Search Results (7,687)

Osteoarthritis (OA) is a common degenerative joint disease that progressively destroys articular cartilage, leading to increased joint friction and severe pain. Therefore, OA can be treated by restoring the lubricating properties of cartilage. In this study, recent advances in lubricants for the treatment of OA are reviewed for both single-function and multifunctional lubricants. Single-function lubricants mainly include glycosaminoglycans, lubricin, and phospholipids, whereas multifunctional lubricants are composed of lubricating and anti-inflammatory bifunctional hydrogels, stem cell-loaded lubricating hydrogels, and drug-loaded lubricating nanoparticles. This review emphasizes the importance of restoring joint lubrication capacity for the treatment of OA and explores the structural features, lubrication properties, and role of these lubricants in modulating intracellular inflammatory responses and metabolism. Current challenges and future research directions in this field are also discussed, with the aim of providing a scientific basis and new ideas for the clinical treatment of OA. Full article

For decades, endovascular embolization (EE) has been a common technique for the treatment of several vascular abnormalities where the affected vessel is occluded using biocompatible embolic agents. In this work, we developed a NIPAAm-based temperature responsive, dual-crosslinking biocompatible and non-toxic injectable hydrogel system as a liquid embolic agent for EE. The swelling and mechanical properties of the hydrogel were tuned and optimized for its in vivo application. The in vivo study was carried out with nine swine models, including three animals for exploratory study and six animals for acute confirmatory study for the occlusion of surgically created aneurysm and rete mirabile. The polymer hydrogel was delivered into the vascular malformation sites using a catheter guided by angiography. After the injection, the liquid embolic agent was transformed into a solid implant in situ via cross-linking through chemical and thermal processes. During the exploratory study, it was observed that one of the three aneurysms and all the RMs were occluded. During the acute confirmatory study, all the aneurysms and the RMs of six animals were successfully occluded. Overall, our study presents the construction and characterization of a novel injectable hydrogel system capable of successfully occluding vascular malformation in large animals. In the future, after further modification and validation, this material may be used as a liquid embolic agent in clinical studies. Full article

As a typical heavy metal pollutant discharged from industrial activities, nickel ions are highly bioaccumulative and carcinogenic, and low concentrations (>0.5 mg/L) can disrupt the balance of aquatic ecosystems and pose a threat to human health. In this study, a bifunctional adsorbent based on a carboxymethyl cellulose/boron nitride hydrogel was prepared for the treatment of nickel-containing wastewater with a high adsorption capacity of Ni²⁺ (800 mg/L, 344 mg/g), and after adsorption, the waste gel was converted into nickel-doped porous carbon material through carbonization and used as a bilayer capacitor electrode to achieve a specific capacitance of 40.6 F/g at a current density of 1 A/g. The capacity retention rate was >98% after 150 cycles. This strategy simultaneously solves the problems of nickel-containing wastewater purification (the adsorption method is applicable to medium- and high-concentration heavy-metal wastewater) and environmental pollution caused by waste adsorbents, and provides a new paradigm of the “adsorption-resourcing” closed-loop treatment of heavy-metal pollutants. Full article

Psoriasis is a chronic inflammatory disease with a complex pathogenesis, influenced by various factors involving environment, genes, and immunity. The main symptoms of psoriasis include erythema, scales, itching, etc. At present, therapeutic drugs for psoriasis are continually evolving towards enhancing treatment efficacy and reducing side effects. Firstly, the pathogenesis and characteristics of psoriasis were summarized. Then, the types and benefits of topical therapy were introduced, such as the aspects of avoiding systemic toxic effects, first pass effect, and gastrointestinal reactions with accelerating the onset time of the drugs and improving its efficacy, and were compared to systemic drugs. In the case of methotrexate, cyclosporin A, Janus kinase (JAK) inhibitors, and phosphodiesterase-4 (PDE-4) inhibitors, this review had a further discussion on the improvement and translation of these molecules from systemic therapy to topical therapy in clinical practice. To further augment the limitation of skin permeability, nanotechnology and novel topical drug delivery system including nanomedicines, hydrogels, ionic liquids, and microneedles were elaborated for psoriasis management. Also, exploration of topical targeting pathogenic genes through small interfering RNA (siRNA) using nanoparticles and ionic liquids (ILs) is of great significance for long-term treatment in psoriasis. Taken together, the development of numerous topical delivery platforms is expected to achieve enhanced penetration, and precise and efficient delivery of small molecule and RNA interference (RNAi) therapeutics in psoriasis with clinical translation prospects. Full article

