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Search Results (1,684)

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16 pages, 9401 KiB  
Article
Influence of DC/DC Converter Control on Source Current Ripple of the Switched Reluctance Motor
by Mateusz Daraż and Piotr Bogusz
Energies 2024, 17(22), 5711; https://doi.org/10.3390/en17225711 (registering DOI) - 15 Nov 2024
Abstract
This paper presents a solution to reduce source current ripple in the electrical power supplying a switched reluctance motor (SRM) drive. Source current ripple negatively affects the power source by introducing a variable frequency component and increasing losses in the power source. Reducing [...] Read more.
This paper presents a solution to reduce source current ripple in the electrical power supplying a switched reluctance motor (SRM) drive. Source current ripple negatively affects the power source by introducing a variable frequency component and increasing losses in the power source. Reducing the source current ripple is important, especially in battery electric vehicles (BEVs). The solution proposed in this paper for reducing source current ripple is to use a classic DC/DC boost converter connected in series with the SRM power supply system. The key to reducing source current ripple is the DC/DC converter control method proposed and described in this article. This method involves controlling the DC/DC converter synchronized with the speed of the SRM motor DC/DC. To verify the correct operation of the proposed solution, simulation and laboratory tests of an SRM drive were performed, the results of which are shown in this paper. Full article
(This article belongs to the Section F3: Power Electronics)
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37 pages, 4566 KiB  
Article
Aperiodic Optimal Chronotherapy in Simple Compartment Tumour Growth Models Under Circadian Drug Toxicity Conditions
by Byron D. E. Tzamarias, Annabelle Ballesta and Nigel John Burroughs
Mathematics 2024, 12(22), 3516; https://doi.org/10.3390/math12223516 - 11 Nov 2024
Viewed by 273
Abstract
Cancer cells typically divide with weaker synchronisation with the circadian clock than normal cells, with the degree of decoupling increasing with tumour maturity. Chronotherapy exploits this loss of synchronisation, using drugs with circadian-clock-dependent activity and timed infusion to balance the competing demands of [...] Read more.
Cancer cells typically divide with weaker synchronisation with the circadian clock than normal cells, with the degree of decoupling increasing with tumour maturity. Chronotherapy exploits this loss of synchronisation, using drugs with circadian-clock-dependent activity and timed infusion to balance the competing demands of reducing toxicity toward normal cells that display physiological circadian rhythms and of efficacy against the tumour. We analysed optimal chronotherapy for one-compartment nonlinear tumour growth models that were no longer synchronised with the circadian clock, minimising a cost function with a periodically driven running cost accounting for the circadian drug tolerability of normal cells. Using Pontryagin’s Minimum Principle (PMP), we show, for drugs that either increase the cell death rate or kill dividing cells, that optimal solutions are aperiodic bang–bang solutions with two switches per day, with the duration of the daily drug administration increasing as treatment progresses; for large tumours, optimal therapy can in fact switch mid treatment from aperiodic to continuous treatment. We illustrate this with tumours grown under logistic and Gompertz dynamics conditions; for logistic growth, we categorise the different types of solutions. Singular solutions can be applicable for some nonlinear tumour growth models if the per capita growth rate is convex. Direct comparison of the optimal aperiodic solution with the optimal periodic solution shows the former presents reduced toxicity whilst retaining similar efficacy against the tumour. We only found periodic solutions with a daily period in one-compartment exponential growth models, whilst models incorporating nonlinear growth had generic aperiodic solutions, and linear multi-compartments appeared to have long-period (weeks) periodic solutions. Our results suggest that chronotherapy-based optimal solutions under a harmonic running cost are not typically periodic infusion schedules with a 24 h period. Full article
(This article belongs to the Section Mathematical Biology)
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15 pages, 9141 KiB  
Article
A Comparative Analysis of Efficiency and Losses in a 5 kW Hybrid and Full-SiC Converter, for PV Applications in Austria
by Rupak Chakraborty, Troy Eskilson, Sumanta Biswas and Markus Makoschitz
Energies 2024, 17(22), 5600; https://doi.org/10.3390/en17225600 - 9 Nov 2024
Viewed by 308
Abstract
Wide Bandgap (WBG) devices like SiC-MOSFETs have become quite popular in recent times due to their superior switching characteristics, high current carrying capability and temperature stability. They are being adopted for many different applications and for a wide range of power levels. For [...] Read more.
