Search Results (65)

Anning Refinery, a large-scale joint venture in southern China, possesses significant potential in regard to polluting local groundwater environments due to its extensive petroleum raw materials. This study aims to mitigate the substantial risks associated with oil spills and prevent consequential groundwater pollution by developing a robust groundwater flow model using the MODFLOW module in GMS software that aligns closely with natural and pumping test conditions. Furthermore, by integrating the MT3DMS model, a groundwater solute transport model is constructed and calibrated using sodium chloride tracer dispersion data. Notably, the wax hydrocracking unit and aviation coal finished product tank area are identified as key pollution sources warranting attention. By considering local constraints such as karst collapse, ground subsidence, and single-well water output capacity, the study introduces a tailored groundwater pollution management model. The research simulates various scenarios of petroleum pollutant migration in groundwater and proposes multi-objective emergency response optimization plans. In Scenario 1, simulations show that petroleum pollutants migrate within the unconfined aquifer and enter the karst aquifer as low-concentration plumes over an extended period. Detection of these plumes in karst water monitoring wells indicates upstream unconfined aquifer contamination at higher concentrations, necessitating immediate activation of the nearest monitoring or emergency wells in both layers. Conversely, in Scenario 2, pollutants reside briefly in the unconfined aquifer before entering the karst aquifer at relatively higher concentrations. Here, low-efficiency pollutant discharge through unconfined aquifer monitoring wells prompts the activation of nearby karst aquifer monitoring or emergency wells for effective pollution control. This model underscores the necessity for proactive monitoring and validates the efficacy of coupled numerical modeling in understanding pollutant behavior, offering valuable insights into pollution control scenario assessments. In summary, the study emphasizes the importance of targeted monitoring and emergency protocols, demonstrating the benefits of integrated modeling approaches in industrial areas prone to pollution risks, and provides critical theoretical and practical guidance for groundwater protection and pollution management, offering transferable insights for similar industrial settings worldwide. Full article

Despite the wide range of applications of the Spatial Synoptic Classification (SSC), its expansion and utility in the tropics remains limited. This research utilized the fifth generation of European ReAnalysis (ERA5) data to develop an SSC scheme tailored for East Africa with a focus on Kenya. The SSC method classifies weather into seven types: Dry Polar (DP), Dry Moderate (DM), Dry Tropical (DT), Moist Polar (MP), Moist Moderate (MM), Moist Tropical (MT), and Transitional (TR). Frequency and trend analysis between 1959 and 2022 show that the MT and DM weather types are the dominant types in Kenya. The DM type is dominant in the December–February (DJF) dry season while the MT type is common from April to September. We find statistically significant decreasing trends in the DM, MP, and MM weather types and increasing trends in the DT and MT weather types. The results suggest that, generally, the number of days with cool and moderate conditions in Kenya is decreasing, while the number of days with warmer conditions is increasing. This research indicates the potential for the SSC to be utilized in different applications in East Africa including investigating heat vulnerability, as increasing temperatures could be a significant risk factor to human health. Full article

Under varying flow rate conditions, the transport and retention of polydisperse microplastics (MPls), with an average particle size of 16 ± 6 µm, were investigated in saturated porous media. First-order reversible and irreversible kinetic sorption models were used to describe the sorption kinetics. Sensitivity analyses provided insight into the effects of each sorption parameter. Both numerical modeling and experimental measurements were utilized to evaluate the retention rates of sand filters. The influence of flow rate on sorption was reflected in variations in the distribution coefficient (K_d), the mass transfer coefficient (β), and the irreversible sorption rate (K₁). Lower flow rates were associated with higher K_d and β values, indicating increased sorption and reduced mass transfer rates. An increase in K_d resulted in a more gradual sorption process, with a decrease in peak concentration, whereas changes in β had a comparatively smaller impact on sorption rate and peak concentration. Lower K₁ values were linked to higher peak concentrations and decreased retention efficiency. Numerical modeling revealed retention rates of 28 ± 1% at a flow rate of 31 mL min⁻¹ and 17 ± 1% at 65 mL min⁻¹. The introduction of MPls into saturated sand environments modifies the transport dynamics within the medium. Consequently, these alterations affect the hydrological characteristics of porous media, impacting groundwater quality and agricultural output. The mean absolute error (MAE) of 6% between the modeled and observed retention rates indicated a high level of accuracy. This study underscores the importance of examining retention efficiency and the accuracy of numerical models in understanding MPl transport in porous media. Full article

