Search Results (72)

We report the results of a survey of farmers and landowners to identify the most likely potential food system disruption scenarios for the UK and compare these with a previous expert elicitation with a much wider set of food system stakeholders. We found that 60% of farmers think a Societal Event in which 1 in 2000 people are injured in the UK is at least 20% likely to occur over the coming decade. Over a timeframe of 50 years, this increased to almost 90% of farmers. These results show that farmers and landowners are considerably more concerned about the vulnerability of the food system in the UK than the wider group of food system experts are. Farmers agreed with experts on the majority of potential causes of such vulnerability, which are climate change, trade policies (import and export), competition for land and ecological collapse (over 50 years). However, they also highlighted the importance of the power structure within the food system, with large corporations supplying to, or buying from, farmers creating lower revenue, making farming an unsustainable business. We conclude that an urgent systematic review of potential interventions that would improve resilience be conducted by the UK Government, in partnership with farmers. Full article

Transcranial electrical stimulation (tES) is increasingly recognized for its potential to modulate cerebral blood flow (CBF) and evoke cerebrovascular reactivity (CVR), which are crucial in conditions like mild cognitive impairment (MCI) and dementia. This study explores the impact of tES on the neurovascular unit (NVU), employing a physiological modeling approach to simulate the vascular response to electric fields generated by tES. Utilizing the FitzHugh–Nagumo model for neuroelectrical activity, we demonstrate how tES can initiate vascular responses such as vasoconstriction followed by delayed vasodilation in cerebral arterioles, potentially modulated by a combination of local metabolic demands and autonomic regulation (pivotal locus coeruleus). Here, four distinct pathways within the NVU were modeled to reflect the complex interplay between synaptic activity, astrocytic influences, perivascular potassium dynamics, and smooth muscle cell responses. Modal analysis revealed characteristic dynamics of these pathways, suggesting that oscillatory tES may finely tune the vascular tone by modulating the stiffness and elasticity of blood vessel walls, possibly by also impacting endothelial glycocalyx function. The findings underscore the therapeutic potential vis-à-vis blood-brain barrier safety of tES in modulating neurovascular coupling and cognitive function needing the precise modulation of NVU dynamics. This technology review supports the human-in-the-loop integration of tES leveraging digital health technologies for the personalized management of cerebral blood flow, offering new avenues for treating vascular cognitive disorders. Future studies should aim to optimize tES parameters using computational modeling and validate these models in clinical settings, enhancing the understanding of tES in neurovascular health. Full article

The FitzHugh–Nagumo model has been used empirically to model certain types of neuronal activities. It is also a non-linear dynamical system applicable to chemical kinetics, population dynamics, epidemiology and pattern formation. In the literature, many approaches have been proposed to study its dynamics. In this paper, initially, we have employed cutting-edge tools from discrete dynamics for discretization and fixed points. It has been proven that an exact discrete scheme exists for this paradigm. This project also considers the phase space and integral surfaces of these evolutionary equations. In addition, it carries out a thorough symmetry analysis of this reaction diffusion system to find equivalent systems. Moreover, steady-state solutions are obtained using ansatzes for traveling wave solutions. The existence of infinite traveling wave solutions has also been proven. Yet again, this investigation establishes the potential of symmetry methods to unravel non-linearity. Finally, singular perturbation theory has been employed to obtain analytical approximations and to study stability in different parameter regimes. Full article

In this article, we propose a new fractional-order delay-coupled FitzHugh–Nagumo neural model. Taking advantage of delay as a bifurcation parameter, we explore the stability and bifurcation of the formulated fractional-order delay-coupled FitzHugh–Nagumo neural model. A delay-independent stability and bifurcation conditions for the fractional-order delay-coupled FitzHugh–Nagumo neural model is acquired. By designing a proper $P{D}^p$ controller, we can efficaciously control the stability domain and the time of emergence of the bifurcation phenomenon of the considered fractional delay-coupled FitzHugh–Nagumo neural model. By exploiting a reasonable hybrid controller, we can successfully adjust the stability domain and the bifurcation onset time of the involved fractional delay-coupled FitzHugh–Nagumo neural model. This study shows that when the delay crosses a critical value, a Hopf bifurcation will arise. When we adjust the control parameter, we can find other critical values to enlarge or narrow the stability domain of the fractional-order delay-coupled FitzHugh–Nagumo neural model. In order to check the correctness of the acquired outcomes of this article, we present some simulation outcomes via Matlab 7.0 software. The obtained theoretical fruits in this article have momentous theoretical significance in running and constructing networks. Full article

