Search Results (327)

Patient experience is a critical healthcare quality indicator, evolving from Patient Satisfaction (PS) and encompassing patients’ concrete healthcare experiences. It is increasingly vital in aging societies where collaborative efforts among patients, families, and healthcare professionals are essential. Studies suggest that enhanced patient experience leads to better adherence, outcomes, and patient safety. This paper reviews patient experience evaluations in older adults with diabetes through randomized controlled trial (RCT)-based findings. The author searched PubMed/MEDLINE, Embase, AMED, and CINAHL. The review focused on RCTs examining interventions affecting patient experience and PS in T2D/T1D patients aged ≥65. A total of 13 RCTs were eligible for this review. This review highlights studies on diabetes management in older adults, assessing the impact of health education, diabetes management programs, treatments, mHealth, and advanced insulin delivery systems. Early studies showed that education improved self-care but had a limited impact on glycemic control. Key findings include the effectiveness of experience-based education in improving HbA1c, the benefits of insulin therapy for elderly patients, and the value of structured peer-to-peer diabetes management programs in enhancing satisfaction. Patient adherence, satisfaction, and personalized support emerged as critical factors influencing diabetes management across various interventions. More recent trials involving mHealth demonstrated improvements in glycemic control and PS through automated data sharing and app-based support. Closed-loop insulin delivery studies reported reduced mental strain, improved glycemic control, and better quality of life, despite barriers such as device cost and occasional system limitations. These interventions highlight the potential of advanced technologies to enhance diabetes care, particularly for aging populations. Previous RCTs show that education, structured management programs, effective insulin therapies, and advanced digital treatments improve patient experience, though well-designed studies focusing on patient experience as a primary outcome are lacking. Developing patient experience assessment scales for aging diabetes patients and adapting healthcare systems to maximize patient experience amid digitalization trends are essential, warranting further research. Full article

Alzheimer’s disease (AD), a leading neurodegenerative disorder, is closely associated with the accumulation of amyloid-beta (Aβ) peptides in the brain. The enzyme β-secretase (BACE1), pivotal in Aβ production, represents a promising therapeutic target for AD. While bioactive peptides derived from food protein hydrolysates have neuroprotective properties, their inhibitory effects on BACE1 remain largely unexplored. In this study, we evaluated the inhibitory potential of protein hydrolysates from gliadin, whey, and casein proteins prepared using bromelain, papain, and thermolysin. Through in vitro and cellular assays, bromelain-hydrolyzed gliadin (G-Bro) emerged as the most potent BACE1 inhibitor, with an IC₅₀ of 0.408 mg/mL. G-Bro significantly reduced BACE1 expression and amyloid precursor protein (APP) processing in N2a/PS/APP cell cultures, suggesting its potential to attenuate Aβ aggregation. The unique peptide profile of G-Bro likely contributes to its inhibitory effect, with proline residues disrupting β-sheets, lysine residues introducing positive charges that hinder aggregation, hydrophobic residues stabilizing binding interactions, and glutamine residues enhancing solubility and stability. These findings highlight gliadin hydrolysates, particularly G-Bro, as potential natural BACE1 inhibitors with applications in dietary interventions for AD prevention. However, further studies are warranted to elucidate specific peptide interactions and their bioactivity in neural pathways to better understand their therapeutic potential. Full article

Information is an experience good, meaning that its value emerges upon use and varies based on individual perceptions. Augmented reality (AR) is a technology designed to deliver immersive informational experiences. This study investigates the impact of AR on the perceived value of information by people experiencing information as consumers or producers. Using Google Maps, we developed an AR mobile map called Tour-It-Yourself (TIY) for city navigation. The TIY app facilitates content consumption and production around local points of interest engagingly and interactively. We discuss the development of the research tool and results from two user studies (N = 37 teenagers and N = 51 students, respectively). Further, we highlight the economic valuation aspect by examining the effects of AR on Willingness-to-Pay and Willingness-to-Accept payment for information. The results indicate a significant main effect of participant experience (consumer/producer) and AR technology on the perceived evaluation of information. Moreover, the addition of AR technology to information improves knowledge regarding points of interest for producers. These findings contribute to our understanding of how AR shapes information value perception and have implications for designing interactive location-based information systems, benefiting tourism, education, and business, as well as fostering a sense of belonging in cities. Full article

