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30 pages, 4135 KiB  
Article
Optimized Accelerated Over-Relaxation Method for Robust Signal Detection: A Metaheuristic Approach
by Muhammad Nauman Irshad, Imran Ali Khoso, Muhammad Muzamil Aslam and Rardchawadee Silapunt
Algorithms 2024, 17(10), 463; https://doi.org/10.3390/a17100463 - 18 Oct 2024
Viewed by 192
Abstract
Massive MIMO technology is recognized as a key enabler for beyond 5G (B5G) and next-generation wireless networks. By utilizing large-scale antenna arrays at the base station (BS), it significantly improves both system capacity and energy efficiency. Despite these advantages, the deployment of a [...] Read more.
Massive MIMO technology is recognized as a key enabler for beyond 5G (B5G) and next-generation wireless networks. By utilizing large-scale antenna arrays at the base station (BS), it significantly improves both system capacity and energy efficiency. Despite these advantages, the deployment of a high number of antennas at the BS presents considerable challenges, particularly in the design of signal detectors that can operate with low computational complexity. While the minimum mean square error (MMSE) detector offers optimal performance in these large-scale systems, it suffers from the computational burden that makes its practical implementation challenging. To mitigate this, various iterative methods and their improved versions have been introduced. However, these iterative methods often converge slowly and are less accurate. To address these challenges, this study introduces an improved variant of traditional accelerated over-relaxation (AOR), called optimized AOR (OAOR). AOR is an over-relaxation method, and its performance is highly dependent on its relaxation parameters. To find the optimal parameters, we have developed an innovative approach that integrates a nature-inspired meta-heuristic algorithm known as Particle Swarm Optimization (PSO). Specifically, we introduce a novel variant of PSO that improves upon basic PSO by enhancing the cognitive coefficients to optimize the relaxation parameters for OAOR. These key modifications to the standard PSO improve its ability to explore various solutions efficiently and help to find the optimal parameters more quickly for signal detection. It facilitates the OAOR with faster convergence towards the optimal solution by reducing the error rate, resulting in high detection accuracy and simultaneously decreasing computational complexity from O(K3) to O(K2) making it suitable for modern wireless communication systems. We conduct extensive simulations across various configurations of massive MIMO systems. The results indicate that our proposed method achieves better performance compared to existing techniques. This improvement is particularly evident in terms of both computational complexity and error rate. Full article
(This article belongs to the Special Issue Evolutionary and Swarm Computing for Emerging Applications)
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13 pages, 3853 KiB  
Article
The Effect of Calcium Sulfate on the Hydration and Properties of Red Mud-Based Calcium Ferroaluminate Cement Clinker
by Nan Shi, Ya Ma, Xiang Zhang, Jun Li, Xiaolei Lu, Lina Zhang and Xin Cheng
Materials 2024, 17(20), 5064; https://doi.org/10.3390/ma17205064 - 17 Oct 2024
Viewed by 248
Abstract
The hydration of high-alkali red mud-based ferroaluminate cement (RCFA) clinker with calcium sulfate needs to be regulated. This study explored the effects of the calcium sulfate type and dosage on the hydration and properties of high-alkali RCFA clinker. The research results show that [...] Read more.
The hydration of high-alkali red mud-based ferroaluminate cement (RCFA) clinker with calcium sulfate needs to be regulated. This study explored the effects of the calcium sulfate type and dosage on the hydration and properties of high-alkali RCFA clinker. The research results show that when 4% gypsum was added, the 3 d compressive strength of cement was 39.1 MPa, and the 28 d compressive strength was 63.2 MPa. The 28 d strength increased by 61.6% compared with the 3 d strength. The properties of cement paste can be adversely affected by excessive anhydrite content. The exothermic hydration of clinker was accelerated by calcium sulfate at the beginning, but the rate declined as the process progressed. Sufficient sulfur supply can enhance the hydration of ye’elimite, thereby increasing the AFt content in the hydration product. The mass loss of the hydration product is mainly caused by the dehydration of ettringite, monosulfoaluminate, and AH3. In addition, the Na element in the RCFA hydration product is mainly present in monosulfoaluminate and unhydrated cement particles. Full article
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14 pages, 778 KiB  
Article
Particle Size Distribution in Holby–Morgan Degradation Model of Platinum on Carbon Catalyst in Fuel Cell: Normal Distribution
by Victor A. Kovtunenko
Technologies 2024, 12(10), 202; https://doi.org/10.3390/technologies12100202 - 17 Oct 2024
Viewed by 291
Abstract
The influence of particle size distribution in platinum catalysts on the aging of PEM fuel cells described by Holby–Morgan electrochemical degradation model is under investigation. The non-diffusive model simulates mechanisms of particle drop by Pt dissolution and particle growth through Pt ion deposition. [...] Read more.
