Traumatic Brain Injury

Avy ramos

Brain anatomy

Definition
Traumatic brain injury (TBI) is damage to the brain caused by a blow to the head. The severity of the injury may range from minor, with few or no lasting consequences, to major, resulting in profound disability or death.

Epidemiology
High incidence relative to other neurologic d/o Highest among males Peak risk is among young adult males between 18-24 yrs old Smaller peaks of TBI risk in the pediatric and geriatric age bracket Causes 50% MVA 25% Fall 15% Assault 10% Sports

Epidemiology

Pathophysiology
PRIMARY BRAIN INJURY Result of an acceleration and deceleration force Resulting damage from skull fractures, contusion of the gray matter and diffuse white matter lesion Local or focal brain damage
Laceration Hematoma herniation Contusion Concussion

Diffuse axonal injury

SECONDARY BRAIN INJURY

Mechanism of injury
1. Open Head Injury Results from bullet wounds, etc. Largely focal damage Penetration of the skull Effects can be just as serious as closed brain injury 2. Closed Head Injury Resulting from a slip and fall, motor vehicle crashes, etc. Focal damage and diffuse damage to axons Effects tend to be broad (diffuse) No penetration to the skull

Mechanism of injury
3. Deceleration Injuries (Diffuse Axonal Injury) The skull is hard and inflexible while the brain is soft with the consistency of gelatin. The brain is encased inside the skull. During the movement of the skull through space (acceleration) and the rapid discontinuation of this action when the skull meets a stationary object (deceleration) causes the brain to move inside the skull. The brain moves at a different rate than the skull because it is soft. Different parts of the brain move at different speeds because of their relative lightness or heaviness. The differential movement of the skull and the brain when the head is struck results in direct brain injury, due to diffuse axonal shearing, contusion and brain swelling. Diffuse axonal shearing: when the brain is slammed back and forth inside the skull it is alternately compressed and stretched because of the gelatinous consistency. The long, fragile axons of the neurons (single nerve cells in the brain and spinal cord) are also compressed and stretched. If the impact is strong enough, axons can be stretched until they are torn. This is called axonal shearing. When this happens, the neuron dies. After a severe brain injury, there is massive axonal shearing and neuron death.

DAI

Mechanism of injury
4. Chemical / Toxic Also known as metabolic disorders This occurs when harmful chemicals damage the neurons Chemicals and toxins can include insecticides, solvents, carbon monoxide poisoning, lead poisoning, etc. 5. Hypoxia (Lack of Oxygen) If the blood flow is depleted of oxygen, then irreversible brain injury can occur from anoxia (no oxygen) or hypoxia (reduced oxygen) It may take only a few minutes for this to occur This condition may be caused by heart attacks, respiratory failure, drops in blood pressure and a low oxygen environment This type of brain injury can result in severe cognitive and memory deficits

Mechanism of injury
6. Tumors Tumors caused by cancer can grow on or over the brain Tumors can cause brain injury by invading the spaces of the brain and causing direct damage Damage can also result from pressure effects around an enlarged tumor Surgical procedures to remove the tumor may also contribute to brain injury 7. Infection The brain and surrounding membranes are very prone to infections if the special blood-brain protective system is breached Viruses and bacteria can cause serious and life-threatening diseases of the brain (encephalitis) and meninges (meningitis)

Mechanism of injury
8. Stroke If blood flow is blocked through a cerebral vascular accident (stroke), cell death in the area deprived of blood will result If there is bleeding in or over the brain (hemorrhage or hematoma) because of a tear in an artery or vein, loss of blood flow and injury to the brain tissue by the blood will also result in brain damage

Severity of TBI
GCS 13-15 9-12 3-8 PTA < 1 DAY >1 TO <7 DAYS >7DAYS LOC 0-30 MINS >30MINS BUT<24HRS >24HRS

DIAGNOSIS
Glasgow Coma Scale I. Motor Response 6 - Obeys commands fully 5 - Localizes to noxious stimuli 4 - Withdraws from noxious stimuli 3 - Abnormal flexion, i.e. decorticate posturing 2 - Extensor response, i.e. decerebrate posturing 1 - No response II. Verbal Response 5 - Alert and Oriented 4 - Confused, yet coherent, speech 3 - Inappropriate words and jumbled phrases consisting of words 2 - Incomprehensible sounds 1 - No sounds III. Eye Opening 4 - Spontaneous eye opening 3 - Eyes open to speech 2 - Eyes open to pain 1 - No eye opening

DIAGNOSIS
Ranchos Los Amigos Scale Level I: No Response Level II: Generalized Response Level III: Localized Response Level IV: Confused-agitated Level V: Confused-inappropriate Level VI: Confused-appropriate Level VII: Automatic-appropriate Level VIII: Purposeful-appropriate

DIAGNOSIS
A detailed neurological examination is important and will bring out evidence of brain injury. Brain imaging with CAT scan, MRI, SPECT and PET scan may be useful. Cognitive evaluation by a Neuropsychologist with formal neuropsychological testing. Evaluations by physical, occupational and speech therapists help clarify the specific deficits of an individual

DIAGNOSIS
AngiogramA test to examine blood vessels in the brain. It involves injecting dye into an artery supplying blood to the brain, usually by means of a catheter inserted in the groin. The test takes 1 to 3 hours. ICP MonitorA device used to measure intracranial pressure (pressure within the brain). It consists of a small tube, placed into or on top of the brain through a small hole in the skull, connected to a transducer that registers the pressure. EEG (electroencephalograph)A test to measure electrical activity in the brain. It uses electrodes, in the form of patches, applied to the head. This painless procedure can be done at bedside or in a hospital's EEG department. The duration of the test varies.

Signs And Symptoms

Blurry or double vision (diplopia) Depression Difficulty concentrating or thinking Difficulty finding words or understanding the speech of others (aphasia) Difficulty swallowing (dysphagia) Dizziness Headache Incoordination of movements Lightheadedness Loss of balance; difficulty walking or sitting Loss of memory Muscle stiffness and/or spasms

Medical Mx
Acuteto stabilize the patient immediately after the injury; Subacuteto rehabilitate and return the patient to the community; and Chronicto continue rehabilitation and treat the long-term impairments.

Medical management

DIFFERENTIAL Dx

PROGNOSIS
Duration of coma Severity of coma in the first few hours after the injury (as measured by the Glasgow Coma Score) Duration of post-traumatic amnesia (PTA) Location and size of contusions and hemorrhages in the brain Severity of injuries to other body systems sustained at the time of the TBI