Search Results (1,041)

This paper investigates the effects of pre-gelation on cellulose dissolved in LiCl/DMAc solutions to enhance the properties of regenerated cellulose materials. This study focuses on characterizing the crystallinity, molecular orientation, and mechanical performance of cellulose fibers and hydrogels prepared with and without pre-gelation treatment. X-ray diffraction (XRD) analysis reveals that crystallinity improvement from 55% in untreated fibers to 59% in fibers pre-gelled for 3 and 7 days, indicating a more ordered arrangement of cellulose chains post-regeneration. Additionally, XRD patterns show improved chain alignment in pre-gelled fibers, as indicated by reduced full width at half the maximum of Azimuthal scans. Mechanical testing demonstrates a 30% increase in tensile strength and a doubling of the compression modulus for pre-gelled fibers compared to untreated fibers. These findings underscore the role of pre-gelation in optimizing cellulose material properties for applications ranging from advanced textiles to biomaterials and sustainable packaging. Future research directions include further exploration of the structural and functional benefits of pre-gelation in cellulose processing and its broader implications in material science and engineering. Full article

Middle borosilicate glass tubes are critical materials for medical packaging, with the drawing machine playing a pivotal role in their production process. However, the effects of the drawing wheel’s motion parameters on the glass tube remain underexplored. Therefore, based on the finite element method simulation and validation experiment, the effects of experimental factors (angle of upper and lower drawing wheel, AUD; friction factor of glass and rubber, FFGR; and distance of upper and lower drawing wheel, DUD) on experimental indexes (maximum effective stress of glass tube, MES; rotational speed of glass tube, RSG; maximum and average forward driving force, MFDF and AFDF; maximum and average rotational driving force, MRDF and ARDF; total energy consumption and power, TEC and TPD; maximum and average forward driving power, MFDP and AFDP; and maximum and average rotational driving power, MRDP and ARDP) were analyzed. The results indicated that compared to FFGR and AUD, the influence of DUD on experimental indexes was the highest. The positive influence of AUD on RSG, ARDP, and MRDP, the positive influence of FFGR and the negative influence of DUD on MRDF, ARDF, TEC, TPD, ARDP, and MRDP were found, respectively. These findings will provide a theoretical reference for the optimization of drawing machines. Full article

Shiqu County, Sichuan Province, forms the eastern edge of the distribution area of the kiang (Equus kiang). It is important to assess the population and habitat status of peripheral populations, as these play a significant role in the development of conservation strategies for kiangs. Based on field transect data collected from July to August 2023, this study predicted the suitable habitat distribution of kiangs in Shiqu County using a MaxEnt model and estimated the population size and density using the ‘Distance’ package. Additionally, it analyzed the responses of the group size of kiangs to environmental factors in Shiqu County. The results showed that the area of suitable habitat for kiangs is 3402.45 km², accounting for 13.51% of the total area of Shiqu County. The estimated population was 1395.00 ± 272.20, with a population density of 0.41 ± 0.08/km². Additionally, the group size of kiangs was significantly positively correlated with the distance from the road and grazing site. The distance from the grazing site, elevation, and temperature annual range are the main environmental factors affecting the distribution of kiangs. This study initially revealed the peripheral population Status and suitable habitat of the kiang on the eastern Tibetan Plateau, and the potential threat of grazing interference and road obstruction. The research results can provide a scientific reference for the population and habitat protection of kiangs in this area. Full article

The organic food market’s rapid expansion necessitates an understanding of factors influencing consumer behavior. This paper investigates the impact of packaging colors on perceptions and willingness to pay (WTP) for organic foods, utilizing an experimental auction among university students. Drawing on previous research, we explore how colors influence perceived healthiness, premiumness, trust, and sustainability. The results indicate nuanced responses to different colors, emphasizing the need for businesses to adopt tailored packaging strategies. White and green dominate organic food packaging, aligning with associations of freshness and health. However, the study uncovers varied consumer responses, suggesting a more intricate relationship between color, trust, premiumness, and healthiness perceptions. Demographic factors such as age, gender, income, and residence areas influence WTP for organic foods with different colors, emphasizing the importance of diverse consumer segments in marketing strategies. Trust and perceived premiumness significantly influence WTP, highlighting their pivotal role in consumer valuation. The results highlight that green packaging builds trust among non-organic buyers, while organic buyers are influenced by a broader range of colors that emphasize premiumness and healthiness. The study concludes that businesses in the organic food market should carefully consider color choices in branding and packaging to effectively communicate product qualities and align with consumer values. Full article

