Search Results (2,566)

Background: Assessing visual function and quality of life in children with visual impairments is crucial for understanding its impact and evaluating interventions. While tools exist for developed countries, there is a lack of instruments for rural school-going children in middle- to low-income countries. This study aimed to develop and validate an instrument to measure Children’s Visual Function Quality of Life (CVF-QoL) for South African children aged 6 to 17 with uncorrected refractive errors, visual impairments, or blindness. Methods: The CVF-QoL instrument was created through a literature review and focus group discussions with experts and children. Readability was assessed, resulting in two versions of the CVF-QoL instrument. The contents of both versions were validated by experts, and pre-testing was performed with school children aged 6–17 years. Results: From the literature review, 769 items were identified, and 477 statements were generated from focus group discussions. After merging and eliminating duplicates, 91 items were classified into eight domains. The tool was divided into Version 1.1 for ages 10–17 (89 items) and Version 2.1 for ages 6–9 (63 items), both demonstrating strong clarity, coherence, and relevance. Conclusions: The CVF-QoL instruments are valid for evaluating the quality of life-related to visual function among rural school-going children with visual impairments in South Africa. This instrument thus provides an additional QoL tool to those already existing that may be more appropriate for measuring quality of life for rural school-going children in low- and middle-income countries. Full article

Climate change impacts are unpredictable and can change rapidly or over time; anthropogenic stressors work synergistically to strengthen their impact on vulnerable ecosystems including in the fisheries sector. This study focused on understanding and documenting the historical occurrence of extreme climate change impacts as exemplified by super typhoon Pablo (Bopha), which wreaked havoc in Baganga, Davao Oriental, almost a decade ago. A mixed-methods approach was used, using semi-structured interviews (N = 120) and focus group discussions (FGD) with small-scale fishers in the four fishing villages to assess the impacts of climate change and their adaptation after the events occurred. Our findings indicate that the fishing villages were exposed to the same impacts of climate change or the super typhoon which destroyed their lives and livelihoods. Consequently, this affected their catch per trip and fishing operations. Moreover, due to the impact of the super typhoon, fishers in Baganga developed psychological distress and trauma (emotional 44% and physical 24%) due to the extreme event. To survive, their adaptation strategies relied on government and non-government assistance provisions and projects, e.g., planting mangrove trees, construction of a seawall with wave breakers, cash-for-work activities, and tourism, as an alternative livelihood. Moreover, our study revealed that the communities have limited knowledge about the impacts of climate change, the local government lacks clear management goals for fisheries conservation and there was widespread use of illegal fishing gear. There is a strong need to implement rules, policies, and adaptation measures to build more resilient fishing communities. Full article

(1) Background: This study used human-centered design (HCD) within a community-based research project to collaboratively develop local strategies aimed at enhancing COVID-19 vaccine confidence among children and youth. (2) Methods: HCD projects were carried out between December 2021 and August 2022 by four community-based design (CBD) teams in Montreal, Canada. The CBD teams were composed of parent and youth community members, public health and social science researchers, and HCD specialists. Process evaluation data, collected from the CBD team members through focus group discussions and written questionnaires, were used to reflect on the use of HCD in this project. (3) Results: The CBD teams designed and implemented projects addressing factors they identified as contributing to COVID-19 vaccine hesitancy for children and youth in their communities, including misinformation, lack of trust, social inequities, and resistance to pandemic-related restrictions. The CBD team members appreciated many aspects of the HCD approach, especially the values it stands for, such as empathy, co-creation, and collaboration. HCD and public health specialists described some tension between the different disciplinary approaches. (4) Conclusions: HCD holds promise for addressing complex public health issues, though further exploration of strategies for integrating HCD within established models of community-based public health research is needed. Full article

If edible coatings are proven to control deterioration reactions by preventing chemical reactions, why aren’t they more widely used in industry applications, especially in the ready-to-eat food sector? This sector is a growing and emerging market and is interesting to diverse consumer groups. The potential of edible coatings as an innovative approach for more eco-friendly packaging systems should be further investigated. This article reviews the state-of-the-art developments of edible coatings for chilled RTE (ready-to-eat) food products as an area of growing interest and innovation, with a focus on sustainability, functionality, and costs. It discusses challenges associated with the use of edible coatings as eco-friendly packaging system in RTE food sector, including compatibility with food products, processing, shelf-life, storage conditions, cost, and regulatory requirements, and emerging trends, including biodegradable and eco-friendly coatings, shelf-life extension, active and intelligent coatings, and customization and personalization opportunities. Overall, while edible coatings offer many potential benefits in the RTE food sector, there are several challenges that must be addressed to ensure their successful implementation. Research and development efforts are needed to optimize the performance and stability of coatings while ensuring compliance with regulatory requirements and addressing cost concerns. The potential of edible coatings as eco-friendly packaging system should be further studied to highlight the full potential of edible coatings. Full article

