Search Results (655)

The endoscopic resection of gastrointestinal tract lesions embraces different types of techniques, ranging from conventional polypectomy/endoscopic mucosal resection (EMR) to the field of third-space endoscopy, including endoscopic submucosal dissection (ESD), full-thickness resection and peroral endoscopic myotomy (POEM). Parallelly, the advent of underwater techniques has served as an add-on for both basic and advanced procedures, since its first report in 2012. We aimed to provide a comprehensive update on the state of the art about the feasibility of underwater basic and advanced techniques for GI endoscopy. Underwater EMR (U-EMR) has proved effective and safe in treating > 10 mm sessile or flat or all-size recurrent colonic lesions. Conversely, although data show good effectiveness and safety for <10 mm lesions, it is preferred when high-grade dysplasia is suspected, favouring cold snare polypectomy for all other cases. Moreover, promising data are emerging regarding the feasibility of U-ESD for difficult-to-resect colonic lesions. U-EMR represents a standard of care for treating < 25 mm superficial non-ampullary duodenal epithelial tumours. Data regarding oesophageal, gastric and ampullary lesions remains limited to small cohorts. Finally, using water immersion for POEM has shown a reduction in procedure time compared to the CO₂ insufflation technique for vessel coagulation, albeit in a single-centre experience. Based on these results, U-EMR has become a standard for treating intermediate-size colonic and non-ampullary duodenal lesions, as highlighted also in the European Society of Gastrointestinal Endoscopy guidelines. Promising results have been shown in third-space endoscopy studies, even though further prospective studies are awaited to standardise the technique for both ESD and POEM. Full article

The Gate rudder system (GRS) was recently introduced as an innovative energy-saving device (ESD) for ships, and it is the most attractive ESD currently used in the market, with double figures of fuel savings in full-scale (>10–35%) compared with a ship with a conventional rudder system (CRS). Although there are few new ship applications of GRS, the recently completed EC-H2020 GATERS project successfully demonstrated its unique energy-saving and manoeuvrability benefits as a “retrofit” solution for an existing general cargo vessel for the first time. The project results suggested that the GRS holds significant potential for retrofitting existing ships to enhance fuel efficiency (~35%) and improve manoeuvrability. Nevertheless, the application was a comprehensive undertaking requiring various work tasks such as component manufacturing, removing existing systems, and modification and upgrading works, with substantial energy consumption and environmental impacts. Therefore, it was insightful to study energy use and environmental impacts in a GRS retrofit process. This study developed and implemented a comprehensive energy consumption and carbon footprint assessment framework for the GRS retrofit in the GATERS project. A detailed assessment of energy consumption and related carbon emissions was performed during the major stages of manufacturing, system removals, and modifications and assembly in the GRS retrofit. Also, the potential savings in energy use and emissions were addressed. The results demonstrated that the manufacturing stage was the most energy-intensive phase, being responsible for 91.4% of total electricity and 46.7% of fuel-based thermal energy use. The system removals accounted for 53.3% of the fuel-based thermal energy, whereas the modification and assembly work accounted for about 7.7% of the total electricity use. Additionally, various measures such as clean electrification, energy efficiency, mould/tool reuse, and component reuse to reduce the energy consumption and related carbon emissions in future GRS retrofit applications were addressed and discussed together with their reduction potentials. Full article

The argument made in this study is that sustainability is a system of beliefs that extends beyond policy and the classroom to transform actions and societies into pro-sustainable behaviours. Therefore, it is crucial to equip trainee teachers to embrace their role as catalysts for change in driving Sustainable development goals, sustainable thinking, systems thinking, wise consumption, sustainable competencies, and sustainable action in their daily lives. The lack of practice-led research on incorporating Education for Sustainable Development (ESD) into trainee teachers’ training programmes is noted in the literature. This qualitative practice-led research explored trainee mathematics and technology teachers’ (TMTTs) experiences learning about sustainability. Kolb’s experiential theory framed this study theoretically. The data were collated from twenty purposively selected TMTTs via semi-structured interviews and reflective diaries. All ethical protocols were observed. The analysis highlighted the core experiences TMTTs gained in learning about sustainability, transformative learning, design thinking, wise consumption, agency, and sustainable teaching strategies. Theoretically, the findings emphasise the importance of using an ESD perspective and experiential learning methods to integrate sustainability education into mathematics and technology teaching. The results suggest that when TMTTs are encouraged to actively engage with sustainability issues in their communities, informed decisions are made about their future roles as teachers, the teaching strategies they intend to use, and the type of learning they aim to foster in their learners. Full article

