Search Results (17,884)

During the normal laying and operation of a three-core umbilical cable, AC current can easily lead to AC electrochemical corrosion on the outer surface of the steel tube. To explore the electrochemical corrosion mechanism and the factors affecting the three-core umbilical cable, this paper optimizes the internal induced potential calculation method for three-core umbilical cables. It analyzes the changes in the characteristics of the induced potential and explores the variations in the density of induced current under different conditions. The research results show that by optimizing the calculation method for the induction potential of the umbilical cable’s steel pipe, for the electromagnetic significance of the smallest repeating unit, the induction potential on the steel pipe’s surface exhibited a cyclic change. The peak part of the induction potential is most likely to experience electrochemical corrosion. Additionally, reducing the radius of the outer insulation aperture of the steel pipe and improving the conductivity of seawater will increase the density of the induced current in the insulation aperture, thereby increasing the risk of electrochemical corrosion. As the cable pitch and AC frequency increase, the current density in the steel pipe pores will also rise. Full article

Background: There is an unmet medical need for the early detection of immune checkpoint inhibitor (ICI)-induced cardiovascular (CV) adverse events due to a lack of adequate biomarkers. This study aimed to provide insights on the incidence of troponin elevations and echocardiographic dynamics during ICI treatment in cancer patients and their role as potential biomarkers for submyocardial damage. In addition, it is the first study to compare hs-TnT and hs-TnI in ICI-treated patients and to evaluate their interchangeability in the context of screening. Results: Among 59 patients, the mean patient age was 68 years, and 76% were men. Overall, 25% of patients received combination therapy. Although 10.6% [95% CI: 5.0–22.5] of the patients developed troponin elevations, none experienced a CV event. No significant changes were found in 3D left ventricular (LV) ejection fraction nor in global longitudinal strain f (56 ± 6% vs. 56 ± 6%, p = 0.903 and −17.8% [−18.5; −14.2] vs. −17.0% [−18.8; −15.1], p = 0.663) at 3 months. There were also no significant changes in diastolic function and right ventricular function. In addition, there was poor agreement between hs-TnT and hs-TnI. Methods: Here, we present a preliminary analysis of the first 59 patients included in our ongoing prospective clinical trial (NCT05699915) during the first three months of treatment. All patients underwent electrocardiography and echocardiography along with blood sampling at standardized time intervals. This study aimed to investigate the incidence of elevated hs-TnT levels within the first three months of ICI treatment. Elevations were defined as hs-TnT above the upper limit of normal (ULN) if the baseline value was normal, or 1.5 ≥ times baseline if the baseline value was above the ULN. Conclusions: Hs-TnT elevations occurred in 10.6% of the patients. However, no significant changes were found on 3D echocardiography, nor did any of the patients develop a CV event. There were also no changes found in NT-proBNP. The study is still ongoing, but these preliminary findings do not show a promising role for cardiac troponins nor for echocardiographic dynamics in the prediction of CV events during the early stages of ICI treatment. Full article

This study developed an optimization model for the strategic location of maintenance resource supply sites and the scheduling of multiple resources following failures in urban metro systems, with the objective of enhancing system resilience. The model employs a multi-objective optimization framework, focusing primarily on minimizing resource scheduling time and reducing costs. It incorporates critical factors such as spatial location, network topology, station size, and passenger flow. A hybrid method, combining the non-dominated sorting genetic algorithm III and the technique for order of preference by similarity to ideal solution, is used to solve the model, with its effectiveness confirmed through a case study of the Nanjing Metro system. The simulation results yielded an optimal number of 21 maintenance resource supply stations and provided their placement. In the event of large-scale failures, the optimal resource scheduling strategy ensures demand satisfaction rates exceed 90% at critical stations, maintaining an overall rate of 87.09%, therefore significantly improving resource scheduling efficiency and the system’s emergency response capabilities and enhancing the physical resilience and recovery capabilities of the urban metro system. Moreover, the model accounts for economic factors, striving to balance emergency response capabilities with production continuity and cost efficiency through effective maintenance strategies and resource utilization. This approach provides a systematic framework for urban metro systems to manage sudden failures, ensuring rapid recovery to normal operations and minimizing operational disruptions in scenarios of limited resources. Full article

