Search Results (3,500)

Melanoma is the most aggressive subtype of cancer, with a higher propensity to spread compared to most solid tumors. The application of OMICS approaches has revolutionized the field of melanoma research by providing comprehensive insights into the molecular alterations and biological processes underlying melanoma development and progression. This review aims to offer an overview of melanoma biology, covering its transition from primary to malignant melanoma, as well as the key genes and pathways involved in the initiation and progression of this disease. Utilizing online databases, we extensively explored the general expression profile of genes, identified the most frequently altered genes and gene mutations, and examined genetic alterations responsible for drug resistance. Additionally, we studied the mechanisms responsible for immune checkpoint inhibitor resistance in melanoma. Full article

The proliferation of fake news and fake profiles on social media platforms poses significant threats to information integrity and societal trust. Traditional detection methods, including rule-based approaches, metadata analysis, and human fact-checking, have been employed to combat disinformation, but these methods often fall short in the face of increasingly sophisticated fake content. This review article explores the emerging role of Large Language Models (LLMs) in enhancing the detection of fake news and fake profiles. We provide a comprehensive overview of the nature and spread of disinformation, followed by an examination of existing detection methodologies. The article delves into the capabilities of LLMs in generating both fake news and fake profiles, highlighting their dual role as both a tool for disinformation and a powerful means of detection. We discuss the various applications of LLMs in text classification, fact-checking, verification, and contextual analysis, demonstrating how these models surpass traditional methods in accuracy and efficiency. Additionally, the article covers LLM-based detection of fake profiles through profile attribute analysis, network analysis, and behavior pattern recognition. Through comparative analysis, we showcase the advantages of LLMs over conventional techniques and present case studies that illustrate practical applications. Despite their potential, LLMs face challenges such as computational demands and ethical concerns, which we discuss in more detail. The review concludes with future directions for research and development in LLM-based fake news and fake profile detection, underscoring the importance of continued innovation to safeguard the authenticity of online information. Full article

Nowadays, integrating Artificial Intelligence (AI) into supply chains (SCs) is a great challenge in research and for manufacturing managers. The main goal of this study is to determine the role of AI in the context of the new SCs, according to the concept of Industry 5.0. in order to improve the level of sustainable production. The research was based on a systematic analysis of the scientific literature and application of the PRISMA methodology. Due to the relatively new vision of introducing AI into SC, it was decided to analyse the years 2021–2024. A total of 1181 research articles were identified in Science Direct, Springer and the Willey Online Library that combined AI-based methods and tools that support SCs in order to identify the impacts and challenges of integrating AI in SCs in the context of sustainable production (SP). In this study, 48 items were then analysed in detail. The results achieved highlighted the main AI-based tools applied in SCs and, secondly, revealed the main benefits of this integration for manufacturing in the following areas of manufacturing: predictive maintenance, production planning and customer relationships. The findings of our study revealed the main challenges and directions: (1) integrating digitalisation and green SP in order to build resilience to the SP, (2) create a sustainable work environment, (3) and develop a sustainable and advanced architecture for relationships with customers. Full article

The rudder surfaces and lifting surfaces of a missile are utilized to acquire aerodynamic forces and moments, adjust the missile’s attitude, and achieve precise strike missions. However, the harsh flying conditions of missiles make the rudder surfaces and lifting surfaces susceptible to faults. In practical scenarios, there is often a scarcity of fault data, and sometimes, it is even difficult to obtain such data. Currently, data-driven fault detection and localization methods heavily rely on fault data, posing challenges for their applicability. To address this issue, this paper proposes an HBOS (Histogram-Based Outlier Score) online fault-detection method based on statistical distribution. This method generates a fault-detection model by fitting the probability distribution of normal data and incorporates an adaptive threshold to achieve real-time fault detection. Furthermore, this paper abstracts the interrelationships between the missile’s flight states and the propagation mechanism of faults into a hierarchical directed graph model. By utilizing bilateral adaptive thresholds, it captures the first fault features of each sub-node and determines the fault propagation effectiveness of each layer node based on the compatibility path principle, thus establishing a fault inference and localization model. The results of semi-physical simulation experiments demonstrate that the proposed algorithm is independent of fault data and exhibits high real-time performance. In multiple sets of simulated tests with randomly parameterized deviations, the fault-detection accuracy exceeds 98% with a false-alarm rate of no more than 0.31%. The fault-localization algorithm achieves an accuracy rate of no less than 97.91%. Full article