The influence of particle size distribution in platinum catalysts on the aging of PEM fuel cells described by Holby–Morgan electrochemical degradation model is under investigation. The non-diffusive model simulates mechanisms of particle drop by Pt dissolution and particle growth through Pt ion deposition. Without spatial dependence, the number of differential equations can be reduced using the first integral of the system. For an accelerated stress test, a non-symmetric square-wave potential profile is applied according to the European harmonized protocol. The normal particle size distribution determined by two probability parameters of the expectation and the standard deviation is represented within finite groups. Numerical solution of the nonlinear diffusion equation justifies dispersion for small and narrowing for large distribution means, decrease or increase in amplitude, and movement of Pt particle diameters towards small sizes, which is faster for small particles. Full article
(This article belongs to the Section Environmental Technology)
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10 pages, 5511 KiB  
Article
Polishing Ceramic Samples with Fast Argon Atoms at Different Angles of Their Incidence on the Sample Surface
by Sergey N. Grigoriev, Alexander S. Metel, Marina A. Volosova, Enver S. Mustafaev and Yury A. Melnik
Plasma 2024, 7(4), 816-825; https://doi.org/10.3390/plasma7040043 - 17 Oct 2024
Viewed by 242
Abstract
Mechanical polishing of a product makes it possible to decrease the roughness of its surface to Ra = 0.001 µm by rubbing it with a fine abrasive contained in a fabric or other soft material. This method takes too much time and is [...] Read more.
Mechanical polishing of a product makes it possible to decrease the roughness of its surface to Ra = 0.001 µm by rubbing it with a fine abrasive contained in a fabric or other soft material. This method takes too much time and is associated with abrasive particles and microscopic scratches remaining after the processing. As such, a non-contact treatment with plasma and accelerated particles has been chosen in the present work to study polishing of ceramic samples. The small angular divergence of fast argon atoms made it possible to obtain the dependence of the sample roughness on the angle α of the atom’s incidence on its surface. It was found that the roughness weakly depends on the angle α, if not exceeding the threshold value αo ~ 50°, and rapidly decreases with increasing α > αo. Polishing with fast argon atoms leads to a noticeable decrease in friction of ceramic samples. Full article
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12 pages, 5565 KiB  
Article
The Effects of Montmorillonite–Humic Acid Composite Particles on the Photolysis of Tetracycline in Water
by Wenfang Zhou, Zirui Wang, Qingfeng Wu, Qinping Nie and Yi Wang
Crystals 2024, 14(10), 896; https://doi.org/10.3390/cryst14100896 - 16 Oct 2024
Viewed by 398
Abstract
Suspended particulate matter (SPM) is an important component of natural water bodies and can significantly influence the photolytic behavior of water pollutants. A comprehensive understanding of the photochemical behavior of water pollutants in natural waters requires consideration of the presence of SPM. In [...] Read more.
