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Search Results (8,791)

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Keywords = 3D printing

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20 pages, 2623 KiB  
Article
Optimization of Foams—Polypropylene Fiber-Reinforced Concrete Mixtures Dedicated for 3D Printing
by Magdalena Rudziewicz, Marcin Maroszek, Kinga Setlak, Mateusz Góra and Marek Hebda
Materials 2024, 17(16), 4106; https://doi.org/10.3390/ma17164106 (registering DOI) - 19 Aug 2024
Abstract
The continued global urbanization of the world is driving the development of the construction industry. In order to protect the environment, intensive research has been carried out in recent years on the development of sustainable materials and ecological construction methods. Scientific research often [...] Read more.
The continued global urbanization of the world is driving the development of the construction industry. In order to protect the environment, intensive research has been carried out in recent years on the development of sustainable materials and ecological construction methods. Scientific research often focuses on developing building materials that are renewable, energy-efficient, and have minimal impact on the environment throughout their life cycle. Therefore, this article presents research results aimed at developing a concrete mixture using cement with reduced CO2 emissions. In the context of increasing ecological awareness and in line with European Union policy, the development of a mixture based on environmentally friendly cement is of key importance for the future development of the construction industry. The article compares the physical properties of two mixtures, their foaming possibilities, and the influence of the added polypropylene (PP) fibers on the strength properties of the produced composites. It was found that bending strength and compressive strength were highest in the material with silica fume and aluminum powder at 5.36 MPa and 28.76 MPa, respectively. Microscopic analysis revealed significant pore structure differences, with aluminum foamed samples having regular pores and hydrogen peroxide foamed samples having irregular pores. Optimizing aluminum powder and water content improved the materials’ strength, crucial for maintaining usability and achieving effective 3D printing. The obtained results are important in the development of research focused on the optimization of 3D printing technology using concrete. Full article
25 pages, 2200 KiB  
Communication
Enhancing 3D Printing with Procedural Generation and STL Formatting Using Python
by Jakub Kopowski, Aleksandra Mreła, Dariusz Mikołajewski and Izabela Rojek
Appl. Sci. 2024, 14(16), 7299; https://doi.org/10.3390/app14167299 - 19 Aug 2024
Abstract
Three-dimensional printing has become a fast-growing industry. The first phase of this technology is the design of a 3D object to personalize it and optimize its production. This paper explores the procedural generation of the 3D model. The article aims to present the [...] Read more.
Three-dimensional printing has become a fast-growing industry. The first phase of this technology is the design of a 3D object to personalize it and optimize its production. This paper explores the procedural generation of the 3D model. The article aims to present the method of procedurally generating 3D objects in Python. Procedural content generation is the automated creation of content using algorithms. Most often, as part of procedural generation, a small number of input parameters and pseudo-random processes are used to generate content that will meet the requirements. The programming techniques for object customization in Python optimize the manufacturing process. Moreover, procedural generation speeds up the model design, and if developers use 3D scanning methods and artificial intelligence, production can be personalized, which is in line with the concept of Industry 4.0. Full article
(This article belongs to the Special Issue Design for Additive Manufacturing: Latest Advances and Prospects)
9 pages, 1594 KiB  
Article
The Effect of 3D Printing Layer Thickness and Post-Polymerization Time on the Flexural Strength and Hardness of Denture Base Resins
by Hamad S. AlRumaih and Mohammed M. Gad
Prosthesis 2024, 6(4), 970-978; https://doi.org/10.3390/prosthesis6040070 - 19 Aug 2024
Abstract
Purpose: This study evaluates and compares the effect of printing layer thickness (LT) and post-polymerization time (PPT) on the flexural strength and hardness of three 3D-printed resins after thermal aging. Methods: A bar shape (64 × 10 × 3.3 mm) and a disc [...] Read more.