The deployment of fifth-generation (5G) wireless networks has already laid the ground-work for futuristic smart cities but along with this, it has also triggered the rapid growth of a wide range of applications, for example, the Internet of Everything (IoE), online gaming, extended/virtual reality (XR/VR), telemedicine, cloud computing, and others, which require ultra-low latency, ubiquitous coverage, higher data rates, extreme device density, ultra-high capacity, energy efficiency, and better reliability. Moreover, the predicted explosive surge in mobile traffic until 2030 along with envisioned potential use-cases/scenarios in a smart city context will far exceed the capabilities for which 5G was designed. Therefore, there is a need to harness the 6th Generation (6G) capabilities, which will not only meet the stringent requirements of smart megacities but can also open up a new range of potential applications. Other crucial concerns that need to be addressed are related to network security, data privacy, interoperability, the digital divide, and other integration issues. In this article, we examine current and emerging trends for the implementation of 6G in the smart city arena. Firstly, we give an inclusive and comprehensive review of potential 6th Generation (6G) mobile communication technologies that can find potential use in smart cities. The discussion of each technology also covers its potential benefits, challenges and future research direction. Secondly, we also explore promising smart city applications that will use these 6G technologies, such as, smart grids, smart healthcare, smart waste management, etc. In the conclusion part, we have also highlighted challenges and suggestions for possible future research directions. So, in a single paper, we have attempted to provide a wider perspective on 6G-enabled smart cities by including both the potential 6G technologies and their smart city applications. This paper will help readers gain a holistic view to ascertain the benefits, opportunities and applications that 6G technology can bring to meet the diverse, massive and futuristic requirements of smart cities. Full article

Advances in artificial intelligence (AI), including intelligent machines, are opening new possibilities to support teaching and learning in higher education. This research has found a ‘proof of concept’ in the application of machine learning in the assessment of educators’ use of four key microskills, drawn from an internationally established framework. The analysis of teaching videos where these microskills were demonstrated multiple times in front of a green screen or in a space formed the data set. Multiple videos of this nature were recorded to allow for increased analysis and deconstruction of the video components to enable the application of machine learning. The results showed how AI can be used to support the collaborative and reflective practice of educators in a time when online teaching has become the norm. Having achieved a ‘proof of concept’, this research has laid the groundwork to allow for the whole framework of ten microskills to be applied in this way thus adding a new dimension to its use. Providing such critical information that is not currently available in such a systematic and personalised way to educators in the higher education sector can also support the validity of formative assessment practices. Full article

The Dark Web is a subset of the Deep Web, requiring special browsers, the Dark Net refers to encrypted networks, the Deep Web encompasses non-indexed online content, and darknet includes unused IP address networks. The Dark Net has become a hotbed of cybercrime, with individuals and groups using the anonymity and encryption provided by the network to carry out a range of criminal activities. One of the most concerning trends in recent years has been the weaponization of cybercrimes, as criminals use their technical skills to create tools and techniques that can be used to launch attacks against individuals, businesses, and governments. This paper examines the weaponization of cybercrimes on the Dark Net, focusing on the question of detection and application. This paper uses a Systematic Literature Review (SLR) method to appraise the Dark Web, examine the crimes and their consequences and identify future measures to reduce crime threats. Data from 88 relevant articles from 2011 to 2023 were extracted and synthesized, along with the latest data from 2024 to answer research questions, providing comprehensive knowledge on growing crimes; assessing social, economic, and ethical impacts; and analyzing established techniques and methods to locate and apprehend criminals. Full article

Computer vision (CV) techniques have been widely studied and applied in the shipping industry and maritime research. The existing literature has primarily focused on enhancing image recognition accuracy and precision for water surface targets by refining CV models themselves. This paper introduces innovative methods to further improve the accuracy of detection and recognition using CV models, including using ensemble learning and integrating shipping domain knowledge. Additionally, we present a novel application of CV techniques in the maritime domain, expanding the research perspective beyond the traditional focus on the accurate detection and recognition of water surface targets. Specifically, a novel solution integrating a CV model and the transfer learning method is proposed in this paper to address the challenge of relatively low-speed and high-charge internet services on ocean-going vessels, aiming to improve the online video viewing experience while conserving network resources. This paper is of importance for advancing further research and application of CV techniques in the shipping industry. Full article

