Daratumumab Post Maintenance after Relapse in Multiple Myeloma

ROBERTO OVILLA MARTINEZ; JOSE ANTONIO DE LA PEÑA CELAYA; NISHALLE RAMIREZ MUÑIZ; PAMELA BAEZ ISLAS; XOCHITL COTA RANGEL; MARTHA ALVARADO IBARRA

doi:10.20944/preprints202406.1349.v1

Preprint Case Report Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 19 June 2024 / Approved: 19 June 2024 / Online: 19 June 2024 (11:55:41 CEST)

We present 4 cases of patients diagnosed with multiple myeloma initially treated without monoclonal antibodies. It was decided to provide the benefit of the drug after maintenance with lenalidomide was initiated to consolidate the post-maintenance response followed by monitoring without any kind of treatment. In this series of 4 cases 100% of the patients achieved a strict complete response with undetectable Minimal Residual Disease (MRD) for flow cytometry after post-maintenance consolidation with daratumumab regardless of the scheme used as induction/consolidation, as well as whether they had received HSCT. Until the last follow-up the patients are under surveillance with no evidence of progression. It should be noted that 3 of 4 of these patients debuted with high-risk disease.

Daratumumab, multiple myeloma, treatment, maintenance

Medicine and Pharmacology, Hematology

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Daratumumab Post Maintenance after Relapse in Multiple Myeloma

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