Suspended particulate matter (SPM) is an important component of natural water bodies and can significantly influence the photolytic behavior of water pollutants. A comprehensive understanding of the photochemical behavior of water pollutants in natural waters requires consideration of the presence of SPM. In this study, montmorillonite–humic acid (MMT-HA) composite particles were synthesized to simulate SPM in natural waters and their effects on the photolysis of tetracycline (TC) were investigated. The results demonstrated that the presence of MMT-HA composite particles in water significantly enhanced the photolysis of TC, with the photolytic kinetics following a pseudo-first-order model. Electron spin resonance spectra and free radical quenching experiments indicated that the photoactive components (MMT and humic acids) in the composite particles induced the generation of reactive oxygen species under light exposure, further contributing to the enhanced photolysis of TC. Comparative analysis of the free radical signals and adsorption experiments revealed that the accelerated photolysis of TC was also related to the interfacial interaction between the MMT in the composite particles and the TC molecules. The formation of surface complexes between TC molecules and the negatively charged sites on the MMT surface facilitated light absorption and electron transfer, thereby accelerating the photolysis of TC. Photoproduct analysis indicated that the primary degradation pathways of TC in the composite particle systems included the addition of hydroxyl radicals to the aromatic ring, as well as demethylation, deamination and dehydration in the side chains. This study shows that SPM in water bodies can affect the photochemical behavior of pollutants and should be taken into account when assessing the phototransformation of pollutants in natural waters. Full article
(This article belongs to the Special Issue Advanced Surface Modifications on Materials)
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17 pages, 1594 KiB  
Article
Accelerated Aging Effects Observed In Vitro after an Exposure to Gamma-Rays Delivered at Very Low and Continuous Dose-Rate Equivalent to 1–5 Weeks in International Space Station
by Juliette Restier-Verlet, Mélanie L. Ferlazzo, Adeline Granzotto, Joëlle Al-Choboq, Camélia Bellemou, Maxime Estavoyer, Florentin Lecomte, Michel Bourguignon, Laurent Pujo-Menjouet and Nicolas Foray
Cells 2024, 13(20), 1703; https://doi.org/10.3390/cells13201703 - 15 Oct 2024
Viewed by 302
Abstract
Radiation impacting astronauts in their spacecraft come from a “bath” of high-energy rays (0.1–0.5 mGy per mission day) that reaches deep tissues like the heart and bones and a “stochastic rain” of low-energy particles from the shielding and impacting surface tissues like skin [...] Read more.
Radiation impacting astronauts in their spacecraft come from a “bath” of high-energy rays (0.1–0.5 mGy per mission day) that reaches deep tissues like the heart and bones and a “stochastic rain” of low-energy particles from the shielding and impacting surface tissues like skin and lenses. However, these two components cannot be reproduced on Earth together. The MarsSimulator facility (Toulouse University, France) emits, thanks to a bag containing thorium salts, a continuous exposure of 120 mSv/y, corresponding to that prevailing in the International Space Station (ISS). By using immunofluorescence, we assessed DNA double-strand breaks (DSB) induced by 1–5 weeks exposure in ISS of human tissues evoked above, identified at risk for space exploration. All the tissues tested elicited DSBs that accumulated proportionally to the dose at a tissue-dependent rate (about 40 DSB/Gy for skin, 3 times more for lens). For the lens, bones, and radiosensitive skin cells tested, perinuclear localization of phosphorylated forms of ataxia telangiectasia mutated protein (pATM) was observed during the 1st to 3rd week of exposure. Since pATM crowns were shown to reflect accelerated aging, these findings suggest that a low dose rate of 120 mSv/y may accelerate the senescence process of the tested tissues. A mathematical model of pATM crown formation and disappearance has been proposed. Further investigations are needed to document these results in order to better evaluate the risks related to space exploration. Full article
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20 pages, 3247 KiB  
Article
A Butterfly Algorithm That Combines Chaos Mapping and Fused Particle Swarm Optimization for UAV Path Planning
by Linlin Wang, Xin Zhang, Huilong Zheng, Chuanyun Wang, Qian Gao, Tong Zhang, Zhongyi Li and Jing Shao
Drones 2024, 8(10), 576; https://doi.org/10.3390/drones8100576 - 11 Oct 2024
Viewed by 342
Abstract
Effective path planning is essential for autonomous drone flight to enhance task efficiency. Many researchers have applied swarm intelligence algorithms to drone path planning. For instance, the traditional Butterfly Optimization Algorithm (BOA) has been used for this purpose. However, traditional BOA faces challenges [...] Read more.
