Search Results (22,093)

The global prevalence of cardiovascular diseases (CVDs), including dyslipidemia and atherosclerosis, is rising. While pharmacological treatments for dyslipidemia and associated CVDs exist, not all individuals can afford them, and those who do often experience adverse side effects. Preclinical studies have indicated the potential benefits of Abelmoschus esculentus and its active phytochemicals in addressing dyslipidemia in rodent models of diabetes. However, there is limited clinical evidence on lipid parameters. Thus, this study aimed to assess the potential impact of Abelmoschus esculentus on dyslipidemia. A literature search was performed on PubMed, Scopus, and Cochrane Library for relevant trials published from inception until 11 August 2024. Data analysis was performed using Jamovi software version 2.4.8 and Review Manager (version 5.4), with effect estimates reported as standardized mean differences (SMDs) and 95% confidence intervals (CI). The evidence from eight studies with nine treatment arms showed that Abelmoschus esculentus reduces total cholesterol (TC), SMD = −0.53 (95% CI: −1.00 to −0.07), p = 0.025), compared to placebo. Additionally, triglyceride (TG) was reduced in Abelmoschus esculentus compared to placebo, SMD = −0.24 (95% CI: −0.46 to −0.02), p = 0.035. Furthermore, low-density lipoprotein (LDL) was also reduced, SMD = −0.35 (95% CI: −0.59 to −0.11), p = 0.004 in Abelmoschus esculentus versus placebo. This remedy substantially increased high-density lipoprotein (HDL), SMD = 0.34 (95% CI: 0.07 to 0.61), p = 0.014). Abelmoschus esculentus substantially improved lipid profile in prediabetes, T2D, obesity, and diabetic nephropathy. While the evidence confirms the potential benefits of Abelmoschus esculentus in reducing dyslipidemia, it is important for future clinical studies to standardize the effective dosage for more reliable results. Therefore, future trials should focus on these markers in well-designed trials with sufficient sample sizes. Furthermore, Abelmoschus esculentus can be supplemented to the diet of the relevant populations to alleviate dyslipidemia. Full article

In this paper, we study the Camassa–Holm type equation, which has applications in mathematical physics and engineering. Its applications extend across disciplines, contributing to our understanding of complex systems and helping to develop innovative solutions in diverse areas of research. Our main aim is to construct closed-form solutions of the equation using a powerful technique, namely the Lie group analysis method. Firstly, we derive the Lie point symmetries of the equation. Thereafter, the equation is reduced to non-linear ordinary differential equations using symmetry reductions. Furthermore, the solutions of the equation are derived using the extended Jacobi elliptic function technique, the simplest equation method, and the power series method. In conclusion, we construct conservation laws for the equation using Noether’s theorem and the multiplier approach, which plays a crucial role in understanding the behavior of non-linear equations, especially in physics and engineering, and these laws are derived from fundamental principles such as the conservation of mass, energy, momentum, and angular momentum. Full article

Maintaining a high level of physical activity provides significant health benefits for children, particularly in enhancing cardiorespiratory fitness and maintaining a healthy weight. This study aimed to investigate the impact of weight status on children’s hemodynamic parameters and aerobic fitness levels. This cross-sectional study included 350 rural primary school children (146 boys and 204 girls) aged 11–13 years, randomly selected from two schools in the King Cetshwayo District, KwaDlangezwa area of KwaZulu-Natal. The anthropometric measurements recorded included height, weight, waist circumference, and hip circumference, with percentiles calculated using Cole’s Lambda, Mu, and Sigma method. Additionally, skinfold measurements were obtained at four sites (biceps, triceps, subscapular, and suprailiac). Hemodynamic measurements included systolic blood pressure, diastolic blood pressure, and heart rate. Aerobic fitness was assessed using the 20 m shuttle run test, which evaluated speed, level, and age. The healthy group demonstrated significantly lower ratios in several measurements compared to those of the overweight group, i.e., the VO₂max was 6% higher (<0.001), the waist-to-hip ratio was 6% lower (<0.001), the body fat percentage was 16% lower (<0.001), the waist circumference was 12% lower (<0.001), and the resting heart rate was 3% lower (p ≤ 0.055). Differences in systolic and diastolic blood pressure were also observed, with the systolic pressure 2% lower (p ≤ 0.116) and the diastolic pressure 3% lower (p ≤ 0.086) in the healthy group. The study revealed a significant association between body weight status, aerobic fitness, and blood pressure parameters. Conducted in rural primary schools in KwaDlangezwa, KwaZulu-Natal, the research highlights notable correlations among weight status, aerobic competence, and blood pressure (BP) in children aged 11 to 13 years. The findings indicate that children with a healthy body weight showed higher VO₂max levels and a reduced risk of developing childhood obesity and hypertension, unlike their overweight or obese peers, who displayed lower aerobic fitness and higher blood pressure. Full article