As the global population ages, the rising prevalence of neurodegenerative diseases, characterized by abnormal protein aggregates, presents significant challenges for early diagnosis and disease monitoring. Identifying accessible tissue biomarkers is crucial for advancing our ability to detect and track the progression of these diseases. Among the most promising biomarkers is the skin, which shares a common embryological origin with the brain and central nervous system (CNS). This biological connection positions the skin as a potential reflection of CNS pathology. Over the past decades, gene expression studies have demonstrated that key genes involved in neurodegenerative diseases are also expressed in skin tissues. Genes such as APP, PSEN1, PPA2, PINK1, LRRK2, PLCB4, MAPT, SPAST, and SPG7 are prominent in this regard. Beyond gene expression, proteins related to neurodegenerative diseases—such as α-synuclein, TAU, PARKIN, and prion protein (PrP)—have been isolated from the skin of affected individuals, underscoring the skin’s capacity to mirror neural degeneration. This non-invasive window into neurodegenerative processes is further enhanced by advances in stem cell technology, which have allowed for the generation of human-induced pluripotent stem cells (iPSCs) from patient-derived fibroblasts. These iPSCs offer a valuable model for studying disease mechanisms and developing therapeutic approaches. This review conducts a comprehensive analysis of the literature from databases such as PubMed, Google Scholar, and ResearchGate, emphasizing the unique potential of the skin as a non-invasive biomarker for neurodegenerative diseases. It explores how the skin serves as a bridge between gene expression and disease pathology in both the skin and the CNS. By leveraging this biological connection, the skin emerges as a promising model for enhancing our understanding of neurodegenerative disorders and developing innovative strategies for early detection and treatment. However, significant limitations remain, requiring further validation to establish the specificity and sensitivity of these biomarkers. Full article

This article concerns the analysis and strengthening of children’s emotional self-regulation as a key process in the sustainable and comprehensive educational development of students from 6 to 8 years of age. The objective of the present study was to design a didactic proposal for technological mediation (WhatsApp) that contributes to emotional self-regulation and underpins the sustainable education of children in the context of the prevalence of COVID-19. The research design involved documentation, field, and propositional work. Regarding the documentation design, the content analysis technique of the Institutional Educational Project and the Coexistence Project of an official educational institution located in Bogotá, Colombia, were used. Regarding the field design, the survey technique was applied through a structured questionnaire for populations made up of second grade primary school students, parents, and teachers of the institution. Among the main results, it stands out that the prevalence of COVID-19 and its post-pandemic implications have generated greater use of available technologies, such as the WhatsApp application, evidencing a positive relationship between the level of emotional self-regulation of children and its use as a didactic mediation agent. These findings serve as input for the design of the interactive TICSR-WA proposal. Full article

With the emergence of containerization 10 years ago, we saw a compact, convenient and portable way of running apps directly concurrently with virtualization. The major difference is in the architecture. Containers share the same kernel as the guest and then do not virtualize low-layer components like the Central Processing Unit (CPU). On the one hand, they are lighter and more flexible than virtual machines (VMs). On the other hand, VMs can more precisely meet the low-layer needs and are completely autonomous systems. Nowadays, what is the best architecture to use to develop an application? In this paper, we will study the two main virtual methods of deploying this. We will compare both methods on several criteria: compatibility based on user experience and the ease of installation/deployment, scalability based on the automatic elasticity facing the workload and energy efficiency in terms of energy and computer resources. After the tests, we conclude that the containerization option is the most ecologically advantageous option in terms of energy consumption. Full article