The service behavior of ductile metallic materials, when they have previously undergone technological plastic deformation, depends on the deformation conditions. These are represented, among others, by the deformation rate, the process temperature, the applied pressures, and the introduced stresses, as well as other process variables. The investigation of the mechanical properties obtained after plastic deformation is an important means that contains two characteristics: on the one hand, to determine to what extent the parameters of the technological manufacturing process influence the main characteristics of the final component; and, on the other hand, on the basis of these characteristics, to analyze whether the component subjected to plastic deformation will be able to function reliably and safely. In the present work, an experimental study was made of the residual stresses developed and hardnesses obtained both in the immediate vicinity of a highly plastically deformed area and in an area previously obtained by rolling, without additional plastic deformation. For the determination of the residual stresses, the tensiometric rosette drilling method was used. By determining the same quantities in a non-plastically deformed area, significant changes in the values of the two quantities in the plastically deformed area were found. An increase in the maximum principal normal stresses by approx. 60 MPa and an increase in the Rockwel hardness by approx. 10 HRC was found. A sample was taken from the area under a plastic deformed circular shape, and was analyzed microscopically. Full article

This paper proposes a new approach to estimating the minimum variance hedge ratio (MVHR) based on the wild bootstrap and evaluates the approach using a spectrum of conservative to aggressive alternative hedging strategies associated with the percentiles of the MVHR’s bootstrap distribution. This approach is suggested to be more informative and effective relative to the conventional method of hedging solely based on a single-point estimate. Furthermore, the percentile-based MVHRs are robust to influential outliers, non-normality, and unknown forms of heteroskedasticity. The bootstrap percentile-based hedging strategies’ effectiveness is compared with those from the naïve method and the asymmetric DCC-GARCH model for a range of financial assets and commodities. The bootstrap percentile-based hedging technique is identified to outperform its alternatives in terms of hedging effectiveness, downside risk, and return variability, suggesting its superiority to other methods in both the literature and in practice. Full article

Data security on the Internet of Things (IoT) is usually implemented through encryption. This paper presents a solution based on routing, in which data are forwarded only to entities that are intended to receive them according to security requirements of secrecy (also called confidentiality), integrity, and conflicts. Our solution is generic in the sense that it can be used in any network, together with encryption as appropriate. We use the fact that, in any network, security requirements generate a partial order of equivalence classes of entities, and each entity can be labeled according to the position of its equivalence class in the partial order. Routing tables among entities can be compiled using the labels. The method is demonstrated in this paper for software-defined networking (SDN) routers and controllers. We propose a centralized IoT architecture with a cloud structure using SDN as networking infrastructure, where storage entities (i.e., cloud servers) are associated with application entities. A small ‘hospital’ example is shown for illustration. Procedures for network reconfigurations are presented. We also demonstrate the method for the normal case where different partial orders, representing distinct but concurrent security requirements, coexist among a set of entities. The method proposed does not impose an overhead on the normal functioning of SDN networks since it requires calculations only when the network must be reconfigured because of administrative intervention or policies. These occasional updates can be done efficiently and offline. Full article

This paper proposes a full-automatic high-efficiency Mueller matrix microscopic imaging (MMMI) system based on the tissue microarray (TMA) for cancer inspection for the first time. By performing a polar decomposition on the sample’s Mueller matrix (MM) obtained by a transmissive MMMI system we established, the linear phase retardance equivalent waveplate fast-axis azimuth and the linear phase retardance are obtained for distinguishing the cancerous tissues from the normal ones based on the differences in their polarization characteristics, where three analyses methods including statistical analysis, the gray-level co-occurrence matrix analysis (GLCM) and the Tamura image processing method (TIPM) are used. Previous MMMI medical diagnostics typically utilized discrete slices for inspection under a high-magnification objective (20×–50×) with a small field of view, while we use the TMA under a low-magnification objective (5×) with a large field of view. Experimental results indicate that MMMI based on TMA can effectively analyze the pathological variations in biological tissues, inspect cancerous cervical tissues, and thus contribute to the diagnosis of postoperative cancer biopsies. Such an inspection method, using a large number of samples within a TMA, is beneficial for obtaining consistent findings and good reproducibility. Full article