Herbal teas are used in South Africa as digestives to lower glycaemia and for other indications. However, the chemical composition of the infusions and their effect on enzymes related to metabolic syndrome is poorly known. The composition of infusions and methanol extracts of B. saligna (Scrophulariaceae), Lippia javanica, L. scaberrima, and Phyla dulcis (Verbenaceae) was assessed and the effect of the infusions and extract was determined towards α-glucosidase, α-amylase, and pancreatic lipase. The commercial herbal products were extracted separately with MeOH or hot water to obtain the extract/infusion for comparative studies. Total phenolic, total flavonoid and antioxidant capacity were assessed. The fingerprints of the MeOH extracts and infusions were compared by HPLD-DAD. The extract constituents were tentatively identified by HPLC-MS/MS and NMR analyses. From the extracts/infusions, 57 compounds were identified, including iridoids, phenylpropanoid glycosides, flavonoids, and caffeic acid derivatives, among others. The MeOH extracts and infusions showed strong inhibition towards α-glucosidase with IC₅₀ in the range of 0.13–0.84 µg/mL for the phenolic-enriched infusion extract (PEI) and 0.47–0.50 µg/mL for the MeOH extracts, respectively. The P. dulcis PEI showed higher inhibition towards α-glucosidase, and the MeOH extract of L. scaberrima was better than the PEI. At 100 µg/mL, the PEI from the four herbal teas reduces the activity of α-amylase by 23.03–28.61%, with L. javanica as the most active tea. Three of the species are high in phenylpropanoid glycosides, while P. dulcis contains rosmarinic acid. Some 26 compounds were identified in the infusion from B. saligna, 28 from L. scaberrima, and 21 from P. dulcis. Four of them are common in all the teas, namely decaffeoylverbascoside, verbascoside, isoverbascoside, and tuberonic acid hexoside. Ten compounds occur in two of the teas and seventeen, fifteen, and eleven compounds were detected only in B. saligna, L. scaberrima, and P. dulcis, respectively. Most of the compounds are reported for the first time from the crude drug infusions. The results give some support for the traditional use of herbal teas as digestives and/or indications for diabetes. The chemical fingerprints set the basis for quality control of the crude drugs, based on the main constituents and differential compounds occurring in the samples. Full article

The savings behavior of individuals has been a topic of both macroeconomic and policy importance throughout history. Theoretical and empirical research shows that savings result from several demographic and economic factors working together to produce long-term, sustainable economic growth. This study therefore examined the nexus between domestic savings and sustainable economic growth in a South African perspective between 1970 and 2022, emphasizing the critical role that savings play in fostering long-term economic stability and environmental resilience. The ARDL framework was used to analyze data from the World Bank and the South African Reserve Bank. The results of the study demonstrate that corporate savings have a major effect on sustainable economic growth, especially over the long term. When corporate savings rise by 1%, the economy expands by 3.12%, which highlights the significant multiplier effect of investment. The extent of this impact depends on factors such as the efficiency of capital allocation, technological capacity, financial market development, government policies, and macroeconomic stability. These factors collectively determine how effectively corporate savings are transformed into productive investments that drive sustainable economic growth. Conversely, savings made by the government and the public, especially in the long run, have no appreciable impact on sustainable economic growth. Given that domestic savings mobilization is the most suitable channel for financing capital accumulation to support economic growth and development, the study suggests reviewing current policies to encourage domestic savings mobilization. This paper contributes to the broader discourse on sustainable economic policies in emerging markets, offering actionable insights for policymakers, financial institutions, and stakeholders promoting a more sustainable economic future for South Africa. Full article

