Diazepam
Diazepam
Diazepam
Name of Drug
Generic: diazepam
Mechanism of Action
Depresses the CNS, probably by potentiating GABA, an inhibitory neurotransmitter. Produces skeletal muscle relaxation by inhibiting spinal polysynaptic afferent pathways. Has anticonvulsant properties due to enhanced presynaptic inhibition. Therapeutic Effects: Relief of anxiety. Sedation. Amnesia. Skeletal muscle relaxation. Decreased seizure activity.
Indication
Adjunct in the management of: Anxiety Disorder. Athetosis, Anxiety relief prior to cardioversion( injection), Stiffman Syndrome, Preoperative sedation, Conscious sedation (provides light anesthesia and anterograde amnesia). Treatment of status epilepticus/uncontrolled seizures (injection). Skeletal muscle relaxant.Management impair ofthe symptoms of alcohol withdrawal.
Side Effects
CNS: dizziness, drowsiness, lethargy
Special Precautions
Hepatic dysfunction; Severe renal impairment; Severe pulmonary impairment; History of suicide attempt or drug dependence; Debilitated patients (dose reduction required); Patients with low albumin
Brand:
Valium
PO (Adults): 210 mg 24 times daily IM, IV (Adults): 210 mg, may repeat in 34 hrs as needed PO (Children >1 mo): 0.12 0.8 mg/kg/day 34 times daily IM,IV (Children >1mo): 0.040.3mg/kg/ dose q 24 hr to amaximumof 0.6mg/kg with in an 8 hr period if necessary
Contraindication
Hypersensitivity; Cross sensitivity with other benzodiazepinesmay occur; Comatose patients; Pre-existing CNS depression; Uncontrolled severe pain; Angleclosure glaucoma; Pregnancy or lactation; Some products contain alcohol, propylene glycol, or tartrazine and should be avoided in patients with known hypersensitivity or intolerance
Adverse Effects
Classification
Therapeutic: antianxiety agents, anticonvulsants, sedative/hypnotics, skeletal muscle relaxants (centrally acting) Pharmacologic: benzodiazepines