Wide Bandgap (WBG) devices like SiC-MOSFETs have become quite popular in recent times due to their superior switching characteristics, high current carrying capability and temperature stability. They are being adopted for many different applications and for a wide range of power levels. For the case of PV applications, manufacturers are considering moving to SiC-based topologies due to higher converter efficiencies and improved power density. However, the present industry largely uses hybrid approaches (IGBT + SiC-diode) to optimize system cost. The aim of this paper is to present a fair comparison of an industry-grade hybrid converter with another similar counterpart where only the Si device has been replaced with the SiC device. The effects of such a direct replacement on the efficiency and losses of the converter are studied under various power ratings. Both converters consist of two stages—a boost converter and a three-phase three-level DC to AC converter. Simulation and experimental results comprehensively indicate a higher efficiency (improvements of up to 8 percent points) for the full-SiC converter, and this is more prominent at low input voltages, where the boost converter is active. However, the gains in efficiency are moderate for high input voltages (1 percent point at nominal voltage), where the boost converter is bypassed, and the losses are almost entirely attributed to the inverter. When set in the backdrop of the Austrian inverter market, the use of SiC devices in PV inverters has the potential for an estimated savings of 37.5 GWh/year in terms of loss reduction. Full article
(This article belongs to the Section A2: Solar Energy and Photovoltaic Systems)
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12 pages, 5731 KiB  
Article
A Programmable Gate Driver Module-Based Multistage Voltage Regulation SiC MOSFET Switching Strategy
by Jixiang Tan, Zhongfu Zhou and Gongjie Zou
Electronics 2024, 13(22), 4379; https://doi.org/10.3390/electronics13224379 - 8 Nov 2024
Viewed by 341
Abstract
Silicon carbide (SiC) metal-oxide semiconductor field-effect transistors (MOSFETs), as a new material, have the advantages of low drain-source resistance, high thermal conductivity, low leakage current, and high switching frequency compared with silicon (Si)-based MOSFETs. Therefore, in many industrial applications, Si MOSFETs have been [...] Read more.
Silicon carbide (SiC) metal-oxide semiconductor field-effect transistors (MOSFETs), as a new material, have the advantages of low drain-source resistance, high thermal conductivity, low leakage current, and high switching frequency compared with silicon (Si)-based MOSFETs. Therefore, in many industrial applications, Si MOSFETs have been replaced by SiC MOSFETs. However, as the switching speed increases exponentially, some problems are amplified, the most serious of which is the overshoot of current and voltage. The increase in voltage and current slope caused by high switching speeds inevitably leads to overshoot, oscillations, and additional losses in the circuit. This paper focusses on the actual performance of the optimised switching strategy (OSS) in circuit testing and combines the existing simulation results to verify the practicability of OSS. In this paper, the optimised switching strategy is introduced first, and then, the LTspice model of SiC MOSFET is established in detail and verifies the feasibility of the OSS through half-bridge circuit simulation. Finally, the test platform is built using a programmable gate drive module (2ASC-12A1HP). Through a 400 V/30 A double-pulse test, the practicality of the OSS is verified. The experiments show that the OSS can greatly improve the switching performance of SiC MOSFETs. Full article
(This article belongs to the Special Issue New Horizons and Recent Advances of Power Electronics)
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23 pages, 4694 KiB  
Technical Note
Arthroscopic Bone Block and Arthroscopic Latarjet for Anterior Shoulder Dislocation—Technical Note with Tricks and Tips for Conversion and Successful Surgery
by Umile Giuseppe Longo, Gianmarco Marcello, Ara Nazarian, Joseph DeAngelis, Margaux D’Hooghe and Pieter D’Hooghe
Osteology 2024, 4(4), 179-201; https://doi.org/10.3390/osteology4040014 - 8 Nov 2024
Viewed by 320
Abstract
Background: The treatment of patients affected by recurrent anterior shoulder instability has received more attention in the last ten years, focusing on the management of bone loss, which is crucial in predicting postoperative recurrence risk. Recently, various bone grafting techniques and different fixation [...] Read more.