Immunotherapy has revolutionized cancer treatment and led to a significant increase in patient survival rates and quality of life. However, the effectiveness of current immunotherapies is limited by various factors, including immune evasion mechanisms and serious side effects. Hydrogels are a type of medical material with an ideal biocompatibility, variable structure, flexible synthesis method, and physical properties. Hydrogels have long been recognized and used as a superior choice for various biomedical applications. The fascinating results were derived from both in vitro and in vivo models. The rapid expansion of this area suggests that the principles and uses of functionalized polysaccharides are transformative, motivating researchers to investigate novel polysaccharide-based hydrogels for wider applications. Polysaccharide hydrogels have proven to be a practicable delivery strategy for tumor immunotherapy due to their biocompatibility, biodegradability, and pronounced bioactive characteristics. This study aims to examine in detail the latest developments of polysaccharide hydrogels in tumor immunotherapy, focusing on their design, mechanism of action, and potential therapeutic applications. Full article

Heavy metal ion pollution in aquatic environments is a critical global issue, damaging ecosystems and threatening human health via bioaccumulation in the food chain. Despite promising progress with biosorbents, the development of environmentally friendly and stable heavy metal adsorbents requires further exploration. In this study, we present an algae-loaded alginate hydrogel as a composite adsorbent for heavy metals. The incorporation of algae enhanced the hydrogel’s adsorption capacity by 38.0%, 20.6%, and 27.1% for Cu²⁺, Cr³⁺, and Co²⁺, respectively. Additionally, the composite hydrogel demonstrated excellent stability and recyclability after adsorption, reducing the ecological risks associated with algae biomass usage. This algae-loaded alginate hydrogel offers an efficient and eco-friendly strategy for removing heavy metal ions from aquatic systems, highlighting its potential for environmental remediation applications. Full article

Flexible sensors are revolutionizing wearable and implantable devices, with conductive hydrogels emerging as key materials due to their biomimetic structure, biocompatibility, tunable transparency, and stimuli-responsive electrical properties. However, their fragility and limited durability pose significant challenges for broader applications. Drawing inspiration from the self-healing capabilities of natural organisms like mussels, researchers are embedding self-repair mechanisms into hydrogels to improve their reliability and lifespan. This review highlights recent advances in self-healing (SH) conductive hydrogels, focusing on synthesis methods, healing mechanisms, and strategies to enhance multifunctionality. It also explores their wide-ranging applications, including in vivo signal monitoring, wearable biochemical sensors, supercapacitors, flexible displays, triboelectric nanogenerators, and implantable bioelectronics. While progress has been made, challenges remain in balancing self-healing efficiency, mechanical strength, and sensing performance. This review offers insights into overcoming these obstacles and discusses future research directions for advancing SH hydrogel-based bioelectronics, aiming to pave the way for durable, high-performance devices in next-generation wearable and implantable technologies. Full article

