Search Results (37)

Background: Transcatheter aortic valve replacement (TAVR) was developed for inoperable patients with severe aortic stenosis. However, despite TAVR advancements, some patients remain untreated due to complex comorbidities, necessitating less-invasive approaches. Non-invasive ultrasound therapy (NIUT), a new treatment modality, has the potential to address this treatment gap, delivering short ultrasound pulses that create cavitation bubble clouds, aimed at softening embedded calcification in stiffened valve tissue. Methods: In the prospective Valvosoft^® Serbian first-in-human study, we assessed the safety and efficacy of NIUT and its impact on aortic valve hemodynamics, on the left ventricle, and on systemic inflammation in patients with severe symptomatic aortic stenosis not eligible for TAVR or surgery. Results: Ten patients were included. Significant improvements were observed in hemodynamic parameters from baseline to one month, including a 39% increase in the aortic valve area (from 0.5 cm² to 0.7 cm², p = 0.001) and a 23% decrease in the mean transvalvular gradient (from 54 mmHg to 38 mmHg, p = 0.01). Additionally, left ventricular global longitudinal strain significantly rose, while global wasted work significantly declined at one month. A dose–response relationship was observed between treatment parameters (peak acoustic power, intensity spatial-peak pulse-average, and mean acoustic energy) and hemodynamic outcomes. NIUT was safely applied, with no clinically relevant changes in high-sensitivity troponin T or C-reactive protein and with a numerical, but not statistically significant, reduction in brain natriuretic peptide (from 471 pg/mL at baseline to 251 pg/mL at one month). Conclusions: This first-in-human study demonstrates that NIUT is safe and confers statistically significant hemodynamic benefits both on the valve and ventricle. Full article

Focused on the unsteady property of a cavitating water jet issuing from an orifice nozzle in a submerged condition, this paper presents a fundamental investigation of the periodicity of cloud shedding and the mechanism of cavitation cloud formation and release by combining the use of high-speed camera observation and flow simulation methods. The pattern of cavitation cloud shedding is evaluated by analyzing sequence images from a high-speed camera, and the mechanism of cloud formation and release is further examined by comparing the results of flow visualization and numerical simulation. It is revealed that one pair of ring-like clouds consisting of a leading cloud and a subsequent cloud is successively shed downstream, and this process is periodically repeated. The leading cloud is principally split by a shear vortex flow along the nozzle exit wall, and the subsequent cloud is detached by a re-entrant jet generated while a fully extended cavity breaks off. The subsequent cavitation cloud catches the leading one, and they coalesce over the range of $x/d\approx 1.8~2.5$. Cavitation clouds shed downstream from the nozzle at two dominant frequencies. The Strouhal number of the leading cavitation cloud shedding varies from 0.21 to 0.29, corresponding to the injection pressure. The mass flow rate coefficient fluctuates within the range of $0.59~0.66$ at the same frequency as the leading cloud shedding under the effect of cavitation. Full article

In this work, within finite liquid spaces confined by elastic walls and the free surface, we investigated the influence of wall and liquid on laser bubble-excited vibrational rarefaction waves, via the dynamics of the laser-induced plasma-mediated bubble and its accompanying small secondary bubble clouds. We observed the modulation of the rebound maximum radius (R_max2) relative to the first oscillation period (T_osc1) for the laser bubble and the periodic appearance of secondary bubble clouds, which were caused by extra rarefaction waves. We found an approximate constant modulation period of R_max2 (T_osc1) and increased time intervals between the adjacent secondary bubble clouds with increasing liquid height in the same cuvette, while both of them were remarkably increased with increasing inner size of cuvettes within the same liquid height. This indicated that the cuvette geometry and liquid volume alter the key characteristics of the vibrational rarefaction waves. It was further confirmed that extra rarefaction waves within the liquid are excited by wall vibrations linked to laser bubble expansion and its induced liquid-mass oscillations. Our study provides a better understanding of the interactions of laser-induced cavitation with liquid and elastic walls in confined geometry, which is essential for intraluminal laser surgery. Full article