Purpose: This study evaluates and compares the effect of printing layer thickness (LT) and post-polymerization time (PPT) on the flexural strength and hardness of three 3D-printed resins after thermal aging. Methods: A bar shape (64 × 10 × 3.3 mm) and a disc shape (15 × 2 mm) were designed for flexural strength and hardness testing, respectively. ASIGA, NextDent, and FormLabs 3D-printed resins were used to print specimens with different LTs (25 µm, 50 µm, and 100 µm). Each thickness group was post-polymerized (PP) for different times (15, 30, 60, and 90 min). All printed specimens were thermally cycled (5000 cycles) and then tested, measuring the flexural strength and hardness using a universal testing machine and Vickers hardness tester, respectively. The data were analyzed using ANOVA and a post hoc Tukey’s test (α = 0.05). Results: A PPT of 90 min showed the highest flexural strength. In comparisons of the LTs, 25 µm and 50 µm significantly increased flexural strength compared with 100 µm, which showed the lowest value for each PPT. The hardness increased as the PPT increased for all materials. In our LT comparison, 25 µm and 50 µm significantly increased the hardness for NextDent and FormLabs resins, while only 25 µm showed high hardness compared with 50 µm and 100 µm for ASIGA. Conclusion: Both parameters (LT and PPT) impact flexural strength and hardness. Increased PPT with the minimum LT is recommended. Full article
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12 pages, 4500 KiB  
Article
Effect of Different Finishing Systems on Surface Roughness and Gloss of a 3D-Printed Material for Permanent Dental Use
by Alessandro Vichi, Dario Balestra and Chris Louca
Appl. Sci. 2024, 14(16), 7289; https://doi.org/10.3390/app14167289 - 19 Aug 2024
Abstract
The object of the study was to assess the effect of different finishing and polishing systems on the roughness and gloss of a 3D-printed permanent restorative material. One 3D printable Permanent material was selected for the study. Squared-shaped specimens (14 mm2; [...] Read more.
The object of the study was to assess the effect of different finishing and polishing systems on the roughness and gloss of a 3D-printed permanent restorative material. One 3D printable Permanent material was selected for the study. Squared-shaped specimens (14 mm2; 5 mm thickness) were obtained by designing and printing. Eighty specimens were produced and randomly assigned (n = 10) to 8 finishing and polishing methods: Sof-Lex™ Spiral Wheels (SW), Sof-Lex™ XT Pop-on Disc (SD), Identoflex Lucent no paste (Ln), Identoflex Lucent + paste (Lp), Resin Nitrogen polymerized (NG), Optiglaze (OG), Opti1Step (OS), and HiLusterPLUS (HL). Surface roughness and gloss were then measured by a roughness meter and a glossmeter, respectively. For roughness, statistically significant differences were found (p < 0.001), with NG(a) > SD(b) = OG(b) = Lp(b); Lp(b) = Ln(bc); Ln(bc) = OS(cd); OS(cd) = SW(de); and SW(de) = HL(e). For gloss, statistically significant differences were also identified (p < 0.001) with NG(a) > SD(b) > Lp(c) = OS(c) = OG(cd); OG(cd) = Ln(d) > HL(e) = SW(e). The nitrogen chamber polymerization showed better results for both roughness and gloss. Multi-step finishing/polishing systems were able to produce smoother surfaces than 1-step and 2-step systems. Full article
(This article belongs to the Special Issue Advanced Materials for Polymeric 3D Printing Applications)
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14 pages, 5673 KiB  
Article
From Tilings of Orientable Surfaces to Topological Interlocking Assemblies
by Reymond Akpanya, Tom Goertzen and Alice C. Niemeyer
Appl. Sci. 2024, 14(16), 7276; https://doi.org/10.3390/app14167276 - 19 Aug 2024
Abstract
A topological interlocking assembly (TIA) is an assembly of blocks together with a non-empty subset of blocks called the frame such that every non-empty set of blocks is kinematically constrained and can therefore not be removed from the assembly without causing intersections between [...] Read more.