This systematic review addressed the need for documentation and analysis of the scope and topical foci of research on education for sustainable development (ESD) in East Asia. The review used descriptive, content, and keyword co-occurrence analyses to synthesize features of 1915 Scopus-indexed journal articles published between 1991 and 2023. The authors found that research interest in ESD in East Asia has grown rapidly, accelerated by the pronouncement of the United Nations Decade of Education for Sustainable Development in 2005 and the Sustainability Agenda 2030 in 2015. Researchers in China, Malaysia, Japan, South Korea, Indonesia, and Thailand have been the leading contributors to this regional knowledge base. Consistent with global ESD reviews, content analysis revealed that this literature emerged from studies of environmental education and gradually expanded to include sociocultural, economic, and integrated perspectives on sustainability. Keyword co-occurrence analysis revealed three thematic clusters: Environmental Sustainability in Education, Social Sustainability in Education, and Teaching and Learning for Sustainability. Temporal co-word analysis highlighted the research front, which includes environmental research focusing on carbon/energy issues, technology-enhanced learning for sustainability, empirical research methods for studying ESD, and, to a lesser degree, studies of the economic pillar of sustainability in education. Recommendations are offered for future research. Full article

Artificial intelligence (AI) has become an instrument used in all domains with good results. The water resources management field is not an exception. Therefore, in this article, we propose two machine learning (ML) techniques—an echo state network (ESN) and sparrow search algorithm–echo state network (SSA-ESN)—for monthly modeling of the water discharge of one of the biggest rivers in Romania for three periods (S, S1, and S2). In both models, R² was over 0.989 on the test and training sets and the mean absolute error (MAE) varied between 4.4826 and 7.6038. The performance of the SSA-ESN was similar, but the ESN had the shortest run time. The influence of anomalies on the models’ quality was assessed by running the algorithms on a series without the aberrant values, which were detected by the seasonal hybrid extreme studentized deviate (S-H-ESD) test. The results indicate that removing the anomalies significantly improved both models’ performance, but the run time was increased. Full article

The purpose of this research is to examine current alignment of tourism, hospitality, culinary, events, and sports management curriculum with the United Nations Sustainable Development Goals (SDG’s) across two departments in Higher Education Institutions in Ireland. To do this, a quantitative approach was adopted utilising a content analysis of programme learning outcomes and surveys with programme specific educators. This permitted an evaluation on the current status of incorporation of SDG’s within existing curricula and an insight into the motivations and challenges of Education for Sustainable Development (ESD) integration from the perspective of educators. Findings revealed weak levels of current alignment of learning outcomes to SDG’s for tourism, hospitality, culinary, events, and sports management curriculum across two sampled departments while educators emphasised a need to upskill on the subject matter in an effort to ensure more comprehensive ESD integration across modules and programmes. The Results overall highlighted the need to ensure future curriculum review and development takes appropriate cognisance of ESD and through communities of Practice within Higher Education Institutions, educators can better embed and advance ESD within third level curricula. The findings presented in this study may have lessons to be learned for other Higher Education Institutions across Ireland and internationally. Full article

This research focuses on analyzing wool samples dyed with synthetic dyes from the early 20th century. A methodology to identify and distinguish wool fibers dyed with azo, triphenylmethane, and xanthene dyes, which are no longer in use, using the ATR-FTIR spectra, is presented. Firstly, the dataset was subjected to PCA, which revealed the similarities and differences among the samples, illustrating a distribution pattern based on dye classes. MCR-ALS was employed to extract the spectral profiles of the dyed fibers, thereby enhancing the efficacy of the analytical techniques and extracting the comprehensive information from a single instrument. The combination of ATR-FTIR spectroscopy with chemometric methods, such as PCA and MCR-ALS, has proven to be an effective strategy for identifying and differentiating wool fibers dyed with early azo, triphenylmethane, and xanthene dyes. This approach has demonstrated particular effectiveness in enabling rapid analysis without requiring sampling or pretreatment. Moreover, the analysis is supported by thorough bibliographic research on these no longer used colorants. In order to maximize the potential of non-destructive spectroscopic techniques, such as ATR-FTIR, the approach used has proven to be crucial. This study underscores how chemometric techniques expand the capabilities of spectroscopy, extracting extensive information from a single instrument and aligning with the goals of cultural heritage analysis. Full article