The artificially submerged cavitation water jet is effectively utilized by ejecting a high-pressure water stream into a low-pressure water stream through concentric nozzles and utilizing the cavitation phenomenon generated by the shear layer formed between the two streams. In this study, we investigated the cavitation characteristics of artificially submerged cavitation water jets by combining numerical simulations and erosion experiments. The results indicate that an appropriate standoff distance can generate more cavitation clouds on the workpiece surface, and the erosion characteristics of the artificially submerged cavitation water jet are most pronounced at a dimensionless standoff distance of S_D = 30. The shear effect formed between the two jets plays a crucial role in generating initial cavitation bubbles within the flow field of the artificially submerged cavitation water jet. Moreover, increasing the convergent angle between the two jets can significantly enhance the cavitation effect between them and lead to a more substantial cavitation effect. Simultaneously, increasing the pressure of the high-pressure inner nozzle also contributes to enhancing the cavitation effect of the artificially submerged cavitation water jet. Full article

Cavitation bubbles near narrow gaps widely exist within microfluidic control devices. In the present paper, a laser-induced cavitation bubble is arranged in a narrow gap composed of two parallel plates. The inception position of the bubble is set to be at the same distance from the two plates so that the dynamic behaviors of the bubble are symmetrical. The collapse and rebound dynamics of the bubble near the boundary of a narrow gap are investigated through high-speed photography. The bubble behaviors (e.g., shape deformation, translational movement, and jet characteristics) are analyzed while considering the influence of the dimensionless distance between the bubble and the boundary and the dimensionless gap width. The principal findings include the following: (1) When the dimensionless distance is small, a violent jet towards the gap is generated during the bubble collapse stage, along with a weak counter-jet towards the boundary appearing during the rebound stage. (2) As the dimensionless distance increases, the translational distance of the bubble during the collapse stage initially decreases, then increases, and finally decreases to zero. (3) Within the parameter range considered in this paper, the dimensionless width mainly affects the expansion degree and movement direction of the bubble cloud during its rebound and subsequent stages. The above research findings can provide experimental support for bubble-driven flow control, pumping, and liquid mixing in microfluidic channels. Full article

Cloud and bubble chambers have historically been used for particle detection, capitalizing on supersaturation and superheating, respectively. Here, we present new results from a prototype snowball chamber, in which an incoming particle triggers the crystallization of a purified, supercooled liquid. We demonstrate, for the first time, simulation agreement with our first results from 5 years ago: the higher temperature of the freezing of water and significantly shorter time spent supercooled compared to the control in the presence of a Cf-252 fission neutron source. This is accomplished by combining Geant4 modeling of neutron interactions with the Seitz nucleation model used in superheated bubble chambers, including those seeking dark matter. We explore the possible implications of using this new technology for GeV-scale WIMP searches, especially in terms of spin-dependent proton coupling, and report the first supercooling of WbLS (water-based liquid scintillator). Full article

In this work, we investigate the effect of dissolved gas concentration on cavitation inception and cavitation development in a transparent sharp-edged orifice, similar to that previously analyzed by Nurick in the context of liquid injectors. The working liquid is water, and carbon dioxide is employed as a non-condensable dissolved gas. Cavitation inception points are determined for different dissolved gas concentration levels by measuring wall-static pressures just downstream of the orifice contraction and visually observing the onset of a localized (vapor) bubble cloud formation and collapse. Cavitation onset correlates with a plateau in wall-static pressure measurements as a function of a cavitation number. An increase in the amount of dissolved carbon dioxide is found to increase the cavitation number at which the onset of cavitation occurs. The transition from cloud cavitation to extended-sheet or full cavitation along the entire orifice length occurs suddenly and is shifted to higher cavitation numbers with increasing dissolved gas content. Volume flow rate measurements are performed to determine the change in the discharge coefficient with the cavitation number and dissolved gas content for the investigated cases. CFD analyses are carried out based on the cavitation model by Zwart et al. and the model by Yang et al. to account for non-condensable gases. Discharge coefficients obtained from the numerical simulations are in good agreement with experimental values, although they are slightly higher in the cavitating case. The earlier onset of fluid cavitation (i.e., cavitation inception at higher cavitation numbers) with increasing dissolved carbon dioxide content is not predicted using the employed numerical model. Full article

