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Acetic Acid-Induced Writhing Test. This Test Was Conducted

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DebbyNovrioza

The document describes an acetic acid-induced writhing test used to test analgesic effects. In the test, mice were pretreated with either a vehicle, various doses of phytol, or indomethacin and morphine as positive controls. They were then injected with acetic acid, and abdominal writhing behaviors were observed and counted as a measure of pain sensation.

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Acetic Acid-Induced Writhing Test. This Test Was Conducted

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DebbyNovrioza
26 views1 page
The document describes an acetic acid-induced writhing test used to test analgesic effects. In the test, mice were pretreated with either a vehicle, various doses of phytol, or indomethacin and morphine as positive controls. They were then injected with acetic acid, and abdominal writhing behaviors were observed and counted as a measure of pain sensation.

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The document describes an acetic acid-induced writhing test used to test analgesic effects. In the test, mice were pretreated with either a vehicle, various doses of phytol, or indomethacin and morphine as positive controls. They were then injected with acetic acid, and abdominal writhing behaviors were observed and counted as a measure of pain sensation.

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© All Rights Reserved
Download as DOC, PDF, TXT or read online from Scribd
Download as doc, pdf, or txt
26 views1 page

Acetic Acid-Induced Writhing Test. This Test Was Conducted

Uploaded by

DebbyNovrioza
The document describes an acetic acid-induced writhing test used to test analgesic effects. In the test, mice were pretreated with either a vehicle, various doses of phytol, or indomethacin and morphine as positive controls. They were then injected with acetic acid, and abdominal writhing behaviors were observed and counted as a measure of pain sensation.

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Acetic Acid-Induced Writhing Test.

This test was conducted


according to the description published by Koster et
al. [24]. The presence of abdominal contortions induced by
an intraperitoneal injection of acetic acid was considered
nociceptive behavior, characterized by abdominal muscle
contractions followed by stretching of the hind limbs [25,
26]. For this experiment, groups of 8 mice received the
following types of pretreatment: vehicle, phytol at the doses
of 25, 50, 100, and 200mg/kg, indomethacin (10mg/kg),
or morphine (10mg/kg). Thirty minutes after pretreatment,
the animals received intraperitoneal injections of a 0.85%
solution of acetic acid (0.1 mL

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