Background: The treatment of patients affected by recurrent anterior shoulder instability has received more attention in the last ten years, focusing on the management of bone loss, which is crucial in predicting postoperative recurrence risk. Recently, various bone grafting techniques and different fixation methods have been developed to preserve native anatomy and reduce complications. Nowadays, glenoid bone reconstruction is usually carried out via the Latarjet procedure or free bone block technique. While the Latarjet procedure has traditionally been considered the best option, the bone block has been demonstrated to be a successful procedure. Even though the indication to perform a free bone block or a Latarjet procedure may be given preoperatively, in cases where the choice between the two procedures is unclear, the decision can be made intraoperatively, given the possibility to switch from one to another. This technical note aims to outline our techniques for the arthroscopic Latarjet procedure and the arthroscopic free bone block, as well as discuss the indications, benefits and downsides of each procedure. Technical tips and tricks are provided. Methods: A step-by-step thorough description of bone block and Latarjet procedures is provided, as well as a comparison of advantages and disadvantages of each technique and tips to avoid complications. Respective indications are discussed. Results: Both the procedures have benefits and downsides. The arthroscopic Latarjet procedure is the most effective in addressing anterior shoulder instability, but is more elaborate, has a shallow learning curve and can have a high complication rate. The bone block technique is an anatomic procedure with a shorter learning curve but has fewer indications. Conclusion: The Latarjet is currently considered the gold standard for glenoid bone grafting. The bone block technique can allegedly be seen as being “in the middle” of the soft tissue repair and Latarjet procedures. Many factors should be considered when choosing the right surgical technique, and treatment plans must be customized for each patient. More studies with long-term follow-up are needed to evaluate the efficacy of arthroscopic bone grafting procedures in various subtypes of patients based on bipolar bone loss assessment and individual risk factors. Full article
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22 pages, 7935 KiB  
Article
Cycle Time-Based Fault Detection and Localization in Pneumatic Drive Systems
by Vladimir Boyko and Jürgen Weber
Actuators 2024, 13(11), 447; https://doi.org/10.3390/act13110447 - 7 Nov 2024
Viewed by 433
Abstract
Compressed air ranks among the most expensive forms of energy. In recent decades, increased efforts have been made to enhance the overall energy efficiency of pneumatic actuator systems and develop reliable fault detection methods for preventing energy losses. However, most of the methods [...] Read more.
Compressed air ranks among the most expensive forms of energy. In recent decades, increased efforts have been made to enhance the overall energy efficiency of pneumatic actuator systems and develop reliable fault detection methods for preventing energy losses. However, most of the methods developed so far require additional sensors, resulting in extra costs, and/or are not applicable during machine operation, which leads to their limited use in the industry. This article introduces a cycle time-based method for detecting faults in pneumatic actuators through the use of proximity switches, enabling cost-effective monitoring in real time without the necessity of further sensors. A systematic analysis is conducted, expanding the current state of knowledge by detailing the influence of all potential leakage points on the movement times of a pneumatic drive and taking into account the different velocity control strategies (meter-out and meter-in) and operating points expressed via the pneumatic frequency ratio. Previously unassessed specifics of internal leakage, including the impact of pressure profiles and differences between differential cylinders and cylinder with equal piston areas, are also presented. The applicability of the proposed method and its detection limits in an industrial environment are examined using pneumatic assembly machines. Full article
(This article belongs to the Section High Torque/Power Density Actuators)
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20 pages, 4322 KiB  
Article
Research on Energy Management Technology of Photovoltaic-FESS-EV Load Microgrid System
by Yahong Xing, Wenping Qin, Haixiao Zhu, Kai Liu and Chengpeng Zhou
World Electr. Veh. J. 2024, 15(11), 508; https://doi.org/10.3390/wevj15110508 - 6 Nov 2024
Viewed by 375
Abstract
This study focuses on the development and implementation of coordinated control and energy management strategies for a photovoltaic–flywheel energy storage system (PV-FESS)-electric vehicle (EV) load microgrid with direct current (DC). A comprehensive PV-FESS microgrid system is constructed, comprising PV power generation, a flywheel [...] Read more.
