Search Results (5,256)

Postoperative neurocognitive disorder (PND) is a cognitive decline after general anesthesia and surgery, influenced by preexisting neurodegenerative conditions, stress, and inflammation. Traumatic brain injury (TBI) is linked to a dysregulated stress response, neuroinflammation, and cognitive issues. Patients with TBI often need extracranial surgeries under general anesthesia (GA), which can increase stress, neuroinflammation, and neurodegenerative changes, raising PND risk. We will search databases like Ovid Medline and Embase for studies on cognitive function in patients with mild to moderate TBI who had extracranial surgeries under general anesthesia (GA). Screening and data extraction will be done manually and with AI-assisted tools (ASReview). Study quality will be assessed using the Newcastle–Ottawa Scale. Statistical analyses will include mean differences, odds ratios, and meta-regression, addressing heterogeneity, sensitivity, and publication bias using Stata/SE. By meta-analyzing clinical studies, we aim to determine if TBI and GA/surgery interact to induce PND. We will use various data sources, subgroup analyses, sensitivity analyses, and meta-regression to assess factors like age, gender, and type of GA/surgery. This meta-analysis will enhance our understanding of PND risks, inform clinical practices, and highlight new research directions. The systematic review is registered in PROSPERO (CRD42024510980). Full article

Every Blockchain architecture relies upon two major pillars: (a) the hash-based, block-binding mechanism and (b) the consensus-achievement mechanism. While the entropic behavior of (a) has been extensively studied in literature over the past decades, the same does not hold for (b). In this work, we explore the entropic behavior of the fully distributed Blockchain consensus mechanisms. We quantify the impact of witnessing as a consensus-achievement process under the perspectives of Shannon information entropy and Lyapunov stability. We demonstrate that Blockchain consensus, expressed as the complement of the collective disagreement in a system, is a Lyapunov function of the number of witnesses W. The more the witnessing in a system, the less the entropy of the system becomes, and it converges to more stable states. We prove that the entropy decline is steepest for low values of W. A new metric for the efficiency of the consensus process based on the Shannon information entropy is introduced, laying the foundations for future studies on Blockchain-based systems optimization. Full article

Brain function declines because of aging and several metabolites change their concentration. However, this decrease may be a consequence or a driver of aging. It has been described that taurine levels decrease with age and that taurine supplementation increases health span in mice and monkeys, finding taurine as a driver of aging. The frontal cortex is one of the most key areas studied to know the normal processes of cerebral aging, due to its relevant role in cognitive processes, emotion, and motivation. In the present work, we analyzed by intracerebral microdialysis in vivo in the prefrontal cortex of young (3 months) and old (24 months) awake rats, the basal- and K⁺-evoked release of taurine, and its precursors methionine and serine. The taurine/serine/methionine (TSM) ratio was also calculated as an index of transmethylation reactions. No changes were found in the basal levels of taurine, serine, or methionine between young and aged animals. On the contrary, a significant decrease in the K⁺-evoked release of serine and taurine appeared in aged rats when compared with young animals. No changes were seen in methionine. TSM ratio also decreased with age in both basal- and K⁺-stimulated conditions. Therefore, taurine and its related precursor serine decrease with age in the frontal cortex of aged animals under K⁺-stimulated but not basal conditions, which supports the importance of the decline of evoked taurine in its functions at the brain level, also supporting the idea proposed by other authors of a pharmacological and/or nutritional intervention to its restoration. A deficit of precursors for transmethylation reactions in the brain with age is also considered. Full article

