Complementary Approaches to Understand Anthelmintic Resistance Using Free-Living and Parasitic Nematodes

Janneke Wit; Clayton Dilks; Erik Andersen

doi:10.20944/preprints202008.0313.v2

Preprint Review Version 2 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 13 August 2020 / Approved: 14 August 2020 / Online: 14 August 2020 (08:56:53 CEST)
Version 2 : Received: 23 November 2020 / Approved: 25 November 2020 / Online: 25 November 2020 (14:47:29 CET)

Anthelmintic drugs are the major line of defense against parasitic nematode infections, but the arsenal is limited and resistance threatens sustained efficacy of the available drugs. Discoveries of the modes of action of these drugs and mechanisms of resistance have predominantly come from studies of a related non-parasitic nematode species, Caenorhabditis elegans, and the parasitic nematode Haemonchus contortus. Here, we discuss how our understanding of anthelmintic resistance and modes of action came from the interplay of results from each of these species. We argue that this “cycle of discovery”, where results from one species inform the design of experiments in the other, can use the complementary strengths of both to understand anthelmintic modes of action and mechanisms of resistance.

drug resistance; natural diversity; C. elegans; anthelmintics

Biology and Life Sciences, Animal Science, Veterinary Science and Zoology

Comment 1

Received: 25 November 2020
Commenter: Clayton Dilks
Commenter's Conflict of Interests: Author

Comment: We have rewritten the article to more explicitly focus on the cycle of discovery between C. elegans and H. contortus. We have remade the first figure to be more informative and include details of each species advantage. We also removed a large amount of background information and history throughout the review.

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Complementary Approaches to Understand Anthelmintic Resistance Using Free-Living and Parasitic Nematodes

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