A topological interlocking assembly (TIA) is an assembly of blocks together with a non-empty subset of blocks called the frame such that every non-empty set of blocks is kinematically constrained and can therefore not be removed from the assembly without causing intersections between blocks of the assembly. TIA provides a wide range of real-world applications, from modular construction in architectural design to potential solutions for sound insulation. Various methods to construct TIA have been proposed in the literature. In this paper, the approach of constructing TIA by applying the Escher trick to tilings of orientable surfaces is discussed. First, the strengths of this approach are highlighted for planar tilings, and the Escher trick is then exploited to construct a planar TIA that is based on the truncated square tiling, which is a semi-regular tiling of the Euclidean plane. Next, the Escher-Like approach is modified to construct TIAs that are based on arbitrary orientable surfaces. Finally, the capabilities of this modified construction method are demonstrated by constructing TIAs that are based on the unit sphere, the truncated icosahedron, and the deltoidal hexecontahedron. Full article
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13 pages, 7364 KiB  
Article
Mechanism of Grain Refinement in 3D-Printed AlSi10Mg Alloy Subjected to Severe Plastic Deformation
by Przemysław Snopiński and Ondřej Hilšer
Materials 2024, 17(16), 4098; https://doi.org/10.3390/ma17164098 - 19 Aug 2024
Viewed by 127
Abstract
In this article, the evolution of microstructural characteristics of selectively laser-melted AlSi10Mg alloy subjected to equal channel angular pressing (ECAP) is investigated. The microstructures were analyzed in detail using scanning electron microscopy (SEM), electron backscatter diffraction (EBSD), transmission Kikuchi diffraction (TKD), and transmission [...] Read more.
In this article, the evolution of microstructural characteristics of selectively laser-melted AlSi10Mg alloy subjected to equal channel angular pressing (ECAP) is investigated. The microstructures were analyzed in detail using scanning electron microscopy (SEM), electron backscatter diffraction (EBSD), transmission Kikuchi diffraction (TKD), and transmission electron microscopy (TEM). A heterogeneous ultrafine-grained microstructure was produced after one ECAP pass at 100 °C. This microstructure was composed of Al/Si cells and sub-micrometer grains. The grains were refined by conventional dislocation processes; however, evidence of dynamic recrystallization was also documented. Furthermore, it was revealed that the Al/Si cells contribute significantly to grain refinement. EBSD/TKD investigations showed that cell misorientation increased after ECAP processing, resulting in an increased fraction of grains with very low misorientation angles. Full article
(This article belongs to the Special Issue Advanced Manufacturing Processes of Metal Forming (2nd Edition))
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12 pages, 3306 KiB  
Article
Mechanical Characteristics of Multi-Level 3D-Printed Silicone Foams
by Zhirong Yang, Jinpeng Wen, Guoqi Zhang, Changyu Tang, Qingtian Deng, Jixin Ling and Haitao Hu
Materials 2024, 17(16), 4097; https://doi.org/10.3390/ma17164097 - 19 Aug 2024
Viewed by 181
Abstract
Three-dimensional-printed silicone rubber foams, with their designable and highly ordered pore structures, have shown exceptional potential for engineering applications, particularly in areas requiring energy absorption and cushioning. However, optimizing the mechanical properties of these foams through structural design remains a significant challenge. This [...] Read more.
