Search Results (27,936)

Long-lasting brain fatigue is a consequence of stroke or traumatic brain injury associated with emotional, psychological, and physical overload, distress in hypertension, atherosclerosis, viral infection, and aging-related chronic low-grade inflammatory disorders. The pathogenesis of brain fatigue is linked to disrupted neurotransmission, the glutamate-glutamine cycle imbalance, glucose metabolism, and ATP energy supply, which are associated with multiple molecular targets and signaling pathways in neuroendocrine-immune and blood circulation systems. Regeneration of damaged brain tissue is a long-lasting multistage process, including spontaneously regulating hypothalamus-pituitary (HPA) axis-controlled anabolic–catabolic homeostasis to recover harmonized sympathoadrenal system (SAS)-mediated function, brain energy supply, and deregulated gene expression in rehabilitation. The driving mechanism of spontaneous recovery and regeneration of brain tissue is a cross-talk of mediators of neuronal, microglia, immunocompetent, and endothelial cells collectively involved in neurogenesis and angiogenesis, which plant adaptogens can target. Adaptogens are small molecules of plant origin that increase the adaptability of cells and organisms to stress by interaction with the HPA axis and SAS of the stress system (neuroendocrine-immune and cardiovascular complex), targeting multiple mediators of adaptive GPCR signaling pathways. Two major groups of adaptogens comprise (i) phenolic phenethyl and phenylpropanoid derivatives and (ii) tetracyclic and pentacyclic glycosides, whose chemical structure can be distinguished as related correspondingly to (i) monoamine neurotransmitters of SAS (epinephrine, norepinephrine, and dopamine) and (ii) steroid hormones (cortisol, testosterone, and estradiol). In this narrative review, we discuss (i) the multitarget mechanism of integrated pharmacological activity of botanical adaptogens in stress overload, ischemic stroke, and long-lasting brain fatigue; (ii) the time-dependent dual response of physiological regulatory systems to adaptogens to support homeostasis in chronic stress and overload; and (iii) the dual dose-dependent reversal (hormetic) effect of botanical adaptogens. This narrative review shows that the adaptogenic concept cannot be reduced and rectified to the various effects of adaptogens on selected molecular targets or specific modes of action without estimating their interactions within the networks of mediators of the neuroendocrine-immune complex that, in turn, regulates other pharmacological systems (cardiovascular, gastrointestinal, reproductive systems) due to numerous intra- and extracellular communications and feedback regulations. These interactions result in polyvalent action and the pleiotropic pharmacological activity of adaptogens, which is essential for characterizing adaptogens as distinct types of botanicals. They trigger the defense adaptive stress response that leads to the extension of the limits of resilience to overload, inducing brain fatigue and mental disorders. For the first time, this review justifies the neurogenesis potential of adaptogens, particularly the botanical hybrid preparation (BHP) of Arctic Root and Ashwagandha, providing a rationale for potential use in individuals experiencing long-lasting brain fatigue. The review provided insight into future research on the network pharmacology of adaptogens in preventing and rehabilitating long-lasting brain fatigue following stroke, trauma, and viral infections. Full article

Phytoplankton has an essential role as a primary producer in lakes, providing information on environmental conditions and water quality. The objective of this research was to inventory, characterize, and assess the diversity of microalgae in the Quimsacocha lake system in Azuay, Ecuador. Water samples were collected from the two most important Quimsacocha lakes to morphologically characterize the microalgae and evaluate their diversity. The diversity and physicochemical parameters were measured to evaluate and explain differences in community richness and composition using multivariate analysis (NMDS and PERMANOVA). The level of organic pollution in the lakes was estimated using the Pollution Index, and the trophic status was assessed using dominant phytoplankton (AARL-PP Score). Eighty morphospecies were identified within 25 genera, 16 families and 8 classes. The Bacillariophyceae class was the most diverse, represented by five families. The genera Synedra, Chlorella, and Cosmarium were the most abundant, suggesting a moderate level of organic pollution and a mesotrophic state in the lakes. Physicochemical parameters such as temperature, pH, dissolved oxygen and electrical conductivity were similar in both lakes. Nonetheless, the lake depth was different, varying between 0.9 and 8 m in LQA (with one extreme value of 22 m), compared to LQB, which had depths between 7 and 19 m. Alpha diversity revealed a significant difference (p = 0.0001) in species abundance between the two lakes, while specific richness was similar (p = 0.8213). In terms of beta diversity, a significant difference in species composition was observed (p = 0.001). This study provides base-line information regarding the ecological status of these Andean lakes, being of great help in developing conservation plans to preserve their biodiversity and water quality for human consumption. Full article