The municipal wellfield in Collierville, Tennessee, is contaminated with trichloroethylene (TCE) and hexavalent chromium (Cr (VI)) due to industrial operations dating back to the 1970s and 1980s. This study aims to elucidate the aquifer’s contaminant transport mechanisms by determining longitudinal and transverse dispersivities through inverse modeling. Utilizing MT3DMS for contaminant transport simulation, based on a well-calibrated groundwater flow model, and leveraging Python’s multiprocessing library for efficiency, the study employs a trial-and-error methodology. Key findings reveal that longitudinal dispersivity values range from 5.5 m near the source to 20.5 m further away, with horizontal and vertical transverse dispersivities between 0.28 m and 3.88 m and between 0.03 m and 0.08 m, respectively. These insights into the aquifer’s dispersivity coefficients, which reflect the scale-dependent nature of longitudinal dispersivity, are crucial for optimizing remediation strategies and achieving cleanup goals. This study underscores the importance of accurate parameter estimation in contaminant transport modeling and contributes to a better understanding of contaminant dynamics in the Collierville wellfield. Full article

We aimed to understand the changes in nutritional parameters and performance of beef cows during the peripartum, whether receiving or not receiving protein supplements. Forty cows were used, divided into two treatments: CON—mineral mix and SUP—protein supplementation. Digestibility trial was performed at 45, 30, and 15 days (d) before the parturition and at 20 and 40 d of lactation. The ADG of cows pre- and postpartum was recorded along with the BCS in gestational (GT) and maternal (MT) tissues in the prepartum. There was an effect of treatment and period (p ≤ 0.044) for intakes of DM and CP. The forage intake was similar (p > 0.90) but varied with the effect of days related to parturition (p < 0.001). There was a 14.37% decrease in DM intake from d −30 to d −15 of prepartum. In the postpartum, at 20 d of lactation, there was an increase of 72.7% in relation to d −15 of prepartum. No differences were observed in postpartum ADG or BCS at parturition and postpartum (p ≥ 0.12). However, higher total and MT ADG (p ≤ 0.02) were observed in animals receiving supplementation, while ADG in GT remained similar (p > 0.14). In conclusion, there is a decrease in intake for pregnant cows close to parturition and greater performance of animals supplemented in prepartum. Full article

The paper investigates the mechanism of seawater intrusion and the performance of free and open-source codes for the simulation of variable density flow problems in coastal aquifers. For this purpose, the research focused on the Marathon Watershed, located in the northeastern tip of Attica, Greece. For the simulation of the groundwater system, MODFLOW, MT3DMS and SEAWAT codes were implemented, while sensitivity analysis and calibration processes were carried out with UCODE. Hydraulic head calibration was performed on the MODFLOW model, and TDS concentration was validated in the SEAWAT model. The calibrated parameters of the MODFLOW model were obtained for the variable density flow simulation with SEAWAT. The MODFLOW and SEAWAT hydraulic head outputs were analyzed and compared to one another. The outcome of this analysis is that SEAWAT produced slightly better results in terms of the hydraulic heads, concluding that parameter transferability can take place between the two models. For the purpose of the seawater intrusion assessment, the use of the SEAWAT code revealed that the aquifer is subjected to passive and passive–active seawater intrusion during wet and dry seasons, respectively. Finally, an irregular shape of a saltwater wedge is developed at a specific area associated with the hydraulic parameters of the aquifer. Full article

