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  • RESEARCH HIGHLIGHT

A selective microbiome-sparing antibiotic

  1. Sarah Crunkhorn
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Most clinically approved antibiotics kill only Gram-positive bacteria, or target both Gram-positive and Gram-negative bacteria. Furthermore, they disrupt the gut microbiome, increasing the risk of colonization of opportunistic infections such as C. difficile. Antibiotics that selectively target pathogenic Gram-negative bacteria are urgently needed.

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Nature Reviews Drug Discovery 23, 581 (2024)

doi: https://doi.org/10.1038/d41573-024-00113-4

References

  1. Muñoz, K. A. et al. A Gram-negative-selective antibiotic that spares the gut microbiome. Nature https://doi.org/10.1038/s41586-024-07502-0 (2024)

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