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17 pages, 493 KiB  
Article
Evaluating the Relationship between Accounting Variables, Value-Based Management Variables, and Shareholder Returns: An Empirical Approach
by Oji Okpusa Oke and Kola Benson Ajeigbe
J. Risk Financial Manag. 2024, 17(8), 371; https://doi.org/10.3390/jrfm17080371 - 19 Aug 2024
Abstract
This study assessed the accounting-based variables and value-based management (VBM) variables that jointly affect firm value and performance. The study applied the causality test and variance decomposition to determine the variability of the variables, and further empirically employed fully modified ordinary least squares [...] Read more.
This study assessed the accounting-based variables and value-based management (VBM) variables that jointly affect firm value and performance. The study applied the causality test and variance decomposition to determine the variability of the variables, and further empirically employed fully modified ordinary least squares (FMOLS) and dynamic ordinary least squares (DOLS) techniques to justify the results. Data covering 356 industries were purposively sampled to arrive at 61 companies spanning 2011–2020. Overall, the causality test found no relationship between economic value added and market value added but only found unidirectional causality from shareholder returns to MVA, EVA to shareholder returns, ROA to MVA, ROE to MVA, EVA to MVA, MVA to EVA, ROE to ROA, EVA to ROA, and EVA to ROE. A very strong bidirectional causality relationship was found between return on asset and shareholder return as a measure of company performance. Further results from the forecast error of the variance decomposition showed that shareholder returns are explained only by its own shock, contributing 45.38 percent in the long run, while the remaining variables, namely market value added, return on asset, return on equity, and economic value added, contribute about 35.96%, 14.06%, 4.08%, and 0.51%, respectively, to predicting the future values of shareholder return. This confirms the relationships between the variables from the short run to the long run. Additionally, results from the FMOL and DOL revealed that all accounting variables and VBM are good approaches for evaluating company performance as the empirical result from ROA, ROE, and EVA revealed positive and significant relationships. This confirms that a combination of both variables would produce a better evaluation as the accounting variables and VBM variables jointly relate to shareholder returns. This study serves as a guide to companies’ management and boards of directors in having better ways to evaluate company performance. Consequently, it is recommended that managers select combinations of accounting and VBM variables that suit their operations and jointly apply them in the performance evaluation of the company. This will be useful in providing both the relative and incremental performance information needed for diverse decision-making. Full article
(This article belongs to the Section Economics and Finance)
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18 pages, 7703 KiB  
Communication
Pre-Launch Calibration of the Bidirectional Reflectance Distribution Function (BRDF) of Ultraviolet-Visible Hyperspectral Sensor Diffusers
by Jinghua Mao, Yongmei Wang, Entao Shi, Jinduo Wang, Shun Yao and Jun Zhu
Appl. Sci. 2024, 14(16), 7278; https://doi.org/10.3390/app14167278 - 19 Aug 2024
Abstract
An Ultraviolet-Visible Hyperspectral Sensors (UVS) instrument is an ultraviolet-visible imaging spectrograph equipped with two-dimensional charge-coupled device detectors. It records both the spectrum and the swath perpendicular to the flight direction, offering a wide 112° swath. This configuration enables global daily ground coverage with [...] Read more.
An Ultraviolet-Visible Hyperspectral Sensors (UVS) instrument is an ultraviolet-visible imaging spectrograph equipped with two-dimensional charge-coupled device detectors. It records both the spectrum and the swath perpendicular to the flight direction, offering a wide 112° swath. This configuration enables global daily ground coverage with high spatial resolution. The absolute values of in-orbit solar irradiance can be evaluated using the bidirectional reflectance distribution function (BRDF), with the measurement accuracy directly affecting the accuracy of constituent inversion. This paper outlines the calibration process for the BRDF of the UVS, detailing the calibration methods and equipment used. It also proposes a BRDF model and discusses key coefficients. The accuracy levels of the UVS in the UV1, UV2, and VIS channels were 2.162%, 2.162%, and 2.173%, respectively. Full article
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18 pages, 4476 KiB  
Article
Beat-by-Beat Estimation of Hemodynamic Parameters in Left Ventricle Based on Phonocardiogram and Photoplethysmography Signals Using a Deep Learning Model: Preliminary Study
by Jiachen Mi, Tengfei Feng, Hongkai Wang, Zuowei Pei and Hong Tang
Bioengineering 2024, 11(8), 842; https://doi.org/10.3390/bioengineering11080842 - 19 Aug 2024
Abstract
Beat-by-beat monitoring of hemodynamic parameters in the left ventricle contributes to the early diagnosis and treatment of heart failure, valvular heart disease, and other cardiovascular diseases. Current accurate measurement methods for ventricular hemodynamic parameters are inconvenient for monitoring hemodynamic indexes in daily life. [...] Read more.