Green crowdsourcing mobile applications provide an appropriate supply chain coordination mechanism for deliveries, harnessing benefits for people, profits and the environment. Despite the benefits, the risks and challenges associated with green crowdsourcing undermine the social, economic and sustainability benefits of last mile logistics. We undertook an exploration of the risks of using the green crowdsourcing Dilivari mobile application (App) innovation in South Africa. The study used an exploratory research case study research design. The study included 54 respondents with rich, in-depth knowledge, 49 participants for focus group discussions (FGDs) and five key informant interviews. Our study established security, legal, human and connectivity risks associated with this app. We focused on the risks and challenges in the literature including critical emergent risks in a developing country context, compatibility of technology, load shedding, mobile penetration, and data costs. Furthermore, we highlighted the security risks posed by theft, robberies and terrorism. Full article

Background/Objectives: During the COVID-19 pandemic, TikTok emerged as a significant app for entertainment and information acquisition for the general public, gradually extending its reach to the older population. Digital technology, exemplified by TikTok, has become an indispensable part of older adults’ lives. However, while prior studies have extensively focused on the impact of internet use on older adults’ health, research on the impact of TikTok during the COVID-19 pandemic remains insufficient. Methods: Utilizing data from the China Family Panel Studies (CFPS) 2020, this study explored the impact of TikTok use on older adults’ self-rated health and its underlying mechanisms through multiple regression and mediation analysis. Results: The study found that (1) TikTok use had a significant positive effect on the self-rated health of older adults; (2) while TikTok use increased the exercise frequency of older adults, exercise frequency did not affect their self-rated health; and (3) TikTok use boosted older adults’ protein intake, contributing substantially to their self-rated health, accounting for 38.7% of the total effect. Conclusions: It is advisable to actively promote the popularity of short video apps such as TikTok among older adults, as they serve as an effective tool for disseminating health information and encouraging healthier lifestyles and behaviors. Full article

Hydrogen sulfide (H₂S) donors are emerging as promising candidates for neuroprotective agents. However, H₂S-dependent neuroprotective mechanisms are not yet fully understood. We have demonstrated that an H₂S donor (sodium sulfide, Na₂S) reduces the expression of inducible NO synthase (iNOS) and amyloid-beta precursor protein (APP) in damaged neural tissue at 24 h and 7 days following traumatic brain injury (TBI). The application of aminooxyacetic acid (AOAA), an inhibitor of cystathionine β-synthase (CBS), produced the opposite effect. Seven days after TBI, iNOS expression was observed not only in the cytoplasm but also in some neuronal nuclei, while APP was exclusively localized in the cytoplasm and axons of damaged neurons. It was also shown that iNOS and APP were present in the cytoplasm of mechanoreceptor neurons (MRNs) in the crayfish, in axons, as well as in certain glial cells 8 h after axotomy. Na₂S and AOAA had opposing effects on axotomized MRNs and ganglia in the ventral nerve cord (VNC). Multiple sequence alignments revealed a high degree of identity among iNOS and APP amino acid residues in various vertebrate and invertebrate species. In the final stage of this study, biomodeling identified unique binding sites for H₂S, hydrosulfide anion (HS⁻), and thiosulfate (S₂O₃²⁻) with iNOS and APP. Full article

The ubiquitous use of mobile devices along with the amount of traffic, transportation services, and travel pattern data available has led to the emergence and deployment of smartphone applications for providing information about personal travel management. Several of these travel apps are aimed at voluntary travel behavior change (VTBC) to support and increase sustainable mobility, and have led to the development of research to investigate their influence on travel behavior. Here, the aim is to study the role of technophilia and goal-framing theory in the intention to adopt and situationally use a prospective VTBC travel app. A Structural Equation Model is developed with the aim of empirically testing a sample of 971 respondents collected in two suburban corridors in the Lisbon Metropolitan Area. The results support that goal-framing theory is important for explaining the adoption of VTBC travel apps. Gain and normative motives are more relevant than hedonic motives, pointing to the importance of their tangible benefits. Frequent car users may benefit from VTBC travel apps in terms of encouraging behavioral changes, supporting sustainable mobility management solutions. The results also outline the importance of technophilia and the current use of travel apps in influencing the intention to use VTBC apps. Full article