Three-dimensional-printed silicone rubber foams, with their designable and highly ordered pore structures, have shown exceptional potential for engineering applications, particularly in areas requiring energy absorption and cushioning. However, optimizing the mechanical properties of these foams through structural design remains a significant challenge. This study addresses this challenge by formulating the research question: How do different 3D-printed topologies and printing parameters affect the mechanical properties of silicone rubber foams, and how can we design a novel topological structure? To answer this, we explored the mechanical behavior of two common structures–simple cubic (SC) and face-centered tetragonal (FCT)–by varying printing parameters such as filament spacing, filament diameter, and layer height. Furthermore, we proposed a novel two-level 3D-printed structure, combining SC and FCT configurations to enhance performance. The results demonstrated that the two-level SC-SC structure exhibited a specific energy absorption of 8.2 to 21.0 times greater than the SC structure and 2.3 to 7.2 times greater than the FCT structure. In conclusion, this study provides new insights into the design of 3D-printed silicone rubber foams, offering a promising approach to developing advanced cushioning materials with superior energy absorption capabilities. Full article
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23 pages, 6560 KiB  
Article
Development of a Portable Residual Chlorine Detection Device with a Combination of Microfluidic Chips and LS-BP Algorithm to Achieve Accurate Detection of Residual Chlorine in Water
by Tongfei Wang, Jiping Niu, Haoran Pang, Xiaoyu Meng, Ruqian Sun and Jiaqing Xie
Micromachines 2024, 15(8), 1045; https://doi.org/10.3390/mi15081045 - 18 Aug 2024
Viewed by 216
Abstract
Chlorine is widely used for sterilization and disinfection of water, but the presence of excess residual chlorine in water poses a substantial threat to human health. At present, there is no portable device which can achieve accurate, rapid, low-cost, and convenient detection of [...] Read more.
Chlorine is widely used for sterilization and disinfection of water, but the presence of excess residual chlorine in water poses a substantial threat to human health. At present, there is no portable device which can achieve accurate, rapid, low-cost, and convenient detection of residual chlorine in water. Therefore, it is necessary to develop a device that can perform accurate, rapid, low-cost, and convenient detection of residual chlorine in water. In this study, a portable residual chlorine detection device was developed. A microfluidic chip was studied to achieve efficient mixing of two-phase flow. This microfluidic chip was used for rapid mixing of reagents in the portable residual chlorine detection device, reducing the consumption of reagents, detection time, and device volume. A deep learning algorithm was proposed for predicting residual chlorine concentration in water, achieving precise detection. Firstly, the microfluidic chip structure for detecting mixed reagents was optimized, and the microfluidic chip was fabricated by a 3D-printing method. Secondly, a deep learning (LS-BP) algorithm was constructed and proposed for predicting residual chlorine concentration in water, which can realize dual-channel signal reading. Thirdly, the corresponding portable residual chlorine detection device was developed, and the detection device was compared with residual chlorine detection devices and methods in other studies. The comparison results indicate that the portable residual chlorine detection device has high detection accuracy, fast detection speed, low cost, and good convenience. The excellent performance of the portable residual chlorine detection device makes it suitable for detecting residual chlorine in drinking water, swimming pool water, aquaculture and other fields. Full article
(This article belongs to the Section E:Engineering and Technology)
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14 pages, 11018 KiB  
Article
Strength and Electrostatic Discharge Resistance Analysis of Additively Manufactured Polyethylene Terephthalate Glycol (PET-G) Parts for Potential Electronic Application
by Julia Talecka, Janusz Kluczyński, Katarzyna Jasik, Ireneusz Szachogłuchowicz and Janusz Torzewski
Materials 2024, 17(16), 4095; https://doi.org/10.3390/ma17164095 - 18 Aug 2024
Viewed by 243
Abstract
Optoelectronic components are crucial across various industries. They benefit greatly from advancements in 3D printing techniques that enable the fabrication of intricate parts. Among these techniques, Material Extrusion (MEX) stands out for its simplicity and cost-effectiveness. Integrating 3D printing into production processes offers [...] Read more.
