Search Results (43)

Background: Boron neutron capture therapy (BNCT) is an innovative binary form of radiation therapy with high selectivity towards cancer tissue based on the neutron capture reaction ¹⁰B(n,$\alpha$)⁷Li, consisting in the exposition of patients to neutron beams after administration of a boron compound with preferential accumulation in cancer cells. The high linear energy transfer products of the ensuing reaction deposit their energy at the cell level, sparing normal tissue. Although progress in accelerator-based BNCT has led to renewed interest in this cancer treatment modality, in vivo dose monitoring during treatment still remains not feasible and several approaches are under investigation. While Compton imaging presents various advantages over other imaging methods, it typically requires long reconstruction times, comparable with BNCT treatment duration. Methods: This study aims to develop deep neural network models to estimate the dose distribution by using a simulated dataset of BNCT Compton camera images. The models pursue the avoidance of the iteration time associated with the maximum-likelihood expectation-maximization algorithm (MLEM), enabling a prompt dose reconstruction during the treatment. The U-Net architecture and two variants based on the deep convolutional framelets framework have been used for noise and artifact reduction in few-iteration reconstructed images. Results: This approach has led to promising results in terms of reconstruction accuracy and processing time, with a reduction by a factor of about 6 with respect to classical iterative algorithms. Conclusions: This can be considered a good reconstruction time performance, considering typical BNCT treatment times. Further enhancements may be achieved by optimizing the reconstruction of input images with different deep learning techniques. Full article

The ability to localize and image radiation sources has found use in various applications for nuclear nonproliferation practices, specifically in treaty verification, nuclear safeguards, and homeland security. Technologies that are capable of angular radiation imaging have been prevalent for years and, recently, 3D imaging technologies making use of emerging media like mixed reality have been rapidly developing and gaining popularity. Modern imaging techniques typically use a Compton camera to record coincident events and reconstruct the incident directional information of a gamma ray-emitting radiation source. However, Compton cameras are limited as they cannot obtain accurate source depth information when used for simple back projection imaging. Neutron scatter cameras are a complementary imaging technique that use double elastic scatters but also have their own limitations. This work presents a framework for multiple scatter-based particle imagers to construct 3D images and to localize a radiation source using gamma rays or fast neutrons. Specifically, localization is achieved by accounting for the position of the imagers. The imaging algorithm was validated using experimental data, measuring a ²⁵²Cf source. A three-dimensional representation of the imaging data provides a more intuitive and informative depiction of source positions and can aid in scenarios with complex environmental geometries such as when sources are in containers. Full article

Nuclear power plant decommissioning requires the rapid and accurate classification of radioactive waste in narrow spaces and under time constraints. Photon-counting detector technology offers an effective solution for the quick classification and detection of radioactive hotspots in a decommissioning environment. This paper characterizes a 5 mm CdTe Timepix3 detector and evaluates its feasibility as a single-layer Compton camera. The sensor’s electron mobility–lifetime product and resistivity are studied across bias voltages ranging from −100 V to −3000 V, obtaining values of ${\mathrm{\mu }}_e{\tau }_e$ = (1.2 ± 0.1) × 10⁻³ cm²V⁻¹, and two linear regions with resistivities of ${\rho }_I=(5.8\pm 0.2) \mathrm{G}\Omega \mathrm{cm}$ and ${\rho }_{II}=(4.1\pm 0.1) \mathrm{G}\Omega \mathrm{cm}$. Additionally, two calibration methodologies are assessed to determine the most suitable for Compton applications, achieving an energy resolution of 16.3 $\mathrm{k}$$\mathrm{e}\mathrm{V}$ for the ¹³⁷Cs photopeak. The electron’s drift time in the sensor is estimated to be (122.3 ± 7.4) ns using cosmic muons. Finally, a Compton reconstruction of two simultaneous point-like sources is performed, demonstrating the detector’s capability to accurately locate radiation hotspots with a ∼51 cm resolution. Full article

