Search Results (3,942)

In most urban areas, mobility is predominantly reliant on automobiles, leading to significant negative environmental impacts, such as noise pollution, air pollution, and greenhouse gas emissions. To meet the objectives of the Paris Agreement, urgent action is required to decarbonize the mobility sector. This necessitates the development of assessment and planning tools to create effective decarbonization scenarios. Urban mobility must evolve to reduce dependency on fossil fuels by increasing public transport options and promoting active modes of transportation. This research presents a methodology to estimate the modal share required to shift car users to active modes and public transport, thereby achieving future CO₂ emission reduction targets in the road transport sector. A case study in Braga, Portugal, demonstrates that to meet the 2040 target of 59,150 tons of CO₂, 63% of trips must be made using active modes (e.g., walking and cycling) and 32% by public transport. Full article

Ursolic acid (UA) and its derivatives have garnered significant attention due to their extensive pharmacological activity. UA is a pentacyclic triterpenoid found in a variety of plants, such as apples, rosemary, thyme, etc., and it possesses a range of pharmacological properties. Researchers have synthesized various derivatives of UA through structural modifications to enhance its potential pharmacological properties. Various in vitro and in vivo studies have indicated that UA and its derivatives possess diverse biological activities, such as anticancer, antifungal, antidiabetic, antioxidant, antibacterial, anti-inflammatory and antiviral properties. This review article provides a review of the biological activities of UA and its derivatives to show their valuable therapeutic properties useful in the treatment of different diseases, mainly focusing on the relevant structure-activity relationships (SARs), the underlying molecular targets/pathways, and modes of action. Full article

The control of powder aging during Selective Laser Sintering (SLS) processing is one of the challenges to be overcome for the implementation of this technique in serial production. Aging phenomena, because of the elevated temperatures and long processing times, need to be considered when a fraction of the polymer powders present in the build chamber and not used to manufacture the parts are reused at various times. The aim of this study was to investigate the influence of successive reuse of blends of pure Polyamide 12 and its blends with two types of flame retardants (FR): ammonium polyphosphate (APP) and zinc borate (ZB). The composition of the blends was 70/30 (wt/wt) PA 12/FR. Four successive processing stages have been carried out by collecting the remaining powder blend each time. The powders were re-used using the same processing parameters after sieving. DSC measurements showed that the incorporation of FRs entailed a reduction in the processing window up to 4 °C; nevertheless, no further reduction was noted after aging. The TGA curves of aged blends of powders were also similar for pure PA 12 and PA 12 with FR. In addition, initial and reused powders presented a higher degree of crystallinity than the specimens processed from the powders. The heterogeneous character of the PA 12 after LS processing or reprocessing was shown through Pyrolysis Combustion Flow Calorimetry (PCFC) and cone calorimeter (CC) tests. FTIR analysis also showed that post-condensation reactions have occurred. The mode of action of the flame retardants was clearly seen on HRR curves at both tests. The first reuses of PA 12 powders entailed a significant reduction in time to ignition at the cone calorimeter (150 for the initial material to around 90 s for the reused material), indicating the formation of short polymer chains. Only in the case of zinc borate was it noticed that re-used powder was detrimental to the fire performance because of a strong increase in the value of pHRR (between 163 and 220 kW/m² for reused material instead of 125 kW/m² for the initial one). Full article