The use of indigo carmine dye in the textile industry, particularly in denim production, presents a significant sustainability challenge due to the large amounts of wastewater generated by this process, since this fabric is one of the most produced around the world. In order to face challenges like this, effluent treatment using polymeric materials has become an area of intense research. In this study, we developed an eco-friendly hydrogel based on oligoglycerol-malic acid polyester crosslinked with citric acid, which was applied to adsorb indigo carmine. The properties of the hydrogel and its precursors were analyzed using spectroscopic, thermal, and morphologic techniques. The hydrogel demonstrated water uptake capacity up to 187% of its own mass and adsorbed approximately 73% of the dye after 24 h of contact. Tests were conducted in the presence of sodium chloride and indicated that the presence of salt impairs the adsorption process. Additionally, the adsorption kinetics and isotherms were evaluated and demonstrated that the adsorption followed a pseudo-second-order model, indicating a chemisorption process, and a Langmuir isotherm, consistent with a monolayer adsorption. These results emphasize the potential of this hydrogel for removing dye and its application in textile industry wastewater treatment, aiming to minimize environmental impacts. Full article

It has been demonstrated that when a low-molecular-weight salt solution flows through a polyelectrolyte gel, an electromotive force is generated, and its polarity depends on the sign of the polyelectrolyte network’s charge. A mathematical model proving the possibility of developing a device for separating a solution of low-molecular salt into enriched and depleted phases under the influence of gravitational forces has been developed. Such a device contains a system of parallel columns filled with different kinds of cross-linked polyelectrolyte networks. The proposed mathematical model is grounded in the theory of double electrical layers forming at the hydrogel/solution interface; these layers deform under non-equilibrium conditions, specifically during the flow of the solution through the cross-linked polyelectrolyte network. An analogous model is proposed describing the case of an analogous device based on an electric current passing through two oppositely charged contacting networks, which provides the possibility of separating the initial solution into enriched and the depleted phases too. The practical applications of the found effect are discussed. In particular, it is demonstrated that a wide number of measurement electronic devices can be created on such a base, including devices to be used within the investigation of polyelectrolyte hydrogels of different types. Full article

Nanocomposite hydrogels are gaining significant attention for biomedical applications in soft tissue engineering due to the increasing demand for highly flexible and durable soft polymer materials. This research paper focused on investigating and optimizing a procedure for the development of novel nanocomposite hydrogels based on poly(2-hydroxyethyl methacrylate)-co-(2-acrylamido-2-methylpropane sulfonic acid) (HEMA/AMPSA) copolymers. These hydrogels were synthesized through a grafting-through process, where the polymer network was formed using a modified clay crosslinker. The layered double hydroxide (LDH) clay modified with 3-(trimethoxysilyl)propyl methacrylate (ATPM) was synthesized using a novel recipe through a two-step procedure. The nanocomposite hydrogel compositions were optimized to achieve soft hydrogels with high flexibility. The developed materials were analyzed for their mechanical and morphological properties using tensile and compressive tests, transmission electron microscopy (TEM), scanning electron microscopy (SEM), and micro-computed tomography (micro-CT). The swelling behavior, network density, and kinetic diffusion mechanism demonstrated the specific characteristics of the materials. The modified LDH-ATPM was further characterized using Thermogravimetry (TGA), FTIR-ATR and X-ray diffraction (XRD). Biological assessments on human adipose-derived stem cells (hASCs) were essential to evaluate the biocompatibility of the nanocomposite hydrogels and their potential for soft tissue applications. Full article

Myocardial infarction (MI) is a cardiovascular disease (CVD) with high morbidity and mortality worldwide, which is a serious threat to human life and health. Inflammatory and immune responses are initiated immediately after MI, and unbalanced inflammation post-MI can lead to cardiac dysfunction, scarring, and ventricular remodeling, emphasizing the critical need for an effective inflammation-regulating treatment. With the development of novel therapies, the drug delivery system specific to inflammatory cells offers significant potential. In this review, we introduce immune cells and fibroblasts involved in the development of MI and summarize the newly developed delivery systems related to the use of injectable hydrogels, cardiac patches, nanoparticles, and extracellular vesicles (EVs). Finally, we highlight the recent trends in the use of inflammatory cell-targeting drug delivery systems involving different strategies that facilitate the effective treatment of MI. Full article