Objectives: The effects of brain tumors located in the supplementary motor area (SMA) have so far been described mainly in the context of motor and speech disorders. There are few studies that have considered other cognitive domains, so this study aimed to fill this gap by focusing on examining attention and working memory in a population of patients with gliomas in the SMA region. Methods: This study included 50 patients diagnosed with gliomas located in the SMA who have not yet had any treatment and 57 demographically matched healthy individuals. A set of neuropsychological tests was conducted to assess attention and working memory: Digit Span from WAIS-R, Visual Elevator from TEA, Verbal Fluency Test (switching condition), and Color Trails Test (CTT). Results: The analyses showed that patients scored lower in most of the evaluated tests and indicators, namely in Digit Span-forward (t = −2.05; p = 0.022), Digit Span-backward (t = −2.63; p = 0.005), CTT-2 (t = 4.24; p = 0.001), CTT-interference (t = 2.31; p = 0.012), Visual Elevator-time (t = 1.83; p = 0.035), Visual Elevator-accuracy (t = −2.42, p = 0.010), and Verbal Fluency-switching (t = −3.41; p = 0.001). A significant relationship was also demonstrated between the grade of tumor malignancy and the results achieved in some of the neuropsychological tests. The lateralization of the tumor, the size of the lesion, and the presence of epilepsy did not prove to be particularly significant. Conclusions: Due to the significant decline in cognitive performance in terms of attention and working memory, we believe that every patient with a tumor in the SMA should undergo a detailed neuropsychological examination, which will profile their functioning and help tailor the best possible psychological care. Full article

Three-dimensional numerical simulation of subsurface flow dynamics in karst conduits at dam sites represents a pivotal component of hydrogeological research, essential for unraveling the intricate behavior of water movement within karstified terrains. This study introduces a novel approach for accounting for the presence of karst conduits and presents a comprehensive three-dimensional flow simulation for the dam site of the Jingxian Pumped Storage Hydropower Plant. This method reduces mesh division, simplifies calculations, and improves model convergence. The findings reveal that the numerical model adeptly captures the declining groundwater levels within the study area, with enhanced precision achieved through the utilization of COMSOL’s Line Mass Source feature. By representing leakage tunnel cylinders as edges, the model significantly improves meshing efficiency, circumventing the computational burden associated with the explicit resolution of intricate geometric details. In the absence of remedial measures, the simulation predicts that groundwater will preferentially drain downstream via two distinct leakage pathways at the dam’s base, presenting a potential threat to the structural integrity and operational stability of the project. To address this risk, the implementation of robust seepage control measures is imperative. Once these measures are established, the dam is expected to function as an effective hydraulic barrier, ensuring the long-term stability and operational efficacy of the hydropower plant. Full article

Forecasting election outcomes is a complex scientific challenge with notable societal implications. Existing approaches often combine statistical analysis, machine learning, and economic indicators. However, research in network science has emphasized the importance of temporal factors in the dissemination of opinions. This study presents a macro-scale temporal attenuation (TA) model, which integrates micro-scale opinion dynamics and temporal epidemic theories to enhance forecasting accuracy using pre-election poll data. The findings suggest that the timing of opinion polls significantly influences opinion fluctuations, particularly as election dates approach. Opinion “pulse” is modeled as a temporal function that increases with new poll inputs and declines during stable periods. Two practical variants of the TA model, ETA and PTA, were tested on datasets from ten elections held between 2020 and 2024 around the world. The results indicate that the TA model outperformed several statistical methods, ARIMA models, and best pollster predictions (BPPs) in six out of ten elections. The two TA implementations achieved an average forecasting error of 6.92–6.95 percentage points across all datasets, compared to 7.65 points for BPP and 14.42 points for other statistical methods, demonstrating a performance improvement of 10–83%. Additionally, the TA methods maintained robust performance even with limited poll availability. As global pre-election survey data become more accessible, the TA model is expected to serve as a valuable complement to advanced election-forecasting techniques. Full article

Background: Acute kidney injury (AKI) is a critical medical condition characterized by a sudden decline in renal function, often resulting in severe complications and increased mortality. In the context of spine surgery, particularly for adult spine deformities, the risk of AKI is significant due to the complexity and duration of these procedures, as well as the substantial intraoperative blood loss and hemodynamic instability they can entail. Despite advancements in surgical and perioperative care, AKI remains a major concern. This paper presents a case report of AKI following spine deformity surgery and conducts a comprehensive literature review to evaluate the incidence and risk factors associated with AKI in this specific surgical population. Methods: A systematic literature search was conducted across the PubMed, Medline, and Cochrane Library databases, focusing on studies published between January 2000 and December 2023. The inclusion criteria targeted studies reporting on adult patients undergoing spine surgery, specifically detailing the incidence and risk factors of AKI. Exclusion criteria included studies on pediatric patients, non-English publications, and those lacking clear AKI diagnostic criteria. Data from the selected studies were independently extracted by two reviewers and analyzed using descriptive statistics and meta-analysis techniques where applicable. The case report highlights a patient who developed AKI following extensive spine surgery for Adult Spine Deformity (ASD), detailing the clinical course, diagnostic approach, and management strategies employed. Results: The literature review revealed that the incidence of AKI in spine surgery varies widely and is influenced by factors such as patient demographics, type of surgery, and perioperative management. Identified risk factors include significant blood loss, prolonged operative time, intraoperative hypotension, and the use of nephrotoxic drugs. The findings underscore the importance of vigilant perioperative monitoring and proactive management strategies to mitigate the risk of AKI. These strategies include optimizing hemodynamic stability, minimizing blood loss, and careful management of nephrotoxic medications. Conclusions: By integrating a detailed case report with a thorough review of the existing literature, this paper aims to enhance the understanding of AKI in spine surgery and inform clinical practices to improve patient outcomes. Full article