In view of the great impact of the pipeline system in a delayed coker unit (DCU) on production and operation safety, we applied computational fluid dynamics (CFD) to investigate the flow in a fractionator overhead vapor line connected to an air cooler in a previous study. The causes of the pipeline damage and the strategies to alleviate the occurrence of the damage were discussed. It is found that if two 24″ pipes are connected and five 18″ pipes are also connected, the force uniformity can be improved, and the forces on the caps, reducers, and T-junctions can be reduced. In this paper, we further applied the finite element method to perform structure analysis to confirm the strength of the original and the improved pipeline system. It is found that the static stress is larger when the pipelines are connected. The first four modes of the pipeline vibration are primarily affected by the vibration of the 30″ main pipe, while the fifth and the sixth modes are primarily affected by the vibration of the smaller pipes. In the case of a magnitude 1 earthquake (parallel mode) and a magnitude 2 wind, the maximum harmonic response stresses (stresses obtained from harmonic response analysis) occur at the same locations. After the pipelines are connected, some positions of the maximum harmonic response stresses are shifted from the 30″ main pipe to the 24″ pipe. In terms of the wind effect, the pipelines connected or unconnected can both withstand moderate typhoons of magnitude 13 without fatigue damage. In terms of the seismic effect, the pipelines connected can withstand a strong earthquake of magnitude 5(+) without fatigue damage, while the pipelines unconnected can withstand a very strong earthquake of magnitude 6(−) without fatigue damage, which is better than the pipelines connected. Under the action of a magnitude 17 severe typhoon, the stresses for the pipelines connected or unconnected are both lower than the yield strength and the ultimate tensile strength (UTS). There is no danger of immediate damage in terms of the wind effect. The pipelines connected or unconnected can withstand magnitude 7 earthquakes up to accelerations of 1718 gal (17.18 m/s²) and 2236 gal (22.36 m/s²), respectively, without exceeding the UTS. The pipelines unconnected are slightly better than the pipelines connected in terms of earthquake resistance. The purpose of this series study is to explore the flow development and the structural strength of the DCU pipeline system to improve its operational safety. Full article

The collapse of thick-hard roofs after coal has been extracted is not a consequential process in all cases. Rather, it happens due to the augmentation of high stress conducted at depth, followed by a wider range of damage as the floor cracks. The extent and spread of the cracks in the floor indicate the intensity of the collapse, and the mine will be submerged by the high-pressure water of the coal ash. Therefore, it is particularly important to study the mechanism of the combined effect of high stress on the roof and confined aquifer on the deformation and failure of the coal seam mining floor. This study analyzes and compares the impact of thick-hard magmatic rocks on the destruction of thin floor rock layers in coal seams. Plastic theory calculations are used to determine the plastic zone yield length of floor destruction under hard roof conditions, and the location and height of the maximum floor destruction depth are solved. An empirical formula and BP neural network are used to establish a prediction model for floor destruction. The results of the model’s prediction of the depth of floor failure were compared with the measured values, with an absolute error of 2.13 m and a residual of 10.3%, which was closer to the true values. The accuracy of the theoretical model and prediction model is verified using numerical simulation and on-site in situ measurements. Based on this, the deformation and destruction forms of the floor under pressure and the water inrush mechanism are summarized for mining under the condition of a thick-hard roof. Thus, the floor is subjected to high vertical stress, accompanied by significant disturbances generated during coal seam mining, resulting in intense working face pressures. The floor near the working face coal wall will experience severe compression and shear deformation and slide towards the goaf. The floor in the goaf is relieved of high vertical stress, and horizontal stress compression will result in shear failure, leading to floor heave and further increasing the height of the floor destruction zone. After the mining of the working face, the goaf will undergo two stages of re-supporting and post-mining compaction. During the re-supporting stage, the floor rock undergoes a transition from high-stress to low-stress conditions, and the instantaneous stress relief will cause plastic deformation and failure in the coal seam floor. The combined action of primary floor fractures and secondary fractures formed during mining can easily create effective water channels. These can connect to the aquifer or water-conducting structures, making them highly dangerous. The main modes of floor water inrush under the condition of a thick-hard roof are as follows: the high-stress mode, inducing a floor destruction zone connected to the water riser zone; the mining damage mode, connecting to water-conducting faults; the mining damage mode, connecting to water collapse columns; and the coupled water inrush mode, between the mining damage zone and the highly pressurized water floor. Full article