Meat is known for its high perishability and short shelf life if not properly packaged or stored. Packaging materials play a crucial role in preserving food quality, and there is a growing demand from consumers, industry professionals, and researchers for natural packaging materials that incorporate health-beneficial extracts. Additionally, there is an increasing emphasis on avoiding non-biodegradable plastics in order to reduce environmental pollution. Currently used polymers in food packaging typically feature properties such as oxygen barriers, moisture resistance, and oxidation inhibition, helping to prevent undesirable aromas, flavors, and colors in food. Packaging not only serves as a container for transportation but also prevents physical damage, maintains quality, and ensures food safety. In the pursuit of more sustainable solutions, various compounds are being explored for food packaging, including those derived from proteins, lipids, waxes, and polysaccharides. These materials can be combined with bioactive compounds, such as natural plant extracts, which provide antioxidant, antimicrobial, anti-inflammatory, and anticancer benefits. Different techniques, such as electrohydrodynamic processes and casting methods, are employed in the preparation of these packaging materials. This review highlights the applications and properties of polymers used in meat packaging and promotes the use of biodegradable materials as a viable solution to reduce environmental pollution. Full article

In light of the growing plastic waste problem worldwide, including in agriculture, this study focuses on the usefulness of both conventional, non-degradable plastics and environmentally friendly bioplastics in the agricultural sector. Although conventional plastic products are still essential in modern, even ecological agriculture, the increasing contamination by these materials, especially in a fragmented form, highlights the urgent need to search for alternative, easily biodegradable materials that could replace the non-degradable ones. According to the literature, polymers are widely used in agriculture for the preparation of agrochemicals (mostly fertilizers) with prolonged release. They also play a role as functional polymers against pests, serve as very useful super absorbents of water to improve crop health under drought conditions, and are commonly used as mulching films, membranes, mats, non-woven fabrics, protective nets, seed coatings, agrochemical packaging, or greenhouse coverings. This widespread application leads to the uncontrolled contamination of soil with disintegrated polymeric materials. Therefore, this study highlights the possible applications of bio-based materials as alternatives to conventional polyolefins or other environmentally persistent polymers. Bio-based polymers align with the strategy of innovative agricultural advancements, leading to more productive farming by reducing plastic contamination and adverse ecotoxicological impacts on aquatic and terrestrial organisms. On the other hand, advanced polymer membranes act as catching agents for agrochemicals, protecting against environmental intoxication. The global versatility of polymer applications in agriculture will not permit the elimination of already existing technologies involving polymers in the near future. However, in line with ecological trends in modern agriculture, more “green” polymers should be employed in this sector. Moreover, we highlight that more comprehensive legislative work on these aspects should be undertaken at the European Union level to guarantee environmental and climate protection. From the EU legislation point of view, the implementation of a unified, legally binding system on applications of bio-based, biodegradable, and compostable plastics should be a priority to be addressed. In this respect, the EU already demonstrates an initial action plan. Unfortunately, these are still projected directions for future EU policy, which require in-depth analysis. Full article

Extracellular vesicles (EVs) are natural carriers of biomolecules that play a crucial role in cell-to-cell communication and tissue homeostasis under normal and pathological conditions, including inflammatory diseases and cancer. Since the discovery of the pro-regenerative and immune-modulating properties of EVs, EV-based therapeutics have entered clinical trials for conditions such as myocardial infarction and autoimmune diseases, among others. Due to their unique advantages—such as superior bioavailability, substantial packaging capacity, and the ability to traverse biological barriers—EVs are regarded as a promising platform for targeted drug delivery. However, achieving a sufficient accumulation of therapeutic agents at the target site necessitates a larger quantity of EVs per dose compared to using EVs as standalone drugs. This challenge can be addressed by administering larger doses of EVs, increasing the drug dosage per administration, or enhancing the selective accumulation of EVs at target cells. In this review, we will discuss methods to improve the isolation and purification of EVs, approaches to enhance cargo packaging—including proteins, RNAs, and small-molecule drugs—and technologies for displaying targeting ligands on the surface of EVs to facilitate improved targeting. Ultimately, this guide can be applied to the development of novel classes of EV-based therapeutics and to overcoming existing technological challenges. Full article