In this paper, a new light event acquisition chain in a three-gamma liquid xenon prototype for medical nuclear imaging is presented. The prototype implements the Multi-Time-Over-Threshold (MTOT) method. This method surpasses the Single-Time-Over-Threshold (STOT) by precisely determining both the number of vacuum ultraviolet (VUV) photons detected by each photomultiplier tube (PMT) and their arrival times for light signal measurement. Based on both the experimental and simulated results, the MTOT method achieved a 70% improvement in reconstructing photoelectrons (PEs) and enhanced the precision of the arrival time estimation by 20–30% compared with STOT. These results will enable an upgrade of the XEMIS2 (Xenon Medical Imaging System) camera, improving its performance as the imaged activity increases. Full article

X-ray polarimetry has been suggested as a prominent tool for investigating the geometrical and physical properties of the emissions from active galactic nuclei (AGN). The successful launch of the Imaging X-ray Polarimetry Explorer (IXPE) on 9 December 2021 has expanded the previously restricted scope of polarimetry into the X-ray domain, enabling X-ray polarimetric studies of AGN. Over a span of two years, IXPE has observed various AGN populations, including blazars and radio-quiet AGN. In this paper, we summarize the remarkable discoveries achieved thanks to the opening of the new window of X-ray polarimetry of AGN through IXPE observations. We will delve into two primary areas of interest: first, the magnetic field geometry and particle acceleration mechanisms in the jets of radio-loud AGN, such as blazars, where the relativistic acceleration process dominates the spectral energy distribution; and second, the geometry of the hot corona in radio-quiet AGN. Thus far, the IXPE results from blazars favor the energy-stratified shock acceleration model, and they provide evidence of helical magnetic fields inside the jet. Concerning the corona geometry, the IXPE results are consistent with a disk-originated slab-like or wedge-like shape, as could result from Comptonization around the accretion disk. Full article

In one and a half years, the Imaging X-ray Polarimetry Explorer has demonstrated the role and the potentiality of Polarimetry in X-ray Astronomy. The next steps include extension to higher energies. There is margin for an extension of the photoelectric approach up to 20–25 keV, but above that energy the only technique is Compton Scattering. Grazing incidence optics can focus photons up to 80 keV, not excluding a marginal extension to 150–200 keV. Given the physical constraints involved, the passage from photoelectric to scattering approach can make less effective the use of optics because of the high background. I discuss the choices in terms of detector design to mitigate the problem and the guidelines for future technological developments. Full article

Conventional maximum likelihood-based algorithms for 3D Compton image reconstruction are often stuck with slow convergence and large data volume, which could be unsuitable for some practical applications, such as nuclear engineering. Taking advantage of the Bayesian framework, we propose a fast-converging iterative maximum a posteriori reconstruction algorithm under the assumption of the Poisson data model and Markov random field-based convex prior in this paper. The main originality resides in developing a new iterative maximization scheme with simultaneous updates following the line search strategy to bypass the spatial dependencies among neighboring voxels. Numerical experiments on real datasets conducted with hand-held Temporal Compton cameras developed by Damavan Imaging company and punctual 0.2 MBq ²²Na sources with zero-mean Gaussian Markov random field confirm the outperformance of the proposed maximum a posteriori algorithm over various existing expectation–maximization type solutions. Full article

(1) Background: The imaging energy range of a typical Compton camera is limited due to the fact that scattered gamma photons are seldom fully absorbed when the incident energies are above 3 MeV. Further improving the upper energy limit of gamma-ray imaging has important application significance in the active interrogation of special nuclear materials and chemical warfare agents, as well as range verification of proton therapy. (2) Methods: To realize gamma-ray imaging in a wide energy range of 0.3~7 MeV, a principle prototype, named a portable three-layer Compton camera, is developed using the scintillation detector that consists of an silicon photomultiplier array coupled with a Gd₃Al₂Ga₃O₁₂:Ce pixelated scintillator array. Implemented in a list-mode maximum likelihood expectation maximization algorithm, a far-field energy-domain imaging method based on the two interaction events is applied to estimate the initial energy and spatial distribution of gamma-ray sources. The simulation model of the detectors is established based on the Monte Carlo simulation toolkit Geant4. The reconstructed images of a ¹³³Ba, a ¹³⁷Cs and a ⁶⁰Co point-like sources have been successfully obtained with our prototype in laboratory tests and compared with simulation studies. (3) Results: The proportion of effective imaging events accounts for about 2%, which allows our prototype to realize the reconstruction of the distribution of a 0.05 μSv/h ¹³⁷Cs source in 10 s. The angular resolution for resolving two ¹³⁷Cs point-like sources is 15°. Additional simulated imaging of the 6.13 MeV gamma-rays from 14.1 MeV neutron scattering with water preliminarily demonstrates the imaging capability for high incident energy. (4) Conclusions: We conclude that the prototype has a good imaging performance in a wide energy range (0.3~7 MeV), which shows potential in several MeV gamma-ray imaging applications. Full article