Large language models (LLMs) have gained immense attention and are being increasingly applied in various domains. However, this technological leap forward poses serious security and privacy concerns. This paper explores a novel approach to data stealing attacks by introducing an adaptive method to extract private training data from pre-trained LLMs via backdooring. Our method mainly focuses on the scenario of model customization and is conducted in two phases, including backdoor training and backdoor activation, which allow for the extraction of private information without prior knowledge of the model’s architecture or training data. During the model customization stage, attackers inject the backdoor into the pre-trained LLM by poisoning a small ratio of the training dataset. During the inference stage, attackers can extract private information from the third-party knowledge database by incorporating the pre-defined backdoor trigger. Our method leverages the customization process of LLMs, injecting a stealthy backdoor that can be triggered after deployment to retrieve private data. We demonstrate the effectiveness of our proposed attack through extensive experiments, achieving a notable attack success rate. Extensive experiments demonstrate the effectiveness of our stealing attack in popular LLM architectures, as well as stealthiness during normal inference. Full article

Vegetation dynamics result from the interaction between human activities and climate change. Numerous studies have investigated the contributions of human activities and climate change to vegetation cover dynamics using statistical methods. However, these studies have not focused much on the spatially non-stationary effects of human activities on vegetation cover changes and future trends. Taking the Three Gorges Reservoir (TGR) area as the case study area, it was divided into 32 combinations by considering the spatially varying effects of five factors related to human activity and climate change, including gross domestic product (GDP), population, land use change, precipitation, and temperature. Regression in terms of pixels was then performed for each combination at the pixel scale. The result showed that from 2001 to 2020, the annual average normalized digital vegetation index (NDVI) in the TGR area exhibited an upward trend (slope = 0.0051, p < 0.01), with the mean NDVI increasing from 0.53 to 0.64. Compared with the regression with climate variables, the proposed model improved the value from 0.2567 to 0.6484, with the p-value in the t-test reduced from 0.2579 to 0.0056. It indicated that changes in vegetation were dominated by human activities and climate change in 48.77% and 3.19% of the TGR area, respectively, and 43.70% of the vegetation coverage was dominated by both human activities and climate change. This study also predicted the future NDVI according to the shared socioeconomic pathways (SSPs) and representative concentration pathway (RCP) scenarios provided by the Intergovernmental Panel on Climate Change. It suggests that, assuming future regional policies are the same as the historical policies in the TGR, the SSP5–8.5 scenario would have the highest and fastest growth in average NDVI, with the average NDVI increasing from 0.68 to 0.89, because of the large increase in the GDP, lower population in this scenario, and adequate hydrothermal conditions. Full article

Background: It has been shown that obesity and a higher body mass index (BMI) are associated with a higher recurrence rate of atrial fibrillation (AF) after successful catheter ablation (CA). The same has been proven for the left atrial volume index (LAVI). It has also been shown that there is a correlation between LAVI and BMI. However, whether the LAVI’s prognostic impact on AF recurrence is BMI-independent remains unclear. Methods: We prospectively included 62 patients with paroxysmal AF who were referred to our institution for CA. All patients underwent radiofrequency CA with standard pulmonary veins isolation. Transthoracic 2-D echocardiography was performed one day after CA to obtain standard measures of cardiac function and morphology. Recurrence was defined as documented AF within 6 months of the follow-up period. Patients were also instructed to visit our outpatient clinic earlier in case of symptoms suggesting AF recurrence. Results: We observed AF recurrence in 27% of patients after 6 months. The mean BMI in our cohort was 29.65 ± 5.08 kg/cm² and the mean LAVI was 38.04 ± 11.38 mL/m². We further divided patients into two groups according to BMI. Even though the LAVI was similar in both groups, we found it to be a significant predictor of AF recurrence only in obese patients (BMI ≥ 30) and not in the non-obese group (BMI < 30). There was also no significant difference in AF recurrence between both cohorts. The significance of the LAVI as an AF recurrence predictor in the obesity group was also confirmed in a multivariate model. Conclusions: According to our results, the LAVI tends to be a significant predictor of AF recurrence after successful catheter ablation in obese patients, but not in normal-weight or overweight patients. This would suggest different mechanisms of AF in non-obese patients in comparison to obese patients. Further studies are needed in this regard. Full article