Bee products, abundant in bioactive ingredients, have been utilized in both traditional and contemporary medicine. Their antioxidant, antimicrobial, and anti-inflammatory properties make them valuable for food, preservation, and cosmetics applications. Honeybees are a vast reservoir of potentially beneficial products such as honey, bee pollen, bee bread, beeswax, bee venom, and royal jelly. These products are rich in metabolites vital to human health, including proteins, amino acids, peptides, enzymes, sugars, vitamins, polyphenols, flavonoids, and minerals. The advancement of nanotechnology has led to a continuous search for new natural sources that can facilitate the easy, low-cost, and eco-friendly synthesis of nanomaterials. Nanoparticles (NPs) are actively synthesized using honeybee products, which serve dual purposes in preventive and interceptive treatment strategies due to their richness in essential metabolites. This review aims to highlight the potential role of bee products in this line and their applications as catalysts and food preservatives and to point out their anticancer, antibacterial, antifungal, and antioxidant underlying impacts. The research used several online databases, namely Google Scholar, Science Direct, and Sci Finder. The overall findings suggest that these bee-derived substances exhibit remarkable properties, making them promising candidates for the economical and eco-friendly production of NPs. Full article

To ensure the sustainable development of artificial intelligence (AI) application in urban and geospatial science, it is important to protect the geographic privacy, or geo-privacy, which refers to an individual’s geographic location details. As a crucial aspect of personal security, geo-privacy plays a key role not only in individual protection but also in maintaining ethical standards in geoscientific practices. Despite its importance, geo-privacy is often not sufficiently addressed in daily activities. With the increasing use of large multimodal models (LMMs) such as GPT-4 for open-source intelligence (OSINT), the risks related to geo-privacy breaches have significantly escalated. This study introduces a novel GPT-4-based model, GeoLocator, integrated with location capabilities, and conducts four experiments to evaluate its ability to accurately infer location information from images and social media content. The results demonstrate that GeoLocator can generate specific geographic details with high precision, thereby increasing the potential for inadvertent exposure of sensitive geospatial information. This highlights the dual challenges posed by online data-sharing and information-gathering technologies in the context of geo-privacy. We conclude with a discussion on the broader impacts of GeoLocator and our findings on individuals and communities, emphasizing the urgent need for increased awareness and protective measures against geo-privacy breaches in the era of advancing AI and widespread social media usage. This contribution thus advocates for sustainable and responsible geoscientific practices. Full article

After the strong success of the previous edition, the 2nd International Electronic Conference on Machines and Applications (IECMA 2024) was held online from 18 to 20 June 2024. Machinery and engineering areas play a key role in an ever-increasing technological society. Transportation, renewable energies, and more efficient buildings are only some of the domains where the intensive application of these systems has been noticed the most. In all these applications, efficiency and reliability, automation and control, and advanced manufacturing are of major concern. The scope of this online conference was to bring together well-known worldwide experts in the fields of machinery and engineering while providing an online forum for presenting and discussing the latest results within such fields. The present report will start by providing an overview of the keynote speeches and the main axes around which the oral sessions were organized. Then, the topics addressed in the detailed abstracts submitted to the IECMA 2024 are presented. Full article

Adherence to hand hygiene procedures is crucial for all populations, and the World Health Organization (WHO) has implemented specific guidelines for infection control. Frequent and correct hand hygiene can prevent infections, but non-compliance with hand hygiene is pervasive. Nursing students address this issue from the beginning of their training. In nursing training, self-efficacy is crucial in enhancing students’ competence, motivation, and clinical performance. We performed a cross-sectional multicenter study in five European countries, with a cross-sectional design with an online application of an instrument measuring hand hygiene knowledge based on WHO guidelines and general self-efficacy and specific self-efficacy for infection control. A total of 638 first-year nursing students participated in this study. The mean percentage of correct answers was 67.9%, with a considerable difference depending on the items. The worst results were obtained for questions related to sources of infection and types of hand hygiene methods in different situations. Finnish students displayed significantly (p < 0.001) higher scores in HH knowledge, whereas Estonian students had significantly (p < 0.001) higher levels of self-efficacy. There were significant correlations between the hand hygiene knowledge score and the self-efficacy score (p < 0.001). A multivariate analysis by linear regression analysis showed significant associations between the hand hygiene knowledge survey score and the students’ age (p < 0.001, OR = 0.18, 95% CI 0.04–0.10), as well as their country of origin (p = 0.01, OR = 0.09, 95% CI 0.03–0.34). HH knowledge is quite low among nursing students, and is correlated with self-efficacy, although the strongest predictors are age and country of origin. Different nursing curricula must favor HH knowledge, with varying degrees of emphasis depending on the country. Full article