Background/Objectives: Remote monitoring (RM) cardiac implantable electronic devices for adults delivers improved patient outcomes. However, previously used bedside transmitters are not optimal due to deficient patient adherence. The goal of this study was to evaluate the efficacy of RM regarding the connectivity of smartphone app-based solutions, adherence to scheduled automatic follow-ups, and prevalence of alert-based events. Methods: We evaluated the adult heart failure (HF) population with an implanted cardiac resynchronization therapy defibrillator (CRT-D) divided into two arms: with app-based RM (abRM) and without app-based RM (control). Results: A total of 81 patients (median age of 69.0) were included in our study. Sixty-five patients received a CRT-D with abRM functionality, and sixteen did not. Twelve patients had no smartphone, and two provided no consent, resulting in their transfer to the control group. Finally, the abRM arm consisted of 51 patients, while 30 patients were in the control group. The median period of follow-up lasted 12 months. Among abRM patients, 98.0% successfully transmitted their first scheduled follow-up, and 80.4% were continuously monitored. Alert-based events were mainly related to arrhythmic events and device functionality with significantly shorter median times to notification (1 day vs. 101 days; p < 0.0001) in the abRM group. Conclusions: Our study showed a high level of compliance with timely initial transmission and adherence to scheduled remote follow-ups. Patient enrollment eligibility was a major challenge due to the limited accessibility of smartphones in the population. App-based RM demonstrated an accurate notification of events and patient-initiated transmissions in emergencies, regardless of location. Full article

Background: The biomedical and health informatics (BMHI) fields have been advancing rapidly, a trend particularly emphasised during the recent COVID-19 pandemic, introducing innovations in BMHI. Over nearly 50 years since its establishment as a scientific discipline, BMHI has encountered several challenges, such as mishaps, delays, failures, and moments of enthusiastic expectations and notable successes. This paper focuses on reviewing the progress made in the BMHI discipline, evaluating key milestones, and discussing future challenges. Methods: To, Structured, step-by-step qualitative methodology was developed and applied, centred on gathering expert opinions and analysing trends from the literature to provide a comprehensive assessment. Experts and pioneers in the BMHI field were assigned thematic tasks based on the research question, providing critical inputs for the thematic analysis. This led to the identification of five key dimensions used to present the findings in the paper: informatics in biomedicine and healthcare, health data in Informatics, nurses in informatics, education and accreditation in health informatics, and ethical, legal, social, and security issues. Results: Each dimension is examined through recently emerging innovations, linking them directly to the future of healthcare, like the role of artificial intelligence, innovative digital health tools, the expansion of telemedicine, and the use of mobile health apps and wearable devices. The new approach of BMHI covers newly introduced clinical needs and approaches like patient-centric, remote monitoring, and precision medicine clinical approaches. Conclusions: These insights offer clear recommendations for improving education and developing experts to advance future innovations. Notably, this narrative review presents a body of knowledge essential for a deep understanding of the BMHI field from a human-centric perspective and, as such, could serve as a reference point for prospective analysis and innovation development. Full article

