Search Results (3,462)

Aimed at solving the problems of single control measures in the electro-spark deposition (ESD) process, difficulty controlling the micro-process using heterogeneous materials (for the electrode and matrix), and the unstable quality and reliability of repairs to the deposition layer, a method of magnetic-field-assistance electro-spark deposition (MFESD) was proposed. An MFESD device was built, and a Ni electrode was used for deposition on the surface of 45 steel under the conditions of deposition voltages of 30 V, 60 V, and 90 V, respectively. This study examined the impact of the magnetic field’s intensity and frequency on the microstructure and mechanical properties of electro-spark deposition layers. The results show that the sputtering and protrusion of the electrode material on the surface of the deposition layer gradually decrease with an increase in the magnetic field’s intensity and frequency, defects such as pores and cracks are obviously improved, and the structure is uninterrupted and compact. The surface roughness of the deposited layer decreases with an increase in the magnetic field’s intensity and frequency, and its surface roughness decreases by 44.3%. The cross-section effect of the deposited layer is improved. The thickness of the deposited layer increases with an increase in the magnetic field’s intensity and frequency; the thickness of the deposited layer increases by 13.39%, and its maximum thickness can reach 54.396 μm. At the same time, the microhardness of the deposited layer increases with an increase in the two aforementioned properties of the magnetic field, and its hardness increases by 5.32%. Using a magnetic field to control ESD can effectively control the microscopic process of deposition and obtain high-quality deposition coatings, which have important significance in the surface remanufacturing of key components of high-end equipment. Full article

Cardiac magnetic resonance (CMR) allows for analysis of cardiac function and myocardial tissue characterization. Increased left ventricular mass (LVM) is an independent predictor of cardiovascular events; however, the diagnosis of left ventricular hypertrophy and its prognostic value strongly depend on the LVM indexation method. Evaluation of the quantity and distribution of late gadolinium enhancement assists in clinical decisions on diagnosis, cardiovascular assessment, and interventions, including the placement of cardiac implantable electronic devices and the choice of an optimal procedural approach. Novel CMR techniques, such as T1 and T2 mapping, may be used for the longitudinal follow-up of myocardial fibrosis and myocardial edema or inflammation in different groups of patients, including patients with systemic sclerosis, myocarditis, cardiac sarcoidosis, amyloidosis, and both ischemic and non-ischemic cardiomyopathy, among others. Moreover, CMR tagging and feature tracking techniques might improve cardiovascular risk stratification in patients with different etiologies of left ventricular dysfunction. This review summarizes the knowledge about the current role of CMR in diagnostics and cardiovascular risk assessment to enable more personalized approach in clinical decision making. Full article

Background: Sirolimus-coated balloons (SCBs) have emerged as a promising alternative to paclitaxel-coated devices for the treatment of femoropopliteal lesions. However, real-world data on SCB performance in also complex peripheral arterial disease remains unknown. We sought to evaluate the safety and 12-month clinical outcomes of the Selution SLR™ balloon angioplasty in a challenging real-world patient cohort. Methods: This single-center, retrospective observational study with prospective follow-up included 21 patients with symptomatic peripheral arterial disease treated with the Selution SLR™ SCB (Med. Alliance, SA, Mont-sur-Rolle, Switzerland) after vessel preparation with rotational atherectomy, between October 2023 and November 2024. The primary endpoints were technical success, 12-month primary patency, and target lesion revascularization (TLR). Secondary endpoints included major adverse cardiac events (MACE), major adverse limb events (MALE), and changes in Rutherford classification and ankle-brachial index (ABI). Results: The median age was 79 years, with 47.6% of patients over 80 years old. Most patients presented with advanced peripheral atherosclerotic disease (PAD) (Rutherford category V, 47.6%). Lesions were predominantly occlusive (76.2%), with a median length of 130 mm and severe/moderate calcified in 71.4% of cases. Technical success was achieved in 95.2% of procedures. The 12-month primary patency was 95%, with a TLR-Rate of 5%. No major amputations or cardiovascular deaths occurred. Significant improvements in Rutherford category and ABI were maintained at 12 months. Conclusions: In this real-world cohort of patients with complex PAD, vessel preparation-assisted Selution SLR™ angioplasty demonstrated safety and promising 12-month outcomes. These findings support the use of SCBs in also challenging peripheral interventions, though larger-scale data and further follow up are needed in order to establish SCBs’ role as crucial in the treatment algorithm of PAD. Full article

