / Accepted: 28 January 2025 / Published: 31 January 2025
(This article belongs to the Section Medicinal Chemistry)
Versions Notes

Abstract

Fatty acid vesicles are natural biomaterials which possess unique bilayer structures and offer biomimetic advantages for drug and gene delivery. Nevertheless, the formation of fatty acid vesicles is limited to neutral alkaline circumstances and cannot adapt to the acidic environment of the living system. In this work, the non-ionic surfactant polysorbate 80 (TW80) was introduced, extending the pH window of vesicles formed by decanoic acid (DA) from 6.90–7.80 to 2.28–6.31. The DA/TW80 composite vesicles were used to encapsulate quercetin (QT), achieving an encapsulation efficiency of up to 75.6%. The formation of DA/TW80/QT composite vesicles was confirmed through Fourier transform infrared spectroscopy, differential scanning calorimetry, and X-ray diffraction. Moreover, free QT was released rapidly, while QT encapsulated in the DA/TW80 composite vesicles demonstrated a slower release profile. Skin permeability studies revealed that the cumulative drug penetration within 24 h using the DA/TW80/QT composite vesicles reached approximately 904.7 μg·cm−2, 1.81 times higher than that of a QT solution. Furthermore, the DA/TW80/QT composite vesicles demonstrated enhanced antioxidant activity and greater antibacterial efficacy compared to either the drug or the vesicles alone. The results provide a crucial foundation for the application of drug-loaded vesicles in cosmetics.
Keywords: fatty acid vesicle; cosmetics carrier; skin permeability; antibacterial activity fatty acid vesicle; cosmetics carrier; skin permeability; antibacterial activity

Share and Cite

MDPI and ACS Style

Yang, Y.; Zou, B.; Fan, X.; Ma, X.; Li, S.; Zhang, X.; Li, J.; Wu, D. Design of Decanoic Acid/Polysorbate 80 Composite Vesicles as Cosmetics Carrier: Stability, Skin Permeability, Antioxidant and Antibacterial Activity. Molecules 2025, 30, 624. https://doi.org/10.3390/molecules30030624

AMA Style

Yang Y, Zou B, Fan X, Ma X, Li S, Zhang X, Li J, Wu D. Design of Decanoic Acid/Polysorbate 80 Composite Vesicles as Cosmetics Carrier: Stability, Skin Permeability, Antioxidant and Antibacterial Activity. Molecules. 2025; 30(3):624. https://doi.org/10.3390/molecules30030624

Chicago/Turabian Style

Yang, Ying, Bohang Zou, Xinyu Fan, Xinyue Ma, Siqi Li, Xiangyu Zhang, Jinlian Li, and Dongmei Wu. 2025. "Design of Decanoic Acid/Polysorbate 80 Composite Vesicles as Cosmetics Carrier: Stability, Skin Permeability, Antioxidant and Antibacterial Activity" Molecules 30, no. 3: 624. https://doi.org/10.3390/molecules30030624

APA Style

Yang, Y., Zou, B., Fan, X., Ma, X., Li, S., Zhang, X., Li, J., & Wu, D. (2025). Design of Decanoic Acid/Polysorbate 80 Composite Vesicles as Cosmetics Carrier: Stability, Skin Permeability, Antioxidant and Antibacterial Activity. Molecules, 30(3), 624. https://doi.org/10.3390/molecules30030624

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