Both nanoscience and nanotechnology have undoubtedly contributed significantly to the development of thermite-based nanoenergetic materials (NEMs) with tunable and tailorable combustion performance and their subsequent integration into devices. Specifically, this review article reflects the immense paybacks in designing and fabricating ordered/disordered assembly of energetic materials over multiple length scales (from nano- to milli-scales) in terms of realization of desired reaction rates and sensitivity. Besides presenting a critical review of present advancements made in the synthesis of NEMs, this article touches upon aspects related to various applications concomitantly. The article concludes with the author’s summary of the insurmountable challenges and the road ahead toward the deployment of nanoenergetic materials in practical applications. The real challenge lies in the ability to preserve the self-assembly of fuel and oxidizer nanoparticles achieved at the nanoscale while synthesizing macroscale energetic formulations using advanced fabrication techniques both in bulk and thin film forms. Most importantly, these self-assembled NEMs have to exhibit excellent combustion performance at reduced sensitivity to external stimuli such as electrostatic discharge (ESD), friction and impact. Full article

In light of mounting environmental concerns surrounding the overuse and accumulation of plastic waste, the United Nations (UN) has turned its attention towards sustainable materials and the Circular Economy (CE). Polymer recycling technologies have the potential to reduce the environmental impact and carbon footprint of plastic waste production, thereby contributing to the achievement of several Sustainable Development Goals (SDGs). In response to this challenge, students enrolled in the fourth year of secondary education, specializing in technology, during the 2021–2022 academic year, developed an open-source prototype that automatically transforms polyethylene terephthalate (PET) bottles into recycled rPET filament for 3D printing using an automated pultrusion model. In this working group, one of the students identified as gifted developed the pultrusion prototype using challenge-based learning and the project method (PM), which is now known as project-based learning. The resulting prototype has the capacity to transform PET bottles into rPET filament with mechanical properties comparable to those of commercial filaments, thereby enabling the manufacture of a wide range of products through 3D printing. It is not the intention of this work to create a commercial product. Rather, it is designed to promote social and sustainable entrepreneurship, CE, and the values of Education for Sustainable Development (ESD) through the recycling of polymers by means of 3D printing production. In addition, it seeks to develop the key competences for sustainability described in the methodological framework established by UNESCO in 2017. Full article

This study investigates the landscape of public funding for adult education for sustainable development (AESD) in Slovenia, focusing on the distribution, types of funding, and their impact on accessibility and quality. This study employs a mixed methods approach to understand the distribution, types of funding, and their impacts on the accessibility and quality of adult education. Data were collected through an online questionnaire completed by 59 organizations providing non-formal AESD, alongside semi-structured interviews conducted with 12 representatives. Key findings reveal a significant disparity between operational funding and that designated for AESD implementation, with non-governmental organizations (NGOs) emerging as the primary recipients of public funds. Notably, project-based funding predominates, raising concerns about the sustainability of AESD programs due to its typically time-limited nature. Public funding is essential for ensuring program accessibility and quality, as it enables organizations to hire experts and enhance curricula. However, the reliance on project-based grants creates instability, complicating long-term planning and program effectiveness. The study underscores the need for systematic and continuous funding strategies to support AESD, highlighting the importance of a cross-sectoral approach to policymaking. Overall, the research elucidates the intricate relationship between funding distribution, program effectiveness, and the advancement of sustainable development education. Full article

On-chip electrostatic discharge (ESD) protection poses a challenge in the chip fabrication process. In this study, a novel electric fuse (E-fuse) device featuring a simple structure of Ni metal on a SiO₂ dielectric for ESD protection was proposed, and the physical mechanism of its operation was investigated in detail. Experimental evaluations, utilizing transmission line pulse (TLP) testing and fusing performance analyses, reveal that the E-fuse, constructed with a Ni metal layer measuring 5 μm in width, 100 μm in length, and 5 nm in thickness, achieved a significant ESD protection voltage of 251 V (V_HBM) and demonstrates low-voltage fusing at a bias voltage of 7 V. Compared to traditional ESD protection devices, the E-fuse boasts a smaller size and removability. To assess fusing performance, devices of varying sizes were tested using a fusing lifetime model. This study supports both theoretical and empirical evidence, enabling the adoption of cost-effective, straightforward E-fuse devices for ESD protection. Full article