In this work, cellulose nanocrystals (CNCs) were obtained from the wood of Acacia farnesiana L. Willd (Huizache) via acid hydrolysis; then, they were used to reinforce polyacrylic acid–co-acrylamide (AAc/AAm) hydrogels synthesized in a solution process via in situ free radical photopolymerization. The nanomaterials were characterized using atomic force microscopy, dynamic light scattering (DLS), and the residual charge on the CNCs; the nanohydrogels were characterized using infrared spectroscopy, scanning electron microscopy, swelling kinetics, and Young’s modulus. Soluble-grade cellulose presented 94.6% α-cellulose, 0.5% β-cellulose, and 2.7% γ-cellulose, as well as a viscosity of 8.25 cp and a degree of polymerization (DP) of 706. The CNCs averaged 180 nm in length and 20 nm in width. In the nanohydrogels, it was observed that the swelling kinetic behavior followed the Schott kinetic model, at times lower than 500 h; after that, it became linear. The results show that the hydrogel swelling capacity depended on the crosslinking agent and CNC concentration, as well as the CNC chemical and morphological properties, rather than the CNC source. The hydrogels with CNCs exhibited a decreased swelling degree compared to the hydrogels without CNCs. Young’s modulus increased with CNC presence and depended on the concentration and characteristics of the CNC as a crosslinking agent. Full article

Peptide-based biomimetic treatments have gained increased attention in the dental field due to their biocompatibility and minimally invasive qualities. These biomimetic approaches can replicate the native architecture of dental tissues, thus contributing to higher success rates and improved longevity of restorations. The aim of this study was first to examine the biocompatibility and stability of an amelogenin peptide-based chitosan hydrogel (P26-CS) against salivary enzymes. Second, we aimed to evaluate its efficacy in biomimetically repairing human dental lesions in situ. White spot lesions (WSLs) in enamel and non-carious cervical lesions (NCCLs) in dentin were artificially created. Chitosan (CS) improved peptide stability, while remineralization of enamel sections with P26-CS was not impeded by salivary enzymes. The peptide was not cytotoxic, irritating, or sensitizing. Fluorescently labeled P26-CS penetrated ~300 μm into the enamel of WSLs and ~100 μm into the dentin of NCCLs. After peptide treatment, quantitative light-induced fluorescence (QLF) and microcomputed tomography (μCT) indicated a gain in mineral density of WSLs. In NCCLs, scanning electron microscopy showed that the dentin was covered by a mineral layer of needle-shaped crystals. Our results show that the repair of artificial WSLs and NCCLs was achieved by P26 peptide-guided remineralization and demonstrate its potential to repair dental lesions. Full article

Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by impaired barrier function and persistent inflammation, necessitating advanced therapeutic solutions. This study presents the development of a novel composite hydrogel scaffold composed of polyvinyl alcohol (PVA), gelatin, and Cnidium monnieri (CM) extract, designed to address the dual challenges of tissue regeneration and inflammation suppression. Fabricated via optimized freeze–thaw crosslinking and lyophilization, the scaffold exhibited a highly porous structure conducive to enhanced cell proliferation and controlled bioactive release. FT-IR analysis confirmed robust intermolecular interactions among PVA, gelatin, and CM bioactives, while SEM imaging revealed a well-developed porous network. The UPLC analysis demonstrated the sustained release of key CM compounds, such as osthole and imperatorin, which contributed to the scaffold’s anti-inflammatory properties. Biological assessments using HaCaT keratinocytes under inflammatory conditions induced by TNF-α and IFN-γ revealed improved cell viability and significant suppression of IL-8 expression, a critical marker in AD-related inflammation. These findings underscore the potential of the PVA/Gel/CM composite hydrogel as an advanced therapeutic platform for inflammatory skin disorders. Full article