Migraines are one of the most common and expensive neurological diseases worldwide. Non-pharmacological and digitally delivered treatment options have long been used in the treatment of migraines. For instance, migraine management tools, online migraine diagnosis or digitally networked patients have been used. Recently, applications of ChatGPT are used in fields of healthcare ranging from identifying potential research topics to assisting professionals in clinical diagnosis and helping patients in managing their health. Despite advances in migraine management, only a minority of patients are adequately informed and treated. It is important to provide these patients with information to help them manage the symptoms and their daily activities. The primary aim of this case study was to examine the appropriateness of ChatGPT to handle symptom descriptions responsibly, suggest supplementary assistance from credible sources, provide valuable perspectives on treatment options, and exhibit potential influences on daily life for patients with migraines. Using a deductive, qualitative study, ten interactions with ChatGPT on different migraine types were analyzed through semi-structured interviews. ChatGPT provided relevant information aligned with common scientific patient resources. Responses were generally intelligible and situationally appropriate, providing personalized insights despite occasional discrepancies in interaction. ChatGPT’s empathetic tone and linguistic clarity encouraged user engagement. However, source citations were found to be inconsistent and, in some cases, not comprehensible, which affected the overall comprehensibility of the information. ChatGPT might be promising for patients seeking information on migraine conditions. Its user-specific responses demonstrate potential benefits over static web-based sources. However, reproducibility and accuracy issues highlight the need for digital health literacy. The findings underscore the necessity for continuously evaluating AI systems and their broader societal implications in health communication. Full article

Weather is a significant factor influencing forest health, productivity, and the carbon cycle. However, our understanding of these effects is limited for many regions and ecosystems. Assessing the impact of weather variability on harvester productivity from plantation forests may assist in forest planning through the use of data modeling. We investigated whether weather data combined with timber harvesting attributes could be used to create a high-performance model that could accurately predict harvester productivity in Eucalyptus plantations using machine learning. Furthermore, we aimed to provide an online application to assist forest managers in applying the model. For the modeling, we considered 15 weather and timber harvesting attributes. We considered productivity as the target attribute. We subjected the database to 24 common algorithms in default mode and compared them according to error metrics and accuracy. From the timber harvesting features combined with weather features, the Catboost model can predict the productivity of harvesters in a tuned mode, with a coefficient of determination of 0.70. The use of weather data combined with timber harvesting attributes in the model is an accurate approach for predicting harvester productivity in Eucalyptus plantations, allowing for the creation of an online, free application to assist forest managers. Full article

Cu pillars serve as interconnecting structures for 3D chip stacking in heterogeneous integration, whose height uniformity directly impacts chip yield. Compared to typical methods such as white-light interferometry and confocal microscopy for measuring Cu pillars, microscopic fringe projection profilometry (MFPP) offers obvious advantages in throughput, which has great application value in on-line bump height measurement in wafer-level packages. However, Cu pillars with large curvature and smooth surfaces pose challenges for signal detection. To enable the MFPP system to measure both the top region of the Cu pillar and the substrate, which are necessary for bump height measurement, we utilized rigorous surface scattering theory to solve the bidirectional reflective distribution function of the Cu pillar surface. Subsequently, leveraging the scattering distribution properties, we propose a hybrid bright-dark-field MFPP system concept capable of detecting weakly scattered signals from the top of the Cu pillar and reflected signals from the substrate. Experimental results demonstrate that the proposed MFPP system can measure the height of Cu pillars with an effective field of view of 15.2 mm × 8.9 mm and a maximum measurement error of less than 0.65 μm. Full article