Due to the complexity of the missile air data system (ADS) and the harshness of the environment in which its sensors operate, the effectiveness of traditional fault diagnosis methods is significantly reduced. To this end, this paper proposes a method fusing the model and neural network based on unscented Kalman filter (UKF) and Inception V3 to enhance fault diagnosis performance. Initially, the unscented Kalman filter model is established based on an atmospheric system model to accurately estimate normal states. Subsequently, in order to solve the difficulties such as threshold setting in existing fault diagnosis methods based on residual observers, the UKF model is combined with a neural network, where innovation and residual sequences of the UKF model are extracted as inputs for the neural network model to amplify fault characteristics. Then, multi-scale features are extracted by the Inception V3 network, combined with the efficient channel attention (ECA) mechanism to improve diagnostic results. Finally, the proposed algorithm is validated on a missile simulation platform. The results show that, compared to traditional methods, the proposed method achieves higher accuracy and maintains its lightweight nature simultaneously, which demonstrates its efficiency and potential of fault diagnosis in missile air data systems. Full article

The rise of comics and games has led to increased artistic processing of portrait photos. With growing commercial demand and advancements in deep learning, neural networks for rapid facial style transfer have become a key research area in computer vision. This involves converting face photos into different styles while preserving content. Face images are more complex than regular images, requiring extensive modification. However, current methods often face issues such as unnatural color transitions, loss of detail in highlighted areas, and noticeable artifacts along edges, resulting in low-quality stylized images. In this study, an enhanced generative adversarial network (GAN) is proposed, which is based on Adaptive Layer Instance Normalization (AdaLIN) + Laplacian. This approach incorporates the AdaLIN normalization method, allowing for the dynamic adjustment of Instance Normalization (IN) and Layer Normalization (LN) parameters’ weights during training. By combining the strengths of both normalization techniques, the model selectively preserves and alters content information to some extent, aiming to strike a balance between style and content. This helps address problems such as unnatural color transitions and loss of details in highlights that lead to color inconsistencies. Furthermore, the introduction of a Laplacian regularization term aids in denoising the image, preventing noise features from interfering with the color transfer process. This regularization also helps reduce color artifacts along the face’s edges caused by noise while maintaining the image’s contour information. These enhancements significantly enhance the quality of the generated face images. To compare our method with traditional CycleGAN and recent algorithms such as XGAN and CariGAN, both subjective and objective evaluations were conducted. Subjectively, our method demonstrates more natural color transitions and superior artifact elimination, achieving higher scores in Mean Opinion Score (MOS) evaluations. Objectively, experiments using our method yielded better scores across three metrics: FID, SSIM, and MS-SSIM. The effectiveness of the proposed methods is validated through both objective and subjective evaluations. Full article

