Odah, M.A.A. Exploring the Dynamic 3D DNA Structures in Genomics: Towards New Diagnostic and Therapeutic Frontiers. African Research Journal of Medical Sciences 2024, 1, 20–34, doi:10.62587/afrjms.1.2.2024.20-34.
Odah, M.A.A. Exploring the Dynamic 3D DNA Structures in Genomics: Towards New Diagnostic and Therapeutic Frontiers. African Research Journal of Medical Sciences 2024, 1, 20–34, doi:10.62587/afrjms.1.2.2024.20-34.
Odah, M.A.A. Exploring the Dynamic 3D DNA Structures in Genomics: Towards New Diagnostic and Therapeutic Frontiers. African Research Journal of Medical Sciences 2024, 1, 20–34, doi:10.62587/afrjms.1.2.2024.20-34.
Odah, M.A.A. Exploring the Dynamic 3D DNA Structures in Genomics: Towards New Diagnostic and Therapeutic Frontiers. African Research Journal of Medical Sciences 2024, 1, 20–34, doi:10.62587/afrjms.1.2.2024.20-34.
Abstract
The exploration of three-dimensional (3D) DNA structures marks a pivotal shift in genomics, offering unprecedented insights into the intricacies of cellular regulation, disease genesis, and the potential for novel diagnostic and therapeutic strategies. This study delves into the dynamic nature of 3D genome organization, investigating how these structures influence cellular functions in response to environmental changes and over time. Through a combination of real-time imaging and advanced computational models, we aim to unravel the complex interplay between 3D DNA structures, non-coding RNAs, and chromatin organization, and their collective impact on gene expression and cellular differentiation. A significant focus is placed on understanding the role of 3D DNA structures in the development and progression of genetic disorders. By employing comprehensive genomic and epigenomic profiling, this research seeks to identify structural aberrations linked to diseases, paving the way for the development of targeted diagnostics and therapies. Additionally, the study explores the potential of genome editing technologies, such as CRISPR-Cas systems, in correcting these structural abnormalities, while also addressing the ethical, legal, and social implications (ELSI) of such interventions. Integrating data from various genomic analyses, we propose the development of advanced computational models to predict the effects of 3D DNA structures on gene expression and cellular function. This integrative approach not only promises to enhance our understanding of genomic regulation but also sets the stage for groundbreaking advances in genomics-based diagnostics and therapeutics. The findings of this study have the potential to revolutionize our approach to treating genetic disorders, offering a new frontier in personalized medicine.
Keywords
3D DNA Structures; Genome Editing (CRISPR-Cas); Genomic Regulation; Genetic Disorders; Computational Genomics; Non-coding RNA Interactions; Ethical, Legal, and Social Implications (ELSI)
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