The innovative trend of “as a service” due to digital development and the rise of issues such as air pollution and traffic congestion led to the emergence of Mobility as a Service (MaaS) in the transportation sector. Companies and governments are experimenting to create a sustainable and efficient transportation future with MaaS. However, MaaS realization and business success from MaaS are still in their growing phase, making this study particularly relevant and timely. This study aims to identify the attributes of users’ selection of integrated mobility app services and the MaaS attributes that affect the behavioral intention to use through the mediation of perceived usefulness and perceived ease of use. This study marked four selection attributes—habit-congruence, information accuracy, relative advantage on efficiency, and IT system quality—for the integrated mobility app service, and 315 actual users of integrated mobility apps in Republic of Korea were sampled and analyzed. In terms of influence, information accuracy, relative advantage on efficiency, and habit-congruence significantly impacted perceived usefulness, in which habit-congruence had the most significant impact on perceived ease of use. In addition, habit-congruence and information accuracy were found to positively affect the behavioral intention to use, mediated by perceived usefulness and perceived ease. We also found that IT system quality was not a user selection attribute where this study was conducted. By providing empirical findings, this study can give management guidelines to companies and researchers in developing integrated mobility app service strategies to increase the number of users and maintain long-term customer relationships. Full article

Amyloid β protein (Aβ) deposition has been implicated as the molecular driver of Alzheimer’s disease (AD) progression. The modulation of the formation of abnormal aggregates and their post-translational modification is strongly suggested as the most effective approach to anti-AD. Beta-site APP-cleaving enzyme 1 (BACE1) acts upstream in amyloidogenic processing to generate Aβ, which rapidly aggregates alone or in combination with acetylcholinesterase (AChE) to form fibrils. Accumulated Aβ promotes BACE1 activation via glycogen synthase kinase-3β (GSK-3β) and is post-translationally modified by glutaminyl cyclase (QC), resulting in increased neurotoxicity. A novel multi-target inhibitor as a potential AD agent was identified using an in silico approach and experimental validation. Magnolia officinalis, which showed the best anti-AD activity in our preliminary study, was subjected to analysis, and 82 compounds were studied. Among 23 compounds with drug-likeness, blood–brain barrier penetration, and safety, honokiol emerged as a lead structure for the inhibition of BACE1, AChE, QC, and GSK-3β in docking and molecular dynamics (MD) simulations. Furthermore, honokiol was found to be an excellent multi-target inhibitor of these enzymes with an IC₅₀ of 6–90 μM, even when compared to other natural single-target inhibitors. Taken together, the present study is the first to demonstrate that honokiol acts as a multiple enzyme inhibitor with an excellent pharmacokinetic and safety profile which may provide inhibitory effects in broad-range areas including the overproduction, aggregation, and post-translational modification of Aβ. It also provides insight into novel structural features for the design and discovery of multi-target inhibitors for anti-AD. Full article

This study aims to investigate how urban residents interact with Urban Green Spaces (UGSs) in Nagpur, India, specifically focusing on the patterns of visitation and engagement. Data were collected via a face-to-face questionnaire survey using the Survey 123 app. The analysis included interaction (types of UGSs, visitation frequency, and UGS availability); engagement (activities); demographics (age, gender, and work status); and nature connection (self-reported) aspects. Using data from 2002 participants, the study employs statistical analyses using R software (4.3.2) to explore the correlations between these variables. The results revealed key factors influencing UGS usage, highlighting the interplay between environmental and social aspects. Neighborhood UGSs, proximity, and accessibility were found to be pivotal in promoting frequent visitation, while physical activity emerged as the most common activity among daily visitors. Older adults visited UGSs less frequently, suggesting potential barriers, while employed individuals visited more often. A strong association between nature connection and UGS interaction was highlighted, emphasizing the psychological and emotional aspects of UGS usage. For example, individuals who felt more connected to nature reported using UGSs for physical activities, mental relaxation, and socializing. These findings underscore the need for integrating UGSs within broader urban social-ecological systems, which means recognizing these spaces as vital components contributing to overall health and resilience and catering to the population’s diverse needs, ensuring that these spaces are accessible and enjoyable for all community members, including those from different cultural, age, and socioeconomic backgrounds. Additionally, fostering nature connectedness through education and exposure to natural environments is recommended to enhance UGS usage, supporting broader urban planning strategies to create sustainable and healthy urban environments. Full article