In the Energy-Harvesting (EH) Cognitive Internet of Things (EH-CIoT) network, due to the broadcast nature of wireless communication, the EH-CIoT network is susceptible to jamming attacks, which leads to a serious decrease in throughput. Therefore, this paper investigates an anti-jamming resource-allocation method, aiming to maximize the Long-Term Throughput (LTT) of the EH-CIoT network. Specifically, the resource-allocation problem is modeled as a Markov Decision Process (MDP) without prior knowledge. On this basis, this paper carefully designs a two-dimensional reward function that includes throughput and energy rewards. On the one hand, the Agent Base Station (ABS) intuitively evaluates the effectiveness of its actions through throughput rewards to maximize the LTT. On the other hand, considering the EH characteristics and battery capacity limitations, this paper proposes energy rewards to guide the ABS to reasonably allocate channels for Secondary Users (SUs) with insufficient power to harvest more energy for transmission, which can indirectly improve the LTT. In the case where the activity states of Primary Users (PUs), channel information and the jamming strategies of the jammer are not available in advance, this paper proposes a Linearly Weighted Deep Deterministic Policy Gradient (LWDDPG) algorithm to maximize the LTT. The LWDDPG is extended from DDPG to adapt to the design of the two-dimensional reward function, which enables the ABS to reasonably allocate transmission channels, continuous power and work modes to the SUs, and to let the SUs not only transmit on unjammed channels, but also harvest more RF energy to supplement the battery power. Finally, the simulation results demonstrate the validity and superiority of the proposed method compared with traditional methods under multiple jamming attacks. Full article

Aramid fiber/epoxy resin (AF/EP) composite has been heavily used as an impact protection material due to its excellent mechanical properties and lightweight merits. Meanwhile, it is also necessary to concern the flammability of matrix resin and the wick effect of aramid fiber, which would constitute a fire risk in harsh environments. In this work, a multifunctional flame-retardant modifier (EAD) was incorporated into the AF/EP system to improve the flame retardation. The addition of 5 wt% EAD made the AF/EP composite exhibit a high limiting oxygen index (LOI) value of 37.5%, self-extinguishment, as well as decreased total heat release and total smoke release. The results from thermogravimetric analysis (TGA) and dynamic mechanical analysis (DMA) demonstrated that the treated composites maintained good thermal stability. Due to the combined action of covalent and noncovalent bonds in the matrix-rich region, the interfacial bonding improved, which endowed AF/EP composite with strengthening and toughening effects. Compared with the control sample AF/EP, the tensile strength and ballistic parameter (V₅₀) of the sample with 5 wt% EAD increased by 17% and 10%, accompanied with ductile failure mode. Furthermore, the flame-retardant mechanism was obtained by analyzing the actions in condensed and gaseous phases. Thanks to good compatibility and interfacial adhesion, the incorporation of EAD solved the inconsistent issue between flame retardancy and mechanical properties, which further expanded the application of AF/EP composite in the protection field. Full article

Herein, we investigated the toxicity and membrane-permeabilizing capabilities of Lpt and Lpt-like peptides, belonging to type I toxin–antitoxin systems carried by plasmid DNA of Lacticaseibacillus strains. These 29 amino acid peptides are predicted to form α-helical structures with a conserved central hydrophobic sequence and differently charged hydrophilic termini. Like Lpt, the expression of Lpt-like in E. coli induced growth arrest, nucleoid condensation, and cell membrane damage, suggesting membrane interaction as the mode of action. The membrane permeabilization activity of both peptides was evaluated by using liposome leakage assays, dynamic light scattering, and CD spectroscopy. Lpt and Lpt-like showed liposome leakage activity, which did not lead to liposome disruption but depended on peptide concentration. Lpt was generally more effective than Lpt-like, probably due to different physical chemical properties. Leakage was significantly reduced in larger liposomes and increased with negatively charged PCPS liposomes, indicating that electrostatic interactions and membrane curvature influence peptide activity. Contrary to most membrane-active peptides, Lpt an Lpt-like progressively lost their α-helical structure upon interaction with liposomes. Our data are inconsistent with the formation of membrane-spanning peptide pores but support a mechanism relying on the transient failure of the membrane permeability barrier possibly through the formation of “lipid pores”. Full article