Background/Objectives: Preoperative muscle atrophy leads to persistent gait abnormalities in patients undergoing total hip arthroplasty (THA). Efficient motor learning of the gluteus medius is crucial for their recovery. In this study, a single-joint hybrid assistive limb (HAL) was developed to assist hip abduction. We aimed to evaluate the muscle activity and safety of this device during hip abduction in healthy adults. Methods: Ten healthy adults (five males and five females; mean age, 40.7 years) with no hip disorders performed one set of 30 repetitions of side-lying hip abduction under three conditions: without HAL (pre-HAL), with HAL, and without HAL (post-HAL). Muscle activities of the gluteus medius, gluteus maximus, tensor fasciae latae, rectus femoris, and biceps femoris (expressed as percentage of maximum voluntary contraction [%MVC]); vital signs; hip visual analog scale (VAS); and hip abduction and flexion angles were assessed. The mean values were compared among the conditions. Results: The %MVC of the gluteus medius significantly increased from 52% (pre-HAL) to 75.4% (HAL) and then decreased slightly to 61.6% (post-HAL). No other muscle groups showed significant changes. Vital signs and hip VAS scores showed no significant variation. Although no significant differences were found in the hip abduction and flexion angles, a reduction in the hip flexion angle was observed in the HAL and post-HAL conditions. Conclusions: The hip abduction HAL effectively and safely enhanced gluteus medius activity. Reduction in the hip flexion angle during HAL and post-HAL suggests the possibility of appropriate abduction movements and motor learning effects. Full article

Pregnant ewes are susceptible to hypoglycemia and ketosis; therefore, monitoring glycemic status is extremely important. Portable blood glucose meters (PBGMs) can assist in quickly and conveniently identifying glycemic disturbances in this species, provided that they meet the criteria of analytical accuracy. This study evaluated the performance of a human PBGM (Accu-Chek Performa^®, Roche Diagnostics, Basel, Switzerland) in the glycemic evaluation of 34 pregnant ewes at days 90 and 120 of pregnancy in comparison with the results of glycemia determination by a reference method (RM). The device showed a high positive correlation (r = 0.71, 95%CI = 0.57–0.82, p < 0.0001) with the RM; however, 96.6% of the PBGM results (58.5 ± 9.82 mg/dL) were higher (p < 0.0001) than those obtained in the laboratory (48.6 ± 9.31 mg/dL). The PBGM tested was considered analytically inaccurate according to ISO 15197:2013, which states that when glucose levels are below 100 mg/dL, 95% of the measurements should deviate by no more than 15 mg/dL from the RM value, and 1/3 of the PBGM results were above this limit. Hypoglycemia (<50 mg/dL) was documented in 60.29% of samples tested on with the RM, but only 17.64% of results were below 50 mg/dL using the PBGM. Due to these limitations, Accu-Check Performa^® results should be interpreted cautiously in pregnant sheep suspected of hypoglycemia. Full article

