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Cancer

Astrocytes are enablers of brain metastases

Nature Cell Biology volume 26, pages 1632–1633 (2024)Cite this article

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Circulating tumour cells from primary carcinomas may reach the brain and establish metastases. In the brain parenchyma, tumour cells initiate extensive interactions with resident astrocytes, microglia and neurons, forming a niche where tumour cells can thrive. A new study reveals a previously unknown type of astrocyte–tumour cell interaction.

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Fig. 1: Schematic view of the interplay between astrocytes and tumour cells in brain metastases as compared to extraneural sites.

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Authors and Affiliations

  1. Research Institute of the McGill University Health Centre, Department of Surgery, Faculty of Medicine and Health Sciences, McGill University, Montreal, Quebec, Canada

    Livia Garzia

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  1. Livia Garzia
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Correspondence to Livia Garzia.

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The author declares no competing interests.

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Garzia, L. Astrocytes are enablers of brain metastases. Nat Cell Biol 26, 1632–1633 (2024). https://doi.org/10.1038/s41556-024-01516-6

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