Conventional passive packaging plays a crucial role in food manufacturing by protecting foods from various external influences. Most packaging materials are polymer-based plastics derived from fossil carbon sources, which are favored for their versatility, aesthetic appeal, and cost-effectiveness. However, the extensive use of these materials poses significant environmental challenges due to their fossil-based origins and persistence in the environment. Global plastic consumption for packaging is expected to nearly triple by 2060, exacerbating the ecological crisis. Moreover, globalization has increased access to a diverse range of foods from around the world, heightening the importance of packaging in providing healthier and safer foods with extended shelf life. In response to these challenges, there is a growing shift to eco-friendly active packaging that not only protects but also preserves the authentic qualities of food, surpassing the roles of conventional passive packaging. This article provides a comprehensive review on the viability, benefits, and challenges of implementing bio-based biodegradable polymers in active food packaging, with the dual goals of environmental sustainability and extending food shelf life. Full article

Energy structural transformation plays a strategically important role in achieving the dual-carbon reduction goals. Among the various approaches to carbon reduction, the Chinese government regards the growth of the new energy industry as an essential means. Considering that the government policy support determines the long-term growth of the new energy industry, how to improve and optimize the policy support system has always been the core issue. Based on the fact that policy evaluation is a prerequisite, and the new energy industrial development requires the government to promote solutions in the form of a policy package rather than just individual policies, we investigate whether the implementation of the new energy industry policy package (NEIPP) is effective through an empirical case study of Shanghai. A two-stage evaluation method, which integrates the content analysis method (CAM) and synthetic control method (SCM), was used to empirically evaluate the actual effect of the NEIPP. At Stage One, four policy goals were summarized. SCM was used to identify the pure multi-effect of the NEIPP. The results showed that the NEIPP had a significant positive effect on green economic growth and industrial structure, while having a negative effect on carbon emissions. The NEIPP had no impact on the promotion of technological innovation. Several policy implications were drawn from this study. Full article

Background: Phenylketonuria (PKU) is the most common amino acid metabolism disorder. Patients with blood phenylalanine (Phe) levels of ≥6 mg/dL require treatment, and the most definitive treatment is the Phe-restricted diet. Bisphenols and phthalates are widely used endocrine-disrupting chemicals (EDCs) found in personal care products, baby bottles, and food packaging. Methods: In this study, we evaluated the possible routes of exposure to these EDCs in patients diagnosed with PKU (n = 105, 2–6 years of age) and determined the relationship between the plasma levels of bisphenol A (BPA), bisphenol F (BPF), di-butyl phthalate (DBP), di-(2-ethylhexyl) phthalate (DEHP), mono-(2ethylhexyl) phthalate (MEHP), and dietary regimens. Participant characteristics and exposure routes were evaluated according to their dietary treatment status. Results: Thirty-four of these patients were on a Phe-restricted diet, while the remaining 71 had no dietary restrictions. DBP and DEHP levels were higher in those using plastic tablecloths (p = 0.049 and p = 0.04, respectively). In addition, plasma DBP levels were higher in those who used bottled water (p = 0.01). Being under 4 years of age, using plastic food containers, and using plastic shower curtains were characteristics associated with higher MEHP levels (p = 0.027, p = 0.019, and p = 0.014, respectively). After adjustment for baseline characteristics (Model 1), the odds of having a plasma BPA level in the upper tertile were 3.34 times higher in the free-diet group (95% CI = 1.09–10.25). When we additionally adjusted for plastic exposure (Model 2), the odds ratio was found to be 18.64 (95% CI = 2.09–166.42) for BPA. In the free-diet group, the probability of having plasma DEHP levels in the upper tertile was increased by a relative risk of 3.01 (p = 0.039, 95% CI = 1.06–8.60). Conclusion: Our results indicate that exposure to bisphenols and phthalates varies with dietary treatment. The difference in sources of exposure to EDCs between the diet and non-diet groups indicates that diet plays an important role in EDC exposure. Full article

