Semyachkina-Glushkovskaya, O.; Postnov, D.; Kurths, J. Blood–Brain Barrier, Lymphatic Clearance, and Recovery: Ariadne’s Thread in Labyrinths of Hypotheses. Int. J. Mol. Sci.2018, 19, 3818.
Semyachkina-Glushkovskaya, O.; Postnov, D.; Kurths, J. Blood–Brain Barrier, Lymphatic Clearance, and Recovery: Ariadne’s Thread in Labyrinths of Hypotheses. Int. J. Mol. Sci. 2018, 19, 3818.
Semyachkina-Glushkovskaya, O.; Postnov, D.; Kurths, J. Blood–Brain Barrier, Lymphatic Clearance, and Recovery: Ariadne’s Thread in Labyrinths of Hypotheses. Int. J. Mol. Sci.2018, 19, 3818.
Semyachkina-Glushkovskaya, O.; Postnov, D.; Kurths, J. Blood–Brain Barrier, Lymphatic Clearance, and Recovery: Ariadne’s Thread in Labyrinths of Hypotheses. Int. J. Mol. Sci. 2018, 19, 3818.
Abstract
The peripheral lymphatic system plays a crucial role in the recovery mechanisms after many pathological changes, such as infection, trauma, vascular, or metabolic diseases. The lymphatic clearance of different tissues from waste products, viruses, bacteria and toxic proteins significantly contributes to the correspondent recovery processes. However, understanding of the meningeal lymphatics functions is a challenging problem. The exploration of mechanisms of lymphatic communication with brain fluids as well as the role of the lymphatic system in the brain drainage, clearance and recovery are still in its infancy.
Here we review novel concepts on the anatomy and physiology of the lymphatics in the brain, which warrant a substantial revision of our knowledge about the role of lymphatics in the rehabilitation of the brain functions after neural pathologies. We discuss a new vision on how to recruit the meningeal lymphatics by the opening of blood-brain barrier as a trigger mechanism of activation of the meningeal lymphatic drainage. This leads to innovative strategies in neurorehabilitation therapy.
Keywords
peripheral and meningeal lymphatics 1; blood-brain barrier 2; neurorehabilitation 3.
Subject
Biology and Life Sciences, Anatomy and Physiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