Therapeutic antibodies designed to target three immune checkpoint proteins have been applied in the treatment of various malignancies, including small and non-small cell lung cancers, melanoma, renal cell carcinoma, and others. These treatments combat cancers by reactivating cytotoxic T cells. Nevertheless, this mode of action was found to be associated with a broad range of immune-related adverse events (irAEs), including pneumonitis, sarcoidosis, myocarditis, nephritis, colitis, and hepatitis. Depending on their severity, these irAEs often necessitate the suspension or discontinuation of treatment and, in rare instances, may lead to fatalities. We analyzed over nineteen million reports and identified over eighty thousand adverse event reports from patients treated with immune checkpoint inhibitors submitted to the Food and Drug Administration’s Adverse Event Reporting System MedWatch. Reports concerning pembrolizumab, nivolumab, cemiplimab, avelumab, durvalumab, atezolizumab, and ipilimumab revealed a statistically significant association between the irAEs and concurrent infectious diseases for five out of seven treatments. Furthermore, the association trend was preserved across all three types of checkpoint inhibitors and each of the five individual therapeutic agent cohorts, while the remaining two showed the same trend, but an increased confidence interval, due to an insufficient number of records. Full article

Modeling the atmospheric boundary layer (ABL) in the area of a wind farm using computational fluid dynamics (CFD) methods allows us to study the characteristics of air movement, the shading effect, the influence of relief, etc., and can be actively used in studies of local territories where powerful wind farms are planned to be located. The operating modes of a wind farm largely depend on meteorological phenomena, the intensity and duration of which cause suboptimal operating modes of wind farms, which require the use of modern tools for forecasting and classifying precipitation. The methods and approaches used to predict meteorological phenomena are well known. However, for designed and operated wind farms, the influence of meteorological phenomena on the operating modes, such as freezing rain and hail, remains an urgent problem. This study presents a multi-layered neural network for the classification of precipitation zones, designed to identify adverse meteorological phenomena for wind farms according to weather stations. The neural network receives ten inputs and has direct signal propagation between six hidden layers. During the training of the neural network, an overall accuracy of 81.78%, macro-average memorization of 81.07%, and macro-average memorization of 75.05% were achieved. The neural network is part of an analytical module for making decisions on the application of control actions (control of the boundary layer of the atmosphere by injection of silver iodide, ionization, etc.) and the formation of the initial conditions for CFD modeling. Using the example of the Ulyanovsk wind farm, a study on the movement of air masses in the area of the wind farm was conducted using the initial conditions of the neural network. Digital models of wind turbines and terrain were created in the Simcenter STAR-CCM+ software package, version 2022.1; an approach based on a LES model using an actuating drive disk model (ADM) was implemented for modeling, allowing calculation with an error not exceeding 5%. According to the results of the modeling of the current layout of the wind turbines of the Ulyanovsk wind farm, a significant overlap of the turbulent wake of the wind turbines and an increase in the speed deficit in the area of the wind farm were noted, which significantly reduced its efficiency. A shortage of speed in the near and far tracks was determined for special cases of group placement of wind turbines. Full article

The brown marmorated stink bug Halyomorpha halys (Stål, 1855), native to East Asia, is an extremely polyphagous pest that infests more than 300 plant species from 49 families. In Europe and North America, this pest causes enormous damage to the production of economically important crops (tree fruit, vegetables, field crops, and ornamental plants). Global warming favours its spread, as the rise in temperature results in the appearance of further generations of the pest. Halyomorpha halys (nymph and adult) causes damage typical of the Pentatomidae family by attacking host plants throughout their development (buds, stems, fruits, and pods). Ripe fruits are often disfigured, and later suberification and necrotic spots form on the fruit surface, making them accessible to plant pathogens that cause fruit rot and rendering them unmarketable. The increasing global importance of the pest suggests that more coordinated measures are needed to contain its spread. Understanding the biology and ecology of this species is crucial for the development of reliable monitoring and management strategies. Most insecticides available for the control of H. halys have a broad spectrum of modes of action and are not compatible with most integrated pest management systems, so biological control by natural enemies has recently been emphasised. Preventing excessive population growth requires early identification and effective control measures that can be developed quickly and applied rapidly while respecting the environment. This paper presents a comprehensive review of the latest findings on the global distribution of this important pest, its potential spread, biology and ecology, key host plants of economic importance, monitoring methods, and effective biological control strategies, as well as future perspectives for sustainable H. halys control measures. Full article