Beat-by-beat monitoring of hemodynamic parameters in the left ventricle contributes to the early diagnosis and treatment of heart failure, valvular heart disease, and other cardiovascular diseases. Current accurate measurement methods for ventricular hemodynamic parameters are inconvenient for monitoring hemodynamic indexes in daily life. The objective of this study is to propose a method for estimating intraventricular hemodynamic parameters in a beat-to-beat style based on non-invasive PCG (phonocardiogram) and PPG (photoplethysmography) signals. Three beagle dogs were used as subjects. PCG, PPG, electrocardiogram (ECG), and invasive blood pressure signals in the left ventricle were synchronously collected while epinephrine medicine was injected into the veins to produce hemodynamic variations. Various doses of epinephrine were used to produce hemodynamic variations. A total of 40 records (over 12,000 cardiac cycles) were obtained. A deep neural network was built to simultaneously estimate four hemodynamic parameters of one cardiac cycle by inputting the PCGs and PPGs of the cardiac cycle. The outputs of the network were four hemodynamic parameters: left ventricular systolic blood pressure (SBP), left ventricular diastolic blood pressure (DBP), maximum rate of left ventricular pressure rise (MRR), and maximum rate of left ventricular pressure decline (MRD). The model built in this study consisted of a residual convolutional module and a bidirectional recurrent neural network module which learnt the local features and context relations, respectively. The training mode of the network followed a regression model, and the loss function was set as mean square error. When the network was trained and tested on one subject using a five-fold validation scheme, the performances were very good. The average correlation coefficients (CCs) between the estimated values and measured values were generally greater than 0.90 for SBP, DBP, MRR, and MRD. However, when the network was trained with one subject’s data and tested with another subject’s data, the performance degraded somewhat. The average CCs reduced from over 0.9 to 0.7 for SBP, DBP, and MRD; however, MRR had higher consistency, with the average CC reducing from over 0.9 to about 0.85 only. The generalizability across subjects could be improved if individual differences were considered. The performance indicates the possibility that hemodynamic parameters could be estimated by PCG and PPG signals collected on the body surface. With the rapid development of wearable devices, it has up-and-coming applications for self-monitoring in home healthcare environments. Full article
(This article belongs to the Special Issue Cardiovascular Hemodynamic Characterization: Prospects and Challenges)
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15 pages, 3060 KiB  
Article
SDCB-YOLO: A High-Precision Model for Detecting Safety Helmets and Reflective Clothing in Complex Environments
by Xiang Yang, Jizhen Wang and Minggang Dong
Appl. Sci. 2024, 14(16), 7267; https://doi.org/10.3390/app14167267 - 19 Aug 2024
Viewed by 161
Abstract
The correct wearing of safety helmets and reflective vests is of great significance in construction sites, offices, and civil engineering sites. Aiming to address the issues of low detection accuracy and high algorithm complexity caused by complex background environments in the small target [...] Read more.