Effective path planning is essential for autonomous drone flight to enhance task efficiency. Many researchers have applied swarm intelligence algorithms to drone path planning. For instance, the traditional Butterfly Optimization Algorithm (BOA) has been used for this purpose. However, traditional BOA faces challenges such as slow convergence and susceptibility to being trapped in local optima. An Improved Butterfly Optimization Algorithm (IBOA) has been developed to identify optimal routes to address these limitations. Initially, ICMIC mapping is utilized to establish the butterfly community, enhancing the initial population’s diversity and preventing premature algorithm convergence. Following this, a population reset strategy is introduced, replacing weaker individuals over a specified number of iterations while maintaining a constant population size. This strategy enhances the algorithm’s ability to avoid local optima and increases its robustness. Additionally, characteristics of the Particle Swarm Optimization (PSO) algorithm are integrated to enhance the butterfly’s location update mechanism, accelerating the algorithm’s convergence rate. To evaluate the performance of the IBOA algorithm, this study designed a CEC2020 function test experiment and compared it with several swarm intelligence algorithms. The results showed that IBOA achieved the best performance in 70% of the function tests, outperforming 75% of the other algorithms. In the path planning experiments within a simulated environment, IBOA quickly converged to the optimal path, and the paths it planned were the shortest and safest compared to those generated by other algorithms. Full article
(This article belongs to the Special Issue Distributed Control, Optimization, and Game of UAV Swarm Systems)
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13 pages, 3605 KiB  
Article
Clindamycin-Loaded Polyhydroxyalkanoate Nanoparticles for the Treatment of Methicillin-Resistant Staphylococcus aureus-Infected Wounds
by Muneeb Ullah, Juho Lee, Nurhasni Hasan, Md. Lukman Hakim, Dongmin Kwak, Hyunwoo Kim, Eunhye Lee, Jeesoo Ahn, Bora Mun, Eun Hee Lee, Yunjin Jung and Jin-Wook Yoo
Pharmaceutics 2024, 16(10), 1315; https://doi.org/10.3390/pharmaceutics16101315 - 10 Oct 2024
Viewed by 506
Abstract
Background/Objectives: Owing to the growing resistance of methicillin-resistant Staphylococcus aureus (MRSA) to conventional antibiotics, the development of innovative therapeutic strategies for the treatment of MRSA-infected cutaneous wounds poses a significant challenge. Methods: Here, by using polyhydroxyalkanoates (PHA), emerging biodegradable and biocompatible polymers naturally [...] Read more.
Background/Objectives: Owing to the growing resistance of methicillin-resistant Staphylococcus aureus (MRSA) to conventional antibiotics, the development of innovative therapeutic strategies for the treatment of MRSA-infected cutaneous wounds poses a significant challenge. Methods: Here, by using polyhydroxyalkanoates (PHA), emerging biodegradable and biocompatible polymers naturally produced by various microorganisms, we developed clindamycin-loaded PHA nanoparticles (Cly-PHA NPs) as a novel approach for the treatment of MRSA-infected cutaneous wounds. Results: Cly-PHA NPs were characterized in terms of mean particle size (216.2 ± 38.9 nm), polydispersity index (0.093 ± 0.03), zeta potential (11.3 ± 0.5 mV), and drug loading (6.76 ± 0.19%). Owing to the sustained release of clindamycin over 2 days provided by the PHA, Cly-PHA NPs exhibited potent antibacterial effects against MRSA. Furthermore, Cly-PHA NPs significantly facilitated wound healing in a mouse model of MRSA-infected full-thickness wounds by effectively eradicating MRSA from the wound bed. Conclusions: Therefore, our results suggest that Cly-PHA NPs offer a promising approach for combating MRSA infections and accelerating cutaneous wound healing. Full article
(This article belongs to the Special Issue Nanoformulations for Local Treatment of Cancer, Infections and Wounds)
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15 pages, 2371 KiB  
Article
Evaluation of Two Particle Number (PN) Counters with Different Test Protocols for the Periodic Technical Inspection (PTI) of Gasoline Vehicles
by Anastasios Melas, Jacopo Franzetti, Ricardo Suarez-Bertoa and Barouch Giechaskiel
Sensors 2024, 24(20), 6509; https://doi.org/10.3390/s24206509 - 10 Oct 2024
Viewed by 298
Abstract
Thousands of particle number (PN) counters have been introduced to the European market, following the implementation of PN tests during the periodic technical inspection (PTI) of diesel vehicles equipped with particulate filters. Expanding the PN-PTI test to gasoline vehicles may face several challenges [...] Read more.