Tire defect detection, as an important application of automatic inspection techniques in the industrial field, remains a challenging task because of the diversity and complexity of defect types. Existing research mainly relies on X-ray images for the inspection of defects with clear characteristics. However, in actual production lines, the major threat to tire products comes from defects of low visual quality and ambiguous shape structures. Among them, bubbles, composing a major type of bulge-like defects, commonly exist yet are intrinsically difficult to detect in the manufacturing process. In this paper, we focused on the detection of more challenging defect types with low visibility on tire products. Unlike existing approaches, our method used laser scanning technology to establish a new three-dimensional (3D) dataset containing tire surface scans, which leads to a new detection framework for tire defects based on 3D point cloud analysis. Our method combined a novel 3D rendering strategy with the learning capacity of two-dimensional (2D) detection models. First, we extracted accurate depth distribution from raw point cloud data and converted it into a rendered 2D feature map to capture pixel-wise information about local surface orientation. Then, we applied a transformer-based detection pipeline to the rendered 2D images. Our method marks the first work on tire defect detection using 3D data and can effectively detect challenging defect types in X-ray-based methods. Extensive experimental results demonstrate that our method outperforms state-of-the-art approaches on 3D datasets in terms of detecting tire bubble defects according to six evaluation metrics. Specifically, our method achieved 35.6, 40.9, and 69.1 mAP on three proposed datasets, outperforming others based on bounding boxes or query vectors. Full article

In numerous industries such as drilling, peening, cleaning, etc., a cavitating jet is adopted. However, it is challenging to simulate the cavitating flow field numerically with accuracy. The flow field of the organ pipe cavitation nozzle is simulated in this research using the RNG k−ε, DES, and LES turbulence models. The LES model can more accurately predict the periodic shedding of a cavitating cloud, which is basically consistent with the jet morphology captured with a high−speed camera. The flow pattern, cavitating cloud evolution and shedding period of a cavitating jet are analyzed. The findings demonstrate that the LES model produces a cavitating effect inside the nozzle that is superior to those produced by the RNG k−ε and DES models. The vortex rings in the diffusion section are simulated using the LES model, which accelerates cavitation. The cavitating clouds of the organ pipe nozzle show periodic evolutions, with stages of generation, development, shedding and collapse. The periodic shedding of the cavitating clouds exhibits a similar pattern in the vorticities simulated using the LES model, and the vorticities display the small-scale structures where the cavitating bubbles collapse. This study can provide a reference for the simulation of a cavitating jet and the analysis of the cavitating mechanism. Full article

This study employs the VOF method to conduct the direct numerical simulation of the collapse progress of the near-wall bubble cluster. Factors such as viscosity, compressibility, and surface tension are taken into account, with an emphasis on the flow field energy evolution. Firstly, the collapse of a cubic bubble cluster comprising 64 bubbles is simulated, validating previous research regarding the morphological evolution and energy release mechanisms during cluster collapse. Overall, the cubic bubble cluster collapse exhibits a layer-by-layer phenomenon, where the outer layer bubbles collapse first, converting a portion of bubble potential energy into fluid kinetic energy, which then contributes to the inner layer bubble collapse. The pressure wave energy is primarily released when the whole bubble cluster completely collapses. Secondly, we investigate the collapse process of columnar bubble clusters, which closely resemble realistic cloud cavitation. By comparing the collapse behavior of bubble clusters with different heights, we reveal the non-linear delay effect of the cluster height on the collapse time. Additionally, we consolidate our long-term research on the bubble cluster and conclude that both the scale and shape of the bubble clusters have a limited impact on the conversion rate $\eta$ of bubble potential energy to pressure wave energy $\eta$. For instance, when the stand-off distance $\eta =1.5$ and the inter-bubble distance $D=2.5$, the conversion rate $\eta$ remains consistently 9–15% for various bubble clusters of different scales and shapes. Full article

In-cloud icing occurred on cables, wind turbines, and aircraft wings and may cause power transmission paralysis, energy dissipation, and unsafe flight. The study of atmospheric ice is crucial to facilitate the development of in-cloud icing prediction/detection and anti-/de-icing systems. Herein, atmospheric ice formed by high-wind-speed, in-cloud icing was obtained and reserved during icing tests in the 3 m × 2 m icing wind tunnel located at CARDC. Microstructures of atmospheric ice formed by high-wind-speed, in-cloud icing were observed and analysed using the microscopic observation method. A better description was established to explore the influence of the icing environment on ice microstructures, such as the size and shape of air bubbles and the boundaries of ice grains. Furthermore, an accurate density measurement was developed to allow a better practical density expression to consider the characteristics of the impacted surface and the effect of the flow field. Full article