Background and aims: Endoscopic submucosal dissection (ESD) has become a standard treatment for early gastric cancer (EGC), often fulfilling guideline criteria (GC) or expanded criteria (EC). When lesions exceed the EC, surgical resection is recommended. However, a subgroup of these patients are not treated surgically. The aim of this study was to investigate the long-term follow-up of patients after ESD for EGC outside the EC (out of indication; OI). Methods: Patients who were included in the prospective German ESD registry were analyzed when ESD was performed for EGC. Patients were stratified in three groups according to histopathological features (GC, EC and OI). The results were evaluated in terms of patient characteristics, procedure characteristics and follow-up data. Results: Over a 48-month period, 195 patients from 14 German centers were included. In total, 71 lesions (36.4%) met the guideline criteria, 70 lesions (35.9%) corresponded to the expanded criteria and 54 lesions (27.7%) turned out to be OI. The R0 resection rate was significantly higher for the GC and EC groups than for the OI group (94.4% vs. 84.3% vs. 55.6%, p < 0.001). Additional surgery was not performed in 72% (39/54) of patients in the OI group. During a mean follow-up of 37 months, overall survival showed no significant difference between the EC and OI groups when endoscopic follow-up was performed without additional surgery (p = 0.064). Conclusions: The results show that a good long-term survival can be achieved after ESD for patients with OI lesions without additional surgery. The treatment decision has to be made on an individual basis, taking the patient’s comorbidities and the risk of surgical resection into account. Full article

During early development of biopharmaceuticals, suboptimal producing clones and production conditions can result in limited quantities of high-purity products. Here we describe a systematic approach, which requires minimal amounts of protein (~10 mg) to assess critical quality attributes of a monoclonal antibody (mAb). A commercial anti-PCSK9 IgG2 (evolocumab, Repatha^®) and an early-stage biosimilar candidate were compared head-to-head using a range of high-throughput physicochemical and in-vitro binding analytical methods. Overall, both mAbs were shown to be highly pure and primarily monomeric, to share an identical primary structure, and to have similar higher-order structural integrity, apparent solubility, aggregation propensity, and physical stability profiles under temperature and pH stress conditions. Low levels of dimers were detected for the innovator (1.2%) and the biosimilar candidate mAb (0.3%), which also presented fragments (1.2%). Regarding charge heterogeneity, the amount of the main charge isoform was 53.6% for the innovator and 61.6% for the biosimilar candidate mAb. Acidic species were 38% for the innovator and 30% for the biosimilar candidate. Variations in the relative content of a few N-glycan species were found. The in-vitro binding affinity to PCSK9 was monitored, and no differences were detected. The mathematical approach called “error spectral difference” (ESD), proposed herein, enabled a quantitative comparison of the biophysical datasets. The workflow used in the present work to characterize CQAs at early stages is helpful in supporting the development of biosimilar mAb candidates. Full article

This article addresses the integration of Education for Sustainable Development (ESD) in higher education institutions, exploring its effects on academic performance and students’ ability to address sustainability challenges. Using the PRISMA 2020 methodology for a systematic literature review, 50 relevant articles were selected from 543 records, providing data on the academic impacts of ESD through bibliometric approaches and surveys. The results revealed that ESD improves academic performance, motivation and engagement, as well as enhances students’ ability to solve complex problems sustainably. However, significant barriers, such as a lack of resources and adequate teacher training, hinder effective implementation. Approximately 60% of students in ESD programs show greater motivation and analytical abilities compared to 50% in traditional programs. ESD enriches academic training and equips students with essential practical skills, preparing them to be agents of positive change. Incorporating emerging technologies and participatory learning methods is crucial to enhancing ESD effectiveness. Greater investment in teacher training and standardized educational materials, along with the promotion of international collaboration to share resources and best practices, is required. Full article

This paper introduces a fully differential asynchronous successive approximation register analog-to-digital converter (SAR ADC) designed for biomedical signal processing. By extending the tracking time and utilizing fully differential inputs in the analog front-end circuit, the signal-to-noise ratio is enhanced in the system. Using an asynchronous clock can reduce power consumption across a wider range of sampling frequencies. In comparison to conventional architecture in high-speed SAR ADC, using an internal clock generator can operate at lower frequencies. A fully differential input can eliminate the DC offset of the analog front-end circuit and reduce the adverse effects of process variation, voltage variation, and temperature variation. The chip is implemented by TSMC 0.18 $\mathsf{\mu }$m complementary metal-oxide-semiconductor (CMOS) technology, and the chip area is 0.680 mm² (including ESD I/O PAD). At a 1.2 V supply, the maximum sampling rate is 10 Kilo Samples per second (KSps). The implemented ADC has an 11-bit resolution, while the input voltage range is 300∼900 mV. The total power consumption is 1.7 $\mathsf{\mu }$W, with the core power consumption at 932 nW. Full article