Thousands of particle number (PN) counters have been introduced to the European market, following the implementation of PN tests during the periodic technical inspection (PTI) of diesel vehicles equipped with particulate filters. Expanding the PN-PTI test to gasoline vehicles may face several challenges due to the different exhaust aerosol characteristics. In this study, two PN-PTI instruments, type-examined for diesel vehicles, measured fifteen petrol passenger cars with different test protocols: low and high idling, with or without additional load, and sharp accelerations. The instruments, one based on diffusion charging and the other on condensation particle counting, demonstrated good linearity compared to the reference instrumentation with R-squared values of 0.93 and 0.92, respectively. However, in a considerable number of tests, they registered higher particle concentrations due to the presence of high concentrations below their theoretical 23 nm cut-off size. The evaluation of the different test protocols showed that gasoline direct injection engine vehicles without particulate filters (GPFs) generally emitted an order of magnitude or higher PN compared to those with GPFs. However, high variations in concentration levels were observed for each vehicle. Port-fuel injection vehicles without GPFs mostly emitted PN concentrations near the lower detection limit of the PN-PTI instruments. Full article
(This article belongs to the Section Physical Sensors)
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26 pages, 6476 KiB  
Article
YOLO-LFPD: A Lightweight Method for Strip Surface Defect Detection
by Jianbo Lu, Mingrui Zhu, Kaixian Qin and Xiaoya Ma
Biomimetics 2024, 9(10), 607; https://doi.org/10.3390/biomimetics9100607 - 8 Oct 2024
Viewed by 591
Abstract
Strip steel surface defect recognition research has important research significance in industrial production. Aiming at the problems of defect feature extraction, slow detection speed, and insufficient datasets, YOLOv5 is improved on the basis of YOLOv5, and the YOLO-LFPD (lightweight fine particle detection) model [...] Read more.
Strip steel surface defect recognition research has important research significance in industrial production. Aiming at the problems of defect feature extraction, slow detection speed, and insufficient datasets, YOLOv5 is improved on the basis of YOLOv5, and the YOLO-LFPD (lightweight fine particle detection) model is proposed. By introducing the RepVGG (Re-param VGG) module, the robustness of the model is enhanced, and the expressive ability of the model is improved. FasterNet is used to replace the backbone network, which ensures accuracy and accelerates the inference speed, making the model more suitable for real-time monitoring. The use of pruning, a GA genetic algorithm with OTA loss function, further reduces the model size while better learning the strip steel defect feature information, thus improving the generalisation ability and accuracy of the model. The experimental results show that the introduction of the RepVGG module and the use of FasterNet can well improve the model performance, with a reduction of 48% in the number of parameters, a reduction of 13% in the number of GFLOPs, an inference time of 77% of the original, and an optimal accuracy compared with the network models in recent years. The experimental results on the NEU-DET dataset show that the accuracy of YOLO-LFPD is improved by 3% to 81.2%, which is better than other models, and provides new ideas and references for the lightweight strip steel surface defect detection scenarios and application deployment. Full article
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24 pages, 8845 KiB  
Article
Numerical Simulation and Parameter Optimization of a New Slant Insertion-Opening Combination Sand Fence
by Yan Wu, Afang Jin and Jianzhou Jiang
Sustainability 2024, 16(19), 8651; https://doi.org/10.3390/su16198651 - 6 Oct 2024
Viewed by 575
Abstract
This paper presents a new slant insertion-opening combination sand fence designed to reduce the hazards of traditional railway sand damage along the line. This new fence aims to decrease the disturbance caused by lateral wind on the high-speed railway and minimize the deposition [...] Read more.