With a common aim of restoring physiological function of defective cells, optogenetics and targeted gene therapies have shown great clinical potential and novelty in the branch of personalized medicine and inherited retinal diseases (IRDs). The basis of optogenetics aims to bypass defective photoreceptors by introducing opsins with light-sensing capabilities. In contrast, targeted gene therapies, such as methods based on CRISPR-Cas9 and RNA interference with noncoding RNAs (i.e., microRNA, small interfering RNA, short hairpin RNA), consists of inducing normal gene or protein expression into affected cells. Having partially leveraged the challenges limiting their prompt introduction into the clinical practice (i.e., engineering, cell or tissue delivery capabilities), it is crucial to deepen the fields of knowledge applied to optogenetics and targeted gene therapy. The aim of this in-depth and novel literature review is to explain the fundamentals and applications of optogenetics and targeted gene therapies, while providing decision-making arguments for ophthalmologists. First, we review the biomolecular principles and engineering steps involved in optogenetics and the targeted gene therapies mentioned above by bringing a focus on the specific vectors and molecules for cell signalization. The importance of vector choice and engineering methods are discussed. Second, we summarize the ongoing clinical trials and most recent discoveries for optogenetics and targeted gene therapies for IRDs. Finally, we then discuss the limits and current challenges of each novel therapy. We aim to provide for the first time scientific-based explanations for clinicians to justify the specificity of each therapy for one disease, which can help improve clinical decision-making tasks. Full article

Autologous platelet-rich plasma (PRP) preparations are prepared at the point of care. Centrifugation cellular density separation sequesters a fresh unit of blood into three main fractions: a platelet-poor plasma (PPP) fraction, a stratum rich in platelets (platelet concentrate), and variable leukocyte bioformulation and erythrocyte fractions. The employment of autologous platelet concentrates facilitates the biological potential to accelerate and support numerous cellular activities that can lead to tissue repair, tissue regeneration, wound healing, and, ultimately, functional and structural repair. Normally, after PRP preparation, the PPP fraction is discarded. One of the less well-known but equally important features of PPP is that particular growth factors (GFs) are not abundantly present in PRP, as they reside outside of the platelet alpha granules. Precisely, insulin-like growth factor-1 (IGF-1) and hepatocyte growth factor (HGF) are mainly present in the PPP fraction. In addition to their roles as angiogenesis activators, these plasma-based GFs are also known to inhibit inflammation and fibrosis, and they promote keratinocyte migration and support tissue repair and wound healing. Additionally, PPP is known for the presence of exosomes and other macrovesicles, exerting cell–cell communication and cell signaling. Newly developed ultrafiltration technologies incorporate PPP processing methods by eliminating, in a fast and efficient manner, plasma water, cytokines, molecules, and plasma proteins with a molecular mass (weight) less than the pore size of the fibers. Consequently, a viable and viscous protein concentrate of functional total proteins, like fibrinogen, albumin, and alpha-2-macroglobulin is created. Consolidating a small volume of high platelet concentrate with a small volume of highly concentrated protein-rich PPP creates a protein-rich, platelet-rich plasma (PR-PRP) biological preparation. After the activation of proteins, mainly fibrinogen, the PR-PRP matrix retains and facilitates interactions between invading resident cells, like macrophages, fibroblast, and mesenchymal stem cells (MSCs), as well as the embedded concentrated PRP cells and molecules. The administered PR-PRP biologic will ultimately undergo fibrinolysis, leading to a sustained release of concentrated cells and molecules that have been retained in the PR-PRP matrix until the matrix is dissolved. We will discuss the unique biological and tissue reparative and regenerative properties of the PR-PRP matrix. Full article

This study aims to examine the differences in drivers’ reaction time (RTs) while driving on horizontal curves and straight roadway segments, among different driver classes, and in different driving environments to better understand human driver behavior in typical car-following situations. Therefore, behavioral measures were extracted from naturalistic car-following trajectories to estimate the RT. The RT was estimated for two stimulus–response pairs, namely, the speed–gap and relative speed–acceleration pairs, by using the cross-classification method. The RT was estimated separately for each driver and aggregated based on location and based on driver class. The results reveal that drivers’ RTs on curves are consistently higher than their RTs on straight segments, and this difference is statistically significant. The comparison between normal drivers and aggressive drivers indicates that regardless of the location, aggressive drivers have a significantly longer RT than normal drivers, as aggressive drivers can accept closer gaps and higher relative speed. Also, cautious drivers have a longer RT compared with normal drivers; however, the difference is not significant in most cases. Furthermore, cautious and normal drivers have longer RTs on curves compared with their RTs on straight segments. Additionally, the RT on rural horizontal curves is longer than the RT on urban curves, yet the differences are insignificant. Full article