Urban street spaces play a crucial role in children’s daily commuting and social activities. Therefore, the design of these spaces must give more consideration to children’s perceptual preferences. Traditional street landscape perception studies often rely on subjective analysis, which lacks objective, data-driven insights. This study overcomes this limitation by using eye-tracking technology to evaluate children’s preferences more scientifically. We collected eye-tracking data from 57 children aged 6–12 as they naturally viewed 30 images depicting school commuting environments. Data analysis revealed that the proportions of landscape elements in different street types influenced the visual perception characteristics of children in this age group. On well-maintained main and secondary roads, elements such as minibikes, people, plants, and grass attracted significant visual attention from children. In contrast, commercial streets and residential streets, characterized by greater diversity in landscape elements, elicited more frequent gazes. Children’s eye-tracking behaviors were particularly influenced by vibrant elements like walls, plants, cars, signboards, minibikes, and trade. Furthermore, due to the developmental immaturity of children’s visual systems, no significant gender differences were observed in visual perception. Understanding children’s visual landscape preferences provides a new perspective for researching the sustainable development of child-friendly cities at the community level. These findings offer valuable insights for optimizing the design of child-friendly streets. Full article

Construction professionals recognize rework’s negative impact on project performance, yet a comprehensive understanding of its critical factors still needs to be provided. Consequently, this study sought to inquire deeply into the causes of construction rework. A systematic framework was employed to achieve the research objectives. Initially, potential causes of rework were identified through a systematic literature review. Subsequently, a survey was developed and emailed to the sample group. Exploratory factor analysis was used to extract critical rework factors (CRFs) and normalized mean value analysis was used to evaluate the criticality of the obtained causes. Structural equation modeling was used to quantify and simulate the effect sizes of the components that were collected. Out of 43 possible causes, this study found 21 critical causes why rework occurs in the Turkish construction sector. Additionally, it uncovered four original CRFs, namely “management and planning deficiencies”, “design and time constraints”, “labor quality and compliance issues”, and “project dynamics and communication challenges”. While numerous studies have explored rework causes using different approaches and methodologies, there remains a lack of insight into the key factors leading to rework. Unlike earlier research, this study offers a thorough and quantitative identification of four distinct critical rework factors in Turkey. Full article

UNESCO designated Borobudur as a World Heritage Site (WHS), a tourist and cultural destination capable of increasing visitor demand. However, the number of international tourists visiting the Borobudur Temple Park is still considered low compared to similar destinations in other countries, such as Angkor Wat in Cambodia. This study aims to identify the determinants of visitor loyalty to Borobudur through consumer preferences, as indicated by service quality and heritage tourism variables. This research employs the reflective measurement model. We conducted this study at the Borobudur Temple tourist site. We used a non-probability sampling technique, specifically accidental sampling, with 248 domestic and foreign tourists visiting Borobudur. The results indicate that price and responsiveness have a positive effect on satisfaction, as well as on loyalty. While communication significantly influences satisfaction, tangibles have a significant impact on loyalty. Furthermore, research has proven that tourist satisfaction positively influences tourist loyalty. The conclusion of this study is that tourists’ high loyalty to Borobudur indicates that individual experiences with service quality and price are important factors influencing travel characteristics and destination loyalty. Full article

The global rise in mental health-related disorders represents a significant health and wellbeing challenge, imposing a substantial social and economic burden on individuals, communities, and healthcare systems. According to the World Health Organization, one in four people globally will be affected by mental or neurological disorders at some point in their lives, highlighting a significant global health concern that warrants carefully considered and innovative responses. While mental health challenges arise from complex, multifaceted factors, emerging research indicates that the built environment—the architecture of our homes, workplaces, and public spaces—may exert a critical but underappreciated influence on mental health outcomes. This paper outlines a novel theoretical framework for how visual stressors in the built environment might trigger neurophysiological stress responses via the HPA and SAM axes, potentially contributing over time to allostatic load. In this paper, it is proposed that chronic physiological strain can alter neuroplastic processes and neurogenesis in key brain regions—such as the hippocampus, prefrontal cortex (PFC), anterior cingulate cortex (ACC), and amygdala—thereby affecting cognitive health, emotional regulation, and overall mental wellbeing. Drawing on the principle of neurosustainability, this paper suggests that long-term exposure to stress-inducing environments may create feedback loops, particularly involving the amygdala, that have downstream effects on other brain areas and may be linked to adverse mental health outcomes such as depression. By presenting this framework, this paper aims to inspire further inquiry and applied experimental research into the intersection of neurophysiology, mental health, and the built environment, with a particular emphasis on rigorous testing and validation of the proposed mechanisms, that may then be translated into practical architectural design strategies for supporting health and wellbeing. In doing so, it is hoped that this work may contribute to a more holistic approach to improving mental health that integrates the creation of nurturing, resilient spaces into the broader public health agenda. Full article