This study focuses on the development and implementation of coordinated control and energy management strategies for a photovoltaic–flywheel energy storage system (PV-FESS)-electric vehicle (EV) load microgrid with direct current (DC). A comprehensive PV-FESS microgrid system is constructed, comprising PV power generation, a flywheel energy storage array, and electric vehicle loads. The research delves into the control strategies for each subsystem within the microgrid, investigating both steady-state operations and transitions between different states. A novel energy management strategy, centered on event-driven mode switching, is proposed to ensure the coordinated control and stable operation of the entire system. Based on the simulation results, the PV system cannot cope with the load demand power when it is increased to a maximum of 2800 W, the effectiveness of the individual control strategies, the coordinated control of the subsystems, and the overall energy management approach are confirmed. The main contribution of this research is the development of a coordinated control mechanism that integrates PV generation with FESS and EV loads, ensuring synchronized operation and enhanced stability of the microgrid. This work provides significant insights into optimizing energy distribution and minimizing losses within microgrid systems, thereby advancing the field of energy management in DC microgrids. Full article
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21 pages, 13060 KiB  
Article
Enhanced Output Performance of Two-Level Voltage Source Inverters Using Simplified Model Predictive Control with Multi-Virtual-Voltage Vectors
by Hyeongyo Chae and Chan Roh
Machines 2024, 12(11), 781; https://doi.org/10.3390/machines12110781 - 6 Nov 2024
Viewed by 379
Abstract
Interest in electric propulsion ships has garnered attention to reduce ship exhaust emissions. This has sparked extensive research on inverters. While two-level voltage source inverters are commonly utilized in small- and medium-sized ships owing to their simple structure and cost-effectiveness, they have limitations, [...] Read more.
Interest in electric propulsion ships has garnered attention to reduce ship exhaust emissions. This has sparked extensive research on inverters. While two-level voltage source inverters are commonly utilized in small- and medium-sized ships owing to their simple structure and cost-effectiveness, they have limitations, such as high switching losses and reduced output performance. To address these issues, a model predictive control technique based on virtual voltage vectors is proposed in this study. Conventional two-level voltage source inverters are restricted to using only eight voltage vectors, which limits their output performance. By incorporating virtual voltage vectors, similar performance to multilevel converters can be achieved. The proposed technique involves a pre-voltage selection method that enhances output performance without increasing computational load. Through simulation and experiments, improved output current THD and current error were observed under various load conditions. This showcases the potential for enhancing the efficiency and performance of electric propulsion ships. Full article
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22 pages, 5486 KiB  
Article
Control of Large Wind Energy Converters for Aeroacoustic Noise Mitigation with Minimal Power Reduction
by Andrea Rivarola and Adrian Gambier
Energies 2024, 17(22), 5530; https://doi.org/10.3390/en17225530 - 5 Nov 2024
Viewed by 398
Abstract
The population is often opposed to wind turbines being erected near their homes, mainly because the machines are noisy, especially at night. In an effort to establish a compromise between the needs of the people and the fulfilment of energy demands, wind turbines [...] Read more.
