Jaleta OG, Jebessa H. 2018. The impact of large scale agriculture on forest and wildlife in Diga Woreda, Western Ethiopia. Asian J Agric 1: 100-113. Large-scale agriculture uses agricultural machinery to mechanize the practices of agriculture. It is one of the leading causes of the loss of forest and wildlife in many countries including our country, Ethiopia. Information on forest cover change that occurred from 1986 to 2006 in Diga Woreda/district (Woyessa Dimtu, Bekiltu Gudina, and Melka Beti Jirma Kebeles) was compared with the present time using Geographic Information System (GIS). The objective of this study was to investigate the impact of large-scale agriculture on forest cover change by using the satellite image of the study area and other data collecting methods such as household's interview, KI, FGD and observation (survey) to detect its effect on wildlife. The study employed both qualitative and quantitative data as well as primary and secondary data sources to collect necessary information. The information providers were purposively selected from sample ‘kebeles' based on their age and experiences, that is, to get a detail and accurate information elders and experts who have lived in the area for many years and who know more how and when the Hanger-Didessa state farm had established were selected. The state farm covered a large area, that is, about four districts such as Sasiga, Diga, Arjo and Guto Gida. For this study, Diga was selected because of its socio-economic characteristics, deforested (degraded) area, local loss of larger mammals and forest cover changes observed in the district. The descriptive research method was used to assess community's knowledge, perception, skill, and feeling about the impact of Local Study Area (LSA) on forest and wildlife in the area. Land cover change analysis for 1986 to 2006 showed that the land cover of the study area is classified as grazing, wood, agricultural, settlement and degraded lands. The result of the analysis showed that agriculture, settlement and degraded lands increased from 19.68% to 32.72%, 12.12% to 26.85% and 2.76% to 4.72% respectively in an expense of a decrease in the grass (grazing) and woodlands. Therefore, LSA is the primary cause for the loss of forest and wildlife in the study area.