Compton scattering imaging with intense, high-energy synchrotron X-rays allows us to visualize a light element substance in an operating electrochemical device. In this paper, we report the first experiment of Compton scattering imaging (CSI) on an operating polymer electrolyte fuel cell (PEFC). The novelty of the CSI technique is a non-destructive direct observation of cross-sectional images with a sensitivity to light elements and a capability of simultaneous measurements with fluorescent X-rays of heavy elements. Analyses of the observed images provide the cross-sectional distribution of generated liquid water and its current density dependency. The results show that the amount of generated water increases in the vicinity of the cathode catalyst layer at current densities ranging from 100 to 500 mA/cm², while it remains constant or slightly decreases from 500 to 900 mA/cm². In both the gas diffusion layer and the channel, liquid water is observed near the channel and rib interface above 500 mA/cm², indicating the formation of a liquid water flow path. In addition, simultaneous measurements of fluorescent Pt-Ka X-rays reveal a significant correlation between the generated liquid water and Pt catalysts, using the Pearson correlation coefficient. The result shows that water is dispersed in the catalyst layer without any correlation with the amount of Pt catalysts at low current densities, but water tends to be distributed in the Pt-rich areas at high current densities. This study demonstrates that Compton scattering imaging is one of the unique techniques to characterize the behavior of generated liquid water in an operating PEFC. Full article

Boron Neutron Capture Therapy (BNCT) is an innovative and highly selective treatment against cancer. Nowadays, in vivo boron dosimetry is an important method to carry out such therapy in clinical environments. In this work, different imaging methods were tested for dosimetry and tumor monitoring in BNCT based on a Compton camera detector. A dedicated dataset was generated through Monte Carlo tools to study the imaging capabilities. We first applied the Maximum Likelihood Expectation Maximization (MLEM) iterative method to study dosimetry tomography. As well, two methods based on morphological filtering and deep learning techniques with Convolutional Neural Networks (CNN), respectively, were studied for tumor monitoring. Furthermore, clinical aspects such as the dependence on the boron concentration ratio in image reconstruction and the stretching effect along the detector position axis were analyzed. A simulated spherical gamma source was studied in several conditions (different detector distances and boron concentration ratios) using MLEM. This approach proved the possibility of monitoring the boron dose. Tumor monitoring using the CNN method shows promising results that could be enhanced by increasing the training dataset. Full article

The use of X-rays for non-invasive imaging has a long history, which has resulted in several well-established methods in preclinical as well as clinical applications, such as tomographic imaging or computed tomography. While projection radiography provides anatomical information, X-ray fluorescence analysis allows quantitative mapping of different elements in samples of interest. Typical applications so far comprise the identification and quantification of different elements and are mostly located in material sciences, archeology and environmental sciences, whereas the use of the technique in life sciences has been strongly limited by intrinsic spectral background issues arising in larger objects, so far. This background arises from multiple Compton-scattering events in the objects of interest and strongly limits the achievable minimum detectable marker concentrations. Here, we review the history and report on the recent promising developments of X-ray fluorescence imaging (XFI) in preclinical applications, and provide an outlook on the clinical translation of the technique, which can be realized by reducing the above-mentioned intrinsic background with dedicated algorithms and by novel X-ray sources. Full article