To investigate how bedding planes affect the energy evolution and failure characteristics of transversely isotropic rock, uniaxial compression tests were conducted on soft–hard interbedded rock-like specimens with varying bedding angles (α) using the RMT-150B rock mechanics loading system. The test results indicate that throughout the loading process, the energy evolution shows obvious stage characteristics, and the change of α mainly affects the accelerating energy dissipation stage and the full energy release stage. With the increase of α, the ability of rock to resist deformation under the action of energy shows the characteristics of “strong–weak–strong”. The energy dissipation process is accelerated by medium angle bedding planes (α = 45°~60°). The precursor points of the ratios of dissipation energy to total energy (R_DT) and elastic energy to dissipation energy (R_ED) can be used to effectively predict early failure. With the gradual increase of α, the difficulty of crack development is gradually reduced. The changes of energy storage limitation and release rate of releasable elastic energy are the immanent cause of different macroscopic failure modes of specimens with varying α. Full article

Motivation: To increase the efficiency of the brake valve by adding a corrective member. Background: The speed of response and smooth transition between modes of operation in the braking system are the primary research questions. Objective and research question: Will the optimal selection of the input parameters of the differentiating part of a conceptual brake valve ensure the speed of operation and enable a smooth transition from the accelerating mode to the tracking mode? Methods: The mathematical model of the differentiating part of the brake valve uses the lumped method, and the solution was obtained by numerical means. Results: Within the assumed range of variation of spring stiffness and control piston bore throughput, the distribution maps of action times and piston lift were determined, and the optimal configuration of the analyzed input parameters was obtained by a genetic algorithm. Future research: future activities will focus on the development of a system of smooth variation of the throughput of the connecting chamber of the differential part of the valve. Conclusions: The determined maps of functional parameter distributions are the basis for the selection of components of the braking system; optimization indicates the directions of modification of the valve in order to obtain an acceptable performance system. Full article

Breast milk (BM) is a unique food due to its nutritional composition and anti-inflammatory characteristics. Evidence has emerged on the role of Presepsin (PSEP) as a reliable marker of early sepsis diagnosis. In the present study, we aimed to investigate the measurability of PSEP in BM according to different maturation stages (colostrum, C; transition, Tr; and mature milks, Mt) and corrected for delivery mode and gender. We conducted a multicenter prospective case–control study in women who had delivered 22 term (T) and 22 preterm (PT) infants. A total of 44 human milk samples were collected and stored at −80 °C. BM PSEP (pg/mL) levels were measured by using a rapid chemiluminescent enzyme immunoassay. PSEP was detected in all samples analyzed. Higher (p < 0.05) BM PSEP concentrations were observed in the PT compared to the T infants. According to the grade of maturation, higher (p < 0.05) levels of PSEP in C compared to Tr and Mt milks were observed in the whole study population. The BM subtypes’ degrees of maturation were delivery mode and gender dependent. We found that PSEP at high concentrations supports its antimicrobial action both in PT and T infants. These results open the door to further studies investigating the role of PSEP. Full article

Niacinamide is a versatile compound widely used in the personal care industry for its ample skin benefits. As a precursor to nicotinamide adenine dinucleotide (NAD+), essential for ATP production and a substrate for poly-ADP-ribose polymerase-1 (PARP-1), studies have highlighted its roles in DNA repair, cellular stress mechanisms, and anti-aging benefits. Niacinamide was also studied for its antimicrobial activity, particularly in the context of host-infection via host immune response, yet its direct antimicrobial activity and the mechanisms of action remain unclear. Its multifunctionality makes it an appealing bioactive molecule for skincare products as well as a potential preservative solution. This study explores niacinamide’s antimicrobial mode of action against four common cosmetic pathogens. Our findings indicate that niacinamide is causing microbial cell cycle arrest; while cells were found to increase their volume and length under treatment to prepare for cell division, complete separation into two daughter cells was prevented. Fluorescence microscopy revealed expanded chromatin, alongside a decreased RNA expression of the DNA-binding protein gene, dps. Finally, niacinamide was found to directly interact with DNA, hindering successful amplification. These unprecedented findings allowed us to add a newly rationalized preservative facete to the wide range of niacinamide multi-functionality. Full article