Ben, H.; Wang, X.; Yang, P.; Li, L.; Liu, P.; Gao, Y.; Wang, Y.; Liu, Y.; Huang, C.; Chen, D. Metagenomics-Based Discovery of New Hepadnaviruses. Preprints2023, 2023111267. https://doi.org/10.20944/preprints202311.1267.v1
APA Style
Ben, H., Wang, X., Yang, P., Li, L., Liu, P., Gao, Y., Wang, Y., Liu, Y., Huang, C., & Chen, D. (2023). Metagenomics-Based Discovery of New Hepadnaviruses. Preprints. https://doi.org/10.20944/preprints202311.1267.v1
Chicago/Turabian Style
Ben, H., Chunyang Huang and Dexi Chen. 2023 "Metagenomics-Based Discovery of New Hepadnaviruses" Preprints. https://doi.org/10.20944/preprints202311.1267.v1
Abstract
Background: With continuous advances in next-generation sequencing (NGS), novel hepadnaviruses have been discovered in many species over the last 10 years. Methods: In this study, the cloud search and analysis of NGS data published in Nature by Edgar et al. was used as a basis to re-mine and reanalyze public NGS data for new hepadnaviruses. Results: Ultimately, at least 41 new species of hepadnaviruses were identified, including hepadnaviruses from the model animals hamster and mouse, frog hepadnavirus with pan-species infectivity, and diverse African cichlid hepadnaviruses that circulate within populations. Conclusions: The discovery of the new species of hepadnaviruses not only provides new clues for the study of the origin and evolution of hepadnaviruses, but also can be used to construct new hepadnavirus animal infection models, which will be helpful for the research of eradicative drugs for hepatitis B virus (HBV).
Keywords
new hepadnaviruses; hepatitis B virus; animal model; HBV cure; viral infection; metagenomics; next-generation sequencing (NGS)
Subject
Biology and Life Sciences, Virology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.