Robotic technology to assist rehabilitation provides practical advantages compared with traditional rehabilitation treatments, but its efficacy is still disputed. This controversial effectiveness is due to different factors, including a lack of guidelines to adapt devices to users’ individual needs. These needs include the specific clinical conditions of people with disabilities, as well as their psychological and cognitive profiles. This pilot study aims to investigate the relationships between psychological, cognitive, and robot-related factors playing a role in human–robot interaction to promote a human-centric approach in robotic rehabilitation. Ten able-bodied volunteers were assessed for their anxiety, experienced workload, cognitive reserve, and perceived exoskeleton usability before and after a task with a lower-limb exoskeleton (i.e., 10 m path walking for 10 trials). Pre-trial anxiety levels were higher than post-trial ones (p < 0.01). While trait anxiety levels were predictive of the experienced effort (Adjusted-r² = 0.43, p = 0.02), the state anxiety score was predictive of the perceived overall workload (Adjusted-r² = 0.45, p = 0.02). High–average cognitive reserve scores were predictive of the perception of exoskeleton usability (Adjusted-r² = 0.45, p = 0.02). A negative correlation emerged between the workload and the perception of personal identification with the exoskeleton (r = −0.67, p-value = 0.03). This study provides preliminary evidence of the impact of cognitive and psychoaffective factors on the perception of workload and overall device appreciation in exoskeleton training. It also suggests pragmatic measures such as familiarization time to reduce anxiety and end-user selection based on cognitive profiles. These assessments may provide guidance on the personalization of training. Full article

Agriculture is vital for providing food and economic benefits, but crop diseases pose significant challenges, including coffee cultivation. Traditional methods for disease identification are labor-intensive and lack real-time capabilities. This study aims to address existing methods’ limitations and provide a more efficient, reliable, and cost-effective solution for coffee leaf disease identification. It presents a novel approach to the real-time identification of coffee leaf diseases using deep learning. We implemented several transfer learning (TL) models, including ResNet101, Xception, CoffNet, and VGG16, to evaluate the feasibility and reliability of our solution. The experiment results show that the proposed models achieved high accuracy rates of 97.30%, 97.60%, 97.88%, and 99.89%, respectively. CoffNet, our proposed model, showed a notable processing speed of 125.93 frames per second (fps), making it suitable for real-time applications. Using a diverse dataset of mixed images from multiple devices, our approach reduces the workload of farmers and simplifies the disease detection process. The findings lay the groundwork for the development of practical and efficient systems that can assist coffee growers in disease management, promoting sustainable farming practices, and food security. Full article

Background/Objectives: The huge concerns associated with biofilm-related infections in surgical procedures, along with the antibiotic resistance demonstrated by an increasing number of bacteria, have highlighted the need for alternative and effective prevention approaches. The aim of this research was to develop novel antimicrobial coatings on surgical sutures for the prevention of surgical site infections through nanotechnology-based methods. Results: The results demonstrated that although very low amounts of silver precursor were adopted for the treatments, the silver coating was effective against Staphylococcus aureus and antibiotic-resistant Pseudomonas aeruginosa in reducing the potential risk of infection. Methods: Nanostructured silver coatings were deposited onto the surface of polyglactin 910 absorbable braided sutures through a technology based on a photo-assisted chemical reaction. The materials were characterized in order to verify the efficacy of the coating in preventing biofilm formation and in reducing the bacterial colonization of the device. Conclusions: As a broad-spectrum antimicrobial agent, silver represents an important option for the prevention and management of surgical site infections. The silver deposition technology adopted in this work provides an interesting strategy for preventing biofilm formation on medical devices such as surgical sutures. Full article

Axillary crutches assist people with lower limb injuries but can lead to upper limb strain with extended use. Spring-loaded crutches offer a potential solution, yet they are rarely tested in clinical settings. This study developed spring-loaded crutches with an integrated force-measuring system to analyze gait dynamics. Three prototypes, each with different spring constants (k), were tested. To measure ground reaction force (GRF), a Nylamid cover was around the crutch stem. Two participants with different weights completed a 15-m route using both the designed spring-loaded and standard crutches. Findings showed that spring-loaded crutches increased mean GFR and impulse, with the prototype matched to the user’s weight yielding the best results. The study’s findings suggest that when properly adjusted to the user’s weight, spring-loaded crutches can offer significant improvements in gait, which may have important implications for the design of mobility assistive devices. Full article