Optoelectronic components are crucial across various industries. They benefit greatly from advancements in 3D printing techniques that enable the fabrication of intricate parts. Among these techniques, Material Extrusion (MEX) stands out for its simplicity and cost-effectiveness. Integrating 3D printing into production processes offers the potential to create components with enhanced electrostatic discharge (ESD) resistance, a critical factor for ensuring the reliability and safety of optoelectronic devices. Polyethylene terephthalate glycol-modified (PET-G) is an amorphous copolymer renowned for its high transparency, excellent mechanical properties, and chemical resistance, which make it particularly suitable for 3D printing applications. This study focuses on analyzing the mechanical, structural, and electrostatic properties of pure PET-G as well as PET-G doped with additives to evaluate the effects of doping on its final properties. The findings highlight that pure PET-G exhibits superior mechanical strength compared to doped variants. Conversely, doped PET-G demonstrates enhanced resistance to electrostatic discharge, which is advantageous for applications requiring ESD mitigation. This research underscores the importance of material selection and optimization in 3D printing processes to achieve desired mechanical and electrical properties in optoelectronic components. By leveraging 3D printing technologies like MEX and exploring material modifications, industries can further innovate and enhance the production of optoelectronic devices, fostering their widespread adoption in specialized fields. Full article
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13 pages, 2453 KiB  
Article
Design and Optimization of 3D-Printed Tablets Containing Mucuna Extracts for Erectile Dysfunction Management: A DoE-Guided Study
by Ratchapoom Wattanawiggan, Sunee Chansakaow, Pensak Jantrawut, Pattaraporn Panraksa, Jutamas Jiaranaikulwanitch, Suruk Udomsom, Patnarin Worajittiphon and Pratchaya Tipduangta
Plants 2024, 13(16), 2294; https://doi.org/10.3390/plants13162294 - 18 Aug 2024
Viewed by 263
Abstract
Erectile dysfunction (ED) refers to the inability of the penis to maintain a firm erection during sexual activity. Mucuna, or M. pruriens, contains levodopa, a compound showing promise in ED treatment. However, formulating Mucuna extract into tablet dosage forms is challenging due [...] Read more.
Erectile dysfunction (ED) refers to the inability of the penis to maintain a firm erection during sexual activity. Mucuna, or M. pruriens, contains levodopa, a compound showing promise in ED treatment. However, formulating Mucuna extract into tablet dosage forms is challenging due to its semisolid nature. This study aimed to develop sustained-release tablets containing Mucuna extract via semisolid extrusion 3D printing. Eudragit RS PO (Eudragit) served as a sustained-release polymer, with poly (vinyl alcohol) (PVA) as a co-polymer for forming the tablet matrices. This study had the following two main phases: screening, which identified the factors affecting the printability, and optimization, which focused on the factors influencing the levodopa release and its consistency. The results showed that both the polymeric solid percentage content (PSPC) in the semisolid slurry and the Eudragit-PVA ratio significantly affected the printability. All of the formulations were printable, and the PSPC and Eudragit-PVA ratios were incorporated into the optimized model. The desired formulation, achieving targeted levodopa release and consistency, had a PSPC of 58.8% and a Eudragit-PVA ratio of 2.87:1. In conclusion, semisolid extrusion 3D printing guided by the design of experiments (DoE) proved feasible for producing reliable 3D-printed tablets with consistent active ingredients and desired release rates. Full article
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22 pages, 4730 KiB  
Article
A Systematic Approach to Developing Sustainable Post-Disaster Shelters in the Southern Region of the United States
by Alka Khadka, Soojin Yoon, Richard G. Walker, Amy King Lewis and Yeonjin Bae
Buildings 2024, 14(8), 2536; https://doi.org/10.3390/buildings14082536 - 17 Aug 2024
Viewed by 411
Abstract
This study aims to propose a sustainable shelter design involving energy savings, less environmental impact, and rapid construction. The structural design of the shelter is based on 3D-printing technology. Sustainability assessments, including life cycle analysis (LCA), life cycle energy assessment (LCEA), and energy [...] Read more.
