BIOLOGICAL SCIENCE

PAUL B. DORONILA

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BIOLOGY
BIOLOGY IS A NATURAL SCIENCE CONCERNED WITH THE STUDY OF LIFE AND LIVING ORGANISMS, INCLUDING THEIR STRUCTURE, FUNCTION, GROWTH, EVOLUTION, DISTRIBUTION, AND TAXONOMY. BIOLOGY HAS MANY SUBDISCIPLINES UNIFIED BY FIVE SO-CALLED AXIOMS OF MODERN BIOLOGY: 1. CELLS ARE THE BASIC UNIT OF LIFE 2. GENES ARE THE BASIC UNIT OF HEREDITY 3. NEW SPECIES AND INHERITED TRAITS ARE THE PRODUCT OF EVOLUTION

4. AN ORGANISM REGULATES ITS INTERNAL ENVIRONMENT TO MAINTAIN A STABLE AND CONSTANT CONDITION
5. LIVING ORGANISMS CONSUME AND TRANSFORM ENERGY

SUBDISCIPLINES OF BIOLOGY
ARE DEFINED BY THE SCALE AT WHICH ORGANISMS ARE STUDIED AND THE METHODS USED TO STUDY THEM: BIOCHEMISTRY EXAMINES THE RUDIMENTARY CHEMISTRY OF LIFE;

MOLECULAR BIOLOGY STUDIES THE COMPLEX INTERACTIONS AMONG BIOLOGICAL MOLECULES;

CELLULAR BIOLOGY EXAMINES THE BASIC BUILDING BLOCK OF ALL LIFE, THE CELL; PHYSIOLOGY EXAMINES THE PHYSICAL AND CHEMICAL FUNCTIONS OF TISSUES, ORGANS, AND ORGAN SYSTEMS OF AN ORGANISM; EVOLUTIONARY BIOLOGY EXAMINES THE PROCESSES THAT PRODUCED THE DIVERSITY OF LIFE; AND ECOLOGY EXAMINES HOW ORGANISMS INTERACT IN THEIR ENVIRONMENT.

HISTORY: BIOLOGY
THE TERM BIOLOGY IS DERIVED FROM THE GREEK WORD , BIOS, "LIFE" AND THE SUFFIX -, -LOGIA, "STUDY OF." THE LATIN FORM OF THE TERM FIRST APPEARED IN 1736 WHEN LINNAEUS (CARL VON LINN) USED BIOLOGI IN HIS BIBLIOTHECA BOTANICA. IT WAS USED AGAIN IN 1766 IN A WORK ENTITLED PHILOSOPHIAE NATURALIS SIVE PHYSICAE: TOMUS III, CONTINENS GEOLOGIAN, BIOLOGIAN, PHYTOLOGIAN GENERALIS, BY MICHAEL CHRISTOPH HANOV, A DISCIPLE OF CHRISTIAN WOLFF.

 THE FIRST GERMAN USE, BIOLOGIE, WAS USED IN A 1771 TRANSLATION OF LINNAEUS' WORK. IN 1797, THEODOR GEORG AUGUST ROOSE USED THE TERM IN A BOOK, GRUNDZGE DER LEHRE VAN DER LEBENSKRAFT, IN THE PREFACE. KARL FRIEDRICH BURDACH USED THE TERM IN 1800 IN A MORE RESTRICTED SENSE OF THE STUDY OF HUMAN BEINGS FROM A MORPHOLOGICAL, PHYSIOLOGICAL AND PSYCHOLOGICAL PERSPECTIVE (PROPDEUTIK ZUM STUDIEN DER GESAMMTEN HEILKUNST).

THE TERM CAME INTO ITS MODERN USAGE WITH THE SIX-VOLUME TREATISE BIOLOGIE, ODER PHILOSOPHIE DER LEBENDEN NATUR (180222) BY GOTTFRIED REINHOLD TREVIRANUS, WHO ANNOUNCED:

THE OBJECTS OF OUR RESEARCH WILL BE THE DIFFERENT FORMS AND MANIFESTATIONS OF LIFE, THE CONDITIONS AND LAWS UNDER WHICH THESE PHENOMENA OCCUR, AND THE CAUSES THROUGH WHICH THEY HAVE BEEN EFFECTED. THE SCIENCE THAT CONCERNS ITSELF WITH THESE OBJECTS WE WILL INDICATE BY THE NAME BIOLOGY [BIOLOGIE] OR THE DOCTRINE OF LIFE [LEBENSLEHRE].