In this study, a novel rapid immunochromatographic (IC) test for African swine fever virus (ASFV) antibodies is presented. An immunochromatographic test (IC) is a detection technique that combines membrane chromatography with immunolabeling. This approach saves time for antibody preparation, resulting in a shorter production cycle. p54 is an important structural protein of African swine fever, and an ideal protein for serotype diagnosis. Gold nanoparticles are attached to the ASFV p54-Fc fusion protein, and the ASFV-specific antigen p54 and Staphylococcus aureus protein A (SPA) are labeled on a nitrocellulose membrane, at positions T and C, respectively. We developed a SPA double sandwich IC test strip, and assessed its feasibility using ASFV p54 and p54-Fc fusion proteins as antigens. ASFV p54 and p54-Fc fusion proteins were expressed and purified. A sandwich cross-flow detection method for p54, which is the primary structural protein of ASFV, was established, using colloidal gold conjugation. Our method can detect ASFV antibodies in field serum samples in about 15 min using a portable colloidal gold detector, demonstrating high specificity and sensitivity (1:320), and the coincidence rate was 98% using a commercial ELISA kit. The dilution of the serum sample can be determined by substituting the absorbance (T-line) interpreted by portable devices into the calibration curve function formula of an African swine fever virus standard serum. In summary, our method is rapid, cost-effective, precise, and highly selective. Additionally, it introduces a new approach for constructing IC test strips using SPA protein without antibody preparation, making it a reliable on-site antibody test for ASFV. Full article

Background: The artificial urinary sphincter has been an effective treatment for stress urinary incontinence caused by intrinsic sphincter deficiency in women. However, the use of this device has been limited by the technical difficulties and risks associated with the open implantation procedure. Preliminary studies using robotic techniques have shown promising results, but only one small study has compared robotic to open procedures. This study aims to compare the outcomes of robotic and open artificial urinary sphincter implantation in women with stress urinary incontinence due to intrinsic sphincter deficiency in a large multicenter cohort. Methods: Data were collected retrospectively from female patients who underwent open or robot-assisted artificial urinary sphincter implantation from 2006 to 2020 at 12 urology departments. The primary outcome was the rate of complications within 30 days after surgery, graded using the Clavien-Dindo Classification. Perioperative and functional outcomes were compared between the two groups. Results: A total of 135 patients were included, with 71 in the robotic group and 64 in the open group. The open group had a higher rate of intraoperative complications (27.4% vs. 12.7%; p = 0.03) and postoperative complications (46.8% vs. 15.5%; p < 0.0001). More patients in the robotic group achieved full continence (83.3% vs. 62.3%; p = 0.01). The open group had higher explantation (27.4% vs. 1.4%; p < 0.0001) and revision rates (17.5% vs. 5.6%; p = 0.02). The estimated 1-year explantation-free survival rate was higher in the robotic group. (98.6% vs. 78.3%; p = 0.001). Conclusions: Robot-assisted implantation may reduce perioperative morbidity and improve functional outcomes compared to open implantation in women with stress urinary incontinence. Full article

The possibilities of the Ambient Assisted Living (AAL)/Enhanced Living Environments (ELE) concept in the environment of a smart home were investigated to improve accessibility and improve the quality of life of a person with disabilities. This paper focuses on the concept of predictive information for a person with disabilities in a smart home environment concept where artificial intelligence (AI) and machine learning (ML) systems use data on the user’s preferences, habits, and possible incident situations. A conceptual mathematical model is proposed, the purpose of which is to provide predictive user information from defined data sets. This paper defines the taxonomy of communication technologies, devices, and sensors in the environment of the user’s smart home and shows the interaction of all elements in the environment of the smart home. Through the integration of assistive technologies, it is possible to adapt the home to users with diverse types of disabilities and needs. The smart home environment with diverse types of sensors whose data are part of sets defined by a mathematical model is also evaluated. The significance of establishing data sets as a foundation for future research, the development of ML models, and the utilization of AI is highlighted in this paper. Full article