Dye-sensitized solar cells (DSSCs) are a type of thin-film solar cell that has been extensively studied for more than two decades due to their low manufacturing cost, flexibility and ability to operate under low-light conditions. However, there are some challenges that need to be addressed, such as energy losses, material integration, weak photocurrent generation and stability, to enhance the performance of DSSCs. One of the approaches to enhance the performance of DSSCs is the use of luminescent materials. These are materials that can absorb light and re-emit at different wavelengths, allowing the conversion of ultraviolet (UV) and near-infrared (NIR) light, which DSSCs do not efficiently utilize, into visible light that can be absorbed. The main objective of this article is to provide an in-depth review of the impact of luminescent materials in DSSCs. Research interest on luminescent materials, particularly down conversion, up-conversion and quantum dots, was analyzed using data from the “Web of Science”. It revealed a remarkable number of over 200,000 publications in the past decade. Therefore, the state of the art of luminescent materials for enhancing the performance of the solar cells was reviewed, which showed significant potential in enhancing the performance of DSSCs. Full article

Copper nanoparticles (CuNPs) are tiny materials with special features such as high electric conductivity, catalytic activity, antimicrobial activity, and optical activity. Published reports demonstrate their utilization in various fields, including biomedical, agricultural, environmental, wastewater treatment, and sensor fields. CuNPs can be produced utilizing traditional procedures; nevertheless, such procedures have restrictions like excessive consumption of energy, low production yields, and the utilization of detrimental substances. Thus, the adoption of environmentally approachable “green” approaches for copper nanoparticle synthesis is gaining popularity. These approaches involve employing plants, bacteria, and fungi. Nonetheless, there is a scarcity of data regarding the application of microbial bioflocculants in the synthesis of copper NPs. Therefore, this review emphasizes copper NP production using microbial flocculants, which offer economic benefits and are sustainable and harmless. The review also provides a characterization of the synthesized copper nanoparticles, employing numerous analytical tools to determine their compositional, morphological, and topographical features. It focuses on scientific advances from January 2015 to December 2023 and emphasizes the use of synthesized copper NPs in wastewater treatment. Full article

This study aimed to examine fungi diversity in dried beef meat sold in Ekiti State, characterize the isolated fungi, and determine the aflatoxin-producing ability of the Aspergillus fungi in the samples. Dried beef meat was collected from different markets in Ekiti State and screened for the presence of filamentous fungi using molecular methods. Samples were cultured aseptically on potato dextrose agar (PDA) for fungi isolation, and molecular identification was performed using DNA extraction, Polymerase chain Reaction (PCR), ITS-1/ITS-4 primer pair, and nucleotide sequencing. The results obtained indicated a range of filamentous fungi genera including Aspergillus, Rhizopus, Penicillium, Fusarium, Cladosporium, Alternaria, and other fungi species contaminating the dried meat at (43%), (42%), (3%), (2%), (2%), (1%), and (7%), respectively. High incidences were recorded for Aspergillus flavus, Aspergillus niger, and Aspergillus fumigatus in most of the screened samples. Aspergillus flavus accounted for (24.7%) of all the Aspergillus species isolated with the presence of the gene needed for aflatoxin production. The occurrences of these filamentous fungal species pose a cause for concern, as most of these fungal species are known producers of certain toxic substances. Maximum likelihood phylogenetic analysis showed a high similarity index score, which indicated a good relationship between isolated Aspergillus Species and the closely related strains from GenBank, isolated from different sources and countries. The implication of this study is that consumer health may be at risk through exposure to contaminated dried meat. Full article