This paper draws from the author’s direct experience with material care, adaptation, renewal, and disposal made while working within Himalayan and Tibetan Buddhist practitioner communities as a museum professional, conservator, and object-based researcher. It considers the function and utility of Buddhist tantric religious objects in terms of their care and capacity for practitioner engagement. In addition to exploring specific examples of what is referred to here as ‘devotional maintenance’, this paper will discuss how these strategies for object custodianship are related to Tibetan and Himalayan religious life and the specific epistemological and soteriological paradigm in which these actions are performed. Working from the perspective of a non-practitioner and material specialist, this research builds on observations of material care-taking to engage with local concepts of continuity, value, and longevity, including practices of accumulation, renewal, or disposal. Thinking critically about the methods and standards of heritage preservation provokes a discussion of how they can be interpreted as acts of care. At the same time, this paper will explore material custodianship through the cultivation of merit and an object’s capacity to transmit ‘blessings’ or the gift of beneficial influence (byin rlabs). Full article

Numerous research studies have long established the causes and consequences of the depopulation of certain regions in Europe, but it seems that there are no systematic approaches to implementing the policy of managing abandoned areas. Following years of demographic decline in settlements, the 2022 census revealed depopulated clusters in Serbia—regions with 20 or fewer residents or even no inhabitants at all. The areas of depopulated settlements are growing territorially from the south towards the north. This paper adopts a broader interpretation of brownfield land, defining it as any previously used land that is no longer employed for commercial purposes, serving as the theoretical foundation. Although they seem economically hopeless, some depopulated clusters have become the subject of research for the exploitation of mineral resources such as gold, copper, zinc, uranium, lithium and coal. The main problem is that depopulated clusters have acquired an ecological stability that would be disrupted by the opening of mines and massive construction. The changes in land use were analyzed using time series data and a formal database of natural resources from these communities. The primary methodological framework was based on the correlation between population size, utilized areas, and the ecological stability coefficient. This study aimed to explore the relationship between the proportion of arable land within a spatial unit and its depopulation rate while also examining how arable land and mineral resources could influence the potential revitalization of rural wastelands in Serbia’s depopulated areas. The primary findings indicate a significant correlation between population decline and changes in the natural environment of abandoned clusters, as well as the significant potential of clusters as rural brownfields. While it is natural to continue with ecological and green space projects, the current liberal and centralized mining management policy can create major problems for the remaining population. Full article

The underrepresentation of women in science fields limits their potential in solving current global challenges. As a lighthouse to close this gender gap, role models are crucial for girls to build their science identity, even in their early years. Therefore, we describe a combined mentoring intervention taking place during scientific summer camps for girls. In these camps, young girls lived for a week undertaking an intensive program conducting cutting-edge research and in close contact with female mentors and other girls within a community of practice. They were mentored in small groups, but there were also chances for participating in talks, entrepreneurial workshops, and social activities all together. On the last day, the girls presented their research results, sharing their perceptions about the camp and their concerns regarding the role of women in science in an open-door final conference. By means of a mixed-method assessment conceptualization, the aim of this study is to provide evidence supporting the impact of non-formal education settings to effectively enhance girls’ science potential by using inspiring female scientists acting as mentors and role models. Furthermore, the study intends to shed light on what were regarded to be the key factors of the camp design that had such an impact on the participating girls. In particular, the findings demonstrate that the participating girls improved their attitudes towards STEM after the camp, highlighting how role models, in several roles, were key to empowering them in science through the building of a gender-responsive and inclusive community. Finally, the paper also discusses the key elements of the intervention based on the lessons learned and its transferability to different educational contexts in order to expand the beneficial effects of a gender-sensitive science education to build an inclusive future. Full article

