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Diazepam

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St.

Anthonys College Nursing Department San Jose, Antique


DRUG STUDY Nursing Responsibilities
Monitor blood pressure, pulse, and respiratory rate prior to and periodically throughout therapy and frequently during IV therapy Assess IV site frequently during administration; diazepam may cause phlebitis and venous thrombosis Patient should be kept on bedrest and observed for at least 3 hr following parenteral administration

Name of Drug
Generic: diazepam

Dose, Route, Freq.,


Antianxiety

Mechanism of Action
Depresses the CNS, probably by potentiating GABA, an inhibitory neurotransmitter. Produces skeletal muscle relaxation by inhibiting spinal polysynaptic afferent pathways. Has anticonvulsant properties due to enhanced presynaptic inhibition. Therapeutic Effects: Relief of anxiety. Sedation. Amnesia. Skeletal muscle relaxation. Decreased seizure activity.

Indication
Adjunct in the management of: Anxiety Disorder. Athetosis, Anxiety relief prior to cardioversion( injection), Stiffman Syndrome, Preoperative sedation, Conscious sedation (provides light anesthesia and anterograde amnesia). Treatment of status epilepticus/uncontrolled seizures (injection). Skeletal muscle relaxant.Management impair ofthe symptoms of alcohol withdrawal.

Side Effects
CNS: dizziness, drowsiness, lethargy

Special Precautions
Hepatic dysfunction; Severe renal impairment; Severe pulmonary impairment; History of suicide attempt or drug dependence; Debilitated patients (dose reduction required); Patients with low albumin

Brand:
Valium

PO (Adults): 210 mg 24 times daily IM, IV (Adults): 210 mg, may repeat in 34 hrs as needed PO (Children >1 mo): 0.12 0.8 mg/kg/day 34 times daily IM,IV (Children >1mo): 0.040.3mg/kg/ dose q 24 hr to amaximumof 0.6mg/kg with in an 8 hr period if necessary

Contraindication
Hypersensitivity; Cross sensitivity with other benzodiazepinesmay occur; Comatose patients; Pre-existing CNS depression; Uncontrolled severe pain; Angleclosure glaucoma; Pregnancy or lactation; Some products contain alcohol, propylene glycol, or tartrazine and should be avoided in patients with known hypersensitivity or intolerance

Adverse Effects

Classification
Therapeutic: antianxiety agents, anticonvulsants, sedative/hypnotics, skeletal muscle relaxants (centrally acting) Pharmacologic: benzodiazepines

Student: Frances Stephanie P. Pe, SN CI :

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