Molecules

9 KiB

Open AccessBook Review

The Weak Hydrogen Bond: Applications to Structural Chemistry and Biology(International Union of Crystallography Monographs on Crystallography, 9). By Gautam R. Desiraju

by Shu-Kun Lin

Molecules 1999, 4(10), 318-319; https://doi.org/10.3390/41000318 - 31 Oct 1999

Cited by 1 | Viewed by 5313

Abstract

This book is an important monograph for those working on the related structural chemistry of the weak hydrogen bond.[...] Full article

6 KiB

Open AccessBook Review

Organic Chemistry: Structure and Function. By K. Peter C. Vollhardt

by Luc Patiny

Molecules 1999, 4(10), 316-317; https://doi.org/10.3390/41000316 - 31 Oct 1999

Cited by 1 | Viewed by 8966

Abstract

Teaching organic chemistry is a challenging task and tools which allow students to understand what is happening during an organic reaction are really difficult to find.[...] Full article

31 KiB

Open AccessArticle

Trimethylcyanosilane as a Convenient Reagent for the Preparation of Trimethylsilyl Enol Ethers of 1,3-Diketones

by Jin-Cong Zhuo

Molecules 1999, 4(10), 310-315; https://doi.org/10.3390/41000310 - 10 Oct 1999

Cited by 2 | Viewed by 5987

Abstract

Trimethylsilyl enol ethers of 1,3-diketones are generated “in situ” or obtained in high isolated yield by the reaction of 1,3-diketones with trimethylcyanosilane in various solvents such as cyclohexane, hexane, benzene, methylene chloride, chloroform, carbon tetrachloride, and acetonitrile. Full article

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Scheme 1

94 KiB

Open AccessShort Note

3,5-Bis[5-(4-tert-butylphenyl)-1,3,4-oxadiazol-2-yl]benzenamine

by Frank Osterod and Arno Kraft

Molecules 1999, 4(10), M115; https://doi.org/10.3390/M115 - 8 Oct 1999

Viewed by 2937

Abstract

The reduction was carried out as described in reference [1] by using a mixture of sulfur (7.10 g, 0.22 mol), Na₂S — 9 H₂O (240 g, 0.22 mol), water (140 mL) and pyridine (20 mL).[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

92 KiB

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3,5-Bis[5-(4-tert-butylphenyl)-1,3,4-oxadiazol-2-yl]nitrobenzene

by Frank Osterod and Arno Kraft

Molecules 1999, 4(10), M114; https://doi.org/10.3390/M114 - 8 Oct 1999

Viewed by 3079

Abstract

A solution of 5-nitroisophthaloyl dichloride (1) [1] (3.92 g, 15.8 mmol) and 4-tert-butylbenzhydrazide (2) [2] (6.08 g, 31.6 mmol) in CHCl₃ (70 mL) was heated to reflux for 12 h.[...] Full article

85 KiB

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4,5-Dimethoxy-2-nitrobenzhydrol

by Sergey K. Smirnov, Tat'yana A. Stroganova and Alexander V. Butin

Molecules 1999, 4(10), M113; https://doi.org/10.3390/M113 - 8 Oct 1999

Viewed by 3506

Abstract

The general part of the experimental section [1] has been presented elsewhere. To a boiling solution of 4,5-dimethoxy-4-nitrobenzophenone (10.0 g, 35 mmol) in ethanol (85 ml), NaBH₄ (0.61 g) was added gradually. Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

85 KiB

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1-(4,5-Dimethoxy-2-nitrophenyl)ethanol

by Dmitrij S. Zavgorodniy, Tat'yana A. Stroganova and Alexander V. Butin

Molecules 1999, 4(10), M112; https://doi.org/10.3390/M112 - 8 Oct 1999

Viewed by 3165

Abstract

The general part of the experimental section [1] has been presented elsewhere.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

84 KiB

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4,5-Dimethoxy-2-nitroacetophenone

by Dmitrij S. Zavgorodniy, Alexander V. Butin and Tat'yana A. Stroganova

Molecules 1999, 4(10), M111; https://doi.org/10.3390/M111 - 8 Oct 1999

Cited by 1 | Viewed by 3217

Abstract

The general part of the experimental section [1] has been presented elsewhere.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

85 KiB

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4,5-Dimethoxy-2-nitrobenzophenone

by Sergey K. Smirnov, Alexander V. Butin and Tat'yana A. Stroganova

Molecules 1999, 4(10), M110; https://doi.org/10.3390/M110 - 8 Oct 1999

Viewed by 3141

Abstract

The general part of the experimental section [1] has been presented elsewhere.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