In this article, we present a five-step block method coupled with an existing fourth-order symmetric compact finite difference scheme for solving time-dependent initial-boundary value partial differential equations (PDEs) numerically. Firstly, a five-step block method has been designed to solve a first-order system of ordinary differential equations that arise in the semi-discretisation of a given initial boundary value PDE. The five-step block method is derived by utilising the theory of interpolation and collocation approaches, resulting in a method with eighth-order accuracy. Further, characteristics of the method have been analysed, and it is found that the block method possesses A-stability properties. The block method is coupled with an existing fourth-order symmetric compact finite difference scheme to solve a given PDE, resulting in an efficient combined numerical scheme. The discretisation of spatial derivatives appearing in the given equation using symmetric compact finite difference scheme results in a tridiagonal system of equations that can be solved by using any computer algebra system to get the approximate values of the spatial derivatives at different grid points. Two well-known test problems, namely the nonlinear Burgers equation and the FitzHugh-Nagumo equation, have been considered to analyse the proposed scheme. Numerical experiments reveal the good performance of the scheme considered in the article. Full article

The number of elderly people is projected to double in the next 50 years worldwide, resulting in an increased prevalence of neurodegenerative diseases. Aging causes changes in brain tissue homeostasis, thus contributing to the development of neurodegenerative disorders. Current treatments are not entirely effective, so alternative treatments or adjuvant agents are being actively sought. Antioxidant properties of phenolic compounds are of particular interest for neurodegenerative diseases whose psychopathological mechanisms strongly rely on oxidative stress at the brain level. Moreover, phenolic compounds display other advantages such as the permeability of the blood–brain barrier (BBB) and the interesting molecular mechanisms that we reviewed in this work. We began by briefly outlining the physiopathology of neurodegenerative diseases to understand the mechanisms that result in irreversible brain damage, then we provided an overall classification of the phenolic compounds that would be addressed later. We reviewed in vitro and in vivo studies, as well as some clinical trials in which neuroprotective mechanisms were demonstrated in models of different neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD), Parkinson’s disease (PD), ischemia, and traumatic brain injury (TBI). Full article

Musical large-scale form is investigated using an electronic dance music piece fed into a Finite-Difference Time-Domain physical model of the cochlea, which again is input into an Impulse Pattern Formulation (IPF) Brain model. In previous studies, experimental EEG data showed an enhanced correlation between brain synchronization and the musical piece’s amplitude and fractal correlation dimension, representing musical tension and expectancy time points within the large-scale form of musical pieces. This is also in good agreement with a FitzHugh–Nagumo oscillator model.However, this model cannot display temporal developments in large-scale forms. The IPF Brain model shows a high correlation between cochlea input and brain synchronization at the gamma band range around 50 Hz, and also a strong negative correlation with low frequencies, associated with musical rhythm, during time frames with low cochlea input amplitudes. Such a high synchronization corresponds to temporal lobe epilepsy, often associated with creativity or spirituality. Therefore, the IPF Brain model results suggest that these conscious states occur at times of low external input at low frequencies, where isochronous musical rhythms are present. Full article

(1) Background: Spinocerebellar ataxias (SCA) is a term that refers to a group of hereditary ataxias, which are neurological diseases characterized by degeneration of the cells that constitute the cerebellum. Studies suggest that magnetic resonance imaging (MRI) supports diagnoses of ataxias, and linear measurements of the aneteroposterior diameter of the midbrain (ADM) have been investigated using MRI. These measurements correspond to studies in spinocerebellar ataxia type 2 (SCA2) patients and in healthy subjects. Our goal was to obtain the cut-off value for ADM atrophy in SCA2 patients. (2) Methods: This study evaluated 99 participants (66 SCA2 patients and 33 healthy controls). The sample was divided into estimations (80%) and validation (20%) samples. Using the estimation sample, we fitted a logistic model using the ADM and obtained the cut-off value through the inverse of regression. (3) Results: The optimal cut-off value of ADM was found to be 18.21 mm. The area under the curve (AUC) of the atrophy risk score was 0.957 (95% CI: 0.895–0.991). Using this cut-off on the validation sample, we found a sensitivity of 100.00% (95% CI: 76.84%–100.00%) and a specificity of 85.71% (95% CI: 42.13%–99.64%). (4) Conclusions: We obtained a cut-off value that has an excellent discriminatory capacity to identify SCA2 patients. Full article

This paper presents an efficient two-step hybrid block method (ETHBM) to obtain an approximate solution to the FitzHugh–Nagumo problem. The considered partial differential equation model problems are semi-discretized, reducing them to equivalent ordinary differential equations using the method of lines. In order to evaluate the effectiveness of the proposed ETHBM, three numerical examples are presented and compared with the results obtained through existing methods. The results demonstrate that the proposed ETHBM produces more efficient results than some other numerical approaches in the literature. Full article

In this paper, a numerical approach employing radial basis functions has been applied to solve time-fractional FitzHugh–Nagumo equation. Spatial approximation is achieved by combining radial basis functions with the collocation method, while temporal discretization is accomplished using a finite difference scheme. To evaluate the effectiveness of this method, we first conduct an eigenvalue stability analysis and then validate the results with numerical examples, varying the shape parameter c of the radial basis functions. Notably, this method offers the advantage of being mesh-free, which reduces computational overhead and eliminates the need for complex mesh generation processes. To assess the method’s performance, we subject it to examples. The simulated results demonstrate a high level of agreement with exact solutions and previous research. The accuracy and efficiency of this method are evaluated using discrete error norms, including ${\mathrm{L}}_2$, ${\mathrm{L}}_{\infty }$, and ${\mathrm{L}}_{rms}$. Full article

