Wine grapes are an important agricultural commodity in the Pacific Northwest where grape powdery mildew (GPM) is one of the main disease problems. The efficacy of different sulfur concentrations and different output volumes from an air blast sprayer retrofitted with the Intelligent Spray System (ISS) were evaluated for the management of GPM. The ISS consists of a LiDAR sensor, Doppler speed sensor, embedded computer, flow controller, and individual pulse-width-modulation solenoid valves at each nozzle. GPM cluster severity ranged from 55% to 75% across all trials in the study when using the ISS at its default spray rate of 62.5 ml m-3 and micronized sulfur at 6 g L-1, which was significantly higher than all other fungicide treatments, but lower than non-treated controls. Similarly, leaf incidence values were highest on non-treated vines, followed by micronized sulfur at 6 g L-1 applied at 62.5 ml m-3 , with all other fungicide treatments being significantly lower in all trials. Using the ISS at the 62.5 ml m-3 rate and a rotation of locally systemic fungicides resulted in the lowest observed GPM leaf incidence, and average cluster severity of 11% in both 2019 and 2020, the lowest cluster severity of all fungicide treatments tested. GPM control using the ISS and micronized sulfur was equivalent to a constant-rate air blast treatment at 6 g L-1 when the spray rate of the ISS was increased to 125ml m-3, or if the concentration of sulfur was increased to 24 g L-1. In those cases, the amount of sulfur applied to vines was at or above the minimum label rate from bloom until the end of the season, or the entire season, respectively. This study has shown that sufficient disease control cannot always be expected when mixing pesticides at the same rate as would be used for a constant-rate sprayer in a variable rate sprayer, especially when using contact fungicides like sulfur . With appropriate adjustments, the variable-rate ISS can be a useful tool to reduce pesticide quantities, water required for mixing, and as a result labor, as fewer trips to refill for a given spray event are required.