The correct wearing of safety helmets and reflective vests is of great significance in construction sites, offices, and civil engineering sites. Aiming to address the issues of low detection accuracy and high algorithm complexity caused by complex background environments in the small target detection of safety helmets and reflective clothing using existing algorithms, an improved algorithm based on YOLOv8n is proposed. Firstly, the SE module is utilized to reduce interference in complex environments. Next, the IOU function is modified to speed up calculations. Then, a lightweight universal upsampling operator (CARAFE) is employed to obtain a larger receptive field. Finally, the Bidirectional Feature Pyramid Network is used to replace the Concat module of the original head layer. Based on these four modifications made to the model, this article names the new model SDCB-YOLO, derived from the initial letters of the four respective modules. The experimental results show that the mAP of the SDCB-YOLO model on the test set reached 97.1%, which is 4.6% higher than YOLOv5s and 3.5% higher than YOLOv8n. Additionally, the model boasts a parameter count of 3,094,304, a computational load of 8.4 GFLOPs, and a model size of 6.13 MB. Compared to YOLOv5s, with a parameter count of 7,030,417, a computational cost of 16.0 GFLOPs, and a model size of 13.79 MB, the SDCB-YOLO model is significantly smaller. When compared to YOLOv8n, with a parameter count of 3,011,628, a computational complexity of 8.2 GFLOPs, and a model size of 6.11 MB, the SDCB-YOLO model’s parameters and model size are only slightly increased, while maintaining a comparable computational load. Therefore, the improved detection algorithm presented in this article not only ensures the lightweight nature of the model but also significantly enhances its detection accuracy. Full article
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19 pages, 14105 KiB  
Article
Identification of Pine Wilt-Diseased Trees Using UAV Remote Sensing Imagery and Improved PWD-YOLOv8n Algorithm
by Jianyi Su, Bingxi Qin, Fenggang Sun, Peng Lan and Guolin Liu
Drones 2024, 8(8), 404; https://doi.org/10.3390/drones8080404 - 18 Aug 2024
Viewed by 344
Abstract
Pine wilt disease (PWD) is one of the most destructive diseases for pine trees, causing a significant effect on ecological resources. The identification of PWD-infected trees is an effective approach for disease control. However, the effects of complex environments and the multi-scale features [...] Read more.
Pine wilt disease (PWD) is one of the most destructive diseases for pine trees, causing a significant effect on ecological resources. The identification of PWD-infected trees is an effective approach for disease control. However, the effects of complex environments and the multi-scale features of PWD trees hinder detection performance. To address these issues, this study proposes a detection model based on PWD-YOLOv8 by utilizing aerial images. In particular, the coordinate attention (CA) and convolutional block attention module (CBAM) mechanisms are combined with YOLOv8 to enhance feature extraction. The bidirectional feature pyramid network (BiFPN) structure is used to strengthen feature fusion and recognition capability for small-scale diseased trees. Meanwhile, the lightweight FasterBlock structure and efficient multi-scale attention (EMA) mechanism are employed to optimize the C2f module. In addition, the Inner-SIoU loss function is introduced to seamlessly improve model accuracy and reduce missing rates. The experiment showed that the proposed PWD-YOLOv8n algorithm outperformed conventional target-detection models on the validation set ([email protected] = 94.3%, precision = 87.9%, recall = 87.0%, missing rate = 6.6%; model size = 4.8 MB). Therefore, the proposed PWD-YOLOv8n model demonstrates significant superiority in diseased-tree detection. It not only enhances detection efficiency and accuracy but also provides important technical support for forest disease control and prevention. Full article
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15 pages, 1647 KiB  
Article
Phase-Based Gait Prediction after Botulinum Toxin Treatment Using Deep Learning
by Adil Khan, Omar Galarraga, Sonia Garcia-Salicetti and Vincent Vigneron
Sensors 2024, 24(16), 5343; https://doi.org/10.3390/s24165343 - 18 Aug 2024
Viewed by 293
Abstract
Gait disorders in neurological diseases are frequently associated with spasticity. Intramuscular injection of Botulinum Toxin Type A (BTX-A) can be used to treat spasticity. Providing optimal treatment with the highest possible benefit–risk ratio is a crucial consideration. This paper presents a novel approach [...] Read more.
Gait disorders in neurological diseases are frequently associated with spasticity. Intramuscular injection of Botulinum Toxin Type A (BTX-A) can be used to treat spasticity. Providing optimal treatment with the highest possible benefit–risk ratio is a crucial consideration. This paper presents a novel approach for predicting knee and ankle kinematics after BTX-A treatment based on pre-treatment kinematics and treatment information. The proposed method is based on a Bidirectional Long Short-Term Memory (Bi-LSTM) deep learning architecture. Our study’s objective is to investigate this approach’s effectiveness in accurately predicting the kinematics of each phase of the gait cycle separately after BTX-A treatment. Two deep learning models are designed to incorporate categorical medical treatment data corresponding to the injected muscles: (1) within the hidden layers of the Bi-LSTM network, (2) through a gating mechanism. Since several muscles can be injected during the same session, the proposed architectures aim to model the interactions between the different treatment combinations. In this study, we conduct a comparative analysis of our prediction results with the current state of the art. The best results are obtained with the incorporation of the gating mechanism. The average prediction root mean squared error is 2.99° (R2 = 0.85) and 2.21° (R2 = 0.84) for the knee and the ankle kinematics, respectively. Our findings indicate that our approach outperforms the existing methods, yielding a significantly improved prediction accuracy. Full article
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20 pages, 3915 KiB  
Article
A Study of Improved Two-Stage Dual-Conv Coordinate Attention Model for Sound Event Detection and Localization
by Guorong Chen, Yuan Yu, Yuan Qiao, Junliang Yang, Chongling Du, Zhang Qian and Xiao Huang
Sensors 2024, 24(16), 5336; https://doi.org/10.3390/s24165336 - 18 Aug 2024
Viewed by 220
Abstract
Sound Event Detection and Localization (SELD) is a comprehensive task that aims to solve the subtasks of Sound Event Detection (SED) and Sound Source Localization (SSL) simultaneously. The task of SELD lies in the need to solve both sound recognition and spatial localization [...] Read more.
