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    AGTR2 angiotensin II receptor type 2 [ Homo sapiens (human) ]

    Gene ID: 186, updated on 9-Dec-2024

    Summary

    Official Symbol
    AGTR2provided by HGNC
    Official Full Name
    angiotensin II receptor type 2provided by HGNC
    Primary source
    HGNC:HGNC:338
    See related
    Ensembl:ENSG00000180772 MIM:300034; AllianceGenome:HGNC:338
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AT2; ATGR2; MRX88
    Summary
    The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus and in neonates, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked cognitive disability. Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and SARS-CoV-2 infection results in down-regulation of angiotensin converting enzyme-2 (ACE2) receptors, the effects of which, triggers serious inflammatory lesions in the tissues involved, primarily in the lungs. The inflammatory reaction appears to be mediated by angiotensin II derivatives, including the angiotensin AT2 receptor which has been found to be upregulated in bronchoalveolar lavage samples from Coronavirus disease 2019 (COVID19) patients. [provided by RefSeq, Jul 2020]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is relevant for disease process.
    Expression
    Biased expression in lung (RPKM 5.8), endometrium (RPKM 4.4) and 2 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See AGTR2 in Genome Data Viewer
    Location:
    Xq23
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (116170744..116174974)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (114580328..114584558)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (115301997..115306227)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene aldo-keto reductase family 1 member B1 pseudogene 8 Neighboring gene NANOG hESC enhancer GRCh37_chrX:115236788-115237353 Neighboring gene apoptosis inhibitor 5 pseudogene 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:115376237-115376764 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chrX:115403048-115404247 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:115462947-115463872 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:115465875-115466567 Neighboring gene NANOG hESC enhancer GRCh37_chrX:115467427-115467937 Neighboring gene NANOG hESC enhancer GRCh37_chrX:115506523-115507090 Neighboring gene RNA, U6 small nuclear 154, pseudogene Neighboring gene solute carrier family 6 member 14

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    No evidence available (Last evaluated 2012-05-10)

    ClinGen Genome Curation Page
    Triplosensitivity

    No evidence available (Last evaluated 2012-05-10)

    ClinGen Genome Curation Page

    EBI GWAS Catalog

    Description
    Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables angiotensin type II receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables angiotensin type II receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables angiotensin type II receptor activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables receptor antagonist activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in G protein-coupled receptor signaling pathway IC
    Inferred by Curator
    more info
    PubMed 
    involved_in G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in angiotensin-activated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in blood vessel remodeling TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in brain development NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in brain renin-angiotensin system IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell surface receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in exploration behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of blood vessel endothelial cell migration NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of cell growth TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of heart rate ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of neurotrophin TRK receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nitric oxide-cGMP-mediated signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in nitric oxide-cGMP-mediated signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of branching involved in ureteric bud morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of extrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of metanephric glomerulus development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of blood pressure TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of metanephros size IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of systemic arterial blood pressure by circulatory renin-angiotensin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in vasodilation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IC
    Inferred by Curator
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    type-2 angiotensin II receptor
    Names
    AT2 receptor
    angiotensin II type-2 receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016326.1 RefSeqGene

      Range
      5040..9270
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000686.5NP_000677.2  type-2 angiotensin II receptor isoform 1

      See identical proteins and their annotated locations for NP_000677.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AI911273, AL732602, BC095504, CR738498, DA538369, U16957
      Consensus CDS
      CCDS14569.1
      UniProtKB/Swiss-Prot
      B2R9V1, P50052, Q13016, Q6FGY7
      Related
      ENSP00000360973.4, ENST00000371906.5
      Conserved Domains (1) summary
      cd15191
      Location:45329
      7tmA_AT2R; type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. NM_001385624.1NP_001372553.1  type-2 angiotensin II receptor isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the non-coding region compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL732602
      Consensus CDS
      CCDS14569.1
      UniProtKB/Swiss-Prot
      B2R9V1, P50052, Q13016, Q6FGY7
      Related
      ENSP00000505750.1, ENST00000681852.1
      Conserved Domains (1) summary
      cd15191
      Location:45329
      7tmA_AT2R; type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      116170744..116174974
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      114580328..114584558
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)