Review
Version 1
Preserved in Portico This version is not peer-reviewed
The Potential Role of Histone Modifications in Glioblastoma Therapy: Review Article.
Version 1
: Received: 19 June 2023 / Approved: 20 June 2023 / Online: 21 June 2023 (03:13:00 CEST)
A peer-reviewed article of this Preprint also exists.
Azab, M.A. The Potential Role of Histone Modifications in Glioblastoma Therapy: Review Article. J. Mol. Pathol. 2023, 4, 196-212. Azab, M.A. The Potential Role of Histone Modifications in Glioblastoma Therapy: Review Article. J. Mol. Pathol. 2023, 4, 196-212.
Abstract
Glioblastoma is considered the most aggressive primary brain tumor. Recurrence after treatment is a significant problem with a failed response to optimal therapies. The recurrence of GBM is linked to different cellular pathways and molecular pathways. Not only genetics are involved in gliomagenesis, but also epigenetics. Epigenetic mechanisms are highly involved in the pathogenesis of GBM. Histone modulation through acetylation, phosphorylation, ubiquitination, and methylation can regulate gene expression and may play a role in the pathogenesis of GBM. Preclinical and clinical studies currently target epigenetic enzymes in gliomas, including a new generation of histone deacetylase (HDAC) inhibitors. Herein, I tried to highlight the current research in glioma epigenetics, focusing on the culprit of histone modifications and the use of HDAC target therapies as a possible treatment line for glioblastoma.
Keywords
glioma; histone; HDAC; therapy
Subject
Medicine and Pharmacology, Oncology and Oncogenics
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Comments (0)
We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.
Leave a public commentSend a private comment to the author(s)
* All users must log in before leaving a comment