The cGASâSTING cytosolic double-stranded-DNA-sensing pathway provides protection against infection but also contributes to inflammatory pathology and thus must be tightly regulated. In this issue, Jie et al. find that endoplasmic-reticulum-associated degradation of the adaptor STING by SEL1LâHRD1 controls steady-state STING levels to limit STING-driven inflammation.
- Kevin MingJie Gao
- Katherine A. Fitzgerald