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the leading cause of dementia, affecting a significant proportion of the elderly population. AD is characterized by cognitive decline and functional impairments due to pathological hallmarks like amyloid β-peptide (Aβ) plaques and neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau. Microglial activation, chronic neuroinflammation, and disruptions in neuronal communication further exacerbate the disease. Emerging research suggests that immune modulation could play a key role in AD treatment given the significant involvement of neuroinflammatory processes. This review focuses on recent advancements in immunotherapy strategies aimed at modulating immune responses in AD, with a specific emphasis on microglial behavior, amyloid clearance, and tau pathology. By exploring these immunotherapeutic approaches, we aim to provide insights into their potential to alter disease progression and improve patient outcomes, contributing to the evolving landscape of AD treatment. Full article

The care of elderly patients with coronary artery disease (CAD) undergoing percutaneous coronary interventions (PCIs) presents unique challenges due to age-related physiological and functional changes. With the global population aging rapidly, this demographic change affects a growing proportion of individuals requiring PCI. However, advanced age is associated with increased susceptibility to ischemic and bleeding complications, driven by physiological changes such as altered coagulation, vascular stiffness, and declining organ function. These factors complicate the management of CAD, making the balance between reducing thrombotic events and minimizing bleeding risks particularly challenging. Antiplatelet therapy is central to post-PCI management, but its benefits and risks differ significantly in elderly patients compared to younger populations. Tools like the PRECISE-DAPT and ARC-HBR provide guidance on dual antiplatelet therapy duration and bleeding risk stratification. However, their applicability and predictive accuracy in elderly patients remain areas of active investigation. This underscores the need for improved risk assessment methods tailored to the unique needs of aging individuals. In this review, we explore the epidemiological, pathophysiological, and clinical aspects of CAD in elderly patients, emphasizing the impact of aging on disease presentation and outcomes. Furthermore, we assess current risk stratification tools and discuss their limitations in predicting adverse events in older populations. By synthesizing these insights, we aim to highlight the complexities of managing elderly CAD patients and identify opportunities for optimizing personalized care to achieve better outcomes in this vulnerable group. Full article

Pelvic organ prolapse (POP) is a prevalent condition characterized by the descent of one or more pelvic organs, such as the bladder, uterus, or rectum, into the vaginal canal due to weakened pelvic floor support. This comprehensive review elucidates the multifactorial etiology of POP, which includes genetic predisposition, hormonal changes, obstetric factors, lifestyle influences, and age-related pelvic floor decline. Epidemiological data underscore its rising prevalence, particularly among older women, highlighting disparities across populations and risk factors such as parity and socioeconomic status. POP frequently coexists with significant comorbidities like urinary incontinence, sexual dysfunction, and pelvic pain, which exacerbate its impact on quality of life. Accurate evaluation through patient history, physical examinations, and imaging modalities like ultrasound and MRI is critical for diagnosis and management. The review emphasizes advancements in POP evaluation methods, including the POP-Q system, and explores the interplay of anatomical, functional, and psychosocial factors affecting patient outcomes. Key findings reveal that a tailored and holistic approach to treatment, addressing both anatomical correction and associated symptoms, significantly improves patient outcomes. Surgical interventions can alleviate related comorbidities, including urinary and bowel dysfunctions, as well as enhance body image and sexual function. However, the long-term success of such treatments necessitates continued research into preventive strategies and innovative therapeutic approaches. In conclusion, understanding the complexities of POP’s etiology, epidemiology, and management is vital for mitigating its burden and improving the health and well-being of affected individuals. This review highlights the need for integrated care strategies and further studies to advance diagnostic and therapeutic paradigms. Full article