To investigate a hypothesis of the orifice flow-induced instability in rocket engine thrust chambers, a single liquid oxygen (LOX) injector with an optically accessible orifice module was used for experiments, with water as a simulant for LOX. The unsteady pressure downstream of the orifice was measured using high-speed piezoelectric sensors under cavitating and non-cavitating intra-injector flow conditions. The cavitating orifice flows were directly visualized via backlight imaging with a high-speed camera through the optically accessible orifice module. Cavitation initiated at the cavitation number of 2.05, and the downstream bubble cloud formation started below 1.91. The unsteady pressure spectrum arising from cavitation comprises multiple peaks over a broad frequency range, which can cause low- and high-frequency instabilities. The dominant frequencies from cavitation decrease with increasing pressure drop, while the frequencies during non-cavitating flow increase. The non-cavitating orifice flow excites the second longitudinal acoustic mode of the injector tube. The acoustic mode excited by the non-cavitating flow becomes stronger when the pressure peak in the range of whistling phenomenon is close to the first longitudinal acoustic mode. In conclusion, the excitation mechanisms of the orifice-induced instability for the cavitating and non-cavitating flows were well identified, despite the limitations of water as a simulant for LOX. Full article

Continuous variable quantum key distribution (CVQKD) has been implemented over the atmospheric channels over free space. However, atmospheric turbulence weakens the quality of the transmitting quantum signals and hence decreases the secret key rate of the system. Here, we suggest an atmospheric turbulence channel model that involves atmospheric turbulence bubbles and demonstrates the implementation feasibility of passive CVQKD with spectrum resources in the terahertz band over the atmospheric turbulence channel. We achieve the channel transmittance characterized by the refractive index and the wavefront distortions. Moreover, an adaptive optics (AO) unit is used for performance improvement while considering the effect of the thermal noise and excess noise on the atmospheric turbulence bubble-modeled channel. Numerical simulations show that the AO-involved detection scheme can result in reductions in excess noise when being faced with the floating clouds and mist in atmospheric turbulence, which results in performance improvements in terms of secret key rate, which confirms the utility of the high-rate and long-distance CVQKD in terahertz (THz) for practical implementations. Full article

This article deals with the numerical simulation of unsteady cavitating flow around hydrofoils, supported by experimental research realized in a cavitation tunnel situated in the Centre of Hydraulic Research. Two straight NACA hydrofoils (NACA0020 and NACA2412) were employed. The comprehensive unsteady CFD analysis was based on scale-resolving simulations (hereinafter SRS) with the aim of capturing correctly the interactions between the cavitation structures and re-entrant flow as well as the compressibility and thermal effects of cavitation. The static pressure fluctuations during the cavity oscillation cycles and the evaporation and condensation processes are discussed in detail. To predict correctly the high-pressure peaks during the bubble cloud collapses and the pressure pulse propagation speed, the real properties of water and the mixture total energy conservation equation were considered. In addition, the estimated content of undissolved air was taken into account. The numerical simulations were validated by means of already published experiments or compared with experiments conducted by the authors, and with good agreement. Full article

The presence of bubbles near the sea surface under certain conditions leads to abnormal sound scattering and a significant change in the acoustic properties of the upper layer of the sea. The article presents some results of sound scattering studies under various sea conditions, up to stormy conditions, when extensive bubble clouds arise. By the method of unsteady acoustic spectroscopy, data on the size distribution of bubbles at various depths have been obtained, which can be described by a power function with exponential decay at small bubble sizes of the order of 10 microns. Estimates of the gas content in bubble clouds and their influence on the acoustic characteristics of the upper layer of the sea have been carried out. It is shown that at sufficiently high concentrations, sharp increases in absorption and dispersion of the sound velocity are observed. Modeling of sound propagation in the presence of a quasi-homogeneous bubble layer shows that it leads both to a change in the laws of the average decay of the sound field along the sound propagation path and to a change in the shallow spatial structure of the field. Full article