Data on 17 rare species of noctuids (Noctuidae) in the fauna of the Republic of Moldova are given in the present paper. The investigations were carried out during 2012-2020 in 26 sites throughout the Republic of Moldova. The genus Actebia Stephens, 1829 and the species Actebia praecox (Linnaeus, 1758) and Xylena solidaginis (Hübner, 1803) are reported as new for the fauna of the Republic of Moldova. Thus, the number of noctuid species in the fauna of the Republic of Moldova reached 427. The species: Acontia titania (Esper, 1798), Aedophron rhodites (Eversmann, 1851), Periphanes delphinii (Linnaeus, 1758), Eucarta amethystina (Hübner, 1803), Dasypolia temples (Thunberg, 1792), Oxytripia orbiculosa (Esper, 1799), Euxoa cos (Hübner, 1824), Gortyna cervago (Eversmann, 1844), Meganephria bimaculosa (Linnaeus, 1758) and Cucullia argentea (Hufnagel, 1766) needs protection and conservation, so it is recommended according to IUCN criteria to be included in the next edition of the Red Book of the Republic of Moldova and the elaboration of concrete management measures.