PreprintReviewVersion 2Preserved in Portico This version is not peer-reviewed
Copper-Based Antibiotic Strategies: Exploring applications in the hospital setting and the targeting of Cu Regulatory Pathways and Current Drug Design Trends
Version 1
: Received: 27 April 2023 / Approved: 28 April 2023 / Online: 28 April 2023 (05:38:16 CEST)
Version 2
: Received: 23 May 2023 / Approved: 23 May 2023 / Online: 23 May 2023 (08:01:12 CEST)
Orta-Rivera, A.M.; Meléndez-Contés, Y.; Medina-Berríos, N.; Gómez-Cardona, A.M.; Ramos-Rodríguez, A.; Cruz-Santiago, C.; González-Dumeng, C.; López, J.; Escribano, J.; Rivera-Otero, J.J.; Díaz-Rivera, J.; Díaz-Vélez, S.C.; Feliciano-Delgado, Z.; Tinoco, A.D. Copper-Based Antibiotic Strategies: Exploring Applications in the Hospital Setting and the Targeting of Cu Regulatory Pathways and Current Drug Design Trends. Inorganics2023, 11, 252.
Orta-Rivera, A.M.; Meléndez-Contés, Y.; Medina-Berríos, N.; Gómez-Cardona, A.M.; Ramos-Rodríguez, A.; Cruz-Santiago, C.; González-Dumeng, C.; López, J.; Escribano, J.; Rivera-Otero, J.J.; Díaz-Rivera, J.; Díaz-Vélez, S.C.; Feliciano-Delgado, Z.; Tinoco, A.D. Copper-Based Antibiotic Strategies: Exploring Applications in the Hospital Setting and the Targeting of Cu Regulatory Pathways and Current Drug Design Trends. Inorganics 2023, 11, 252.
Orta-Rivera, A.M.; Meléndez-Contés, Y.; Medina-Berríos, N.; Gómez-Cardona, A.M.; Ramos-Rodríguez, A.; Cruz-Santiago, C.; González-Dumeng, C.; López, J.; Escribano, J.; Rivera-Otero, J.J.; Díaz-Rivera, J.; Díaz-Vélez, S.C.; Feliciano-Delgado, Z.; Tinoco, A.D. Copper-Based Antibiotic Strategies: Exploring Applications in the Hospital Setting and the Targeting of Cu Regulatory Pathways and Current Drug Design Trends. Inorganics2023, 11, 252.
Orta-Rivera, A.M.; Meléndez-Contés, Y.; Medina-Berríos, N.; Gómez-Cardona, A.M.; Ramos-Rodríguez, A.; Cruz-Santiago, C.; González-Dumeng, C.; López, J.; Escribano, J.; Rivera-Otero, J.J.; Díaz-Rivera, J.; Díaz-Vélez, S.C.; Feliciano-Delgado, Z.; Tinoco, A.D. Copper-Based Antibiotic Strategies: Exploring Applications in the Hospital Setting and the Targeting of Cu Regulatory Pathways and Current Drug Design Trends. Inorganics 2023, 11, 252.
Abstract
Classical antibacterial drugs were designed to target specific bacterial properties distinct from host human cells to maximize potency and selectivity. These designs were quite effective as they could be easily derivatized to bear next generation drugs. However, the rapid mutation of bacteria and their associated acquired drug resistance have led to the rise of highly pathogenic superbug bacterial strains for which treatment with first line drugs is no match. More than ever, there is a dire need for antibacterial drug design that goes beyond conventional standards. Taking inspiration by the body’s innate immune response to employ its own supply of labile copper ions in a toxic attack against pathogenic bacteria, which have a very low Cu tolerance, this review article examines the feasibility of Cu-centric strategies for antibacterial preventative and therapeutic applications. Promising results are shown for the use of Cu-containing materials in the hospital setting to minimize patient bacterial infections. Studies directed at disrupting bacterial Cu regulatory pathways elucidate new drug targets that can enable toxic increase of Cu levels and perturb bacterial dependence on iron. Likewise, Cu intracellular chelation/prochelation strategies effectively induce bacterial Cu toxicity. Cu-based small molecules and nanoparticles demonstrate the importance of the Cu ions in their mechanism and display potential synergism with classical drugs.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received:
23 May 2023
Commenter:
Arthur Tinoco
Commenter's Conflict of Interests:
Author
Comment:
The title of the manuscript was revised and the text was upated to correct grammatically mistakes and referencing issues. We have also corrected the name of one of the editors.
Commenter: Arthur Tinoco
Commenter's Conflict of Interests: Author