Sound Event Detection and Localization (SELD) is a comprehensive task that aims to solve the subtasks of Sound Event Detection (SED) and Sound Source Localization (SSL) simultaneously. The task of SELD lies in the need to solve both sound recognition and spatial localization problems, and different categories of sound events may overlap in time and space, making it more difficult for the model to distinguish between different events occurring at the same time and to locate the sound source. In this study, the Dual-conv Coordinate Attention Module (DCAM) combines dual convolutional blocks and Coordinate Attention, and based on this, the network architecture based on the two-stage strategy is improved to form the SELD-oriented Two-Stage Dual-conv Coordinate Attention Model (TDCAM) for SELD. TDCAM draws on the concepts of Visual Geometry Group (VGG) networks and Coordinate Attention to effectively capture critical local information by focusing on the coordinate space information of the feature map and dealing with the relationship between the feature map channels to enhance the feature selection capability of the model. To address the limitation of a single-layer Bi-directional Gated Recurrent Unit (Bi-GRU) in the two-stage network in terms of timing processing, we add to the structure of the two-layer Bi-GRU and introduce the data enhancement techniques of the frequency mask and time mask to improve the modeling and generalization ability of the model for timing features. Through experimental validation on the TAU Spatial Sound Events 2019 development dataset, our approach significantly improves the performance of SELD compared to the two-stage network baseline model. Furthermore, the effectiveness of DCAM and the two-layer Bi-GRU structure is confirmed by performing ablation experiments. Full article
(This article belongs to the Special Issue Sensors and Techniques for Indoor Positioning and Localization)
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16 pages, 1812 KiB  
Article
Enhancing E-Commerce Recommendation Systems with Multiple Item Purchase Data: A Bidirectional Encoder Representations from Transformers-Based Approach
by Minseo Park and Jangmin Oh
Appl. Sci. 2024, 14(16), 7255; https://doi.org/10.3390/app14167255 - 17 Aug 2024
Viewed by 468
Abstract
This study proposes how to incorporate concurrent purchase data into e-commerce recommendation systems to improve their predictive accuracy. We identified that concurrent purchases account for about 23% of total orders on Katcher’s, a Korean e-commerce platform. Despite the prevalence of concurrent [...] Read more.
This study proposes how to incorporate concurrent purchase data into e-commerce recommendation systems to improve their predictive accuracy. We identified that concurrent purchases account for about 23% of total orders on Katcher’s, a Korean e-commerce platform. Despite the prevalence of concurrent purchases, existing algorithms often overlook this aspect. We introduce a novel transformer-based recommendation algorithm to process a user’s order history, including concurrent purchases. Each order is represented as a natural language sentence, capturing the order timestamp, product names and their attribute values, their corresponding categories, and whether multiple products were purchased together in a single order (i.e., a concurrent purchase). These sentences form a sequence, which serves as a training dataset for fine-tuning Bidirectional Encoder Representations from Transformers (BERT) with the Next Sentence Prediction objective. We validate our ideas by conducting experiments on Katcher’s platform, demonstrating the proposed method’s improved prediction performance compared to existing recommendation systems, with enhanced accuracy and F1 score. Notably, the normalized discounted cumulative gain (NDCG) showed a significant improvement with a large margin. Furthermore, we demonstrate the beneficial impact of integrating concurrent purchase information on prediction performance. Full article
(This article belongs to the Special Issue Recommender Systems and Their Advanced Application)
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19 pages, 2111 KiB  
Review
Assembly, Activation, and Helicase Actions of MCM2-7: Transition from Inactive MCM2-7 Double Hexamers to Active Replication Forks
by Zhiying You and Hisao Masai
Biology 2024, 13(8), 629; https://doi.org/10.3390/biology13080629 - 17 Aug 2024
Viewed by 262
Abstract
In this review, we summarize the processes of the assembly of multi-protein replisomes at the origins of replication. Replication licensing, the loading of inactive minichromosome maintenance double hexamers (dhMCM2-7) during the G1 phase, is followed by origin firing triggered by two serine–threonine kinases, [...] Read more.