Intimate partner violence (IPV) during pregnancy is closely associated with adverse maternal and fetal outcomes. To develop prevention strategies and interventions, the exploration of cultural norms, societal attitudes, and perceptions related to IPV is vital. This study explored community perspectives on IPV during pregnancy in rural Ethiopia. We used an exploratory qualitative study design to collect data. Data were collected through in-depth interviews (IDIs) and focus group discussions (FGDs) guided by a semi-structured topic guide. The data were analyzed using a thematic analysis approach, revealing the following four themes: (1) threats to the health of the mother and the fetus; (2) the contributing factors of IPV during pregnancy; (3) coping strategies for IPV during pregnancy; and (4) the need for intervention. Supportive attitudes toward IPV, early marriage, lack of awareness among offenders about its consequences, alcohol use, poor couple communication, and provocation by wives were found to be the causes of IPV during pregnancy. Participants in this study perceived IPV as a normal and unavoidable aspect of marital relationships. Comprehensive interventions that address challenging the cultural norms that condone IPV, increase community awareness of its detrimental effects, improve couples’ communication skills, and address alcohol abuse among men could play a crucial role in preventing or reducing IPV during pregnancy. Full article

The Jordan Valley in the West Bank in Palestine provides a unique social, environmental, and geopolitical context in regard to the global challenge of water insecurity, where its impacts on child and maternal health are only partly understood. Existing research has been largely limited to investigations of water quantity/quality and direct health outcomes, such as infectious disease. This qualitative study aimed to provide a holistic perspective of the challenge of water insecurity and child health, by investigating household water insecurity in Palestine. Focus group discussions explored the lived experiences of women from marginalized communities. These were then thematically analyzed, in reference to social theory. The study identified context-specific aspects of water insecurity, shaped by the background in Palestine involving the occupation and ongoing violent conflict in the area. These challenges disproportionately affect women, who are primarily responsible for water management within their communities, leading to embodied experiences, heightened negative emotions, and increased conflict, both within households and the broader community. Consequently, these stressors heavily impact children: limited caretaking time, due to economic pressures, children’s involvement in water-related tasks, and the disruption of social cohesion at both the community and household level, ultimately affect their physical and mental health and their ability to learn and play. Our findings could guide research and policy efforts in developing context-sensitive tools, such as a child water stress index for Palestine. Full article

Background: Mental health outcomes among female refugees are complex and multifaceted. This study examines the mental health outcomes and coping resources of female Ukrainian refugees in Germany using a mixed methods approach with qualitative focus groups and quantitative assessments. Methods: This study employs a mixed methods approach, combining qualitative and quantitative methodologies. Three focus group discussions with fifteen participants were conducted in Hamburg in April 2023. A stepwise qualitative data analysis was done using a deductive coding technique. The quantitative analysis focused on descriptive statistics to summarize the data and provide an overview of participants’ mental health and well-being. Results: Our findings show that 43% of participants reported anxiety symptoms, and 21% showed signs of depression—many experienced isolation and disconnection and were struggling with cultural adaptation and the emotional toll of displacement. Despite challenges, participants utilized various coping strategies, such as staying active, volunteering, and seeking community support. However, significant barriers to accessing mental health services, especially for children, were identified. Conclusions: The study underscores the need for tailored interventions, including language support, accessible mental health resources, and community engagement, to foster resilience and well-being. It highlights the importance of comprehensive support systems for refugee populations in host countries, such as active lifestyles, social support, volunteer work, and successful integration. Full article