Background: Coronary artery bypass grafting (CABG) is one of the main treatments for coronary heart disease (CHD). Gut microbiota, including bacteria, fungi, archaea, and virus, has been reported to be associated with CHD. However, the changes in the multi-kingdom gut microbiota after CABG are not yet clear. This study aimed to explore the changes in multi-kingdom gut microbiota during the early postoperative period of CABG. Methods: We collected fecal samples from 40 patients before and 1 week after CABG surgery. Metagenomic sequencing was used to detect the microbial spectrum and gene functions in the patients’ fecal samples. Results: Post-CABG patients exhibited significant changes in the composition of multi-kingdom gut microbiota and gene functions. Among bacteria, beneficial species such as Bifidobacterium, Bacteroides, and Blautia were significantly reduced after CABG, while the harmful species Enterococcus was significantly increased. In fungi, Schizosaccharomyces pombe was significantly decreased in the postoperative group, while Saccharomyces cerevisiae and Aspergillus chevalieri were significantly increased postoperatively. Spearman correlation analysis indicated that Schizosaccharomyces pombe had positive interactions with beneficial bacteria such as Lachnospiraceae, Ruminococcus, and Blautia. Among archaea, the preoperatively enriched Methanomethylovorans-SGB40959 was significantly reduced postoperatively, and Spearman correlation analysis showed a significant positive interaction with probiotics Ruminococcus and Dorea. In viruses, the phage Enterococcus virus EFP01, which infects Enterococcus, was significantly increased postoperatively and showed a significant positive interaction with Enterococcus. Additionally, postoperative dysregulation of gene functions such as the Phosphoenolpyruvate-dependent Sugar Phosphotransferase System (PTS), Transposition, DNA-mediated, and Transposase Activity was observed, and Spearman correlation analysis indicated significant correlations between the dysregulated gene functions and the microbial communities. Conclusions: This study comprehensively revealed the changes in multi-kingdom species post-CABG. The reduction of beneficial microorganisms and the increase of harmful microorganisms after surgery are of significant clinical importance for understanding the overall health status of post-CABG patients and for optimizing postoperative treatment plans. Future research needs to further explore how to improve the prognosis of post-CABG patients by modulating the gut microbiota. Full article

Being both a driver and a manifestation of the current ecological, climate, and social crises, urban sustainability has become a major contemporary issue. Rather than framing the challenges that populations are confronted to as external factors, especially in deprived and segregated neighborhoods, we collected narratives about their experience of their living environments. Our work assumed an innovative interdisciplinary perspective in response to the complex interconnexions of the issues at stake. We aimed to highlight the significance of a situated perspective and an experience-based approach to fully embrace the idea of a research engaged with and for the communities, especially those suffering from marginalization and social deprivation. Our empirical results, rooted in expressions of place attachment (or not), in four disadvantaged neighborhoods in France, are presented in the form of a heuristic device, a non-normative framework that iteratively produced a representation with six dimensions that we called feelings. Together, they can be used to explore the manifestations of well-being, through place attachment related to one’s living environment, in a relational and open way, as people make sense of their place and possibly engage in its defense. We suggest further attention should be directed to concepts such as agency, freedom, and social recognition, as major conditions of the possibility of well-being or leading a good life. These dimensions could be major targets for policies trying to respond to the current sustainability challenges, such as social and environmental justice in the face of an unequal and changing world. Full article

Since architectural education has been integrated into academic campuses, the design studio has become its most prominent pedagogical approach. However, in the last three decades, advances in computer-aided design (CAD) and online communication led to the development of virtual design studio (VDS) formats, which gained prominence during the COVID-19 pandemic. VDS and physical design studio (PDS) are characterized by different sociomaterial environments, each offering unique learning opportunities. This study examines how these environments influence learning processes, analyzing two desk critique sessions—one conducted in a VDS and the other in a PDS. Our data, comprising video recordings and on-site observations, were analyzed and interpreted through a sociomaterial lens. The findings indicate that PDS facilitates more spontaneous interactions, allowing for the communication of complex ideas and better addressing misunderstandings compared to VDS, which is constrained by the limitations of digital communication platforms. This research provides both theoretical and pedagogical contributions. Theoretically, it demonstrates how architectural concepts emerge through sociomaterial interactions, framing architectural learning as material practice. In addition, it illustrates the role of sociomaterials in communicating complex ideas and shaping collaborative learning processes. Pedagogically, the findings emphasize the importance of creating rich sociomaterial environments that effectively support intended learning processes. Full article