This study aims to propose a sustainable shelter design involving energy savings, less environmental impact, and rapid construction. The structural design of the shelter is based on 3D-printing technology. Sustainability assessments, including life cycle analysis (LCA), life cycle energy assessment (LCEA), and energy justice of the designed shelter, were conducted to prove the sustainable shelter design. The outcomes of this study for several scenarios will not only allow decision-makers to design permanent shelters with maximized utilization of limited resources but also help local communities strengthen their ability to recover with minimal outside assistance post-disaster. Furthermore, residents can utilize the sustainable shelter to maintain critical functions, including business continuity and local business in emergencies. Full article
(This article belongs to the Special Issue Advanced Building Technologies for Energy Savings and Decarbonization)
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18 pages, 4906 KiB  
Article
Outcome One Year after Acetabular Rim Extension Using a Customized Titanium Implant for Treating Hip Dysplasia in Dogs
by Irin Kwananocha, Joëll Magré, Amir Kamali, Femke Verseijden, Koen Willemsen, Yuntao Ji, Bart C. H. van der Wal, Ralph J. B. Sakkers, Marianna A. Tryfonidou and Björn P. Meij
Animals 2024, 14(16), 2385; https://doi.org/10.3390/ani14162385 - 17 Aug 2024
Viewed by 171
Abstract
The acetabular rim extension (ACE-X) implant is a custom-made three-dimensionally printed titanium device designed for the treatment of canine hip dysplasia. In this study, 34 dogs (61 hips) underwent ACE-X implantation, and assessments were conducted using computed tomography, force plate analysis, Ortolani’s test, [...] Read more.
The acetabular rim extension (ACE-X) implant is a custom-made three-dimensionally printed titanium device designed for the treatment of canine hip dysplasia. In this study, 34 dogs (61 hips) underwent ACE-X implantation, and assessments were conducted using computed tomography, force plate analysis, Ortolani’s test, and the Helsinki chronic pain index (HCPI) questionnaires at five intervals: the pre-operative day, the surgery day, and the 1.5-month, 3-month, and 12-month follow-ups. Statistically significant increases in femoral head coverage with a negative Ortolani subluxation test were observed immediately after surgery and persisted throughout the study. Osteoarthritis (OA) scores remained stable, but osteophyte size significantly increased between the surgery day and the 12-month follow-up, especially in hips with a baseline OA score of 2 compared to those with a score of 1. The force plate data showed no significant changes during the study. The HCPI demonstrated a significant decrease in pain score from pre-operative value to six-week follow-up and gradually decreased over time. Major complications were identified in six hips (9.8%) of four dogs. In conclusion, the ACE-X implant effectively increased femoral head coverage, eliminated subluxation, and provided long-term pain relief with minimal complications, benefiting over 90% of the study population. The study supports the ACE-X implant as a valuable alternative treatment for canine hip dysplasia. Full article
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28 pages, 36682 KiB  
Article
Augmented Data-Driven Approach towards 3D Printed Concrete Mix Prediction
by Saif Ur Rehman, Raja Dilawar Riaz, Muhammad Usman and In-Ho Kim
Appl. Sci. 2024, 14(16), 7231; https://doi.org/10.3390/app14167231 - 16 Aug 2024
Viewed by 468
Abstract
Formulating a mix design for 3D concrete printing (3DCP) is challenging, as it involves an iterative approach, wasting a lot of resources, time, and effort to optimize the mix for strength and printability. A potential solution is mix formulation through artificial intelligence (AI); [...] Read more.
Formulating a mix design for 3D concrete printing (3DCP) is challenging, as it involves an iterative approach, wasting a lot of resources, time, and effort to optimize the mix for strength and printability. A potential solution is mix formulation through artificial intelligence (AI); however, being a new and emerging field, the open-source availability of datasets is limited. Limited datasets significantly restrict the predictive performance of machine learning (ML) models. This research explores data augmentation techniques like deep generative adversarial network (DGAN) and bootstrap resampling (BR) to increase the available data to train three ML models, namely support vector machine (SVM), artificial neural network (ANN), and extreme gradient boosting regression (XGBoost). Their performance was evaluated using R2, MSE, RMSE, and MAE metrics. Models trained on BR-augmented data showed higher accuracy than those trained on the DGAN-augmented data. The BR-trained XGBoost exhibited the highest R2 scores of 0.982, 0.970, 0.972, 0.971, and 0.980 for cast compressive strength, printed compressive strength direction 1, 2, 3, and slump flow respectively. The proposed method of predicting the slump flow (mm), cast, and anisotropic compressive strength (MPa) can effectively predict the mix design for printable concrete, unlocking its full potential for application in the construction industry. Full article
(This article belongs to the Special Issue Robotics and Automation Systems in Construction: Trends and Prospects)
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15 pages, 2186 KiB  
Review
Technological Advances in the Diagnosis of Cardiovascular Disease: A Public Health Strategy
by Maria Restrepo, Oscar Araque and Luz Adriana Sanchez-Echeverri
Int. J. Environ. Res. Public Health 2024, 21(8), 1083; https://doi.org/10.3390/ijerph21081083 - 16 Aug 2024
Viewed by 254
Abstract
This article reviews technological advances and global trends in the diagnosis, treatment, and monitoring of cardiovascular diseases. A bibliometric analysis was conducted using the SCOPUS database, following PRISMA-ScR guidelines, to identify relevant publications on technologies applied in the diagnosis and treatment of cardiovascular [...] Read more.