Purpose: Cancer survivors in rural and underserved areas face barriers such as limited access to oncology exercise programs and limited facilities, contributing to health inequities in cancer survivorship. This study explored cancer survivors’ thoughts on exercise and mobile technology for exercising with a mobile application (app) during and after treatment in rural and remote areas. Methods: Three online focus groups were conducted in February 2024 using semi-structured interviews with 12 open-ended questions. Eligible participants were adult cancer survivors or caregivers living in medically underserved areas, English-speaking, consented to being audiotaped, and attended one 60-min group interview. The discussions were transcribed verbatim and analyzed via a content analysis approach with consensus. Results: Fifteen participants attended from four States. None of the participants were advised to exercise; availability of exercise resources depended on geographic location and a cancer-specific exercise app was desired. They understood the benefits of exercise after diagnosis but expressed a need for more guidance during treatment. Geographic location shaped their activities, with most engaging in daily physical tasks rather than structured exercise. Most participants were receptive to using an exercise app to manage fatigue. Suggested key features to exercise with an app included live trainers, exercise checklists, visual benchmarks, and programs tailored to different fitness levels. Conclusions: These results emphasize the need for personalized resources, guidance, and on-demand accessibility to an exercise oncology app. A cancer-specific exercise mobile app will mitigate health inequities for cancer survivors residing in rural and remote areas. Full article

The Cholera-Hospital-based-Intervention-for-7-Days (CHoBI7) mobile health (mHealth) program is a targeted water treatment and hygiene (WASH) program for the household members of diarrhea patients, initiated in the healthcare facility with a single in-person visit and reinforced through weekly voice and text messages for 3 months. A recent randomized controlled trial of the CHoBI7 mHealth program in urban Dhaka, Bangladesh, found that this intervention significantly increased WASH behaviors and reduced diarrhea prevalence. The objective of this present study was to conduct formative research using an implementation science framework to adapt the CHoBI7 mHealth program for scalable implementation in rural Bangladesh, and to promote construction of self-made handwashing stations (CHoBI7 Scale-up program). We conducted a 3-month multi-phase pilot with 275 recipients and 25 semi-structured interviews, 10 intervention planning workshops, and 2 focus group discussions with intervention recipients and program implementers. High appropriateness, acceptability, and adoption of the CHoBI7 Scale-up program was observed, with most recipients constructing self-made handwashing stations (90%) and chlorinating drinking water (63%) and 50% of participants observed handwashing with soap in the final pilot phase. At the recipient level, facilitators included weekly voice and text messages with videos on handwashing station construction, which served as reminders for the promoted water treatment and hand hygiene behaviors. Barriers included perceptions that self-made iron filters commonly used in households also removed microbial contamination from water and therefore chlorine treatment was not needed, and mobile messages not always being shared among household members. At the implementer level, facilitators for program implementation included follow-up phone calls to household members not present at the healthcare facility at the time of intervention delivery, and the promotion of multiple self-made handwashing station designs. Barriers included high patient volume in healthcare facilities, as well as the high iron in groundwater in the area that reduced chlorination effectiveness. These findings provide valuable evidence for adapting the CHoBI7 mHealth program for a rural setting, with a lower-cost, scalable design, and demonstrated the important role of formative research for tailoring WASH programs to new contexts. Full article

This essay takes its cue from a re-examination of a previous research report. In particular, this paper aims to present some additional reflections, which have also been shaped by discussions with recent research on lived religiosity. The 2017 study involved 2675 individuals of Catholic faith who completed a detailed questionnaire, representing an opportunistic sample, and another 372 people who formed the comparison group. The objective was to investigate the languages, forms, and structures of religious experience and religiosity. In this new interpretation, we instead focus on those elements of the 2017 study that suggest new shared attitudes or possible historical transformations of religiosity among the subjects initially consulted. Full article

Computational approaches applied in drug discovery have advanced significantly over the past few decades. These techniques are commonly grouped under the term “computer-aided drug design” (CADD) and are now considered one of the key pillars of pharmaceutical discovery pipelines in both academic and industrial settings. In this work, we review Quantitative Structure–Activity Relationships (QSARs), one of the most used ligand-based drug design (LBDD) methods, with a focus on its application in the discovery and development of anti-breast cancer drugs. Critical steps in the QSAR methodology, essential for its correct application—but often overlooked, leading to insignificant or misleading models—are examined. Additionally, current anti-breast cancer treatment strategies were briefly overviewed, along with some targets for future treatments. The review covers QSAR studies from the past five years and includes a discussion of notable works that could serve as models for future applications of this interdisciplinary and complex method and that may help in feature drug design and development. Full article

