Abstract
Vaccine efficacies against typical pertussis after household exposure to Bordetella pertussis were estimated to be 75.4% for an acellular five-component vaccine, 42.4% for an acellular two-component vaccine, and 28.5%, for a licensed US whole cell vaccine, compared to placebo. Logistic regression analyses demonstrated statistically significant correlations between clinical protection and the presence of IgG antibodies against pertactin, fimbriae 2/3 and pertussis toxin in pre-exposure sera. Multicomponent pertussis vaccines of proven high efficacy in recent Swedish NIAID-sponsored efficacy trials induced higher antibody levels against pertactin and fimbriae 2/3 than less efficacious vaccines. Anti-pertactin, anti-fimbriae 2/3, and anti-PT may be used as surrogate markers of protection for multicomponent acellular and whole-cell vaccines against pertussis.
Publication types
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Clinical Trial
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Multicenter Study
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Randomized Controlled Trial
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adhesins, Bacterial / immunology
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Antibodies, Bacterial / blood*
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Antigens, Bacterial / immunology
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Bacterial Outer Membrane Proteins / immunology
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Bacterial Proteins / immunology
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Biomarkers / blood
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Bordetella pertussis / immunology*
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Community-Acquired Infections
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Diphtheria-Tetanus-Pertussis Vaccine / immunology*
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Diphtheria-Tetanus-acellular Pertussis Vaccines
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Enzyme-Linked Immunosorbent Assay
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Female
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Fimbriae Proteins*
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Fimbriae, Bacterial / immunology
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Hemagglutinins / immunology
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Humans
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Immunoglobulin G / analysis
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Infant
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Male
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Nasal Lavage Fluid / microbiology
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Nasopharynx / microbiology
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Pertussis Toxin
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Pertussis Vaccine / immunology*
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Treatment Outcome
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Virulence Factors, Bordetella / immunology
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Whooping Cough / immunology
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Whooping Cough / prevention & control
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Whooping Cough / transmission
Substances
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Adhesins, Bacterial
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Antibodies, Bacterial
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Antigens, Bacterial
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Bacterial Outer Membrane Proteins
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Bacterial Proteins
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Biomarkers
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Diphtheria-Tetanus-Pertussis Vaccine
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Diphtheria-Tetanus-acellular Pertussis Vaccines
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Hemagglutinins
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Immunoglobulin G
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Pertussis Vaccine
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Virulence Factors, Bordetella
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filamentous hemagglutinin adhesin, Bordetella pertussis
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fim2 protein, Bordetella
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Fimbriae Proteins
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pertactin
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Pertussis Toxin