Takamatsu, T.; Tanaka, H.; Yano, T. Near-Infrared Fluorescence Imaging Sensor with Laser Diffuser for Visualizing Photoimmunotherapy Effects under Endoscopy. Sensors2024, 24, 1487.
Takamatsu, T.; Tanaka, H.; Yano, T. Near-Infrared Fluorescence Imaging Sensor with Laser Diffuser for Visualizing Photoimmunotherapy Effects under Endoscopy. Sensors 2024, 24, 1487.
Takamatsu, T.; Tanaka, H.; Yano, T. Near-Infrared Fluorescence Imaging Sensor with Laser Diffuser for Visualizing Photoimmunotherapy Effects under Endoscopy. Sensors2024, 24, 1487.
Takamatsu, T.; Tanaka, H.; Yano, T. Near-Infrared Fluorescence Imaging Sensor with Laser Diffuser for Visualizing Photoimmunotherapy Effects under Endoscopy. Sensors 2024, 24, 1487.
Abstract
Treatment with tumor-selective photosensitive substances, such as photodynamic therapy and photoimmunotherapy, has been reported to enable the visualization of tumor drug accumulation in real time and identify the required light irradiation dose by fluorescence imaging. However, fluorescence observation is difficult during treatments performed under gastrointestinal endoscopy because of the challenges associated with including the fluorescence filter in the camera part. To address this issue, this study developed a device that integrates a narrow camera and a laser diffuser to enable fluorescence imaging through a forceps port. This device was employed to demonstrate that a laser diffuser with an NIR fluorescence imaging sensor could be delivered through a 3.2-mm-diameter port. In addition, fluorescence images of Cetuximab-IR700 were successfully observed in two mice, and the fluorescence intensity confirmed that the fluorescence decayed within 330 s. This device is expected to have practical application as a tool to identify the optimal irradiation dose for tumor-selective photosensitive substances under endoscopy.
Keywords
NIR fluorescence imaging; Photosensitive substance; Endoscope; in vivo; Forceps port
Subject
Biology and Life Sciences, Life Sciences
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