Cerebrovascular disease accounts for major neurologic disabilities in patients with type 2 diabetes mellitus (DM). A potential association of mitochondrial DNA (mtDNA) and inflammation with cerebral vessel remodeling in patients with type 2 DM was evaluated. A cohort of 150 patients and 30 healthy controls were assessed concerning urinary albumin/creatinine ratio (UACR), synaptopodin, podocalyxin, kidney injury molecule-1 (KIM-1), N-acetyl-β-(D)-glucosaminidase (NAG), interleukins IL-17A, IL-18, IL-10, tumor necrosis factor-alpha (TNFα), intercellular adhesion molecule-1 (ICAM-1). MtDNA-CN and nuclear DNA (nDNA) were quantified in peripheral blood and urine by qRT-PCR. Cytochrome b (CYTB) gene, subunit 2 of NADH dehydrogenase (ND2), and beta 2 microglobulin nuclear gene (B2M) were assessed by TaqMan assays. mtDNA-CN was defined as the ratio of the number of mtDNA/nDNA copies, through analysis of the CYTB/B2M and ND2/B2M ratio; cerebral Doppler ultrasound: intima-media thickness (IMT)—the common carotid arteries (CCAs), the pulsatility index (PI) and resistivity index (RI)- the internal carotid arteries (ICAs) and middle cerebral arteries (MCAs), the breath-holding index (BHI). The results showed direct correlations of CCAs-IMT, PI-ICAs, PI-MCAs, RI-ICAs, RI-MCAs with urinary mtDNA, IL-17A, IL-18, TNFα, ICAM-1, UACR, synaptopodin, podocalyxin, KIM-1, NAG, and indirect correlations with serum mtDNA, IL-10. BHI correlated directly with serum IL-10, and serum mtDNA, and negatively with serum IL-17A, serum ICAM-1, and NAG. In neurologically asymptomatic patients with type 2 DM cerebrovascular remodeling and impaired cerebrovascular reactivity may be associated with mtDNA variations and inflammation from the early stages of diabetic kidney disease. Full article

Type 2 diabetes mellitus (T2DM) accounts for one-sixth of deaths globally, whereas cancer is the second leading cause of death in the U.S. T2DM is a known risk factor for many cancers. Reactive oxygen species (ROS)-altered metabolic and signaling pathways link T2DM to cancer. These reprogrammed metabolic and signaling pathways contribute to diabetic complications, impact the redox balance (oxidative stress), and have differential roles in the early and late stages of cancer. A respiratory chain that is highly reduced (as under hyperglycemic conditions) or if reduced cofactors accumulate, ROS are greatly elevated. ROS may cause mutations in mitochondrial DNA (mtDNA) that result in further ROS elevations. The amplification of ROS results in the activation of PKC, an overarching signaling pathway that activates MAPK with a subsequent regulation in several factors that result in pathophysiological manifestations of T2DM and cancer. An upregulation in PKC leads to a deregulation in NF-kß, which regulates the PKB/P13/Akt pathway and orchestrates the cell survival, growth, proliferation, and glucose metabolism manifested in cancer. It also affects Insulin Receptor Substrate (IRS-1), decreasing insulin-stimulated glucose transport and glucose uptake, disrupting subsequent cell signaling pathways contributing to the development of T2DM. Dyslipidemia is a hallmark of T2DM and cancer. ROS-induced lipid peroxidation leads to systemic inflammation, producing inflammatory prostaglandins, cytokines, and chemokines that result in tumor proliferation, rapid tumor growth, and modulation of immunity. The dual role of ROS in the early and late stages of cancer makes antioxidant therapy precarious and may be responsible for controversial results. A system that delivers an antioxidant directly to mitochondria may be useful in inhibiting the formation of ROS early during the pre-diabetic stage, whereas antioxidant therapy must be halted in later stages to retard metastasis. Full article

Jinan, China, is famous for its springs. However, societal and economic development over the past decades has detrimentally altered the natural water cycle in the spring area. Managed aquifer recharge (MAR) is an effective measure to ensure the normal gushing of springs. Balancing water resource utilisation, ecological effects, and water quality risks is not always easy to implement. This study focused on the potential effects of MAR projects that divert water from multiple local surface water sites, e.g., the Yellow River and South-to-North Water Diversion (SNWD) Project. A numerical simulation model for the entire spring area was built using MODFLOW and MT3DMS. The SNWD Project diverts water with relatively high total dissolved solids (TDS) to the Yufu River, which consequently recharges groundwater and poses a potential risk to the downstream karst water in the Jinan Spring area. Different simulation scenarios were set, and the results showed that the 90% recovery ratio scheme yields the highest TDS reduction efficiency as well as the largest karst water extraction volume. In addition, the water table remains stable as a whole. The benefits of the designed scheme are multifold, including improving water quality up to Standard III groundwater quality and meeting the water needs of the economy. The study provides a novel method of addressing the groundwater quality risks posed by artificial recharge. Full article