HISTORY: MODERN BIOLOGY

MODERN BIOLOGY IS A RELATIVELY RECENT DEVELOPMENT, SCIENCES RELATED TO AND INCLUDED WITHIN IT HAVE BEEN STUDIED SINCE ANCIENT TIMES. NATURAL PHILOSOPHY WAS STUDIED AS EARLY AS THE ANCIENT CIVILIZATIONS OF MESOPOTAMIA, EGYPT, THE INDIAN SUBCONTINENT, AND CHINA. HOWEVER, THE ORIGINS OF MODERN BIOLOGY AND ITS APPROACH TO THE STUDY OF NATURE ARE MOST OFTEN TRACED BACK TO ANCIENT GREECE.

 THE FORMAL STUDY OF MEDICINE DATES BACK TO HIPPOCRATES (CA. 460 BC CA. 370 BC), IT WAS ARISTOTLE (384 BC 322 BC) WHO CONTRIBUTED MOST EXTENSIVELY TO THE DEVELOPMENT OF BIOLOGY. ESPECIALLY IMPORTANT ARE HIS HISTORY OF ANIMALS AND OTHER WORKS WHERE HE SHOWED NATURALIST LEANINGS, AND LATER MORE EMPIRICAL WORKS THAT FOCUSED ON BIOLOGICAL CAUSATION AND THE DIVERSITY OF LIFE. ARISTOTLE'S SUCCESSOR AT THE LYCEUM, THEOPHRASTUS, WROTE A SERIES OF BOOKS ON BOTANY THAT SURVIVED AS THE MOST IMPORTANT CONTRIBUTION OF ANTIQUITY TO THE PLANT SCIENCES, EVEN INTO THE MIDDLE AGES.

SCHOLARS OF THE MEDIEVAL ISLAMIC WORLD WHO WROTE ON BIOLOGY INCLUDED AL-JAHIZ (781869), AL-DINAWARI (828896), WHO WROTE ON BOTANY, AND RHAZES (865925) WHO WROTE ON ANATOMY AND PHYSIOLOGY. MEDICINE WAS ESPECIALLY WELL STUDIED BY ISLAMIC SCHOLARS WORKING IN GREEK PHILOSOPHER TRADITIONS, NATURAL HISTORY DREW HEAVILY ON ARISTOTELIAN THOUGHT, ESPECIALLY IN UPHOLDING A FIXED HIERARCHY OF LIFE.

HISTORY: MICROSCOPE
BIOLOGY BEGAN TO QUICKLY DEVELOP AND GROW WITH ANTONY VAN LEEUWENHOEK'S IMPROVEMENT OF THE MICROSCOPE. IT WAS THEN THAT SCHOLARS DISCOVERED SPERMATOZOA, BACTERIA, INFUSORIA AND THE DIVERSITY OF MICROSCOPIC LIFE. INVESTIGATIONS BY JAN SWAMMERDAM LED TO NEW INTEREST IN ENTOMOLOGY AND HELPED TO DEVELOP THE BASIC TECHNIQUES OF MICROSCOPIC DISSECTION AND STAINING. ADVANCES IN MICROSCOPY ALSO HAD A PROFOUND IMPACT ON BIOLOGICAL THINKING.

HISTORY: CELL THEORY

IN THE EARLY 19TH CENTURY, A NUMBER OF BIOLOGISTS POINTED TO THE CENTRAL IMPORTANCE OF THE CELL. IN 1838, SCHLEIDEN AND SCHWANN BEGAN PROMOTING THE NOW UNIVERSAL IDEAS THAT (1) THE BASIC UNIT OF ORGANISMS IS THE CELL AND (2) THAT INDIVIDUAL CELLS HAVE ALL THE CHARACTERISTICS OF LIFE, ALTHOUGH THEY OPPOSED THE IDEA THAT

(3) ALL CELLS COME FROM THE DIVISION OF OTHER CELLS.

THE WORK OF ROBERT REMAK AND RUDOLF VIRCHOW, HOWEVER, BY THE 1860S MOST BIOLOGISTS ACCEPTED ALL THREE TENETS OF WHAT CAME TO BE KNOWN AS CELL THEORY.