91 KiB

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4-[5-(4-methylphenyl)-2-furfuryl]iden-2-butenolide

by Lyudmila N. Sorotskaya, Larisa A. Badovskaya, Tatyana Ya. Kaklyuginac and Aryan Younessi

Molecules 1999, 4(10), M109; https://doi.org/10.3390/M109 - 8 Oct 1999

Viewed by 3302

Abstract

The general part of the experimental section [1] has been presented elsewhere.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

92 KiB

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4-(2,4-Dimethoxybenzyliden)-2-butenolide

by Lyudmila N. Sorotskaya, Tatyana Ya. Kaklyugina and Larisa A. Badovskaya

Molecules 1999, 4(10), M108; https://doi.org/10.3390/M108 - 8 Oct 1999

Cited by 1 | Viewed by 2819

Abstract

The general part of the experimental section [1] has been presented elsewhere.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

91 KiB

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N-(3-Phenyl-2-propinoyl)benzamide

by Dieter Hubmann and Urs Séquin

Molecules 1999, 4(10), M107; https://doi.org/10.3390/M107 - 8 Oct 1999

Viewed by 3065

Abstract

During the synthesis of a series of carboximides using acyl isocyanates [1], the title compound 3 was synthesised as a model compound from benzoyl isocyanate (1) and lithium phenylacetylide (2).[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

94 KiB

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Ethyl N-(3-Phenyl-2-propynoyl)carbamate

by Dieter Hubmann and Urs Séquin

Molecules 1999, 4(10), M106; https://doi.org/10.3390/M106 - 8 Oct 1999

Viewed by 2596

Abstract

During the synthesis of a series of carboximides using acyl isocyanates [1], the title compound 3 was synthesised in a model reaction from 3-phenyl-2-propynoyl isocyanate (2) and ethanol. Isocyanate 2 was generated in situ from the corresponding carboxamide (1) [...] Read more.

During the synthesis of a series of carboximides using acyl isocyanates [1], the title compound 3 was synthesised in a model reaction from 3-phenyl-2-propynoyl isocyanate (2) and ethanol. Isocyanate 2 was generated in situ from the corresponding carboxamide (1) with oxalyl chloride [2].[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

92 KiB

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2-Amino-4,10-dimethylpyrrolo[3,4-b]carbazole-1,3(2H,5H)-dione

by Norbert Haider and Richard Wanko

Molecules 1999, 4(10), M105; https://doi.org/10.3390/M105 - 8 Oct 1999

Cited by 3 | Viewed by 2787

Abstract

The general part of the experimental section [1] was presented elsewhere.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

88 KiB

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Synthesis of (4R,5R)-2-Ethoxy-4,5-bis[(1-methoxy-1-methyl)ethyl]-1,3-dioxolane

by Luc Patiny

Molecules 1999, 4(10), M104; https://doi.org/10.3390/M104 - 8 Oct 1999

Viewed by 2670

Abstract

The title compound was prepared from 5 g (89 mmol, 1 eq) of (3R,4R)-2,5-dimethoxy-2,5-dimethyl- 3,4-hexanediol [1], 4.4 ml (3.95 g, 27 mmol, 1.1 eq) of triethyl orthoformate, 0.05 g (0.25 mmol, 0.01 eq) of p-toluenesulfonic acid monohydrate in 35 ml of cyclohexane under [...] Read more.

The title compound was prepared from 5 g (89 mmol, 1 eq) of (3R,4R)-2,5-dimethoxy-2,5-dimethyl- 3,4-hexanediol [1], 4.4 ml (3.95 g, 27 mmol, 1.1 eq) of triethyl orthoformate, 0.05 g (0.25 mmol, 0.01 eq) of p-toluenesulfonic acid monohydrate in 35 ml of cyclohexane under inert atmosphere.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

91 KiB

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4-Carboxylphenyl Methylphosphonate

by Jianhua Yu, Dejun Ma, Qibin Huang, Yufeng Jia and Yundu Deng

Molecules 1999, 4(10), M103; https://doi.org/10.3390/M103 - 8 Oct 1999

Viewed by 3103

Abstract

Methylphosphonic acid monoesters have been explored for many different purposes [1, 2].[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

136 KiB

Open AccessArticle

Synthesis of N-7-Substituted Purines from Imidazole Precursors

by Stanislaw Ostrowski

Molecules 1999, 4(10), 287-309; https://doi.org/10.3390/41000287 - 25 Sep 1999

Cited by 19 | Viewed by 8469

Abstract

Synthesis of purines and purine mono-1-oxides from the respective 5-substituted 4-nitroimidazole derivatives is described. The commercially available 4-nitroimidazole, in a few simple steps (including Vicarious Nucleophilic Substitution of Hydrogen), was transformed into: 4-aminoimidazoyl-5-carboximes, N-[1-(4-amino-1H-imidazol-5-yl)methylidene]-N-(aryl)amine derivatives or into 4-amino-5-aminomethyl-imidazole. [...] Read more.

