Nature

Neuroscience articles from across Nature Portfolio

Neuroscience is a multidisciplinary science that is concerned with the study of the structure and function of the nervous system. It encompasses the evolution, development, cellular and molecular biology, physiology, anatomy and pharmacology of the nervous system, as well as computational, behavioural and cognitive neuroscience.

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Harnessing a brain parasite as a tool for delivery of therapeutics to the brain

Toxoplasma gondii, a eukaryotic brain parasite that infects one in three people worldwide, was engineered to deliver therapeutics to neurons in the mouse brain. This technology opens the door to deliver multiple large proteins that have been undeliverable with previous approaches. Further development, such as vector attenuation, will be necessary for many applications.

News & Views29 Jul 2024 Nature Microbiology
P: 1-2
Mental maps help monkeys to navigate without sensory input

Cognitive maps are internal representations of the external environment. Evidence from monkeys shows that a cognitive map can support the mental navigation of an array of landmarks without sensory input.

News & Views29 Jul 2024 Nature
Complex roles for mitochondrial complexes in microglia

Metabolism impacts various cellular types, and microglia are no exception. Two recent studies in Nature Metabolism demonstrate that impairing the mitochondrial respiratory chain, via deficiencies in complex I or complex III, affects microglia in a highly context-dependent manner.
- Rosa C. Paolicelli
- Stefano Pluchino
News & Views24 Jul 2024 Nature Metabolism
P: 1-3

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Latest Research and Reviews

Low-level brain somatic mutations in exonic regions are collectively implicated in autism with germline mutations in autism risk genes
- Il Bin Kim
- Myeong-Heui Kim
- Jeong Ho Lee
ResearchOpen Access01 Aug 2024 Experimental & Molecular Medicine
P: 1-13
Astrocytic 5-HT_1A receptor mediates age-dependent hippocampal LTD and fear memory extinction in male mice
- Qian-Yun Wu
- Lian-Hong Lin
- Ji-Hong Liu
ResearchOpen Access01 Aug 2024 Experimental & Molecular Medicine
P: 1-13
Therapeutic effects of extinction require hippocampal input and BDNF signaling in IL
- Denisse Paredes
- David A. Morilak
Research31 Jul 2024 Neuropsychopharmacology
P: 1-2
Prevalence and risk factors of self-reported hearing loss, tinnitus, and dizziness in a population-based sample from rural northeastern Germany
- Friedrich Ihler
- Tina Brzoska
- Till Ittermann
ResearchOpen Access31 Jul 2024 Scientific Reports
Volume: 14, P: 17739
Longitudinal study on hippocampal subfields and glucose metabolism in early psychosis
- Reetta-Liina Armio
- Heikki Laurikainen
- Jarmo Hietala
ResearchOpen Access31 Jul 2024 Schizophrenia
Volume: 10, P: 66
Dopamine biases decisions by limiting temporal integration

In Drosophila, dopamine sets motivational state during mating by regulating the integration of competing drives in copulation decision neurons, potentially indicative of a more general role for control over neuronal integration time in the regulation of behavioural decisions.
- Aditya K. Gautham
- Lauren E. Miner
- Michael A. Crickmore
Research31 Jul 2024 Nature
P: 1-8

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News and Comment

Psilocybin desynchronization persists in the human brain

Longitudinal precision functional mapping reveals that acute desynchronization of functional connectivity organization induced by the psychedelic psilocybin can persist long-term in the human brain.
- Jake Rogers
Research Highlights31 Jul 2024 Nature Reviews Neuroscience
P: 1
Reply to: âCorrespondence to bipolar disorder-iPSC derived neural progenitor cells exhibit dysregulation of store-operated Ca²⁺ entry and accelerated differentiationâ by Yde Ohki and colleagues
- Tristen Hewitt
- BegÃ¼m Alural
- Jasmin Lalonde
Correspondence31 Jul 2024 Molecular Psychiatry
P: 1-3
Microglial complex I activity: a crucial factor for smoldering inflammation in the central nervous system
- Jana K. Sonner
- Christina Mayer
- Manuel A. Friese
Research HighlightsOpen Access31 Jul 2024 Signal Transduction and Targeted Therapy
Volume: 9, P: 185
How pregnancy transforms the brain to prepare it for parenthood

Itâs a transformational time long neglected by neuroscience. That is starting to change.
- Liam Drew
News31 Jul 2024 Nature
Volume: 632, P: 22-24
Chimeric brain organoids

An article in Nature reports the generation of human chimeric brain organoids that integrate cells from multiple donors.
- Caroline Beyer
Research Highlights30 Jul 2024 Nature Reviews Bioengineering
P: 1
Variants in a noncoding gene drive prevalent neurodevelopmental disorder

Two studies use large-scale genome sequencing data to identify variants in a noncoding gene that cause a neurodevelopmental syndrome in many individuals.
- Katherine Whalley
Research Highlights29 Jul 2024 Nature Reviews Neuroscience
P: 1

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