In this review, we summarize the processes of the assembly of multi-protein replisomes at the origins of replication. Replication licensing, the loading of inactive minichromosome maintenance double hexamers (dhMCM2-7) during the G1 phase, is followed by origin firing triggered by two serine–threonine kinases, Cdc7 (DDK) and CDK, leading to the assembly and activation of Cdc45/MCM2-7/GINS (CMG) helicases at the entry into the S phase and the formation of replisomes for bidirectional DNA synthesis. Biochemical and structural analyses of the recruitment of initiation or firing factors to the dhMCM2-7 for the formation of an active helicase and those of origin melting and DNA unwinding support the steric exclusion unwinding model of the CMG helicase. Full article
(This article belongs to the Special Issue The Replication Licensing System)
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11 pages, 3392 KiB  
Article
First Examples of Metal-Organic Frameworks with Pore-Encapsulated [Co(CO)4] Anions: Facile Synthesis, Crystal Structures and Stability Studies
by Caihong Xiao and Shaowu Du
Crystals 2024, 14(8), 731; https://doi.org/10.3390/cryst14080731 - 17 Aug 2024
Viewed by 209
Abstract
Three ionic metal-organic frameworks (MOFs) with pore-capsulated Co(CO)4 anions, formulated as [Co(bix)3][Co(CO)4]2 (1), [Co(bibp)3][Co(CO)4]2 (2), and [Co(bmibp)2][Co(CO)4]2 (3); (bix = [...] Read more.
Three ionic metal-organic frameworks (MOFs) with pore-capsulated Co(CO)4 anions, formulated as [Co(bix)3][Co(CO)4]2 (1), [Co(bibp)3][Co(CO)4]2 (2), and [Co(bmibp)2][Co(CO)4]2 (3); (bix = 1,4-bis(imidazol-1-yl-methyl)-benzene); bibp = 4,4′-bis(imidazolyl)biphenyl); bmibp = 4,4′-bis(2-methyl-imidazolyl)biphenyl), have been facilely synthesized for the first time through direct reactions of Co2(CO)8 with the respective bis(imidazole) ligands under mild hydro(solvo)thermal conditions. Single-crystal X-ray diffraction analysis reveals distinct structural motifs among the frameworks: MOF 1 exhibits a single pcu net, MOF 2 features a 3-fold interpenetrating pcu net, both based on 6-connected Co2+ centers and ditopic bix or bibp ligands, while MOF 3 forms a 2-fold interpenetrating sql layer constructed by 4-connected Co2+ ions and bmibp linkers. The [Co(CO)4] anions reside within the channels of the cationic frameworks. Moreover, these MOFs, characterized by periodically ordered tetracarbonylcobaltate arrays, demonstrate notable thermal stability and maintain structural integrity in air, water, and alkaline solutions for several days. Full article
(This article belongs to the Section Organic Crystalline Materials)
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17 pages, 2325 KiB  
Article
Multi-Modal Emotion Recognition Based on Wavelet Transform and BERT-RoBERTa: An Innovative Approach Combining Enhanced BiLSTM and Focus Loss Function
by Shaohua Zhang, Yan Feng, Yihao Ren, Zefei Guo, Renjie Yu, Ruobing Li and Peiran Xing
Electronics 2024, 13(16), 3262; https://doi.org/10.3390/electronics13163262 - 16 Aug 2024
Viewed by 507
Abstract
Emotion recognition plays an increasingly important role in today’s society and has a high social value. However, current emotion recognition technology faces the problems of insufficient feature extraction and imbalanced samples when processing speech and text information, which limits the performance of existing [...] Read more.