Older adults are both vulnerable to the impacts of climate change and uniquely positioned to contribute to climate action. However, their ability and willingness to engage vary significantly due to health disparities, financial constraints, and cultural factors. To ensure inclusivity, climate policies must reflect these differences and empower older adults to participate effectively. This research focused on 30 London-based older adults aged 60–85 (18 women, 12 men) selected via purposive sampling and stratified by gender and climate awareness. All participants were interested in climate issues and engaged in seven small focus groups facilitated by two researchers. Discussions addressed climate perceptions, low-carbon behaviors, and policy recommendations. The findings reveal that tailored communication, featuring simplified language and visual materials, resonates deeply with older adults, fostering better understanding and emotional connection. Participants highlighted practical low-carbon actions they already undertake, such as energy conservation, food waste reduction, and public transport use. They also proposed innovative strategies for promoting climate awareness, including integrating cultural and emotional elements, encouraging intergenerational learning, and providing economic incentives for green practices. To enhance the engagement of older adults in climate action, governments and corporations should develop inclusive communication strategies, provide financial support for adopting green technologies, and foster intergenerational collaboration to share knowledge and experiences in the communities. This study amplifies the voices of older adults in climate discourse, offering actionable insights for shaping communication strategies and policies. While this study provides valuable insights into older adults’ contributions to climate action, future research could expand the sample size and geographic diversity to enhance the generalizability of findings. Full article

Water crises are prevalent globally, but effective water governance can help mitigate these issues. This study, conducted in Soc Trang, a coastal province of the Vietnamese Mekong Delta, assessed water governance trends and identified local challenges using the OECD (Organization for Economic Cooperation and Development) water governance framework, which comprises 12 principles. Data were gathered through 15 questionnaires and two focus group discussions with the Department of Natural Resources and Environment and the Department of Agriculture and Rural Development. The findings indicate that all 12 principles have improved over the past decade, particularly in areas such as data management, the clarity of roles, appropriate basin scales, and innovative governance approaches. However, challenges remain, including external risks, limited human resources, ineffective coordination, and insufficient funding and facilities. While the OECD framework offers a comprehensive guide for water governance, it is crucial to provide clear explanations to local stakeholders during implementation. This ensures a shared understanding throughout the assessment process. A key aspect of this is translating scientific and technical terms into the local language and context, which enhances communication and engagement among all participants involved in the study. Full article

Group 11 metals form with pyrazolate ligand complexes with a general formula of [MPz]_n. The value of “n” varies depending on the type of substituent in the ligand and the metal atom. Copper(I) and silver(I) ions mainly form cyclic di-, tri-, and tetra-nuclear complexes or polymeric structures. Cyclic trinuclear d¹⁰ metal pyrazolates [MPz^m]₃ (M = Cu(I) and Ag(I); Pz = substituted pyrazolate ligand) are of particular interest because their planar structure allows them to form supramolecular aggregates via noncovalent metal–metal, metal–π, and metal–electron donor interactions. Designing complexes based on these interactions has been a focus of research for the last two decades. The ability of cyclic trinuclear copper(I) and silver(I) pyrazolates to form coordination and supramolecular structures determines their properties and potential applications in catalysis, gas sensing, molecular recognition, and photoluminescence. In this review, we discuss noncovalent interactions between cyclic trinuclear silver(I) and copper(I) complexes with various types of ligands. Full article

Urban green infrastructures (UGIs) are important elements of the urban matrix providing ecological functions and several ecosystem services beneficial to citizens. Recently, their contribution to the well-being and quality of life of citizens has been widely recognized by both the scientific community and policymakers. This study aims to explore the social relevance of UGI ecosystem services through a mixed qualitative–quantitative case study approach. First, a quantitative literature review was conducted using bibliometric network analysis, followed by a participatory process through a Scientific Café with a sample of Italian stakeholders involved in the UGIs’ planning and management. The bibliometric network analysis identified 443 documents (from 2000 to 2024) primarily focused on three ecosystem services provided by UGIs—climate change mitigation, biodiversity conservation, and cultural services, such as health benefits, aesthetic, and recreation. The qualitative results of Scientific Café highlight a particular interest of stakeholders in cultural services such as physical and mental benefits provided by UGIs, as well as improving the urban aesthetic value. Additionally, the role of UGIs in microclimate regulation and heat mitigation was emphasized. The combined analysis of perspectives from the scientific community, policy-makers, stakeholders, and citizens provides a foundation for developing a participatory governance approach to UGIs. Full article