This paper presents a new slant insertion-opening combination sand fence designed to reduce the hazards of traditional railway sand damage along the line. This new fence aims to decrease the disturbance caused by lateral wind on the high-speed railway and minimize the deposition of track sand particles. Numerical modeling and wind tunnel testing were employed to examine the structure’s defensive capabilities. Using the computational fluid dynamics (CFD) method and the Eulerian–Eulerian two-fluid model, the wind protection effect and airflow characteristics of the new sand fence with different slant insertion angles and spacings were simulated, and the optimal configuration parameters were selected. The study found that the new mechanical sand fence exhibits similar performance to the traditional sand fence. Since there is a “narrow tube effect”, the leeward side of the inclined plate generates a local high-speed airflow zone. In the top acceleration zone, the new mechanical sand fence efficiently lowers air velocity, thereby enhancing its protective capabilities. Moreover, the optimal protective performance of the new mechanical sand fence is achieved with an inclination angle of 15°, with improved protection observed as the angle increases. Additionally, the protective performance of double rows of these fences is influenced by the spacing between them. Increasing the distance between the two rows enhances protective performance, with the optimal protection achieved at a spacing of 25H. Beyond this distance, protective performance decreases. Full article
(This article belongs to the Section Environmental Sustainability and Applications)
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16 pages, 11726 KiB  
Article
Future Circular Lepton Collider Vibrational Crosstalk
by Purinut Lersnimitthum, Audrey Piccini, Federico Carra, Tirawat Boonyatee, Niphon Wansophark and Nopdanai Ajavakom
Vibration 2024, 7(4), 912-927; https://doi.org/10.3390/vibration7040048 - 4 Oct 2024
Viewed by 755
Abstract
CERN, the European Organisation for Nuclear Research is studying the feasibility of the Future Circular Collider, considering both financial and technical aspects. One of the challenges is that the performance of particle accelerators relies on the dynamic stability of structures, affected by multiple [...] Read more.
CERN, the European Organisation for Nuclear Research is studying the feasibility of the Future Circular Collider, considering both financial and technical aspects. One of the challenges is that the performance of particle accelerators relies on the dynamic stability of structures, affected by multiple sources of vibrations, including crosstalk vibration between two particle accelerators, the Booster and Collider, in the Future Circular Lepton Collider. This research aims to find a methodology for determining transfer functions, specifically crosstalk transfer functions, between the Collider and Booster within an underground tunnel. Also, it aims to determine how significant crosstalk is compared to the vibration from other sources, such as ground vibrations. The transfer functions of the tunnel were independently determined from internal structures using the Finite Element Method, employing 2D plane strain and the standard absorbing boundary to model the underground tunnel. It was found that the overall gain of crosstalk was less than 10% of that of ground-to-magnetic axis of either the Collider or Booster. This method may be used to optimize the tunnel layout from a vibration point of view. It appears that vibrations from crosstalk are far lower compared to vibrations from ground vibrations. Full article
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13 pages, 4605 KiB  
Article
Modeling and Parametric Study of Spent Refractory Material Dissolution in an Aluminum Reduction Cell
by Xia Hu, Wenyuan Hou, Wei Liu, Mao Li and Hesong Li
Metals 2024, 14(10), 1128; https://doi.org/10.3390/met14101128 - 3 Oct 2024
Viewed by 517
Abstract
Utilizing spent refractory material (SRM), generated after the overhaul of aluminum electrolytic cells, as a raw material for producing Al-Si alloys presents an efficient approach towards achieving full resource utilization of SRM. However, a bottleneck restricting this technology has become the dissolution of [...] Read more.