HISTORY: EVOLUTION THEORY

TAXONOMY AND CLASSIFICATION BECAME THE FOCUS OF NATURAL HISTORIANS. CARL LINNAEUS PUBLISHED A BASIC TAXONOMY FOR THE NATURAL WORLD IN 1735 (VARIATIONS OF WHICH HAVE BEEN IN USE EVER SINCE), AND IN THE 1750S INTRODUCED SCIENTIFIC NAMES FOR ALL HIS SPECIES. GEORGES-LOUIS LECLERC, COMTE DE BUFFON, TREATED SPECIES AS ARTIFICIAL CATEGORIES AND LIVING FORMS AS MALLEABLEEVEN SUGGESTING THE POSSIBILITY OF COMMON DESCENT. THOUGH HE WAS OPPOSED TO EVOLUTION, BUFFON IS A KEY FIGURE IN THE HISTORY OF EVOLUTIONARY THOUGHT; HIS WORK INFLUENCED THE EVOLUTIONARY THEORIES OF BOTH LAMARCK AND DARWIN.

SERIOUS EVOLUTIONARY THINKING ORIGINATED WITH THE WORKS OF JEAN-BAPTISTE LAMARCK, WHO WAS THE FIRST TO PRESENT A COHERENT THEORY OF EVOLUTION. HE POSITED THAT EVOLUTION WAS THE RESULT OF ENVIRONMENTAL STRESS ON PROPERTIES OF ANIMALS, MEANING THAT THE MORE FREQUENTLY AND RIGOROUSLY AN ORGAN WAS USED, THE MORE COMPLEX AND EFFICIENT IT WOULD BECOME, THUS ADAPTING THE ANIMAL TO ITS ENVIRONMENT. LAMARCK BELIEVED THAT THESE ACQUIRED TRAITS COULD THEN BE PASSED ON TO THE ANIMAL'S OFFSPRING, WHO WOULD FURTHER DEVELOP AND PERFECT THEM.

 IT WAS THE BRITISH NATURALIST CHARLES DARWIN, COMBINING THE BIOGEOGRAPHICAL APPROACH OF HUMBOLDT, THE UNIFORMITARIAN GEOLOGY OF LYELL, MALTHUS'S WRITINGS ON POPULATION GROWTH, AND HIS OWN MORPHOLOGICAL EXPERTISE AND EXTENSIVE NATURAL OBSERVATIONS, WHO FORGED A MORE SUCCESSFUL EVOLUTIONARY THEORY BASED ON NATURAL SELECTION; SIMILAR REASONING AND EVIDENCE LED ALFRED RUSSEL WALLACE TO INDEPENDENTLY REACH THE SAME CONCLUSIONS.

ALTHOUGH IT WAS THE SUBJECT OF CONTROVERSY (WHICH CONTINUES TO THIS DAY), DARWIN'S THEORY QUICKLY SPREAD THROUGH THE SCIENTIFIC COMMUNITY AND SOON BECAME A CENTRAL AXIOM OF THE RAPIDLY DEVELOPING SCIENCE OF BIOLOGY.

HISTORY: HEREDITY
THE DISCOVERY OF THE PHYSICAL REPRESENTATION OF HEREDITY CAME ALONG WITH EVOLUTIONARY PRINCIPLES AND POPULATION GENETICS. IN THE 1940S AND EARLY 1950S, EXPERIMENTS POINTED TO DNA AS THE COMPONENT OF CHROMOSOMES THAT HELD THE TRAIT-CARRYING UNITS THAT HAD BECOME KNOWN AS GENES. A FOCUS ON NEW KINDS OF MODEL ORGANISMS SUCH AS VIRUSES AND BACTERIA, ALONG WITH THE DISCOVERY OF THE DOUBLE HELICAL STRUCTURE OF DNA IN 1953, MARKED THE TRANSITION TO THE ERA OF MOLECULAR GENETICS. FROM THE 1950S TO PRESENT TIMES, BIOLOGY HAS BEEN VASTLY EXTENDED IN THE MOLECULAR DOMAIN.

 THE GENETIC CODE WAS CRACKED BY HAR GOBIND KHORANA, ROBERT W. HOLLEY AND MARSHALL WARREN NIRENBERG AFTER DNA WAS UNDERSTOOD TO CONTAIN CODONS.

FINALLY, THE HUMAN GENOME PROJECT WAS LAUNCHED IN 1990 WITH THE GOAL OF MAPPING THE GENERAL HUMAN GENOME. THIS PROJECT WAS ESSENTIALLY COMPLETED IN 2003, WITH FURTHER ANALYSIS STILL BEING PUBLISHED.
THE HUMAN GENOME PROJECT WAS THE FIRST STEP IN A GLOBALIZED EFFORT TO INCORPORATE ACCUMULATED KNOWLEDGE OF BIOLOGY INTO A FUNCTIONAL, MOLECULAR DEFINITION OF THE HUMAN BODY AND THE BODIES OF OTHER ORGANISMS.