In recent years, due to various anthropogenic activities, such as agriculture and livestock, the presence of nitrogen-associated contaminants has been increasing in surface- and groundwater resources. Among these, the main compounds present in groundwater are ammonia, nitrite, and nitrate. However, it is sometimes difficult to assess such effects given the scarcity or lack of information and the complexity of the system. In the current study, a methodology is proposed to assess nitrate in groundwater from diffuse sources considering spatiotemporal patterns of hydrological systems using a coupled SWAT/MODFLOW/MT3DMS model. The application of the model is carried out using a simplified simulation scheme of hydrological and agricultural systems because of the limited spatial and temporal data. The study area includes the Cuitzeo Lake basin in superficial flow form and the Morelia–Querendaro aquifer in groundwater flow form. The results within the methodology are surface runoff, groundwater levels, and nitrate concentrations present in surface- and groundwater systems. The results indicate that the historical and simulated nitrate concentrations were obtained within acceptable values of the statistical parameters and, therefore, are considered adequate. Full article

Previous studies have shown that interaction between polyphenols and proteins can benefit health, but the mechanism of its antidiabetic effect has not been thoroughly elucidated. Therefore, this study aimed to investigate the impact of the metallothionein (MT)–kidney bean polyphenol complex on the blood glucose levels and gut microbiota of rats with type 2 diabetes mellitus (T2DM) induced by a high-fat diet combined with streptozotocin (STZ). After 7 weeks of intervention, the MT–kidney bean polyphenol complex can significantly improve the loss of body weight, the increase in blood glucose and blood lipids, and insulin resistance caused by T2DM in rats. In addition, it can effectively alleviate the damage to the pancreas and liver in rats. The MT–kidney bean polyphenol complex also significantly increased the concentrations of six short-chain fatty acids (SCFAs) in the intestinal contents of rats, especially acetic acid, propionic acid, and butyric acid (296.03%, 223.86%, and 148.97%, respectively). More importantly, the MT–kidney bean polyphenol complex can significantly reverse intestinal microflora dysbiosis in rats caused by T2DM, increase intestinal microorganism diversity, improve the abundance of various beneficial bacteria, and reshape the gut microbiota. In summary, the hypoglycemic effect of the MT–kidney bean polyphenol complex and its possible mechanism was expounded in terms of blood glucose level, blood lipid level, and gut microbiota, providing a new perspective on the development of the MT–kidney bean polyphenol complex as functional hypoglycemic food. Full article

In this study, we present artificial neural networks (ANNs) to aid in a reconnaissance evaluation of an aquifer storage and recovery (ASR) well. Recovery effectiveness (REN) is the proportion of ASR-injected water recovered during subsequent extraction from the same well. ANN-based predictors allow rapid REN prediction without requiring preparation for and execution of solute transport simulations. REN helps estimate blended water quality resulting from a conservative solute in an aquifer, extraction for environmental protection, and other uses, respectively. Assume that into an isotropic homogenous portion of an unconfined, one-layer aquifer, extra surface water is injected at a steady rate during two wet months (61 days) through a fully penetrating ASR well. And then, water is extracted from the well at the same steady rate during three dry months (91-day period of high demand). The presented dimensionless input parameters were designed to be calibrated within the ANNs to match REN values. The values result from groundwater flow and solute transport simulations for ranges of impact factors of unconfined aquifers. The ANNs calibrated the weighting coefficients associated with the input parameters to predict the achievable REN of an ASR well. The ASR steadily injects extra surface water during periods of water availability and, subsequently, steadily extracts groundwater for use. The total extraction volume equaled the total injection volume at the end of extraction day 61. Subsequently, continuing extraction presumes a pre-existing groundwater right. Full article

