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Work and power reduced in L-dopa naïve patients in the early-stages of Parkinson's disease

Arq Neuropsiquiatr. 2016 Apr;74(4):287-92. doi: 10.1590/0004-282X20160014.

Abstract

Studies which have investigated muscular performance during the initial stages of Parkinson's disease (PD) without L-dopa treatments were not found.

Objective: to assess whether muscular performance, work and power, of the trunk and lower limbs in L-dopa naïve patients in the early stages of PD was lower than those of healthy subjects and to compare muscular performance between the lower limbs.

Method: Ten subjects with PD, Hoehn and Yahr (HY) I-II, L-dopa naïve and 10 subjects in the control group were assessed with the isokinetic dynamometer.

Results: ANOVAs revealed that work and power measures of the trunk, hip, knee, and ankle muscular groups were lower in PD compared with the control group (p < 0.05). There were no significant differences in muscular performance between the lower limbs.

Conclusion: The results suggested the use of specific exercises, as rehabilitation strategies, to improve the ability to produce work and power with this population.

MeSH terms

  • Activities of Daily Living
  • Analysis of Variance
  • Antiparkinson Agents / therapeutic use
  • Case-Control Studies
  • Disease Progression
  • Female
  • Humans
  • Levodopa / therapeutic use
  • Lower Extremity / physiopathology
  • Male
  • Middle Aged
  • Motor Activity / physiology
  • Muscle Strength / physiology*
  • Muscle Strength Dynamometer
  • Parkinson Disease / physiopathology*
  • Parkinson Disease / rehabilitation
  • Reference Values
  • Statistics, Nonparametric
  • Time Factors
  • Torso / physiopathology

Substances

  • Antiparkinson Agents
  • Levodopa