Listeria monocytogenes (Lm) is ubiquitous in nature and known for its ability to contaminate foods during production processes. Near real-time monitoring of whole genome sequences from food and human isolates, complemented with epidemiological data, has been used in the Netherlands since 2019 to increase the speed and success rate of source finding in the case of (active) clusters. Nine clusters with 4 to 19 human cases investigated between January 2019 and May 2023 are described. Fish production sites were most often linked to outbreaks of listeriosis (six clusters), though other types of food businesses can face similar Lm problems, as the production processes and procedures determine risk. The results showed that low levels of Lm in food samples can still be linked to disease. Therefore, the investigation of a cluster of cases and deployment of the precautionary principle helps to focus on safe food and to prevent further cases. Good practice of environmental monitoring within a food business allows early detection of potential issues with food safety and helps food businesses to take appropriate measures such as cleaning to prevent regrowth of Lm and thus future outbreaks. Full article

We report the results of a structured expert elicitation to identify the most likely types of potential food system disruption scenarios for the UK, focusing on routes to civil unrest. We take a backcasting approach by defining as an end-point a societal event in which 1 in 2000 people have been injured in the UK, which 40% of experts rated as “Possible (20–50%)”, “More likely than not (50–80%)” or “Very likely (>80%)” over the coming decade. Over a timeframe of 50 years, this increased to 80% of experts. The experts considered two food system scenarios and ranked their plausibility of contributing to the given societal scenario. For a timescale of 10 years, the majority identified a food distribution problem as the most likely. Over a timescale of 50 years, the experts were more evenly split between the two scenarios, but over half thought the most likely route to civil unrest would be a lack of total food in the UK. However, the experts stressed that the various causes of food system disruption are interconnected and can create cascading risks, highlighting the importance of a systems approach. We encourage food system stakeholders to use these results in their risk planning and recommend future work to support prevention, preparedness, response and recovery planning. Full article

The aim of this work is to describe the dynamics of a discrete fractional-order reaction–diffusion FitzHugh–Nagumo model. We established acceptable requirements for the local asymptotic stability of the system’s unique equilibrium. Moreover, we employed a Lyapunov functional to show that the constant equilibrium solution is globally asymptotically stable. Furthermore, numerical simulations are shown to clarify and exemplify the theoretical results. Full article

Plants have evolved signaling mechanisms such as the multi-step phosphorelay (MSP) to respond to different internal and external stimuli. MSP responses often result in gene transcription regulation that is modulated through transcription factors such as B-type Arabidopsis response regulator (ARR) proteins. Among these proteins, ARR2 is a key component that is expressed ubiquitously and is involved in many aspects of plant development. Although it has been noted that B-type ARRs bind to their cognate genes through a DNA-binding domain termed the GARP domain, little is known about the structure and function of this type of DNA-binding domain; thus, how ARRs bind to DNA at a structural level is still poorly understood. In order to understand how the MSP functions in planta, it is crucial to unravel both the kinetics as well as the structural identity of the components involved in such interactions. For this reason, this work focusses on resolving how the GARP domain of ARR2 (GARP2) binds to the promoter region of ARR5, one of its native target genes in cytokinin signaling. We have established that GARP2 specifically binds to the ARR5 promoter with three different bi-molecular interaction systems—qDPI-ELISA, FCS, and MST—and we also determined the K_D of this interaction. In addition, structural modeling of the GARP2 domain confirms that GARP2 entails a HTH motif, and that protein–DNA interaction most likely occurs via the α₃-helix and the N-terminal arm of this domain since mutations in this region hinder ARR2’s ability to activate transcription. Full article

We have previously demonstrated that circulating extracellular vesicles (EVs) are essential to the beneficial effect of young serum on the skeletal muscle regenerative cascade. Here, we show that infusions of young serum significantly improve age-associated memory deficits, and that these effects are abolished after serum depletion of EVs. RNA-seq analysis of the choroid plexus demonstrates EV-mediated effects on genes involved in barrier function and trans-barrier transport. Comparing the differentially expressed genes to recently published chronological aging clock genes reveals a reversal of transcriptomic aging in the choroid plexus. Following young serum treatment, the hippocampal transcriptome demonstrates significant upregulation of the anti-aging gene Klotho, along with an abrogated effect after EV depletion. Transcriptomic profiling of Klotho knockout and heterozygous mice shows the downregulation of genes associated with transport, exocytosis, and lipid transport, while upregulated genes are associated with activated microglia. The results of our study indicate the significance of EVs as vehicles to deliver signals from the periphery to the brain and the importance of Klotho in maintaining brain homeostasis. Full article