Macroscopic X-ray fluorescence analysis (MA-XRF) is a non-destructive analytical technique that allows for the rapid and thorough investigation of paintings; therefore, it is nowadays increasingly involved in relevant studies. In the present work, a state-of-the-art MA-XRF set-up is utilized to identify the painting materials and techniques and document the state of preservation of an early 19th-century AD Greek religious panel painting (“icon”). The artifact in consideration has received extensive restoration interventions in the past and is considerably decayed; for these reasons, the interpretation of the relevant MA-XRF elemental intensity distribution maps is challenging. In this framework, it is demonstrated how the elemental distribution maps can be explored and interpreted to lead to a thorough investigation of the painting in consideration. In particular, the MA-XRF data interpretation allowed for the identification of the original palette that includes the rather rarely employed–in icon painting-yellow lead-antimonate pigment, led to the spotting of an invisible inscription, to the documentation of the preparation/gesso layer and the preliminary drawing. Additionally, it was possible to discriminate between the original painting and the later interventions, while the collected data revealed that the painting originally had two cross-bars attached to its back. Ultimately, the presented case study can be utilized as a guide for the proper interpretation of MA-XRF data from decayed and altered icons. Full article

(1) Background: Gamma cameras have wide applications in industry, including nuclear power plant monitoring, emergency response, and homeland security. The desirable properties of a gamma camera include small weight, good resolution, large field of view (FOV), and wide imageable source energy range. Compton cameras can have a 4π FOV but have limited sensitivity at low energy. Coded-aperture gamma cameras are operatable at a wide photon energy range but typically have a limited FOV and increased weight due to the thick heavy metal collimators and shielding. In our lab, we previously proposed a 4π-view gamma imaging approach with a 3D position-sensitive detector, with which each detector element acts as the collimator for other detector elements. We presented promising imaging performance for ^99mTc, ¹⁸F, and ¹³⁷Cs sources. However, the imaging performance for middle- and high-energy sources requires further improvement. (2) Methods: In this study, we present a new gamma camera design to achieve satisfactory imaging performance in a wide gamma energy range. The proposed gamma camera consists of interspaced bar-shaped GAGG (Ce) crystals and tungsten absorbers. The metal bars enhance collimation for high-energy gamma photons without sacrificing the FOV. We assembled a gamma camera prototype and conducted experiments to evaluate the gamma camera’s performance for imaging ⁵⁷Co, ¹³⁷Cs, and ⁶⁰Co point sources. (3) Results: Results show that the proposed gamma camera achieves a positioning accuracy of <3° for all gamma energies. It can clearly resolve two ¹³⁷Cs point sources with 10° separation, two ⁵⁷Co and two ⁶⁰Co point sources with 20° separation, as well as a 2 × 3 ¹³⁷Cs point-source array with 20° separation. (4) Conclusions: We conclude that the proposed gamma camera design has comprehensive merits, including portability, 4π-view FOV, and good angular resolution across a wide energy range. The presented approach has promising potential in nuclear security applications. Full article

Blazars whose synchrotron spectral energy distribution (SED) peaks at X-ray energies need to accelerate electrons to energies in the >100 GeV range in relativistic plasma jets at distances of parsecs from the central engine. Compton scattering by the same electrons can explain high luminosities at very high photon energies (>100 GeV) from the same objects. Turbulence combined with a standing conical shock can accomplish this. Such a scenario can also qualitatively explain the level and variability of linear polarization observed at optical frequencies in these objects. Multi-wavelength polarization measurements, including those at X-ray energies by the Imaging X-ray Polarimetry Explorer (IXPE), find that the degree of polarization is several times higher at X-ray than at optical wavelengths, in general agreement with the turbulence-plus-shock picture. Some detailed properties of the observed polarization can be naturally explained by this scenario, while others pose challenges that may require modifications to the model. Full article

The realization of compact X-ray sources is one of the most intriguing applications of laser-plasma based electron acceleration. These sources based on the oscillation of short micron-sized bunches of relativistic electrons provide femtosecond X-ray pulses that are collimated, bright, and partially coherent. The state-of-the-art laser plasma X-ray sources can provide photon flux of over 10¹¹ photons/shot. The photon flux can further be enhanced with the availability of high repetition rate, high-power lasers, providing capacities complementary to the large scale facilities such as synchrotrons and X-ray free-electron lasers. Even though the optimization of such sources has been underway for the last two decades, their applications in material and biological sciences are still emerging, which entail the necessity of a user-oriented X-ray beamlines. Based on this concept, a high-power-laser-based user-oriented X-ray source is being developed at ELI Beamlines. This article reports on the ELI Gammatron beamline and presents an overview of the research accessible with the ultrashort hard X-ray pulses at the ELI Gammatron beamline. Full article