Emotion recognition plays an increasingly important role in today’s society and has a high social value. However, current emotion recognition technology faces the problems of insufficient feature extraction and imbalanced samples when processing speech and text information, which limits the performance of existing models. To overcome these challenges, this paper proposes a multi-modal emotion recognition method based on speech and text. The model is divided into two channels. In the first channel, the extended Geneva Minimalistic Acoustic Parameter Set (eGeMAPS) feature set is extracted from OpenSmile, and the original eGeMAPS feature set is merged with the wavelet transformed eGeMAPS feature set. Then, speech features are extracted through a sparse autoencoder. The second channel extracts text features through the BERT-RoBERTa model. Then, deeper text features are extracted through a gated recurrent unit (GRU), and the deeper text features are fused with the text features. Emotions are identified by the attention layer, the dual-layer Bidirectional Long Short-Term Memory (BiLSTM) model, and the loss function, combined with cross-entropy loss and focus loss. Experiments show that, compared with the existing model, the WA and UA of this model are 73.95% and 74.27%, respectively, on the imbalanced IEMOCAP dataset, which is superior to other models. This research result effectively solves the problem of feature insufficiency and sample imbalance in traditional sentiment recognition methods, and provides a new way of thinking for sentiment analysis application. Full article
(This article belongs to the Section Circuit and Signal Processing)
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19 pages, 2382 KiB  
Article
Spatial Dynamic Interaction Effects and Formation Mechanisms of Air Pollution in the Central Plains Urban Agglomeration in China
by Jie Huang, Hongyang Lu and Yajun Huang
Atmosphere 2024, 15(8), 984; https://doi.org/10.3390/atmos15080984 - 16 Aug 2024
Viewed by 211
Abstract
Accurately identifying the dynamic interaction effects and network structure characteristics of air pollution is essential for effective collaborative governance. This study investigates the spatial dynamic interactions of air pollution among 30 cities in the Central Plains Urban Agglomeration using convergent cross mapping. Social [...] Read more.
Accurately identifying the dynamic interaction effects and network structure characteristics of air pollution is essential for effective collaborative governance. This study investigates the spatial dynamic interactions of air pollution among 30 cities in the Central Plains Urban Agglomeration using convergent cross mapping. Social network analysis is applied to assess the overall and node characteristics of the spatial interaction network, while key driving factors are analyzed using an exponential random graph model. The findings reveal that air pollution levels in the Central Plains Urban Agglomeration initially increase before they decrease, with heavily polluted cities transitioning from centralized to sporadic distribution. Among the interactions, Heze’s air pollution impact on Kaifeng was the strongest, while Xinxiang’s impact on Changzhi was the weakest. The emission and receiving effects peaked during 2010–2012. The air pollution interactions among cities exhibit significant network characteristics, with block model results indicating that emitting and receiving relationships are primarily concentrated in the bidirectional spillover plate. Natural factors such as temperature and precipitation significantly influence the spatial interaction network. Economic and social factors like economic level and industrial sector proportion also have a significant impact. However, population density does not influence the spatial interaction network. This study contributes to understanding the spatial network of air pollution, thereby enhancing strategies for optimizing regional collaborative governance efforts to address air pollution. Full article
(This article belongs to the Section Air Pollution Control)
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20 pages, 5927 KiB  
Article
Research on Transformer Condition Prediction Based on Gas Prediction and Fault Diagnosis
by Can Ding, Wenhui Chen, Donghai Yu and Yongcan Yan
Energies 2024, 17(16), 4082; https://doi.org/10.3390/en17164082 - 16 Aug 2024
Viewed by 277
Abstract
As an indispensable part of the power system, transformers need to be continuously monitored to detect anomalies or faults in a timely manner to avoid serious damage to the power grid and society. This article proposes a combined model for transformer state prediction, [...] Read more.
As an indispensable part of the power system, transformers need to be continuously monitored to detect anomalies or faults in a timely manner to avoid serious damage to the power grid and society. This article proposes a combined model for transformer state prediction, which integrates gas concentration prediction and fault diagnosis models. First, based on the historical monitoring data, each characteristic gas sequence is subjected to one optimal variational mode decomposition (OVMD) and one complete ensemble empirical mode decomposition with adaptive noise (CEEMDAN). The decomposed sub-sequences are input into a bi-directional long short-term memory network (Bi-LSTM) optimized by the sparrow search algorithm (SSA) for prediction, and the predicted value of each sub-sequence was then superimposed to be the predicted value of the characteristic gas. We input the predicted values of each gas into the improved sparrow search algorithm-optimized support vector machine (ISSA-SVM) model, which can output the final fault type. After the construction of the combined model of state prediction is completed, this paper uses three actual cases to test the model, and at the same time, it uses the traditional fault diagnosis methods to judge the cases and compare these methods with the model in this paper. The results show that the combined model of transformer state prediction constructed in this paper is able to predict the type of transformer faults in the future effectively, and it is of great significance for the practical application of transformer fault type diagnosis. Full article
(This article belongs to the Section F3: Power Electronics)
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36 pages, 1910 KiB  
Review
Unveiling the Dynamic Interplay between Cancer Stem Cells and the Tumor Microenvironment in Melanoma: Implications for Novel Therapeutic Strategies
by Patrizia Limonta, Raffaella Chiaramonte and Lavinia Casati
Cancers 2024, 16(16), 2861; https://doi.org/10.3390/cancers16162861 - 16 Aug 2024
Viewed by 227
Abstract
Cutaneous melanoma still represents a significant health burden worldwide, being responsible for the majority of skin cancer deaths. Key advances in therapeutic strategies have significantly improved patient outcomes; however, most patients experience drug resistance and tumor relapse. Cancer stem cells (CSCs) are a [...] Read more.