Innovative and sustainable food preservation techniques are vital for enhancing food quality, safety, and reducing environmental impact. In this review, the methods aligned with sustainability goals are explored, focusing on their mechanisms, applications, and environmental benefits. It examines non-thermal technologies such as cold plasma, pulsed light technology, high-pressure processing (HPP), pulsed electric fields (PEFs), and ultraviolet (UV) radiation, which effectively inactivate microbes while preserving nutritional and sensory qualities. Natural preservatives, including plant extracts, microbial agents, and enzymes, are highlighted as eco-friendly alternatives to synthetic chemicals, supporting clean label initiatives. Advanced packaging solutions, such as biodegradable materials, intelligent packaging systems, and modified atmosphere packaging (MAP), are assessed for their role in reducing plastic waste, maintaining product quality, and extending shelf life. The review uses life cycle analyses to evaluate these techniques’ environmental impact, considering factors like energy consumption, greenhouse gas emissions, water use, and waste reduction. It also explores the potential of emerging technologies, such as plasma-activated water (PAW) and nanotechnology, to further enhance sustainability. By identifying research gaps and discussing industry challenges, the review calls for innovation and the broader adoption of these practices to promote food security, improve public health, and foster a more sustainable and resilient food system Full article

Background/Objectives: Transgene applications, ranging from gene therapy to the development of stable cell lines and organisms, rely on maintaining the expression of transgenes. To date, the use of plasmid-based transgenes has been limited by the loss of their expression shortly after their delivery into the target cells. The short-lived expression of plasmid-based transgenes has been largely attributed to host-cell-mediated degradation and/or silencing of transgenes. The development of chromatin-based strategies for gene delivery has the potential to facilitate defining the requirements for establishing epigenetic states and to enhance transgene expression for numerous applications. Methods: To assess the impact of “priming” plasmid-based transgenes to adopt accessible chromatin states to promote gene expression, nucleosome positioning elements were introduced at promoters of transgenes, and vectors were pre-assembled into nucleosomes containing unmodified histones or mutants mimicking constitutively acetylated states at residues 9 and 14 of histone H3 or residue 16 of histone H4 prior to their introduction into cells, then the transgene expression was monitored over time. Results: DNA sequences capable of positioning nucleosomes could positively impact the expression of adjacent transgenes in a distance-dependent manner in the absence of their pre-assembly into chromatin. Intriguingly, the pre-assembly of plasmids into chromatin facilitated the prolonged expression of transgenes relative to plasmids that were not pre-packaged into chromatin. Interactions between pre-assembled chromatin states and nucleosome positioning-derived effects on expression were also assessed and, generally, nucleosome positioning played the predominant role in influencing gene expression relative to priming with hyperacetylated chromatin states. Conclusions: Strategies incorporating nucleosome positioning elements and the pre-assembly of plasmids into chromatin prior to nuclear delivery can modulate the expression of plasmid-based transgenes. Full article

