Fungi extracellular vesicles:  extraction, cargo, and the immune system response

Marcelo Augusto Kazuo Ikeda; Renato Massis Souza Campos; Jennifer Lacerda Da Silva; Karen Spadari Ferreira

doi:10.20944/preprints202307.1553.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 20 July 2023 / Approved: 21 July 2023 / Online: 24 July 2023 (10:28:58 CEST)

Like other organisms, fungi produce extracellular vesicles (EVs) that are involved in various biological processes, including intercellular communication and the transport of molecules between cells. These EVs can be applied in fungal pathogenesis, virulence, and interactions with other organisms, including host cells, in the case of fungal infections. While some types of mycoses are relatively common and easily treatable, certain neglected mycoses pose significant public health challenges, such as sporotrichosis, chromoblastomycosis, and paracoccidioidomycosis. These infectious diseases can cause significant morbidity and disability, leading to a reduced quality of life for the patients. So, research about the virulence factor is essential to understand how fungi escape the immune system. In this context, this manuscript reviews the study of fungi EVs, their cargo, their obtaining, and their role during the infectious process, which is extremely important for understanding this neglected mycosis.

Extracellular Vesicles, immune response, mycosis

Biology and Life Sciences, Immunology and Microbiology

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Fungi extracellular vesicles: extraction, cargo, and the immune system response

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