Objectives: Heart failure (HF) remains a significant public health issue, with heart transplantation (HT) being the gold standard treatment for end-stage HF. The increasing use of mechanical circulatory support, particularly left ventricular assist devices (LVADs), as a bridge to transplant (BTT), presents new perspectives for increasingly complex clinical scenarios. This study aimed to compare long-term clinical outcomes in patients in heart failure with reduced ejection fraction (HFrEF) receiving an LVAD as BTT to those undergoing direct-to-transplant (DTT) without mechanical support, focusing on survival and post-transplant complications. Methods: A retrospective, single-center study included 105 patients who underwent HT from 2010. Patients were divided into two groups: BTT (n = 28) and DTT (n = 77). Primary endpoints included overall survival at 1 and 7 years post-HT. Secondary outcomes involved late complications, including organ rejection, renal failure, cardiac allograft vasculopathy (CAV), and cerebrovascular events. Results: At HT, the use of LVADs results in longer cardiopulmonary bypass and cross-clamping times in the BTT group; nevertheless, surgical complexity does not affect 30-day mortality. Survival at 1 year was 89.3% for BTT and 85.7% for DTT (p = 0.745), while at 7 years, it was 80.8% and 77.1%, respectively (p = 0.840). No significant differences were observed in the incidence of major complications, including permanent dialysis, organ rejection, and CAV. However, a higher incidence of cerebrovascular events was noted in the BTT group (10.7% vs. 2.6%). Conclusions: LVAD use as BTT does not negatively impact early post-transplant survival compared to DTT. At long-term follow-up, clinical outcomes remained similar across groups, supporting LVADs as a viable option for bridging patients to transplant. Full article

The integration of a photodetector that converts optical signals into electrical signals is essential for scalable integrated lithium niobate photonics. Two-dimensional materials provide a potential high-efficiency on-chip detection capability. Here, we demonstrate an efficient on-chip photodetector based on a few layers of MoTe₂ on a thin film lithium niobate waveguide and integrate it with a microresonator operating in an optical telecommunication band. The lithium-niobate-on-insulator waveguides and micro-ring resonator are fabricated using the femtosecond laser photolithography-assisted chemical–mechanical etching method. The lithium niobate waveguide-integrated MoTe₂ presents an absorption coefficient of 72% and a transmission loss of 0.27 dB µm⁻¹ at 1550 nm. The on-chip photodetector exhibits a responsivity of 1 mA W⁻¹ at a bias voltage of 20 V, a low dark current of 1.6 nA, and a photo–dark current ratio of 10⁸ W⁻¹. Due to effective waveguide coupling and interaction with MoTe₂, the generated photocurrent is approximately 160 times higher than that of free-space light irradiation. Furthermore, we demonstrate a wavelength-selective photonic device by integrating the photodetector and micro-ring resonator with a quality factor of 10⁴ on the same chip, suggesting potential applications in the field of on-chip spectrometers and biosensors. Full article

Conventional endoscopy is limited in its ability to examine the small bowel and perform long-term monitoring due to the risk of infection and tissue perforation. Wireless Capsule Endoscopy (WCE) is a painless and non-invasive method of examining the body’s internal organs using a small camera that is swallowed like a pill. The existing active locomotion technologies do not have a practical localization system to control the capsule’s movement within the body. A robust localization system is essential for safely guiding the WCE device through the complex gastrointestinal (GI) tract. Moreover, having access to the capsule’s trajectory data is highly desirable for drug delivery and surgery, as well as for creating accurate user profiles for diagnosis and future reference. Therefore, a robust, real-time, and practical localization system is imperative to advance the field of WCE and make it desirable for clinical trials. In this work, we have identified salient features of different localization techniques and categorized studies in comprehensive tables. This study is self-contained as it offers a comprehensive overview of emerging localization techniques based on magnetic field, radio frequency (RF), video, and hybrid methods. A summary at the end of each method is provided to point out the potential gaps and give directions for future research. The main point of this work is to present an in-depth review of the most recent localization techniques published in the past five years. This will assist researchers in comprehending current techniques and pinpointing potential areas for further investigation. This review can be a significant reference and guide for future research on WCE localization. Full article