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    Causes of Thyrotoxicosis

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    khadzx
    Thyrotoxicosis without hyperthyroidism: Sub acute thyroiditis, Silent thyroiditis. Iatrogenic: Activating mutation of the TSH receptor (mccunealbright syndrome) iodine excess, radiation, infarction of adenoma, excess thyroid hormone.

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    Causes of Thyrotoxicosis

    Uploaded by

    khadzx
    607 views2 pages
    Thyrotoxicosis without hyperthyroidism: Sub acute thyroiditis, Silent thyroiditis. Iatrogenic: Activating mutation of the TSH receptor (mccunealbright syndrome) iodine excess, radiation, infarction of adenoma, excess thyroid hormone.

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    Thyrotoxicosis without hyperthyroidism: Sub acute thyroiditis, Silent thyroiditis. Iatrogenic: Activating mutation of the TSH receptor (mccunealbright syndrome) iodine excess, radiation, infarction of adenoma, excess thyroid hormone.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
    Download as doc, pdf, or txt
    607 views2 pages

    Causes of Thyrotoxicosis

    Uploaded by

    khadzx
    Thyrotoxicosis without hyperthyroidism: Sub acute thyroiditis, Silent thyroiditis. Iatrogenic: Activating mutation of the TSH receptor (mccunealbright syndrome) iodine excess, radiation, infarction of adenoma, excess thyroid hormone.

    Copyright:

    Attribution Non-Commercial (BY-NC)
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    of 2

    Causes of thyrotoxicosis Causes of Hypothyroidism

    A.Primary hyperthyroidism A.Primary Hypothyroidism


    1) Graves' disease 1) Autoimmune hypothyroidism:
    2) Toxic multinodular goiter  Hashimoto's thyroiditis
    3) Toxic adenoma  Atrophic thyroiditis
    4) Functioning thyroid carcinoma metastases 2) Drugs:
    5) Activating mutation of the TSH receptor  iodine excess (including iodine-containing contrast
    6) Activating mutation of Gsα (McCune-Albright media)
    syndrome)  Amiodarone
    7) Struma ovarii  Lithium
    8) Drugs: iodine excess (Jod-Basedow phenomenon)
    B. Secondary hyperthyroidism
     Anti-thyroid drugs

    1) TSH-secreting pituitary adenoma  p-aminosalicyclic acid


     interferon-α
    2) Thyroid hormone resistance syndrome: occasional
     other cytokines, aminoglutethimide
    patients may have features of thyrotoxicosis
    3) HCG-secreting tumors 3) Iatrogenic:
    4) Gestational thyrotoxicosis  131
    I treatment
    C. Thyrotoxicosis without hyperthyroidism  Subtotal or total thyroidectomy
    1) Sub acute thyroiditis  External irradiation of neck for lymphoma or
    2) Silent thyroiditis cancer
    3) Other causes of thyroid destruction: amiodarone, 4) Congenital hypothyroidism
    radiation, infarction of adenoma  absent or ectopic thyroid gland
    4) Ingestion of excess thyroid hormone (thyrotoxicosis
     dyshormonogenesis
    factitia)
     TSH-R mutation
    Nb. Circulating TSH levels are low in these forms of 5) Infiltrative disorders
    secondary hyperthyroidism.  Amyloidosis
     Sarcoidosis
     Hemochromatosis
     Scleroderma
     Cystinosis
     Riedel's thyroiditi
    6) Iodine deficiency
    7) Overexpression of type 3 deoiodinase in infantile
    hemangioma
    8) Transient
    9) Silent thyroiditis, including postpartum thyroiditis
    10) Subacute thyroiditis
    11) Withdrawal of thyroxine treatment in individuals
    with an intact thyroid
    B.Secondary Hypothyroidism
    1) Hypopituitarism: tumors, pituitary surgery or
    irradiation, infiltrative disorders, Sheehan's
    syndrome, trauma, genetic forms of combined
    pituitary hormone deficiencies
    2) Isolated TSH deficiency or inactivity
    3) Bexarotene treatment
    4) Hypothalamic disease: tumors, trauma, infiltrative
    disorders, idiopathic

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