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Senescent stromal fibroblasts in bladder tumors support cancer progression

Nature Aging volume 4, pages 1527–1528 (2024)Cite this article

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Aging is associated with biological processes (such as the accumulation of senescent cells) that are relevant to the development of cancer. Using genetically modified mouse models, we discovered that p16high senescent cells with a secretory phenotype accumulate in the bladder during aging, which leads to cancer progression.

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Fig. 1: Senolysis suppressed transplanted bladder cancer progression and improved survival probability.

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This is a summary of: Meguro, S. et al. Preexisting senescent fibroblasts in the aged bladder create a tumor-permissive niche through CXCL12 secretion. Nat. Aging https://doi.org/10.1038/s43587-024-00704-1 (2024).

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Senescent stromal fibroblasts in bladder tumors support cancer progression. Nat Aging 4, 1527–1528 (2024). https://doi.org/10.1038/s43587-024-00738-5

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