The Irisin/FNDC5 protein family has emerged as a pivotal link between exercise and the prevention of age-associated diseases. Irisin is highly expressed during exercise from skeletal and cardiac muscle cells, playing a critical role in mediating systemic health benefits through its actions on various tissues. However, Irisin levels decline with age, correlating with a heightened incidence of diseases such as muscle weakness, cardiovascular disorders, and neurodegeneration. Notably, the administration of Irisin has shown significant potential in both preventing and treating these conditions. Recently, an Irisin/FNDC5 homolog was identified in an invertebrate Drosophila model, providing valuable insights into its conserved role in exercise physiology. Importantly, Irisin/FNDC5 has been demonstrated to regulate autophagy—a process essential for clearing excessive nutrients, toxic aggregates, and dysfunctional organelles—in both flies and mammals. Dysregulated autophagy is often implicated in age-related diseases, highlighting its relevance to Irisin/FNDC5’s functions. These findings deepen our understanding of Irisin/FNDC5’s roles and its potential as a therapeutic target for mitigating aging-related health decline. Further studies are needed to elucidate the precise mechanisms by which Irisin regulates autophagy and its broader impact on physiological aging and related diseases. Full article

Background: Oryza sativa L. is one of the main staple crops in the South Korea. While rice production has remained stable over the past decades, rice consumption has gradually declined, leading to a rapid stockpile in rice inventory. Conventional rice storage methods often fail to preserve functional properties and long-term stability, necessitating innovative processing techniques. Methods: To address this issue, we developed a grain stabilization technique (GST) to enhance the functionality and shelf life of white rice (WR), brown rice (BR), and rice germ (RG). The GST process was conducted in a single-batch system, integrating a controlled temperature cycle (65~85 °C) with 60 rpm rotation, far-infrared (26,400 W/m²), and ultraviolet (254 nm, 60,880 J/m²) irradiation in an enclosed chamber equipped with an exhaust system for moisture, odor, and impurity removal. The process was followed by air drying (25 °C, 15 h) to ensure stability. Results: The GST significantly increased resistant starch content in WR and BR by 214% and 27%, respectively, but not in RG. Additionally, GST enhanced the contents of campesterol, stigmasterol, β-sitosterol, and octacosanol in BR and RG, but not significantly in WR. Furthermore, this technique markedly reduced moisture content, acidity, and bacterial counts over a 90-day storage period and kept mycotoxin levels within safe limits in WR, BR, and RG. GST also altered the microstructures of WR and BR, indicating gelatinization and amorphization of starch granules. Conclusions: These findings contribute to advancing food science by presenting GST as a transformative method to extend shelf life and improve the nutritional profile of rice, aligning with global efforts to reduce food waste, improve dietary health, and develop sustainable food processing technologies. Full article

Soil calcium is a vital component in plant growth and soil health. Earthworm activities impact metal distribution and speciation a lot by changing soil pH. Nevertheless, little is known about how ecological earthworm species, particularly in Terra Rossa soil, affect soil Ca speciation distribution. This research examined the effects of the activities of four different earthworm species (epigeic species Eisenia fetida (noted as EF), endogeic species Amynthas robustus (noted as AR) and Pontoscolex corethrurus (noted as PC), anecic species Amynthas aspergillum (noted as AA)) on Ca speciations (water-soluble (Ca_Ws), exchangeable (Ca_Ex), acid-soluble bound (Ca_Ac), organic-bound (Ca_Or), and residual (Ca_Re)), soil pH, the release contents of exchangeable cations (Ca, Mg, K, and Na), total calcium (Ca_Total) contents, total nitrogen (TN) contents, soil organic carbon (SOC) concentrations, cation-exchange capacity (CEC), and NIRS spectral characteristics in Terra Rossa soil for 40 days under lab conditions. In contrast to control soil, 108.3%, 158.3%, 91.7%, and 125.0% of Ca_Ws contents in casts and 116.6%, 108.3%, 58.3% and 91.6% of Ca_Ws in uningested soil increased significantly with the inoculation of EF, PC, AR, and AA, respectively. In addition, compared with control, for casts, the contents of exchangeable Ca, Mg, K, CEC, and available-K were significantly increased in the presence of EF, PC, AR, and AA, respectively. In the casts of EF, PC, AR, and AA, soil pH values declined by 0.72, 0.80, 0.45, and 0.60 units relative to control soil, while they decreased by 0.65, 0.84, 0.34, and 0.59 units in uningested soil. The soil inoculated with PC had higher soil pH values and Ca_Ws contents than those with the other three earthworm species. Principal component analysis revealed significant differences in soil pH, Ca speciation, NIR spectra, and exchangeable base cation release between casts and uningested soil in treatments with EF, PC, AR, and AA inoculation. These findings expand, for the first time, to the ecological functions of earthworm species, especially for PC, demonstrating a capacity to alter soil Ca speciation, decrease soil pH, affect the exchangeable base cations’ release, and participate in and regulate the geochemical circulation processes in limestone regions. Full article