Synthesis of purines and purine mono-1-oxides from the respective 5-substituted 4-nitroimidazole derivatives is described. The commercially available 4-nitroimidazole, in a few simple steps (including Vicarious Nucleophilic Substitution of Hydrogen), was transformed into: 4-aminoimidazoyl-5-carboximes, N-[1-(4-amino-1H-imidazol-5-yl)methylidene]-N-(aryl)amine derivatives or into 4-amino-5-aminomethyl-imidazole. These intermediates were cyclized to the final products. Full article

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Figure 1

46 KiB

Open AccessArticle

Synthetical Application of Alkyl 2-isothiocyanatocarboxylates. A Simple Synthesis of 5-Substituted-3-amino-2-thioxo-4-imidazolidinones (3-Amino-2-thiohydantoins)

by Lubomir Floch, Vladimir Oremus and Martin Kovac

Molecules 1999, 4(10), 279-286; https://doi.org/10.3390/41000279 - 22 Sep 1999

Cited by 6 | Viewed by 6440

Abstract

The title 3-amino-2-thiohydantoins 3 has been prepared in very good yields by the reaction of alkyl isothiocynatocarboxylates 1 with hydrazine hydrate.The synthesis of starting isothiocyanates as well as spectral data of 3-aminothiohydantoins and alkyl isothiocyanatocarboxylates has been presented. Full article

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Scheme 1

42 KiB

Open AccessArticle

Stereoselective Transformation of Cyclodecene-1,4-dione Systems, Derived from Steroids, to the Corresponding spiro-γ-lactones. A Semiempirical MO Study

by Ljubinka Lorenc, Vladimir Pavlovich, Ivan Juranich, Mihailo Lj. Mihailovich, Lidija Bondarenko- Gheorghiu, Natalija Krstich and Milan Dabovich

Molecules 1999, 4(10), 272-278; https://doi.org/10.3390/41000272 - 12 Sep 1999

Cited by 2 | Viewed by 8797

Abstract

The thermal and acid-catalyzed intramolecular rearrangement of the (Z)- and (E)-cyclodecene-1,4-dione compounds deriving from steroids, 2a,b and 3a,b, respectively, proceeds stereoselectively to give the corresponding configurationally different spiro-γ-lactone derivatives, the (5R,9R)-isomers 4a,b (from the (Z)-cyclodecenediones 2a,b) and the (5R,9S)-isomers 5a,b (from the (E)-cyclodecenediones [...] Read more.

The thermal and acid-catalyzed intramolecular rearrangement of the (Z)- and (E)-cyclodecene-1,4-dione compounds deriving from steroids, 2a,b and 3a,b, respectively, proceeds stereoselectively to give the corresponding configurationally different spiro-γ-lactone derivatives, the (5R,9R)-isomers 4a,b (from the (Z)-cyclodecenediones 2a,b) and the (5R,9S)-isomers 5a,b (from the (E)-cyclodecenediones 3a,b). The semiempirical MNDOAM1 and PM3 molecular orbital methods were applied to elucidate the possible mechanistic pathway of the observed intramolecular process leading to the spiro-γ-lactone structures. Full article

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Figure 1

74 KiB

Open AccessArticle

Fluorescent 2,7-Dialkylamino-[1,8]-Naphthyridines: Preparation and Spectroscopic Properties

by Christoph Hoock, Jörg Reichert and M. Schmidtke

Molecules 1999, 4(10), 264-271; https://doi.org/10.3390/41000264 - 6 Sep 1999

Cited by 22 | Viewed by 6799

Abstract

Substitution of 4-methyl-[1,8]-naphthyridine in 2 and 7 position by alkylamines leads to highly fluorescent compounds. The arrangement of hydrogen donor and acceptor groups of these naphthyridines allows interactions with guanine and guanine cytosine base pairs. The described synthesis offers easy access to these [...] Read more.

Substitution of 4-methyl-[1,8]-naphthyridine in 2 and 7 position by alkylamines leads to highly fluorescent compounds. The arrangement of hydrogen donor and acceptor groups of these naphthyridines allows interactions with guanine and guanine cytosine base pairs. The described synthesis offers easy access to these small and stable fluorescent probes. Full article

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Figure 1

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Molecules, Volume 4, Issue 10 (October 1999) – 20 articles , Pages 264-319, Articles M103-M115

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