Worldwide, cancer ranks among the foremost contributors to mortality despite recent medical progress. Alternative approaches in controlling various forms of cancer are being highly explored by researchers. This study provides the global research trends in the utilization of medicinal plant-synthesized nanoparticles for cancer treatment over the span of 18 years using scientometric analysis. Recent research advances on medicinal plant-derived nanoparticles for cancer treatment and their possible mechanisms of action were described. Relevant articles published between 2005 and 2023 were retrieved from Scopus and Web of Science and analyzed using RStudio and VOSViewer. Scientometric indicators were employed to analyze the results. The initial search returned 5695 articles, with a publication growth rate of 3.71% annually. Countries from Asia contributed the most (61.37%) to the total number of publications. The therapeutic effects of nanoparticles derived from medicinal plants can be attributed to various mechanistic pathways, including induced apoptosis from reactive oxygen species generation, as well as mitochondrial and cell membrane disruption, amongst others. Although some reported studies demonstrated promising safety and efficacy against certain cancer cells in vivo and in vitro, the little to no clinical data on medicinal plant-synthesized nanoparticles hinder the ability to make informed decisions about their clinical potential in cancer treatment. Full article

The global environment has recently been facing sustainability threats owing to industrial and economic expansions. Accordingly, this study empirically examines the impact of carbon emissions and the directional causality between carbon emissions and environmental quality, financial development, and economic growth. We used data from 65 economies from 2010 to 2021, applying fully modified ordinary least squares (FMOLS) and dynamic ordinary least squares (DOLS) approaches. Generally, the findings from the analysis revealed that the estimated coefficients of carbon emissions were negative and significant across the model, except for greenhouse gas emissions, which produced an insignificant result in developed economies. This result proves that an increase in carbon emissions and other forms of pollution are detrimental to environmental quality, economic growth, and financial development. Further results revealed that fossil fuels are positively and significantly related to the economic growth and financial development of selected countries. Empirical outcomes indicate that ineffective control of environmental pollution and carbon emissions is a major challenge to the economic growth trajectories of the selected countries, especially in emerging economies. The results from directional relationships revealed that bi-directional causality exists between CO₂ and GDP; between total greenhouse gas emissions and economic growth, with no directional relationship of CO₂ emissions to financial development and vice versa; and economic growth to CO₂ emissions from gaseous fuel consumption and vice versa. Generally, this outcome indicates that improved environmental quality control can accelerate economic growth and financial development worldwide. This study provides insights to governments, policymakers, international organizations, researchers, and many other stakeholders. This study suggests that stricter fiscal and monetary policies, laws, and regulations, such as environmental taxes and carbon emission taxes, with strong implementation strategies, especially in emerging economies, are strongly recommended worldwide. Further recommendations suggest the development of technologically innovative policies that can counter all the impacts of devastating human activities on the environment, and these are encouraged. A greater consumption of renewable energy and the use of other innovative machines that are environmentally friendly and can help control various forms of pollution and carbon emissions have been encouraged globally. Full article

Nowadays, improved fishing technology and depleted stocks cause fishery shocks in sensitive regions that lead to job losses and added insecurity. In fishery-dependent communities, more and more fishers are moving countries looking for a living. This study aims to know the perception of migrants in Spain about the sustainability of fishing in their countries of origin and how this perception influenced their individual behaviors and their decision to move. To this end, 203 families from 32 countries differentially affected by fishery shocks in Africa and Latin America were interviewed face-to-face to quantify the perceived weight of fishery changes on their decision to move, compared with socioeconomic and security reasons. The perception of fishing declines and their importance as a cause of mobility were positively and significantly correlated. Our study highlights the important and unexplored link between human mobility and fishery depletion, supporting the idea that fishing declines—induced at least partially by climate change—are one of the causes of mobility. Full article

This study evaluates the effectiveness of stone bunds in enhancing soil moisture, vegetation health, and crop yields in Ghana’s semi-arid Upper East Region, an important area for agricultural productivity in West Africa. In this region, agricultural practices are heavily impacted by erratic rainfall and poor soil moisture retention, threatening food security. Despite the known benefits of traditional soil conservation practices like stone bunds, their effectiveness in this context has not been fully quantified. Field and remote sensing data were used to evaluate the influence of stone bunds on soil moisture dynamics, vegetation growth, and crop yield. Experimental plots with and without stone bunds were monitored for climate, soil water infiltration, and soil moisture and analyzed using the NDVI from Sentinel-2 satellite imagery over two growing seasons under sorghum production (2022–2023). The results indicated that stone bunds enhanced soil moisture retention and increased infiltration rates. The NDVI analysis consistently revealed higher vegetation health and growth in the plots with stone bunds, particularly during critical growth periods. The intermediate results of the conducted experiment indicated that stone bunds increased sorghum yields by over 35% compared to the control plots. The substantial agronomic benefits of stone bunds as a soil and water conservation strategy were evident, improving soil water infiltration, water retention, vegetation health, and crop yields. The findings support the broader adoption of stone bunds in semi-arid regions to enhance agricultural productivity and resilience against climate variability. Further research is recommended to explore the long-term impacts and the integration of stone bunds with other sustainable farming practices to optimize rainfed agricultural outcomes. Full article