The hypothalamus is the advanced center that regulates visceral activities under the cerebral cortex. It plays some key roles, such as regulating body temperature, assessing feed intake, and balancing blood glucose and endocrine gland activities. Heat stress is known to trigger a series of detrimental consequences, prominently featuring a reduction in feed intake, an elevation in body temperature, and other related phenomena. To understand the mechanisms of how heat stress affects the function of the hypothalamus, broilers were allocated to three groups: the normal control (NC) group, the heat-stress (HS) group, and the pair-fed (PF) group. The PF group was established with the aim of eliminating the confounding effect of reduced feed intake. The trial lasted for two weeks, from the age of 28 to 42 d. A total of 280 differential expressed genes (DEGs) were identified (p_adj < 0.05, |log₂(FC)| ≥ 1) among three groups, including 3 up-regulated and 112 down-regulated genes in the HS group compared to the NC group, and 3 up-regulated and 13 down-regulated genes between the PF and NC groups. Compared with the HS group, a total of 149 genes were identified in the PF group, of which 125 genes were up-regulated and 24 genes were down-regulated. Gene Ontology enrichment indicated that a subset of DEGs was involved in brain development, the central nervous system (CNS), nerve signal transduction, and calcium homeostasis. The solute carrier family 1 member A6 and solute carrier family 6 member 13, identified as down-regulated genes (p_adj < 0.05) in the HS group, were considered as key genes in Gamma-aminobutyric acid (GABA) transportation, the normal expression of which ensures that extracellular GABA is maintained at a certain level and provides the amino acids needed for metabolism. Simultaneously, the solute carrier family 13 member 4 and solute carrier family 16 member 8 were also identified as down-regulated, which indicated that heat stress resulted in disorder and physiologic derangement in the hypothalamus. Meanwhile, the anorexigenic part of pro-opiomelanocortin genes was up-regulated significantly in the HS group. The transcriptome sequencing results can help us understand the regulatory mechanism of feed intake decline in broilers under heat stress at the genetic level. Full article

The impact of municipal pollution on the larvae of the Ukrainian brook lamprey and the European brook lamprey was studied in the River Gać, a left-bank tributary of the River Pilica. Both lamprey species share similar morphologies and habits, including filtration-based feeding and burial in soft river sediments. This study focused on a 200 m stretch of the river, divided by sewage discharge from a municipal wastewater treatment plant into unpolluted (above the discharge) and polluted (below the discharge) sections. The Ukrainian brook lamprey exhibited higher densities (1612 individuals in total over the study period) compared to those of the European brook lamprey (336 in total). Survival methods, such as body length-frequency charts, were used to determine age. These diagrams, showing multimodal distributions, facilitated the differentiation of age groups and the application of the von Bertalanffy growth function to determine growth parameters. The growth curves revealed that the Ukrainian brook lamprey achieve greater body lengths (246.7 mm for the unpolluted section; 256.3 mm for the polluted section) at the same age and asymptotic lengths when compared to those of the European brook lamprey (187.2 mm for the unpolluted section; 180.7 mm for the polluted section). Furthermore, the European brook lamprey exhibited inferior growth in the polluted river section compared to that of the Ukrainian brook lamprey. The response of both lamprey species to municipal pollution suggests that such pollution could promote the expansion of the Ukrainian brook lamprey, while causing the decline of European brook lamprey in areas of their overlapping habitat. Full article