This article reviews technological advances and global trends in the diagnosis, treatment, and monitoring of cardiovascular diseases. A bibliometric analysis was conducted using the SCOPUS database, following PRISMA-ScR guidelines, to identify relevant publications on technologies applied in the diagnosis and treatment of cardiovascular diseases. An increase in scientific output since 2018 was observed, reflecting a growing interest in the technologies available for the treatment of cardiovascular diseases, with terms such as “telemedicine”, “artificial intelligence”, “image analysis”, and “cardiovascular disease” standing out as some of the most commonly used terms in reference to CVDs. Significant trends were identified, such as the use of artificial intelligence in precision medicine and machine learning algorithms to analyse data and predict cardiovascular risk, as well as advances in image analysis and 3D printing. Highlighting the role of artificial intelligence in the diagnosis and continuous monitoring of cardiovascular diseases, showing its potential to improve prognosis and reduce the incidence of acute cardiovascular events, this study presents the integration of traditional cardiology methods with digital health technologies—through a transdisciplinary approach—as a new direction in cardiovascular health, emphasising individualised care and improved clinical outcomes. These advances have great potential to impact healthcare, and as this field expands, it is crucial to understand the current research landscape and direction in order to take advantage of each technological advancement for improving the diagnosis, treatment, and quality of life of cardiovascular patients. It is concluded that the integration of these technologies into clinical practice has important implications for public health. Early detection and personalised treatment of cardiovascular diseases (CVDs) can significantly reduce the morbidity and mortality associated with these diseases. In addition, the optimisation of public health resources through telemedicine and telecare can improve access to quality care. The implementation of these technologies can be a crucial step towards reducing the global burden of cardiovascular diseases. Full article
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24 pages, 6028 KiB  
Review
The Prospect of Hepatic Decellularized Extracellular Matrix as a Bioink for Liver 3D Bioprinting
by Wen Shi, Zhe Zhang and Xiaohong Wang
Biomolecules 2024, 14(8), 1019; https://doi.org/10.3390/biom14081019 - 16 Aug 2024
Viewed by 417
Abstract
The incidence of liver diseases is high worldwide. Many factors can cause liver fibrosis, which in turn can lead to liver cirrhosis and even liver cancer. Due to the shortage of donor organs, immunosuppression, and other factors, only a few patients are able [...] Read more.
The incidence of liver diseases is high worldwide. Many factors can cause liver fibrosis, which in turn can lead to liver cirrhosis and even liver cancer. Due to the shortage of donor organs, immunosuppression, and other factors, only a few patients are able to undergo liver transplantation. Therefore, how to construct a bioartificial liver that can be transplanted has become a global research hotspot. With the rapid development of three-dimensional (3D) bioprinting in the field of tissue engineering and regenerative medicine, researchers have tried to use various 3D bioprinting technologies to construct bioartificial livers in vitro. In terms of the choice of bioinks, liver decellularized extracellular matrix (dECM) has many advantages over other materials for cell-laden hydrogel in 3D bioprinting. This review mainly summarizes the acquisition of liver dECM and its application in liver 3D bioprinting as a bioink with respect to availability, printability, and biocompatibility in many aspects and puts forward the current challenges and prospects. Full article
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