Vehicle platooning leverages advanced communication and coordination among vehicles to increase traffic efficiency and safety and reduce environmental impact. This study addresses crucial research gaps in vehicle platooning by focusing on communication media, controller selection, and applicability across diverse vehicle types. The research centers on utilizing Wi-Fi for uni- and bidirectional information flow topology, employing a reconfigurable input/output controller and a customized electric car and two-wheeler, within a software environment. The investigation begins with simulations involving reconfigurable input/output controllers placed at varying distances (5 m, 10 m, and 15 m) to estimate the average latency. This controller was subsequently integrated into the electric car and two-wheeler, evaluating latencies at similar distances. Notably, the average simulation latencies at 5 m, 10 m, and 15 m are 0.2052 s, 0.643 s, and 0.735 s, respectively. The field test averages at the same distances are 0.233 s, 0.673 s, and 0.783 s, indicating remarkable proximity and minimal error between the two datasets and thereby demonstrating practical suitability. The findings suggest that a distance of 10 m between vehicles is better for vehicle platooning applications on the basis of the observed latency patterns. This study contributes valuable insights into implementing Wi-Fi-based information flow topology for enhancing vehicle platooning performance and viability in real-world scenarios. Full article

This article presents the results of applied research focused on the development of a hybrid software solution, which is based on the ABB RobotStudio 2021 suite, because even in the latest version, RobotStudio 10 does not have a dedicated virtual commissioning module. The aim of the study is to explore the potential communication capabilities between ABB RobotStudio and Siemens Simatic Robot Integrator and to unify control systems for performing virtual commissioning tasks. The proposed solution offers valuable procedures for any end user responsible for implementing robotic cell virtual commissioning tasks and ensures the compatibility between hardware and software components from ABB and Siemens manufacturers integrated into any robotic cell type. Siemens, one of the leading PLC manufacturers, offers the complex PLM platform Process Simulate, which can be integrated with the Totally Integrated Automation (TIA) Portal and Mechatronics Concept Designer (MCD) for developing virtual commissioning (VC) applications. The TIA Portal is recognized by robotics application integrators as the most efficient work environment for VC. However, there is currently no direct compatibility between the ABB RobotStudio (RS) platform and Siemens TIA Portal. To address integration challenges, Siemens has introduced the Simatic Robot Integrator (SRI) platform, which ensures compatibility with certain proprietary software from various robot manufacturers, including KUKA, Motoman, and Staubli. While Siemens has collaborated with manufacturers like KUKA and Kawasaki, major industry manufacturers such as ABB and Fanuc have yet to establish a standardized interface within the Siemens SRI platform. A mathematical model was also developed, which serves as a key perspective and a valuable tool for the future integration of double-portal-type robots into the working environments of ABB and Siemens. This integration aims to facilitate virtual commissioning in scenarios where such robots need to be implemented. Currently, ABB’s library does not include double-portal-type robots, despite the fact that leading manufacturers of double-portal robot types utilize ABB’s IRC5 controllers. Full article

Background: The prevalence of chronic kidney disease (CKD) is rising, increasing demand for renal replacement therapy (RRT). Community pharmacies, as accessible healthcare hubs, can play a pivotal role in CKD prevention. This study aimed to develop care models for community pharmacies to optimize medication use, encourage behavior modification, and promote self-management among at-risk individuals. Methods: Conducted between June 2017 and July 2018, this study utilized an action research approach. Microalbuminuria was assessed using urine dipsticks, and pharmacists applied behavioral change and self-management support (SMS) strategies to slow CKD progression. Participants were categorized by albuminuria levels and enrolled in pharmacist-led care programs, with follow-up assessments at weeks 0 and 12. Results: Of 521 participants screened, 57% tested positive for albuminuria. For these individuals, serum creatinine testing and referrals to primary care were initiated. Self-management behavior assessment (S1) scores significantly improved (p = 0.024). Key factors associated with urine albumin levels included age < 60 years (OR = 0.44), diabetes (OR = 3.69), hypertension (OR = 2.01), BMI < 27.5 kg/m² (OR = 0.42), eGFR ≥ 60 mL/min/1.73 m² (OR = 3.34), lower systolic (OR = 0.55) and diastolic blood pressure (OR = 0.34), and fasting plasma glucose < 126 mg/dL (OR = 0.29). Conclusions: Community pharmacist-led albuminuria screening effectively supports CKD prevention and enhances self-awareness within communities. Full article