The population is often opposed to wind turbines being erected near their homes, mainly because the machines are noisy, especially at night. In an effort to establish a compromise between the needs of the people and the fulfilment of energy demands, wind turbines have the ability to switch between day and night operation by reducing the rotation speed during the night, resulting in a loss of generated power. The present study investigates simple models for noise emission, propagation, and prediction, with the objective of proposing a control system configuration that continuously adjusts the rotational speed as much as necessary until it matches sound level regulations while minimising power losses. Thus, several approaches are implemented and tested with a very large reference wind turbine. The simulation results of a reference wind turbine show that the approaches provide significant improvements in sound reduction as well as in power conversion. Full article
(This article belongs to the Topic Advances in Wind Energy Technology)
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20 pages, 1652 KiB  
Article
A Novel High-Gain Multi-Stage Switched-Capacitor-Based DC-DC Boost Converter with Closed-Loop Control
by Priyanshu Kumar, Moina Ajmeri, Ashutosh Kumar Singh, Rajib Kumar Mandal and Akshay Kumar Saha
Energies 2024, 17(21), 5501; https://doi.org/10.3390/en17215501 - 3 Nov 2024
Viewed by 692
Abstract
In this manuscript, a direct current (DC) boost converter based on a switched-capacitor circuit with closed-loop control, tailored for applications with high-voltage gain, is introduced. The converter utilizes a network with switching capacitors to enhance voltage gain without relying on inductors, making it [...] Read more.
In this manuscript, a direct current (DC) boost converter based on a switched-capacitor circuit with closed-loop control, tailored for applications with high-voltage gain, is introduced. The converter utilizes a network with switching capacitors to enhance voltage gain without relying on inductors, making it ideal for high-voltage scenarios. An active disturbance rejection control (ADRC)-based control scheme is used to maintain output voltage stability in the presence of disturbances. The proposed converter’s functionality and performance are assessed through simulations and experimental tests under various load conditions. A loss analysis, considering the losses from switches and diodes, is provided to determine the net efficiency. The results from both simulations and experiments show that the proposed converter achieves a high-voltage gain, excellent load regulation, and rapid transient response, highlighting its potential for applications that require a high-voltage boosting operation. Full article
(This article belongs to the Section F1: Electrical Power System)
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22 pages, 794 KiB  
Article
Simplified Modelling Techniques for Dynamic Wireless Power Transfer
by Krzysztof Jakubiak, Jun Liang, Liana Cipcigan, Chuanyue Li and Jingzhe Wu
Electronics 2024, 13(21), 4300; https://doi.org/10.3390/electronics13214300 - 31 Oct 2024
Viewed by 460
Abstract
Recent advancements in Dynamic Wireless Power Transfer (DWPT) have highlighted the need for further research, particularly in the area of modelling and simulation techniques. As the power transferred between charging pads depends on vehicle position, the load profile of the DWPT is therefore [...] Read more.
Recent advancements in Dynamic Wireless Power Transfer (DWPT) have highlighted the need for further research, particularly in the area of modelling and simulation techniques. As the power transferred between charging pads depends on vehicle position, the load profile of the DWPT is therefore a function of the vehicle’s movement which is dependent on user behaviour and is inherently stochastic. For DWPT, these events involve high instantaneous power and are short in duration. To better understand the impact of DWPT, accurate models are required to test control systems and potential solutions. Additionally, these systems require high-frequency simulation for DWPT, which results in long simulation times during development. This paper presents a simplified model for circuit components that eliminates high-frequency switching elements, enabling the use of larger simulation time steps and significantly reducing simulation time. By applying circuit analysis and calculating equivalent impedances, the model provides average circuit values that effectively represent waveform amplitudes without the need to simulate instantaneous, high-frequency variations. To ensure the efficiency of grid-connected simulations and achieve a level of accuracy that reflects the internal dynamics of wireless charging, subsystem simulations demonstrated significant time improvements at the cost of minimal accuracy loss. For DC/DC converters operating at 2 kHz, simulation time was reduced by 3× with only a 1% error. The DWPT subsystem, operating at 85 kHz, achieved an 18× reduction in simulation time with a 2.5% deviation. When combined, the full system resulted in a 30-fold reduction in simulation time with only a 6% deviation from the base model. Full article
(This article belongs to the Special Issue Advanced Applications of Power Electronics in Net-Zero Power Systems)
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16 pages, 11983 KiB  
Article
A Study on Series-Parallel Winding Changeover Circuit and Control Method for Expanding the High-Efficiency Operating Range of IPMSM for xEV Drive Systems
by Yangjin Shin, Suyeon Cho and Ju Lee
World Electr. Veh. J. 2024, 15(11), 501; https://doi.org/10.3390/wevj15110501 - 31 Oct 2024
Viewed by 513
Abstract
The motor characteristics control method using the winding changeover technique can improve the matching ratio between the most frequent operating point of electric vehicle (EV) and the motor’s high-efficiency operating point, thereby enhancing the overall average efficiency of the drive system. This technology [...] Read more.
