Version 1
: Received: 13 August 2020 / Approved: 14 August 2020 / Online: 14 August 2020 (08:56:53 CEST)
Version 2
: Received: 23 November 2020 / Approved: 25 November 2020 / Online: 25 November 2020 (14:47:29 CET)
How to cite:
Wit, J.; Dilks, C.; Andersen, E. Complementary Approaches to Understand Anthelmintic Resistance Using Free-Living and Parasitic Nematodes. Preprints2020, 2020080313. https://doi.org/10.20944/preprints202008.0313.v2
Wit, J.; Dilks, C.; Andersen, E. Complementary Approaches to Understand Anthelmintic Resistance Using Free-Living and Parasitic Nematodes. Preprints 2020, 2020080313. https://doi.org/10.20944/preprints202008.0313.v2
Wit, J.; Dilks, C.; Andersen, E. Complementary Approaches to Understand Anthelmintic Resistance Using Free-Living and Parasitic Nematodes. Preprints2020, 2020080313. https://doi.org/10.20944/preprints202008.0313.v2
APA Style
Wit, J., Dilks, C., & Andersen, E. (2020). Complementary Approaches to Understand Anthelmintic Resistance Using Free-Living and Parasitic Nematodes. Preprints. https://doi.org/10.20944/preprints202008.0313.v2
Chicago/Turabian Style
Wit, J., Clayton Dilks and Erik Andersen. 2020 "Complementary Approaches to Understand Anthelmintic Resistance Using Free-Living and Parasitic Nematodes" Preprints. https://doi.org/10.20944/preprints202008.0313.v2
Abstract
Anthelmintic drugs are the major line of defense against parasitic nematode infections, but the arsenal is limited and resistance threatens sustained efficacy of the available drugs. Discoveries of the modes of action of these drugs and mechanisms of resistance have predominantly come from studies of a related non-parasitic nematode species, Caenorhabditis elegans, and the parasitic nematode Haemonchus contortus. Here, we discuss how our understanding of anthelmintic resistance and modes of action came from the interplay of results from each of these species. We argue that this “cycle of discovery”, where results from one species inform the design of experiments in the other, can use the complementary strengths of both to understand anthelmintic modes of action and mechanisms of resistance.
Keywords
drug resistance; natural diversity; C. elegans; anthelmintics
Subject
Biology and Life Sciences, Animal Science, Veterinary Science and Zoology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received:
25 November 2020
Commenter:
Clayton Dilks
Commenter's Conflict of Interests:
Author
Comment:
We have rewritten the article to more explicitly focus on the cycle of discovery between C. elegans and H. contortus. We have remade the first figure to be more informative and include details of each species advantage. We also removed a large amount of background information and history throughout the review.
Commenter: Clayton Dilks
Commenter's Conflict of Interests: Author