Clean Intermittent Catheterization in Children under 12 Years Does Not Have a Negative Impact on Long-Term Graft Survival following Pediatric Kidney Transplantation
Abstract
:1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Causes of ESRD in Children <12 Years Old in Our Center | n = 44 |
---|---|
Posterior urethral valves (PUVs) | 13 (29.5%) |
Renal aplasia/hypoplasia/dysplasia | 7 (15.9%) |
Reflux nephropathy | 6 (13.6%) |
VACTERL association | 4 (9.0%) |
Focal segmental glomerulosclerosis (FSGS) | 2 (4.5%) |
Congenital nephrotic syndrome | 2 (4.5%) |
Hemolytic uremic syndrome | 2 (4.5%) |
Polycystic kidney disease | 2 (4.5%) |
Other (cystinosis, bilateral nephrectomy, etc.) | 6 |
Parameter | Control Group (No LUTD) n = 18 | LUTD CIC Group n = 8 | LUTD No CIC n = 15 | p |
---|---|---|---|---|
Organ donation | 0.013 | |||
Living donation | 0 | 2 | 0 | |
Postmortem donation | 18 | 6 | 15 | |
Recipient sex | 0.036 | |||
Male | 8 | 7 | 12 | |
Female | 10 | 1 | 3 | |
Age of the recipient (years; median (IQR)) | 7 (5–8) | 7 (4–10.5) | 6 (5–7) | 0.527 |
Age of the donor (years; median (IQR)) | 32 (16–51) | 43 (35–53) | 34 (20–46) | 0.475 |
BSA of the recipients at transplant (m2; median (IQR)) | 0.84 (0.72–0.93) | 0.89 (0.71–1.14) | 0.80 (0.70–0.83) | 0.492 |
Pretransplant time of the recipient on dialysis (months; median (IQR)) | 24 (15–33) | 21 (11–34) | 41 (21–53) | 0.105 |
HLA mismatches (n; median (IQR)) | 3 (2–3) | 3 (2–4) | 2 (2–3) | 0.652 |
Cold ischemia time of the graft (h; median (IQR)) | 12 (10–16) | 14 (8–17) | 12 (11–15) | 0.930 |
Urinary tract infections (n; median (IQR)) | 1 (0–2) | 2.5 (2–4) | 2 (0.5–3) | 0.045 |
Follow-up of kidney grafts (months; median (IQR)) | 114 (86–144) | 135 (122–152) | 126 (72–135) | 0.420 |
Parameter | HR (95% CI) | p |
---|---|---|
Organ donation | ||
Living donation | 1 (Reference) | |
Postmortem donation | 1.103 (0.132–9.235) | 0.928 |
Recipient sex | ||
Female | 1 (Reference) | |
Male | 2.587 (0.551–12.160) | 0.229 |
Age of the recipient (years; median (IQR)) | 0.928 (0.738–1.167) | 0.524 |
Age of the donor (years; median (IQR)) | 1.063 (1.011–1.119) | 0.018 |
BSA of the recipients at transplant (m2; median (IQR)) | 0.775 (0.021–28.18) | 0.889 |
Pretransplant time of the recipient on dialysis (months; median (IQR)) | 1.011 (0.989–1.042) | 0.489 |
HLA mismatches (n; median (IQR)) | 1.004 (0.503–1.901) | 0.990 |
Cold ischemia time of the graft (h; median (IQR)) | 1.013 (0.909–1.130) | 0.813 |
Urinary tract infections (n; median (IQR)) | 1.220 (1.024–1.454) | 0.026 |
Grouping | ||
Control (no LUTD) | 1 (Reference) | |
LUTD CIC group | 4.091 (0.789–21.200) | 0.093 |
LUTD no CIC | 3.197 (0.558–18.320) | 0.192 |
Parameter | HR (95% CI) | p |
---|---|---|
Age of the donor (years; median (IQR)) | 1.066 (0.999–1.136) | 0.051 |
Urinary tract infections (n; median (IQR)) | 1.192 (0.978–1.454) | 0.083 |
Grouping | ||
Control (no LUTD) | 1 (Reference) | |
LUTD CIC group | 0.978 (0.125–7.659) | 0.983 |
LUTD no CIC | 2.222 (0.357–13.834) | 0.392 |
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Marcou, M.; Galiano, M.; Tzschoppe, A.; Sauerstein, K.; Wach, S.; Taubert, H.; Wullich, B.; Hirsch-Koch, K.; Apel, H. Clean Intermittent Catheterization in Children under 12 Years Does Not Have a Negative Impact on Long-Term Graft Survival following Pediatric Kidney Transplantation. J. Clin. Med. 2024, 13, 33. https://doi.org/10.3390/jcm13010033
Marcou M, Galiano M, Tzschoppe A, Sauerstein K, Wach S, Taubert H, Wullich B, Hirsch-Koch K, Apel H. Clean Intermittent Catheterization in Children under 12 Years Does Not Have a Negative Impact on Long-Term Graft Survival following Pediatric Kidney Transplantation. Journal of Clinical Medicine. 2024; 13(1):33. https://doi.org/10.3390/jcm13010033
Chicago/Turabian StyleMarcou, Marios, Matthias Galiano, Anja Tzschoppe, Katja Sauerstein, Sven Wach, Helge Taubert, Bernd Wullich, Karin Hirsch-Koch, and Hendrik Apel. 2024. "Clean Intermittent Catheterization in Children under 12 Years Does Not Have a Negative Impact on Long-Term Graft Survival following Pediatric Kidney Transplantation" Journal of Clinical Medicine 13, no. 1: 33. https://doi.org/10.3390/jcm13010033