The motor characteristics control method using the winding changeover technique can improve the matching ratio between the most frequent operating point of electric vehicle (EV) and the motor’s high-efficiency operating point, thereby enhancing the overall average efficiency of the drive system. This technology reduces back electromotive force and winding resistance by adjusting the effective number of motor winding turns according to the EV’s operating speed, ultimately improving the average efficiency. In this paper, we propose a winding changeover circuit and control method that maximizes the average efficiency in the main driving regions to extend the driving range per charge and improve the fuel efficiency of EVs. The proposed circuit is constructed using thyristor switching devices, offering the advantage of relatively lower overall system losses compared to conventional circuits. Due to the characteristics of the thyristor switching devices used in the proposed circuit, seamless winding changeover is possible during motor operation. Additionally, no extra snubber circuits are required, and the relatively low switch losses suggest the potential for improved efficiency and lightweight design in EV drive systems. To verify the proposed winding changeover circuit and control scheme, experiments were conducted using a dynamometer with an 80 kW permanent magnet motor, inverter, and the developed prototype of the winding changeover circuit. Full article
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12 pages, 8249 KiB  
Article
Characteristics of a 1200 V Hybrid Power Switch Comprising a Si IGBT and a SiC MOSFET
by Alireza Sheikhan and E. M. Sankara Narayanan
Micromachines 2024, 15(11), 1337; https://doi.org/10.3390/mi15111337 - 31 Oct 2024
Viewed by 475
Abstract
Hybrid Power Switches (HPS) combine the advantages of SiC unipolar and Si bipolar devices and therefore can bridge the gap between these technologies. In this paper, the performance of a hybrid power switch configuration based on the latest SiC MOSFET and Si IGBT [...] Read more.
Hybrid Power Switches (HPS) combine the advantages of SiC unipolar and Si bipolar devices and therefore can bridge the gap between these technologies. In this paper, the performance of a hybrid power switch configuration based on the latest SiC MOSFET and Si IGBT technologies is presented. The device is evaluated through experimental measurements of its characteristics under various conditions. The results show the HPS can achieve switching losses as low as a SiC MOSFET while offering the high current capability of the IGBT without significant increase in costs. Full article
(This article belongs to the Special Issue Insulated Gate Bipolar Transistor (IGBT) Modules)
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17 pages, 9813 KiB  
Article
The Analysis of the Thermal Processes Occurring in the Contacts of Vacuum Switches During the Conduction of Short-Circuit Currents
by Karol Nowak, Krzysztof Nowak and Slawomir Rabczak
Energies 2024, 17(21), 5408; https://doi.org/10.3390/en17215408 - 30 Oct 2024
Viewed by 313
Abstract
This article presents the results of research on the thermal state of vacuum switch contacts during the conduction of short-circuit currents. This state is directly related to the value of the flowing current and the operating conditions of the switch. These conditions are [...] Read more.
