Material Safety Data Sheet

Saccharin Sodium

Section 1 - Chemical Product and Company Identification
MSDS Name: Saccharin Sodium
Catalog Numbers: S394-100LB, S394-12, S394-212, S394-500
Synonyms: Sodium saccharin; 1,2-Benzisothiazol-3(2H)-one, 1,1-dioxide, sodium salt; Saccharin, sodium
salt; Saccharin soluble.
Company Identification:
Fisher Scientific
1 Reagent Lane
Fair Lawn, NJ 07410
For information, call: 201-796-7100
Emergency Number: 201-796-7100
For CHEMTREC assistance, call: 800-424-9300
For International CHEMTREC assistance, call: 703-527-3887
Section 2 - Composition, Information on Ingredients

CAS# Chemical Name Percent EINECS/ELINCS
128-44-9 Sodium saccharin 100 204-886-1

Section 3 - Hazards Identification

EMERGENCY OVERVIEW
Appearance: white solid.
Caution! May cause irritation.
Target Organs: None.


Potential Health Effects
Eye: May cause eye irritation.
Skin: Low hazard for usual industrial handling.
Ingestion: The toxicological properties of this substance have not been fully investigated.
Inhalation: Inhalation of dust may cause respiratory tract irritation.
Chronic: Several studies in rats & mice have linked sodium saccharin to bladder tumors, but the
mechanism believed to induce cancer in those animals does not appear to occur in humans. Rats & mice
have a different urinary pH than do humans.
Section 4 - First Aid Measures


Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower
eyelids. Get medical aid.
Skin: Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and
shoes. Get medical aid if irritation develops or persists.
Ingestion: Get medical aid if irritation or symptoms occur.
Inhalation: Remove from exposure and move to fresh air immediately. Get medical aid if cough or other
symptoms appear.
Notes to Physician: Treat symptomatically and supportively.
Section 5 - Fire Fighting Measures


General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand,
MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam.
Flash Point: Not applicable.
Autoignition Temperature: Not applicable.
Explosion Limits, Lower:Not available.
Upper: Not available.
NFPA Rating: (estimated) Health: 0; Flammability: 1; Instability: 0
Section 6 - Accidental Release Measures


General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Avoid generating
dusty conditions. Provide ventilation.
Section 7 - Handling and Storage


Handling: Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with
skin and eyes. Avoid ingestion and inhalation.
Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from
incompatible substances.
Section 8 - Exposure Controls, Personal Protection


Engineering Controls: Good general ventilation should be sufficient to control airborne levels.
Exposure Limits
Chemical Name ACGIH NIOSH OSHA - Final PELs
Sodium saccharin none listed none listed none listed

OSHA Vacated PELs: Sodium saccharin: No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and
face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin: Wear appropriate protective gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN
149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded
or if irritation or other symptoms are experienced.
Section 9 - Physical and Chemical Properties


Physical State: Solid
Appearance: white
Odor: none reported
pH: Not available.
Vapor Pressure: Not available.
Vapor Density: Not available.
Evaporation Rate:Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point:Not available.
Decomposition Temperature:Not available.
Solubility: Freely Soluble.
Specific Gravity/Density:Not available.
Molecular Formula:C7H4O3NSNa
Molecular Weight:205.17
Section 10 - Stability and Reactivity


Chemical Stability: Stable under normal temperatures and pressures.
Conditions to Avoid: Dust generation.
Incompatibilities with Other Materials: Strong oxidizing agents.
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, oxides of sulfur, carbon dioxide,
toxic fumes of sodium oxide.
Hazardous Polymerization: Has not been reported.
Section 11 - Toxicological Information


RTECS#:
CAS# 128-44-9: DE4550000
LD50/LC50:
CAS# 128-44-9:
Oral, mouse: LD50 = 17500 mg/kg;
Oral, rat: LD50 = 14200 mg/kg;
.

Carcinogenicity:
CAS# 128-44-9: Not listed by ACGIH, IARC, NTP, or CA Prop 65.

Epidemiology: Several studies in rats & mice have linked sodium saccharin to bladder tumors, but the
mechanism believed to induce cancer in those animals does not appear to occur in humans.
Teratogenicity: No data available.
Reproductive Effects: See actual entry in RTECS for complete information.
Mutagenicity: See actual entry in RTECS for complete information.
Neurotoxicity: No data available.
Other Studies:
Section 12 - Ecological Information


Ecotoxicity: No data available. The product is chemically identical to the natural amino acid L-Serine and
can therefore can be degraded microbiologically.
Environmental: No information available.
Physical: No information available.
Other: No information available.
Section 13 - Disposal Considerations

Chemical waste generators must determine whether a discarded chemical is classified as a hazardous
waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally,
waste generators must consult state and local hazardous waste regulations to ensure complete and accurate
classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.
Section 14 - Transport Information

US DOT Canada TDG
Shipping Name: Not regulated as a hazardous material No information available.
Hazard Class:
UN Number:
Packing Group:

Section 15 - Regulatory Information

US FEDERAL

TSCA
CAS# 128-44-9 is listed on the TSCA inventory.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
None of the chemicals in this material have an RQ.
SARA Section 302 Extremely Hazardous Substances
None of the chemicals in this product have a TPQ.
Section 313 No chemicals are reportable under Section 313.
Clean Air Act:
This material does not contain any hazardous air pollutants.
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product are listed as Hazardous Substances under the CWA.
None of the chemicals in this product are listed as Priority Pollutants under the CWA.
None of the chemicals in this product are listed as Toxic Pollutants under the CWA.
OSHA:
None of the chemicals in this product are considered highly hazardous by OSHA.
STATE
CAS# 128-44-9 can be found on the following state right to know lists: Pennsylvania, Massachusetts.

California Prop 65

California No Significant Risk Level: None of the chemicals in this product are listed.

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
Not available.
Risk Phrases:

Safety Phrases:

WGK (Water Danger/Protection)
CAS# 128-44-9: 0
Canada - DSL/NDSL
CAS# 128-44-9 is listed on Canada's DSL List.
Canada - WHMIS
not available.
This product has been classified in accordance with the hazard criteria of the Controlled Products
Regulations and the MSDS contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
Section 16 - Additional Information

MSDS Creation Date: 5/12/1998
Revision #6 Date: 11/20/2008

The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty
of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use.
Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall Fisher
be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if Fisher has been advised of the possibility of such damages.