Green hydrogen production is expected to play a major role in the context of the shift towards sustainable energy stipulated in the Fit for 55 package. Green hydrogen and its derivatives have the capacity to act as effective energy storage vectors, while fuel cell-powered vehicles will foster net-zero emission mobility. This study evaluates the potential of green hydrogen production in Power-to-Gas (P2G) systems operated in former mining sites where sand and gravel aggregate has been extracted from lakes and rivers under wet conditions (below the water table). The potential of hydrogen production was assessed for the selected administrative unit in Poland, the West Pomerania province. Attention is given to the legal and organisational aspects of operating mining companies to identify the sites suitable for the installation of floating photovoltaic facilities by 2050. The method relies on the use of GIS tools, which utilise geospatial data to identify potential sites for investments. Basing on the geospatial model and considering technical and organisational constraints, the schedule was developed, showing the potential availability of the site over time. Knowing the surface area of the water reservoir, the installed power of the floating photovoltaic plant, and the production capacity of the power generation facility and electrolysers, the capacity of hydrogen production in the P2G system can be evaluated. It appears that by 2050 it should be feasible to produce green fuel in the P2G system to support a fleet of city buses for two of the largest urban agglomerations in the West Pomerania province. Simulations revealed that with a water coverage ratio increase and the planned growth of green hydrogen generation, it should be feasible to produce fuel for net-zero emission urban mobility systems to power 200 buses by 2030, 550 buses by 2040, and 900 buses by 2050 (for the bus models Maxi (40 seats) and Mega (60 seats)). The results of the research can significantly contribute to the development of projects focused on the production of green hydrogen in a decentralised system. The disclosure of potential and available locations over time can be compared with competitive solutions in terms of spatial planning, environmental and societal impact, and the economics of the undertaking. Full article

Background: The opioid crisis remains a significant public health challenge in North America, highlighted by the substantial need for tools to analyze and understand opioid potency and prescription patterns. Methods: The OralOpioids package automates the retrieval, processing, and analysis of opioid data from Health Canada’s Drug Product Database (DPD) and the U.S. Food and Drug Administration’s (FDA) National Drug Code (NDC) database. It includes functions such as load_Opioid_Table, which integrates country-specific data processing and Morphine Equivalent Dose (MED) calculations, providing a comprehensive dataset for analysis. The package facilitates a comprehensive examination of opioid prescriptions, allowing researchers to identify high-risk opioids and patterns that could inform policy and healthcare practices. Results: The integration of MED calculations with Canadian and U.S. data provides a robust tool for assessing opioid potency and prescribing practices. The OralOpioids R package is an essential tool for public health researchers, enabling a detailed analysis of North American opioid prescriptions. Conclusions: By providing easy access to opioid potency data and supporting cross-national studies, the package plays a critical role in addressing the opioid crisis. It suggests a model for similar tools that could be adapted for global use, enhancing our capacity to manage and mitigate opioid misuse effectively. Full article

Food waste and by-products are intricately linked to sustainable food production, as reducing waste can play a significant role in achieving a more sustainable and efficient food system. Sustainable utilization and recovery of by-products can significantly contribute by creating strategies that can lead to cost savings and increased efficiency across the food supply chain. Worldwide, more than 40% of whey from cheese production is discarded, resulting in the loss of valuable nutrients and potentially polluting the environment. Effective use of whey reduces environmental impact and enhances manufacturing sustainability. Thus, a circular approach to food waste management in the dairy industry supports sustainability goals and creates opportunities for innovation. Whey contains most of the soluble components of milk, including a large number of serum proteins and all the essential amino acids, making it suitable for producing beverages with high nutritional value. This study aims to produce whey-based beverages with different additions to obtain dairy products with high nutritional value. Three different ingredients, sea buckthorn, ginger, and cinnamon, were chosen for their numerous health benefits to the consumer. Six samples were prepared utilizing both unmodified and deproteinized whey in a 75% proportion, with the addition of 25% sea buckthorn juice, 0.75% ginger juice, and 0.2% cinnamon powder. The resultant samples were packaged in 200 mL bottles and maintained at a controlled temperature of 6 °C to ensure optimal preservation. Given the paramount importance of consumer acceptability in novel beverage development, a comprehensive evaluation was conducted to assess the sensory properties of the formulated beverages. In addition, physico-chemical properties and their evolution over 14 days of storage were examined. The sample containing whey, sea buckthorn juice, ginger juice, and cinnamon powder received the highest marks from the tasters. The values of the physico-chemical parameters varied depending on the type of whey used and the storage period. Thus, a pH of approximately 5 and an acidity between 30 and 80 °T were recorded. The average lactose content was 4%, the average protein content was 2.5%, and the total soluble solids content was 11.5 °Brix. The beverages developed in this study represent viable alternatives for diversifying food production through sustainable, environmentally friendly technological variants. By applying circular economy principles, these products contribute to reducing food waste in the dairy industry. Full article