Durban Port in South Africa is the largest container port and the busiest shipping terminal in sub-Saharan Africa. Approximately 60% of the country’s containerised cargo and 40% of break-bulk cargo transit through Durban. The port is near the central business district, which has a positive spin-off in terms of tourism, recreation, and accessibility to transport and other business activities. The juxtaposition of industry, the port, and the community has resulted in sustained public health implications, a relic of the apartheid era. Like most ports in Africa, Durban Port lacks proper quantification of emissions from marine mobile sources. This study is aimed at estimating atmospheric emissions from ocean-going vessels (OGVs) in and around Durban Port for a period of one year from 1 January 2018 to 31 December 2018 using a mid-tier (activity-based) approach to supplement existing understandings of emissions from local industries. Emission estimates were then inputted to the AERMOD atmospheric dispersion model to allow for a comparison between ambient concentrations and national ambient air quality standards to assess potential health impacts. The study is an advancement in understanding the impact of mobile sources, particularly shipping, on air quality and health, and offers an example for other African ports to follow. Full article

Background: Effective wound dressing is the key solution to combating the increased death rate and prolonged hospital stay common to patients with wounds. Methods: Sodium alginate-based single- and double-layer membranes incorporated with Capparis sepiaria root extract were designed using the solvent-casting method from a combination of polyvinyl alcohol (PVA), Pluronic F127 (PF127), and gum acacia. Results: The successful preparation of the membranes and loading of the extract were confirmed using Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD). The prepared membranes were biodegradable and non-toxic to human skin cells (HaCaT), with high biocompatibility of 92 to 112% cell viability and good hemocompatibility with absorbance ranging from 0.17 to 0.30. The membrane’s highest water vapor transmission rate was 1654.7333 ± 0.736 g/m²/day and the highest % porosity was 76%. The membranes supported cellular adhesion and migration, with the highest closure being 68% after 4 days compared with the commercial wound dressings. This membrane exhibited enhanced antimicrobial activity against the pathogens responsible for wound infections. Conclusions: The distinct features of the membranes make them promising wound dressings for treating infected wounds. Full article

In dry flue gas treatment systems, gas–solid interactions are modulated by the reagent molecular composition and physical attributes. In the present investigation, sodium- and calcium-based sorbents were screened for structural and compositional variations for their subsequent application in sulphur dioxide capture. Mined sodium bicarbonate (NaHCO₃) in its unprocessed form and commercial-grade hydrated lime (Ca(OH)₂) were subjected to morphological analyses, employing scanning electron microscopy (SEM), particle size distribution (PSD), Brunauer–Emmett–Teller surface area evaluation, and Barrett–Joyner–Halenda (BJH) pore structure classification. Fourier Transform Infrared Spectroscopy (FTIR) was leveraged for a surface elemental chemical assessment. Pursuant to the BET report, Ca(OH)₂ presented a larger specific surface area (4.2360 m²/g) as opposed to NaHCO₃ (0.2303 m²/g), which was supported by the weighted mean value (D43) from the PSD analysis. Although Ca(OH)₂ had a higher pore volume (0.089822 cm³/g), the totality of the NaHCO₃ pore size (117.312 Å) was classified as mesoporous. The SEM assessment suggested that the lower NaHCO₃ surface area stemmed from larger particle sizes. The FTIR spectrum indicated a greater carbonate concentration in the NaHCO₃ sorbent material, which also structures the pore morphology of the reagent. These findings offer critical information pertinent to the intricate dry flue gas desulphurisation process. The data generated will help us to design fixed bed experiments in a subsequent study. Full article