Background and Objectives: Physical exercise is an important therapeutic modality for treating and managing diabetes. High-intensity interval training (HIIT) is considered one of the best non-drug strategies for preventing and treating type 2 diabetes mellitus (T2DM) by improving mitochondrial biogenesis and function. This study aimed to determine the effects of 12 weeks of HIIT training on the expression of tumor suppressor protein-p53, mitochondrial cytochrome c oxidase (COX), and oxidative stress in patients with T2DM. Methods: A total of thirty male sedentary patients aged (45–60 years) were diagnosed with established T2DM for more than five years. Twenty healthy volunteers, age- and sex-matched, were included in this study. Both patients and control subjects participated in the HIIT program for 12 weeks. Glycemic control variables including p53 (U/mL), COX (ng/mL), total antioxidant capacity (TAC, nmole/µL), 8-hydroxy-2′-deoxyguanosine (8-OHdG, ng/mL), as well as genomic and mitochondrial DNA content were measured in both the serum and muscle tissues of control and patient groups following exercise training. Results: There were significant improvements in fasting glucose levels. HbA1c (%), HOMA-IR (mUmmol/L²), fasting insulin (µU/mL), and C-peptide (ng/mL) were reported in T2DM and healthy controls. A significant decrease was also observed in p53 protein levels. COX, 8-OhdG, and an increase in the level of TAC were reported in T2DM following 12 weeks of HIIT exercise. Before and after exercise, p53; COX, mt-DNA content, TAC, and 8-OhdG showed an association with diabetic control parameters such as fasting glucose (FG), glycated hemoglobin (HbA1C, %), C-peptide, fasting insulin (FI), and homeostatic model assessment for insulin resistance (HOMA-IR) in patients with T2DM. These findings support the positive impact of HIIT exercise in improving regulation of mitochondrial biogenesis and subsequent control of diabetes through anti-apoptotic and anti-oxidative pathways. Conclusions: A 12-week HIIT program significantly improves diabetes by reducing insulin resistance; regulating mitochondrial biogenesis; and decreasing oxidative stress capacity among patients and healthy controls. Also; p53 protein expression; COX; 8-OhdG; and TAC and mt-DNA content were shown to be associated with T2DM before and after exercise training. Full article

Mitochondrial dysfunction is an important mechanism contributing to the development and progression of diabetic kidney disease (DKD). Mitochondrial DNA (mtDNA) levels in blood and urine were evaluated in relation to podocyte injury and proximal tubule (PT) dysfunction, as well as to a specific inflammatory response in normoalbuminuric DKD. A total of 150 type 2 diabetes mellitus (DM) patients (52 normoalbuminuric, 48 microalbuminuric, and 50 macroalbuminuric ones, respectively) and 30 healthy controls were assessed concerning the urinary albumin/creatinine ratio (UACR), biomarkers of podocyte damage (synaptopodin and podocalyxin), PT dysfunction (kidney injury molecule-1 (KIM-1) and N-acetyl-β-(D)-glucosaminidase (NAG)), and inflammation (serum and urinary interleukins (IL-17A, IL-18, and IL-10)). MtDNA-CN and nuclear DNA (nDNA) were quantified in peripheral blood and urine via qRT-PCR. MtDNA-CN was defined as the ratio of the number of mtDNA/nDNA copies via analysis of the CYTB/B2M and ND2/B2M ratio. Multivariable regression analysis provided models in which serum mtDNA directly correlated with IL-10 and indirectly correlated with UACR, IL-17A, and KIM-1 (R² = 0.626; p < 0.0001). Urinary mtDNA directly correlated with UACR, podocalyxin, IL-18, and NAG, and negatively correlated with eGFR and IL-10 (R² = 0.631; p < 0.0001). Mitochondrial DNA changes in serum and urine display a specific signature in relation to inflammation both at the podocyte and tubular levels in normoalbuminuric type 2 DM patients. Full article

Groundwater contamination is a rising issue worldwide, and it must be treated well as most of the world relies on it. Groundwater pollution occurs when undesirable substances in groundwater rise. Understanding, simulating, and predicting solute mobility in groundwater helps to treat polluted groundwater. MT3DMS has been used to model contaminant movement with a non-linear Freundlich sorption isotherm. MT3DMS stands for “Modular three-dimensional multispecies transport model”. MT3DMS software has several categories of solute transport solution techniques, like FDM and the higher-order finite-volume TVD method, in a unique single code. Applying the combination of these solution techniques is believed to give the best possible solution with greater precision and accuracy. In the current work, the benchmark problem (P2) of the MT3DMS package was taken, and the chemical reaction package was modified according to our problem. Multiple simulations were run with different adsorption capacities and intensities, incorporating the nonlinear Freundlich sorption isotherm. After that analysis of BTC trends, at a position 8 cm from the source, the pulse input of contamination was discharged for 160 s. The simulation lasted 1500 s. The observation output files were imported to plot BTCs for trend analysis and visualize simulation results. After comparing the various BTCs, it was found that the adsorption capability of porous medium enhances retention capacity so contaminants are sorbed and retarded by the solid phase more, slowing the contaminant movement and delaying the BTC peak. For similar adsorption capacity at a lower adsorption intensity, the solid retains more contaminant and the peak is attenuated as well as delayed; but, as the adsorption intensity increases, the relative concentration in the aqueous phase increases, and the peak is enhanced early as the solid retains less contaminant. Full article