Utilizing spent refractory material (SRM), generated after the overhaul of aluminum electrolytic cells, as a raw material for producing Al-Si alloys presents an efficient approach towards achieving full resource utilization of SRM. However, a bottleneck restricting this technology has become the dissolution of SRM. Based on the heat and mass transfer mechanism, the shrinkage core model of SRM particle dissolution was established. The effects of alumina concentration, silica concentration, electrolyte superheat, particle temperature, and turbulent kinetic energy dissipation rate on the mass dissolution rate and dissolution time of SRM particles were investigated. Calculation results and experimental data were compared to confirm the accuracy of the established model. The results show that by maintaining low alumina and silica concentrations, increasing the electrolyte superheat and particle preheating temperature, and increasing the electrolyte turbulent kinetic energy dissipation rate, SRM particles can dissolve faster. The dissolution of agglomerated particles is greatly influenced by the turbulent kinetic energy dissipation rate and superheat. The present research provides promising guidance for practical application in predicting particle dissolution time, controlling process parameters, and accelerating the dissolution of SRM particles. Full article
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16 pages, 2047 KiB  
Article
Safety and Humoral Immunogenicity of Different Dose Levels of Ad26.COV2.S as a 2-Dose Regimen in COVID-19 Vaccine-Naïve Healthy Adults: A Phase 3 Randomized Clinical Trial
by Veronica V. Rezelj, Fred Paddenburg, Marie Enajite Diegbe, Julius Nangosyah, Emil C. Reisinger, Weihong Hu, Carla Truyers, Gert Scheper, Mathieu Le Gars, Jenny Hendriks, Frank Struyf, Macaya Douoguih, Hanneke Schuitemaker and Javier Ruiz-Guiñazú
Vaccines 2024, 12(10), 1136; https://doi.org/10.3390/vaccines12101136 - 3 Oct 2024
Viewed by 688
Abstract
Background: This study aimed to support the end-of-shelf life specification (2.5 × 1010 virus particles [vp]) for the standard Ad26.COV2.S dose (5 × 1010 vp). Methods: This randomized, double-blind Phase 3 study evaluated immunogenicity, reactogenicity, and safety of several Ad26.COV2.S dose [...] Read more.
Background: This study aimed to support the end-of-shelf life specification (2.5 × 1010 virus particles [vp]) for the standard Ad26.COV2.S dose (5 × 1010 vp). Methods: This randomized, double-blind Phase 3 study evaluated immunogenicity, reactogenicity, and safety of several Ad26.COV2.S dose levels (range 1.25 to 9 × 1010 vp) in 1593 adults between June 2021 and July 2023. Results: Spike-binding antibody responses 28 days post-dose 1 were non-inferior for the 9 × 1010 vp, but not the 2.5 × 1010 vp group when compared with the standard dose. Non-inferiority was demonstrated in terms of spike-binding antibody responses 14 days post-dose 2 for each dose level, including the lowest dose level of 1.25 × 1010 vp, compared to 28 days after one dose and 14 days after two doses of the standard dose. Spike-binding antibody levels correlated well with virus neutralizing titers. There was no impact of pre-existing Ad26.COV2.S neutralizing titers on immunogenicity at any dose level. All dose levels were well tolerated. Conclusions: This study highlights the challenges associated with conducting clinical studies in a rapidly evolving environment and underscores the importance of platform data that can guide initial vaccine specifications such as shelf life during accelerated vaccine development. The present study supports the end-of-shelf life specifications for the approved Ad26.COV2.S dose, and could provide useful information in future vaccine developments using adenovirus vector vaccines. Full article
(This article belongs to the Section Attenuated/Inactivated/Live and Vectored Vaccines)
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10 pages, 4820 KiB  
Review
Probing Magnetic Fields in Young Supernova Remnants with IXPE
by Patrick Slane, Riccardo Ferrazzoli, Ping Zhou and Jacco Vink
Galaxies 2024, 12(5), 59; https://doi.org/10.3390/galaxies12050059 - 2 Oct 2024
Viewed by 424
Abstract
Synchrotron emission from the shocked regions in supernova remnants provides, through its polarization, crucial details about the magnetic field strength and orientation in these regions. This, in turn, provides information on particle acceleration in these shocks. Due to the rapid losses of the [...] Read more.
Synchrotron emission from the shocked regions in supernova remnants provides, through its polarization, crucial details about the magnetic field strength and orientation in these regions. This, in turn, provides information on particle acceleration in these shocks. Due to the rapid losses of the highest-energy relativistic electrons, X-ray polarization measurements allow for investigations of the magnetic field to be carried outvery close to the sites of particle acceleration. Measurements of both the geometry of the field and the levels of turbulence implied by the observed polarization degree thus provide unique insights into the conditions leading to efficient particle acceleration in fast shocks. The Imaging X-ray Polarimetry Explorer (IXPE) has carried out observations of multiple young SNRs, including Cas A, Tycho, SN 1006, and RX J1713.7−3946. In each, significant X-ray polarization detections provide measurements of magnetic field properties that show some common behavior but also considerable differences between these SNRs. Here, we provide a summary of results from IXPE studies of young SNRs, providing comparisons between the observed polarization and the physical properties of the remnants and their environments. Full article
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