This article presents the results of research on the thermal state of vacuum switch contacts during the conduction of short-circuit currents. This state is directly related to the value of the flowing current and the operating conditions of the switch. These conditions are mildest in the case of the conduction of operating currents through closed contacts. The situation worsens significantly when short-circuit currents are conducted, and the greatest destructive effects occur during commutation processes. Exceeding a certain level of contact destruction usually leads to the loss of the switching capacity of the switch. In vacuum switches, tracking the thermal state of the contacts is particularly difficult due to the inaccessibility of transducers or measurement sensors inside the chamber. In such a case, simulation studies verified by experimental results are important. This paper presents the results of such studies, directed at their practical implementation in the design and operation of vacuum switches. Simulation studies were conducted to analyze the thermal processes occurring in the contacts of vacuum switches during the conduction of short-circuit currents. Special attention was paid to the influence of contact parameters on the thermal processes occurring during the conduction of short-circuit currents. In addition to simulations, experimental studies were carried out to verify the simulation results. Ultimately, the research results presented are intended to provide practical knowledge of the design and operation of vacuum switches, particularly with regard to the contact heating processes during the conduction of short-circuit currents. Full article
(This article belongs to the Section F: Electrical Engineering)
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13 pages, 3255 KiB  
Article
Switch/Sucrose Non-Fermentable (SWI/SNF) Complex—Partial Loss in Sinonasal Squamous Cell Carcinoma: A High-Grade Morphology Impact and Progression
by Roberto Onner Cruz-Tapia, Ana María Cano-Valdez, Abelardo Meneses-García, Lorena Correa-Arzate, Adriana Molotla-Fragoso, Guillermo Villagómez-Olea, Diana Brisa Sevilla-Lizcano and Javier Portilla-Robertson
Curr. Issues Mol. Biol. 2024, 46(11), 12183-12195; https://doi.org/10.3390/cimb46110723 - 30 Oct 2024
Viewed by 413
Abstract
Sinonasal carcinomas are aggressive neoplasms that present a high morbidity and mortality rate with an unfavorable prognosis. This group of tumors exhibits morphological and genetic diversity. Genetic and epigenetic alterations in these neoplasms are the current targets for diagnosis and treatment. The most [...] Read more.
Sinonasal carcinomas are aggressive neoplasms that present a high morbidity and mortality rate with an unfavorable prognosis. This group of tumors exhibits morphological and genetic diversity. Genetic and epigenetic alterations in these neoplasms are the current targets for diagnosis and treatment. The most common type of cancer originating in the sinonasal tract is sinonasal squamous cell carcinomas (SNSCCs), which present different histological patterns and variable histological aggressiveness. A significant number of alterations have been reported in sinonasal tumors, including deficiencies in the Switch/Sucrose non-fermentable (SWI/SNF) chromatin remodeling complex. In the sinonasal tract, deficiencies of the subunits SMARCB1/INI1, SMARCA4/BRG1, and SMARCA2 have been noted in carcinomas, adenocarcinomas, and soft tissue tumors with a distinctive high-grade morphology and a fatal prognosis. Objective: The objective of this study is to identify the status of the SWI/SNF complex using immunohistochemistry in sinonasal squamous cell carcinomas and their association with morphology and survival. Methods: A total of 103 sinonasal carcinomas with different grades of squamous differentiation were analyzed; the selection was based on those cases with high-grade morphology. The carcinomas were then evaluated immunohistochemically for SMARCB1 and SMARCA4 proteins. Their expression was compared with the biological behavior and survival of the patients. Results: Among the SNSCCs, 47% corresponded to the non-keratinizing squamous cell carcinoma (NKSCC) type with high-grade characteristics, 40% were keratinizing squamous cell carcinomas (KSCCs), 9% were SMARCB1-deficient carcinomas, and 4% were SMARCA4-deficient carcinomas. Mosaic expression for SMARCB1 (NKSCC—33%; KSCC—21.9%) and SMARCA4 (NKSCC—14.6%; KSCC—12.2%) was identified, showing an impact on tumor size and progression. Conclusions: We identified that that the partial loss (mosaic expression) of SMARCB1 in SNSCCs is associated with high-grade malignant characteristics and a negative effect on patient survival; meanwhile, SMARCA4-mosaic expression in SNSCCs is associated with high-grade malignant characteristics and an increase in tumor size concerning the intact SMARCA4. Full article
(This article belongs to the Special Issue Adhesion, Metastasis and Inhibition of Cancer Cells, 2nd Edition)
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