Cutaneous melanoma still represents a significant health burden worldwide, being responsible for the majority of skin cancer deaths. Key advances in therapeutic strategies have significantly improved patient outcomes; however, most patients experience drug resistance and tumor relapse. Cancer stem cells (CSCs) are a small subpopulation of cells in different tumors, including melanoma, endowed with distinctive capacities of self-renewal and differentiation into bulk tumor cells. Melanoma CSCs are characterized by the expression of specific biomarkers and intracellular pathways; moreover, they play a pivotal role in tumor onset, progression and drug resistance. In recent years, great efforts have been made to dissect the molecular mechanisms underlying the protumor activities of melanoma CSCs to provide the basis for novel CSC-targeted therapies. Herein, we highlight the intricate crosstalk between melanoma CSCs and bystander cells in the tumor microenvironment (TME), including immune cells, endothelial cells and cancer-associated fibroblasts (CAFs), and its role in melanoma progression. Specifically, we discuss the peculiar capacities of melanoma CSCs to escape the host immune surveillance, to recruit immunosuppressive cells and to educate immune cells toward an immunosuppressive and protumor phenotype. We also address currently investigated CSC-targeted strategies that could pave the way for new promising therapeutic approaches for melanoma care. Full article
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23 pages, 2498 KiB  
Review
The Influence of Cecal Microbiota Transplantation on Chicken Injurious Behavior: Perspective in Human Neuropsychiatric Research
by Yuechi Fu and Heng-Wei Cheng
Biomolecules 2024, 14(8), 1017; https://doi.org/10.3390/biom14081017 - 16 Aug 2024
Viewed by 228
Abstract
Numerous studies have evidenced that neuropsychiatric disorders (mental illness and emotional disturbances) with aggression (or violence) pose a significant challenge to public health and contribute to a substantial economic burden worldwide. Especially, social disorganization (or social inequality) associated with childhood adversity has long-lasting [...] Read more.
Numerous studies have evidenced that neuropsychiatric disorders (mental illness and emotional disturbances) with aggression (or violence) pose a significant challenge to public health and contribute to a substantial economic burden worldwide. Especially, social disorganization (or social inequality) associated with childhood adversity has long-lasting effects on mental health, increasing the risk of developing neuropsychiatric disorders. Intestinal bacteria, functionally as an endocrine organ and a second brain, release various immunomodulators and bioactive compounds directly or indirectly regulating a host’s physiological and behavioral homeostasis. Under various social challenges, stress-induced dysbiosis increases gut permeability causes serial reactions: releasing neurotoxic compounds, leading to neuroinflammation and neuronal injury, and eventually neuropsychiatric disorders associated with aggressive, violent, or impulsive behavior in humans and various animals via a complex bidirectional communication of the microbiota–gut–brain (MGB) axis. The dysregulation of the MGB axis has also been recognized as one of the reasons for the prevalence of social stress-induced injurious behaviors (feather pecking, aggression, and cannibalistic pecking) in chickens. However, existing knowledge of preventing and treating these disorders in both humans and chickens is not well understood. In previous studies, we developed a non-mammal model in an abnormal behavioral investigation by rationalizing the effects of gut microbiota on injurious behaviors in chickens. Based on our earlier success, the perspective article outlines the possibility of reducing stress-induced injurious behaviors in chickens through modifying gut microbiota via cecal microbiota transplantation, with the potential for providing a biotherapeutic rationale for preventing injurious behaviors among individuals with mental disorders via restoring gut microbiota diversity and function. Full article
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